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Ashraf S Ibrahim

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
Phone(310) 222-6424
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    Collapse Research 
    Collapse Research Activities and Funding
    Cross-Kingdom Vaccine Targeting Healthcare-Associated Priority Pathogens
    NIH/NIAID R01AI141202Jan 9, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Humanized monoclonal antibodies to treat mucormycosis
    NIH/NIAID R43AI138904Aug 9, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    Arf6 Inhibition as Novel Treatment for Multidrug Resistance Gram Negative Infections
    NIH/NIAID R33AI119339Jul 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Arf6 Inhibition as Novel Treatment for Multidrug Resistance Gram Negative Infections
    NIH/NIAID R21AI119339Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    An Ftr1 vaccine to abrogate mucormycosis
    NIH/NIAID R21AI082414Feb 15, 2010 - Jan 31, 2013
    Role: Principal Investigator
    Novel Antifungal Strategies for Lethal Mucormycosis
    NIH/NIAID R21AI064716Jul 15, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Iron Uptake and Mucormycosis Pathogenesis
    NIH/NIAID R56AI063503Jul 1, 2005 - Jan 31, 2006
    Role: Principal Investigator
    Novel Toxins and Receptors in Mucormycosis Pathogenesis
    NIH/NIAID R01AI063503Dec 1, 2004 - Jun 30, 2020
    Role: Principal Investigator
    Treatment of Fungal Infections with ATAK Cells
    NIH/NIAID R03AI054531Apr 1, 2003 - Mar 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gebremariam T, Zhang L, Alkhazraji S, Gu Y, Youssef EG, Tong Z, Kish-Trier E, Bajji A, de Araujo CV, Rich B, French SW, Li DY, Mueller AL, Odelberg SJ, Zhu W, Ibrahim AS. Preserving Vascular Integrity Protects Mice Against Multidrug-Resistant Gram-Negative Bacterial Infection. Antimicrob Agents Chemother. 2020 May 11. PMID: 32393494.
      View in: PubMed
    2. Hamdy R, Soliman SSM, Alsaadi AI, Fayed B, Hamoda AM, Elseginy SA, Husseiny MI, Ibrahim AS. Design and synthesis of new drugs inhibitors of Candida albicans hyphae and biofilm formation by upregulating the expression of TUP1 transcription repressor gene. Eur J Pharm Sci. 2020 Apr 06; 148:105327. PMID: 32272212.
      View in: PubMed
    3. Gebremariam T, Alkhazraji S, Alqarihi A, Wiederhold NP, Shaw KJ, Patterson TF, Filler SG, Ibrahim AS. Fosmanogepix (APX001) is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus. Antimicrob Agents Chemother. 2020 Mar 23. PMID: 32205345.
      View in: PubMed
    4. Alkhazraji S, Gebremariam T, Alqarihi A, Gu Y, Mamouei Z, Singh S, Wiederhold NP, Shaw KJ, Ibrahim AS. Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis. Antimicrob Agents Chemother. 2020 02 21; 64(3). PMID: 31818813.
      View in: PubMed
    5. Youssef EG, Zhang L, Alkhazraji S, Gebremariam T, Singh S, Yount NY, Yeaman MR, Uppuluri P, Ibrahim AS. Monoclonal IgM Antibodies Targeting Candida albicans Hyr1 Provide Cross-Kingdom Protection Against Gram-Negative Bacteria. Front Immunol. 2020; 11:76. PMID: 32153560.
      View in: PubMed
    6. Gebremariam T, Alkhazraji S, Gu Y, Singh S, Alqarihi A, Shaw KJ, Ibrahim AS. Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2019 12 20; 64(1). PMID: 31685475.
      View in: PubMed
    7. Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, Hoenigl M, Jensen HE, Lagrou K, Lewis RE, Mellinghoff SC, Mer M, Pana ZD, Seidel D, Sheppard DC, Wahba R, Akova M, Alanio A, Al-Hatmi AMS, Arikan-Akdagli S, Badali H, Ben-Ami R, Bonifaz A, Bretagne S, Castagnola E, Chayakulkeeree M, Colombo AL, Corzo-León DE, Drgona L, Groll AH, Guinea J, Heussel CP, Ibrahim AS, Kanj SS, Klimko N, Lackner M, Lamoth F, Lanternier F, Lass-Floerl C, Lee DG, Lehrnbecher T, Lmimouni BE, Mares M, Maschmeyer G, Meis JF, Meletiadis J, Morrissey CO, Nucci M, Oladele R, Pagano L, Pasqualotto A, Patel A, Racil Z, Richardson M, Roilides E, Ruhnke M, Seyedmousavi S, Sidharthan N, Singh N, Sinko J, Skiada A, Slavin M, Soman R, Spellberg B, Steinbach W, Tan BH, Ullmann AJ, Vehreschild JJ, Vehreschild MJGT, Walsh TJ, White PL, Wiederhold NP, Zaoutis T, Chakrabarti A. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis. 2019 Dec; 19(12):e405-e421. PMID: 31699664.
