Shakti Singh

Title(s)Assistant Professor-in-Residence, Medicine
ORCID ORCID Icon0000-0001-6521-0998 Additional info
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    National Cancer Institute, Frederick, MarylandPostdoctoral Research01/2017Immunology
    University of Alberta, Edmonton, Alberta, CanadaPhD11/2015Experimental Surgery (Immunology)
    CCS University, Meerut, IndiaMSc06/2005Microbiology

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    Dr. Singh Singh is an expert immunologist and vaccinologist. Dr. Singh joined as an Assistant Professor at the David Geffen School of Medicine at UCLA in 2023, while also continuing as an Investigator at The Lundquist Institute at Harbor-UCLA Medical Center. Dr. Singh's laboratory is engaged in pioneering research on novel Candida auris surface proteins, investigating their role in virulence and their potential application in the development of vaccines and immunotherapies. To achieve these goals, Dr. Singh employs cutting-edge methodologies such as bioinformatics, immuno-proteomics, and molecular biology techniques.

    Dr. Singh's academic training includes a doctorate degree in Experimental Surgery from the University of Alberta, Canada. His doctoral research focused on investigating the immune response against the Hepatitis C virus (HCV) and uncovering the phenomenon of adaptive heterologous immunity. Dr. Singh did his first post-doctoral training at the National Cancer Institute (NIH) in Frederick, Maryland. Here, he dedicated his efforts to the development of DNA-protein-based vaccines and immunotherapeutic strategies for HIV infection. Continuing his pursuit of scientific excellence, Dr. Singh joined The Lundquist Institute at Harbor-UCLA Medical Center in 2017 as a Postdoctoral Fellow and later in 2019 as a Research Scientist. Here, Dr. Singh's research