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    8. Singh S, Uppuluri P, Mamouei Z, Alqarihi A, Elhassan H, French S, Lockhart SR, Chiller T, Edwards JE, Ibrahim AS. The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection. PLoS Pathog. 2019 08; 15(8):e1007460. PMID: 31381597.
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    9. Gebremariam T, Alkhazraji S, Soliman SSM, Gu Y, Jeon HH, Zhang L, French SW, Stevens DA, Edwards JE, Filler SG, Uppuluri P, Ibrahim AS. Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis. Sci Adv. 2019 06; 5(6):eaaw1327. PMID: 31206021.
      View in: PubMed
    10. Alqarihi A, Singh S, Edwards JE, Ibrahim AS, Uppuluri P. NDV-3A vaccination prevents C. albicans colonization of jugular vein catheters in mice. Sci Rep. 2019 04 17; 9(1):6194. PMID: 30996274.
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    11. Gebremariam T, Alkhazraji S, Alqarihi A, Jeon HH, Gu Y, Kapoor M, Shaw KJ, Ibrahim AS. APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2019 02; 63(2). PMID: 30455236.
      View in: PubMed
    12. Andrianaki AM, Kyrmizi I, Thanopoulou K, Baldin C, Drakos E, Soliman SSM, Shetty AC, McCracken C, Akoumianaki T, Stylianou K, Ioannou P, Pontikoglou C, Papadaki HA, Tzardi M, Belle V, Etienne E, Beauvais A, Samonis G, Kontoyiannis DP, Andreakos E, Bruno VM, Ibrahim AS, Chamilos G. Author Correction: Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species. Nat Commun. 2018 11 22; 9(1):5015. PMID: 30467313.
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    13. Mamouei Z, Alqarihi A, Singh S, Xu S, Mansour MK, Ibrahim AS, Uppuluri P. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018 10 31; 3(5). PMID: 30381356.
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    14. Baldin C, Soliman SSM, Jeon HH, Alkhazraji S, Gebremariam T, Gu Y, Bruno VM, Cornely OA, Leather HL, Sugrue MW, Wingard JR, Stevens DA, Edwards JE, Ibrahim AS. PCR-Based Approach Targeting Mucorales-Specific Gene Family for Diagnosis of Mucormycosis. J Clin Microbiol. 2018 10; 56(10). PMID: 30068535.
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    15. Andrianaki AM, Kyrmizi I, Thanopoulou K, Baldin C, Drakos E, Soliman SSM, Shetty AC, McCracken C, Akoumianaki T, Stylianou K, Ioannou P, Pontikoglou C, Papadaki HA, Tzardi M, Belle V, Etienne E, Beauvais A, Samonis G, Kontoyiannis DP, Andreakos E, Bruno VM, Ibrahim AS, Chamilos G. Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species. Nat Commun. 2018 08 20; 9(1):3333. PMID: 30127354.
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    16. Watkins TN, Gebremariam T, Swidergall M, Shetty AC, Graf KT, Alqarihi A, Alkhazraji S, Alsaadi AI, Edwards VL, Filler SG, Ibrahim AS, Bruno VM. Inhibition of EGFR Signaling Protects from Mucormycosis. mBio. 2018 08 14; 9(4). PMID: 30108171.
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    17. Uppuluri P, Singh S, Alqarihi A, Schmidt CS, Hennessey JP, Yeaman MR, Filler SG, Edwards JE, Ibrahim AS. Human Anti-Als3p Antibodies Are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis. Front Immunol. 2018; 9:1349. PMID: 29963049.
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    18. Edwards JE, Schwartz MM, Schmidt CS, Sobel JD, Nyirjesy P, Schodel F, Marchus E, Lizakowski M, DeMontigny EA, Hoeg J, Holmberg T, Cooke MT, Hoover K, Edwards L, Jacobs M, Sussman S, Augenbraun M, Drusano M, Yeaman MR, Ibrahim AS, Filler SG, Hennessey JP. A Fungal Immunotherapeutic Vaccine (NDV-3A) for Treatment of Recurrent Vulvovaginal Candidiasis-A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial. Clin Infect Dis. 2018 06 01; 66(12):1928-1936. PMID: 29697768.
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    19. Uppuluri P, Lin L, Alqarihi A, Luo G, Youssef EG, Alkhazraji S, Yount NY, Ibrahim BA, Bolaris MA, Edwards JE, Swidergall M, Filler SG, Yeaman MR, Ibrahim AS. The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection. PLoS Pathog. 2018 05; 14(5):e1007056. PMID: 29746596.
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    20. Shumilov E, Bacher U, Perske C, Mohr A, Eiffert H, Hasenkamp J, Trümper L, Wulf GG, Ströbel P, Ibrahim AS, Venkataramani V. In Situ Validation of the Endothelial Cell Receptor GRP78 in a Case of Rhinocerebral Mucormycosis. Antimicrob Agents Chemother. 2018 05; 62(5). PMID: 29483124.
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    21. Soliman SSM, Alsaadi AI, Youssef EG, Khitrov G, Noreddin AM, Husseiny MI, Ibrahim AS. Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens. Molecules. 2017 Dec 20; 22(12). PMID: 29261103.
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    22. Ibrahim AS, Voelz K. The mucormycete-host interface. Curr Opin Microbiol. 2017 Dec; 40:40-45. PMID: 29107938.
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    23. Gebremariam T, Alkhazraji S, Lin L, Wiederhold NP, Garvey EP, Hoekstra WJ, Schotzinger RJ, Patterson TF, Filler SG, Ibrahim AS. Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection. Antimicrob Agents Chemother. 2017 09; 61(9). PMID: 28652241.
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    24. Gebremariam T, Alkhazraji S, Baldin C, Kovanda L, Wiederhold NP, Ibrahim AS. Prophylaxis with Isavuconazole or Posaconazole Protects Immunosuppressed Mice from Pulmonary Mucormycosis. Antimicrob Agents Chemother. 2017 05; 61(5). PMID: 28264840.
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    25. Liu H, Lee MJ, Solis NV, Phan QT, Swidergall M, Ralph B, Ibrahim AS, Sheppard DC, Filler SG. Aspergillus fumigatus CalA binds to integrin a5ß1 and mediates host cell invasion. Nat Microbiol. 2016 Nov 14; 2:16211. PMID: 27841851.
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    26. Gebremariam T, Wiederhold NP, Alqarihi A, Uppuluri P, Azie N, Edwards JE, Ibrahim AS. Monotherapy or combination therapy of isavuconazole and micafungin for treating murine mucormycosis. J Antimicrob Chemother. 2017 02; 72(2):462-466. PMID: 27798213.
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    27. Chibucos MC, Soliman S, Gebremariam T, Lee H, Daugherty S, Orvis J, Shetty AC, Crabtree J, Hazen TH, Etienne KA, Kumari P, O'Connor TD, Rasko DA, Filler SG, Fraser CM, Lockhart SR, Skory CD, Ibrahim AS, Bruno VM. An integrated genomic and transcriptomic survey of mucormycosis-causing fungi. Nat Commun. 2016 07 22; 7:12218. PMID: 27447865.
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    28. Gebremariam T, Lin L, Liu M, Kontoyiannis DP, French S, Edwards JE, Filler SG, Ibrahim AS. Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis. J Clin Invest. 2016 06 01; 126(6):2280-94. PMID: 27159390.
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    29. Bellanger AP, Tatara AM, Shirazi F, Gebremariam T, Albert ND, Lewis RE, Ibrahim AS, Kontoyiannis DP. Statin Concentrations Below the Minimum Inhibitory Concentration Attenuate the Virulence of Rhizopus oryzae. J Infect Dis. 2016 07 01; 214(1):114-21. PMID: 26984141.
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    30. Gebremariam T, Wiederhold NP, Fothergill AW, Garvey EP, Hoekstra WJ, Schotzinger RJ, Patterson TF, Filler SG, Ibrahim AS. VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection. Antimicrob Agents Chemother. 2015 Dec; 59(12):7815-7. PMID: 26369977.
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    31. Chan LC, Chaili S, Filler SG, Barr K, Wang H, Kupferwasser D, Edwards JE, Xiong YQ, Ibrahim AS, Miller LS, Schmidt CS, Hennessey JP, Yeaman MR. Nonredundant Roles of Interleukin-17A (IL-17A) and IL-22 in Murine Host Defense against Cutaneous and Hematogenous Infection Due to Methicillin-Resistant Staphylococcus aureus. Infect Immun. 2015 Nov; 83(11):4427-37. PMID: 26351278.
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    32. Liu M, Lin L, Gebremariam T, Luo G, Skory CD, French SW, Chou TF, Edwards JE, Ibrahim AS. Fob1 and Fob2 Proteins Are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine. PLoS Pathog. 2015 May; 11(5):e1004842. PMID: 25974051.
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    33. Chibucos MC, Etienne KA, Orvis J, Lee H, Daugherty S, Lockhart SR, Ibrahim AS, Bruno VM. The genome sequence of four isolates from the family Lichtheimiaceae. Pathog Dis. 2015 Jul; 73(5). PMID: 25857734.
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    34. Shirazi F, Kontoyiannis DP, Ibrahim AS. Iron starvation induces apoptosis in Rhizopus oryzae in vitro. Virulence. 2015; 6(2):121-6. PMID: 25830548.
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    35. Yeaman MR, Filler SG, Chaili S, Barr K, Wang H, Kupferwasser D, Hennessey JP, Fu Y, Schmidt CS, Edwards JE, Xiong YQ, Ibrahim AS. Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):E5555-63. PMID: 25489065.
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    36. Walsh TJ, Skiada A, Cornely OA, Roilides E, Ibrahim A, Zaoutis T, Groll A, Lortholary O, Kontoyiannis DP, Petrikkos G. Development of new strategies for early diagnosis of mucormycosis from bench to bedside. Mycoses. 2014 Dec; 57 Suppl 3:2-7. PMID: 25475924.
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    37. Mendoza L, Vilela R, Voelz K, Ibrahim AS, Voigt K, Lee SC. Human Fungal Pathogens of Mucorales and Entomophthorales. Cold Spring Harb Perspect Med. 2014 Nov 06; 5(4). PMID: 25377138.
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    38. Yeaman MR, Filler SG, Schmidt CS, Ibrahim AS, Edwards JE, Hennessey JP. Applying Convergent Immunity to Innovative Vaccines Targeting Staphylococcus aureus. Front Immunol. 2014; 5:463. PMID: 25309545.
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    39. Ibrahim AS. Host-iron assimilation: pathogenesis and novel therapies of mucormycosis. Mycoses. 2014 Dec; 57 Suppl 3:13-7. PMID: 25178879.
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    40. Luo G, Gebremariam T, Clemons KV, Stevens DA, Ibrahim AS. Heat-killed yeast protects diabetic ketoacidotic-steroid treated mice from pulmonary mucormycosis. Vaccine. 2014 Jun 17; 32(29):3573-6. PMID: 24814556.
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    41. Luo G, Gebremariam T, Lee H, Edwards JE, Kovanda L, Ibrahim AS. Isavuconazole therapy protects immunosuppressed mice from mucormycosis. Antimicrob Agents Chemother. 2014; 58(4):2450-3. PMID: 24492363.
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    42. Gebremariam T, Liu M, Luo G, Bruno V, Phan QT, Waring AJ, Edwards JE, Filler SG, Yeaman MR, Ibrahim AS. CotH3 mediates fungal invasion of host cells during mucormycosis. J Clin Invest. 2014 Jan; 124(1):237-50. PMID: 24355926.
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    43. Ibrahim AS, Kontoyiannis DP. Update on mucormycosis pathogenesis. Curr Opin Infect Dis. 2013 Dec; 26(6):508-15. PMID: 24126718.
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    44. Ibrahim AS, Luo G, Gebremariam T, Lee H, Schmidt CS, Hennessey JP, French SW, Yeaman MR, Filler SG, Edwards JE. NDV-3 protects mice from vulvovaginal candidiasis through T- and B-cell immune response. Vaccine. 2013 Nov 12; 31(47):5549-56. PMID: 24063977.
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    45. Luo G, Gebremariam T, Lee H, French SW, Wiederhold NP, Patterson TF, Filler SG, Ibrahim AS. Efficacy of liposomal amphotericin B and posaconazole in intratracheal models of murine mucormycosis. Antimicrob Agents Chemother. 2013 Jul; 57(7):3340-7. PMID: 23650163.
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    46. Fu Y, Phan QT, Luo G, Solis NV, Liu Y, Cormack BP, Edwards JE, Ibrahim AS, Filler SG. Investigation of the function of Candida albicans Als3 by heterologous expression in Candida glabrata. Infect Immun. 2013 Jul; 81(7):2528-35. PMID: 23630968.
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    47. Schmidt CS, White CJ, Ibrahim AS, Filler SG, Fu Y, Yeaman MR, Edwards JE, Hennessey JP. NDV-3, a recombinant alum-adjuvanted vaccine for Candida and Staphylococcus aureus, is safe and immunogenic in healthy adults. Vaccine. 2012 Dec 14; 30(52):7594-600. PMID: 23099329.
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    48. Spellberg B, Kontoyiannis DP, Fredricks D, Morris MI, Perfect JR, Chin-Hong PV, Ibrahim AS, Brass EP. Risk factors for mortality in patients with mucormycosis. Med Mycol. 2012 Aug; 50(6):611-8. PMID: 22435877.
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    49. Luo G, Spellberg B, Gebremariam T, Bolaris M, Lee H, Fu Y, French SW, Ibrahim AS. Diabetic murine models for Acinetobacter baumannii infection. J Antimicrob Chemother. 2012 Jun; 67(6):1439-45. PMID: 22389456.
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    50. Ibrahim AS, Spellberg B, Walsh TJ, Kontoyiannis DP. Pathogenesis of mucormycosis. Clin Infect Dis. 2012 Feb; 54 Suppl 1:S16-22. PMID: 22247441.
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    51. Spellberg B, Ibrahim A, Roilides E, Lewis RE, Lortholary O, Petrikkos G, Kontoyiannis DP, Walsh TJ. Combination therapy for mucormycosis: why, what, and how? Clin Infect Dis. 2012 Feb; 54 Suppl 1:S73-8. PMID: 22247449.
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    52. Kontoyiannis DP, Lewis RE, Lortholary O, Lotholary O, Spellberg B, Petrikkos G, Roilides E, Roillides E, Ibrahim A, Walsh TJ. Future directions in mucormycosis research. Clin Infect Dis. 2012 Feb; 54 Suppl 1:S79-85. PMID: 22247450.
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    53. Luo G, Lin L, Ibrahim AS, Baquir B, Pantapalangkoor P, Bonomo RA, Doi Y, Adams MD, Russo TA, Spellberg B. Active and passive immunization protects against lethal, extreme drug resistant-Acinetobacter baumannii infection. PLoS One. 2012; 7(1):e29446. PMID: 22253723.
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    54. Lin L, Ibrahim AS, Baquir B, Palosaari A, Spellberg B. Luminescent-activated transfected killer cells to monitor leukocyte trafficking during systemic bacterial and fungal infection. J Infect Dis. 2012 Jan 15; 205(2):337-47. PMID: 22124127.
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    55. Luo G, Ibrahim AS, French SW, Edwards JE, Fu Y. Active and passive immunization with rHyr1p-N protects mice against hematogenously disseminated candidiasis. PLoS One. 2011; 6(10):e25909. PMID: 22028796.
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    56. Spellberg B, Ibrahim AS, Chin-Hong PV, Kontoyiannis DP, Morris MI, Perfect JR, Fredricks D, Brass EP. The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial. J Antimicrob Chemother. 2012 Mar; 67(3):715-22. PMID: 21937481.
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    57. Ibrahim AS. Host cell invasion in mucormycosis: role of iron. Curr Opin Microbiol. 2011 Aug; 14(4):406-11. PMID: 21807554.
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    58. Ibrahim AS, Gebremariam T, Luo G, Fu Y, French SW, Edwards JE, Spellberg B. Combination therapy of murine mucormycosis or aspergillosis with iron chelation, polyenes, and echinocandins. Antimicrob Agents Chemother. 2011 Apr; 55(4):1768-70. PMID: 21263057.
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    59. Spellberg B, Ibrahim AS. Recent advances in the treatment of mucormycosis. Curr Infect Dis Rep. 2010 Nov; 12(6):423-9. PMID: 21308550.
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    60. Liu H, Gravelat FN, Chiang LY, Chen D, Vanier G, Ejzykowicz DE, Ibrahim AS, Nierman WC, Sheppard DC, Filler SG. Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis. Mol Microbiol. 2010 Nov; 78(4):1038-54. PMID: 21062375.
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    61. Lin L, Ibrahim AS, Baquir B, Fu Y, Applebaum D, Schwartz J, Wang A, Avanesian V, Spellberg B. Safety and efficacy of activated transfected killer cells for neutropenic fungal infections. J Infect Dis. 2010 Jun 01; 201(11):1708-17. PMID: 20397927.
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    62. Luo G, Ibrahim AS, Spellberg B, Nobile CJ, Mitchell AP, Fu Y. Candida albicans Hyr1p confers resistance to neutrophil killing and is a potential vaccine target. J Infect Dis. 2010 Jun 01; 201(11):1718-28. PMID: 20415594.
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    63. Ibrahim AS, Gebremariam T, Lin L, Luo G, Husseiny MI, Skory CD, Fu Y, French SW, Edwards JE, Spellberg B. The high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis. Mol Microbiol. 2010 Aug; 77(3):587-604. PMID: 20545847.
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    64. Liu M, Spellberg B, Phan QT, Fu Y, Fu Y, Lee AS, Edwards JE, Filler SG, Ibrahim AS. The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice. J Clin Invest. 2010 Jun; 120(6):1914-24. PMID: 20484814.
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    65. Baquir B, Lin L, Ibrahim AS, Fu Y, Avanesian V, Tu A, Edwards J, Spellberg B. Immunological reactivity of blood from healthy humans to the rAls3p-N vaccine protein. J Infect Dis. 2010 Feb 01; 201(3):473-7. PMID: 20039802.
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    66. Lin L, Ibrahim AS, Xu X, Farber JM, Avanesian V, Baquir B, Fu Y, French SW, Edwards JE, Spellberg B. Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog. 2009 Dec; 5(12):e1000703. PMID: 20041174.
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    67. Ibrahim AS, Gebremariam T, French SW, Edwards JE, Spellberg B. The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis. J Antimicrob Chemother. 2010 Feb; 65(2):289-92. PMID: 19942619.
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    68. Ma LJ, Ibrahim AS, Skory C, Grabherr MG, Burger G, Butler M, Elias M, Idnurm A, Lang BF, Sone T, Abe A, Calvo SE, Corrochano LM, Engels R, Fu J, Hansberg W, Kim JM, Kodira CD, Koehrsen MJ, Liu B, Miranda-Saavedra D, O'Leary S, Ortiz-Castellanos L, Poulter R, Rodriguez-Romero J, Ruiz-Herrera J, Shen YQ, Zeng Q, Galagan J, Birren BW, Cuomo CA, Wickes BL. Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. PLoS Genet. 2009 Jul; 5(7):e1000549. PMID: 19578406.
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    69. Spellberg B, Walsh TJ, Kontoyiannis DP, Edwards J, Ibrahim AS. Recent advances in the management of mucormycosis: from bench to bedside. Clin Infect Dis. 2009 Jun 15; 48(12):1743-51. PMID: 19435437.
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    70. Spellberg B, Andes D, Perez M, Anglim A, Bonilla H, Mathisen GE, Walsh TJ, Ibrahim AS. Safety and outcomes of open-label deferasirox iron chelation therapy for mucormycosis. Antimicrob Agents Chemother. 2009 Jul; 53(7):3122-5. PMID: 19433555.
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    71. Lin L, Ibrahim AS, Baquir B, Avanesian V, Fu Y, Spellberg B. Immunological surrogate marker of rAls3p-N vaccine-induced protection against Staphylococcus aureus. FEMS Immunol Med Microbiol. 2009 Apr; 55(3):293-5. PMID: 19159425.
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    72. Ibrahim AS, Edwards JE, Bryant R, Spellberg B. Economic burden of mucormycosis in the United States: can a vaccine be cost-effective? Med Mycol. 2009; 47(6):592-600. PMID: 18798118.
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    73. Ibrahim AS, Spellberg B, Edwards J. Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment. Curr Opin Infect Dis. 2008 Dec; 21(6):620-5. PMID: 18978530.
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    74. Ibrahim AS, Gebremariam T, Schwartz JA, Edwards JE, Spellberg B. Posaconazole mono- or combination therapy for treatment of murine zygomycosis. Antimicrob Agents Chemother. 2009 Feb; 53(2):772-5. PMID: 18936190.
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    75. Ibrahim AS, Gebremariam T, Liu M, Chamilos G, Kontoyiannis D, Mink R, Kwon-Chung KJ, Fu Y, Skory CD, Edwards JE, Spellberg B. Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosis. J Infect Dis. 2008 Oct 01; 198(7):1083-90. PMID: 18694335.
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    76. Reed C, Bryant R, Ibrahim AS, Edwards J, Filler SG, Goldberg R, Spellberg B. Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis. Clin Infect Dis. 2008 Aug 01; 47(3):364-71. PMID: 18558882.
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    77. Spellberg B, Ibrahim AS, Yeaman MR, Lin L, Fu Y, Avanesian V, Bayer AS, Filler SG, Lipke P, Otoo H, Edwards JE. The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus. Infect Immun. 2008 Oct; 76(10):4574-80. PMID: 18644876.
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    78. Spellberg B, Ibrahim AS, Lin L, Avanesian V, Fu Y, Lipke P, Otoo H, Ho T, Edwards JE. Antibody titer threshold predicts anti-candidal vaccine efficacy even though the mechanism of protection is induction of cell-mediated immunity. J Infect Dis. 2008 Apr 01; 197(7):967-71. PMID: 18419471.
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    79. Ibrahim AS, Gebremariam T, Husseiny MI, Stevens DA, Fu Y, Edwards JE, Spellberg B. Comparison of lipid amphotericin B preparations in treating murine zygomycosis. Antimicrob Agents Chemother. 2008 Apr; 52(4):1573-6. PMID: 18227182.
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    80. Ibrahim AS, Gebremariam T, Fu Y, Edwards JE, Spellberg B. Combination echinocandin-polyene treatment of murine mucormycosis. Antimicrob Agents Chemother. 2008 Apr; 52(4):1556-8. PMID: 18212099.
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    81. Lin L, Ibrahim AS, Avanesian V, Edwards JE, Fu Y, Baquir B, Taub R, Spellberg B. Considerable differences in vaccine immunogenicities and efficacies related to the diluent used for aluminum hydroxide adjuvant. Clin Vaccine Immunol. 2008 Mar; 15(3):582-4. PMID: 18184821.
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    82. Fu Y, Luo G, Spellberg BJ, Edwards JE, Ibrahim AS. Gene overexpression/suppression analysis of candidate virulence factors of Candida albicans. Eukaryot Cell. 2008 Mar; 7(3):483-92. PMID: 18178776.
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    83. Ibrahim AS, Gebermariam T, Fu Y, Lin L, Husseiny MI, French SW, Schwartz J, Skory CD, Edwards JE, Spellberg BJ. The iron chelator deferasirox protects mice from mucormycosis through iron starvation. J Clin Invest. 2007 Sep; 117(9):2649-57. PMID: 17786247.
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    84. Skory CD, Ibrahim AS. Native and modified lactate dehydrogenase expression in a fumaric acid producing isolate Rhizopus oryzae 99-880. Curr Genet. 2007 Jul; 52(1):23-33. PMID: 17551728.
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    85. Phan QT, Myers CL, Fu Y, Sheppard DC, Yeaman MR, Welch WH, Ibrahim AS, Edwards JE, Filler SG. Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells. PLoS Biol. 2007 Mar; 5(3):e64. PMID: 17311474.
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    86. Spellberg BJ, Collins M, Avanesian V, Gomez M, Edwards JE, Cogle C, Applebaum D, Fu Y, Ibrahim AS. Optimization of a myeloid cell transfusion strategy for infected neutropenic hosts. J Leukoc Biol. 2007 Mar; 81(3):632-41. PMID: 17158608.
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    87. Reed C, Ibrahim A, Edwards JE, Walot I, Spellberg B. Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis. Antimicrob Agents Chemother. 2006 Nov; 50(11):3968-9. PMID: 17000743.
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    88. Spellberg B, Schwartz J, Fu Y, Avanesian V, Adler-Moore J, Edwards JE, Ibrahim AS. Comparison of antifungal treatments for murine fusariosis. J Antimicrob Chemother. 2006 Nov; 58(5):973-9. PMID: 16973654.
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    89. Ibrahim AS, Edwards JE, Fu Y, Spellberg B. Deferiprone iron chelation as a novel therapy for experimental mucormycosis. J Antimicrob Chemother. 2006 Nov; 58(5):1070-3. PMID: 16928702.
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    90. Rieg G, Spellberg B, Schwartz J, Fu Y, Edwards JE, Sheppard DC, Ibrahim AS. Antifungal prophylaxis is effective against murine invasive pulmonary aspergillosis. Antimicrob Agents Chemother. 2006 Aug; 50(8):2895-6. PMID: 16870798.
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    91. Mertens JA, Skory CD, Ibrahim AS. Plasmids for expression of heterologous proteins in Rhizopus oryzae. Arch Microbiol. 2006 Jul; 186(1):41-50. PMID: 16804680.
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    92. Spellberg BJ, Ibrahim AS, Avanesian V, Fu Y, Myers C, Phan QT, Filler SG, Yeaman MR, Edwards JE. Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis. J Infect Dis. 2006 Jul 15; 194(2):256-60. PMID: 16779733.
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    93. Ibrahim AS, Spellberg BJ, Avanesian V, Fu Y, Edwards JE. The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis. Infect Immun. 2006 May; 74(5):3039-41. PMID: 16622247.
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    94. Attallah AM, Ismail H, Ibrahim AS, Al-Zawawy LA, El-Ebiary MT, El-Waseef AM. Immunochemical identification and detection of a 36-kDa Toxoplasma gondii circulating antigen in sera of infected women for laboratory diagnosis of toxoplasmosis. J Immunoassay Immunochem. 2006; 27(1):45-60. PMID: 16450868.
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    95. Ibrahim AS, Magee BB, Sheppard DC, Yang M, Kauffman S, Becker J, Edwards JE, Magee PT. Effects of ploidy and mating type on virulence of Candida albicans. Infect Immun. 2005 Nov; 73(11):7366-74. PMID: 16239535.
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    96. Spellberg BJ, Ibrahim AS, Avenissian V, Filler SG, Myers CL, Fu Y, Edwards JE. The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised mice. Infect Immun. 2005 Sep; 73(9):6191-3. PMID: 16113347.
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    97. Spellberg B, Edwards J, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev. 2005 Jul; 18(3):556-69. PMID: 16020690.
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    98. Spellberg B, Ibrahim AS, Edwards JE, Filler SG. Mice with disseminated candidiasis die of progressive sepsis. J Infect Dis. 2005 Jul 15; 192(2):336-43. PMID: 15962230.
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    99. Spellberg BJ, Collins M, French SW, Edwards JE, Fu Y, Ibrahim AS. A phagocytic cell line markedly improves survival of infected neutropenic mice. J Leukoc Biol. 2005 Aug; 78(2):338-44. PMID: 15857941.
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    100. Toenjes KA, Munsee SM, Ibrahim AS, Jeffrey R, Edwards JE, Johnson DI. Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans. Antimicrob Agents Chemother. 2005 Mar; 49(3):963-72. PMID: 15728890.
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    101. Spellberg B, Fu Y, Edwards JE, Ibrahim AS. Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice. Antimicrob Agents Chemother. 2005 Feb; 49(2):830-2. PMID: 15673781.
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    102. Ibrahim AS, Spellberg B, Avanessian V, Fu Y, Edwards JE. Rhizopus oryzae adheres to, is phagocytosed by, and damages endothelial cells in vitro. Infect Immun. 2005 Feb; 73(2):778-83. PMID: 15664916.
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    103. Ibrahim AS, Spellberg BJ, Avenissian V, Fu Y, Filler SG, Edwards JE. Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity. Infect Immun. 2005 Feb; 73(2):999-1005. PMID: 15664943.
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    104. Ibrahim AS, Bowman JC, Avanessian V, Brown K, Spellberg B, Edwards JE, Douglas CM. Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis. Antimicrob Agents Chemother. 2005 Feb; 49(2):721-7. PMID: 15673756.
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    105. Fu Y, Lee H, Collins M, Tsai HF, Spellberg B, Edwards JE, Kwon-Chung KJ, Ibrahim AS. Cloning and functional characterization of the Rhizopus oryzae high affinity iron permease (rFTR1) gene. FEMS Microbiol Lett. 2004 Jun 01; 235(1):169-76. PMID: 15158278.
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    106. VandenBerg AL, Ibrahim AS, Edwards JE, Toenjes KA, Johnson DI. Cdc42p GTPase regulates the budded-to-hyphal-form transition and expression of hypha-specific transcripts in Candida albicans. Eukaryot Cell. 2004 Jun; 3(3):724-34. PMID: 15189993.
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    107. Sheppard DC, Yeaman MR, Welch WH, Phan QT, Fu Y, Ibrahim AS, Filler SG, Zhang M, Waring AJ, Edwards JE. Functional and structural diversity in the Als protein family of Candida albicans. J Biol Chem. 2004 Jul 16; 279(29):30480-9. PMID: 15128742.
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    108. Sheppard DC, Rieg G, Chiang LY, Filler SG, Edwards JE, Ibrahim AS. Novel inhalational murine model of invasive pulmonary aspergillosis. Antimicrob Agents Chemother. 2004 May; 48(5):1908-11. PMID: 15105158.
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    109. Loza L, Fu Y, Ibrahim AS, Sheppard DC, Filler SG, Edwards JE. Functional analysis of the Candida albicans ALS1 gene product. Yeast. 2004 Apr 30; 21(6):473-82. PMID: 15116430.
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    110. Spellberg B, Johnston D, Phan QT, Edwards JE, French SW, Ibrahim AS, Filler SG. Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis. Infect Immun. 2003 Oct; 71(10):5756-64. PMID: 14500497.
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    111. Ibrahim AS, Avanessian V, Spellberg B, Edwards JE. Liposomal amphotericin B, and not amphotericin B deoxycholate, improves survival of diabetic mice infected with Rhizopus oryzae. Antimicrob Agents Chemother. 2003 Oct; 47(10):3343-4. PMID: 14506054.
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    112. Fu Y, Ibrahim AS, Sheppard DC, Chen YC, French SW, Cutler JE, Filler SG, Edwards JE. Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway. Mol Microbiol. 2002 Apr; 44(1):61-72. PMID: 11967069.
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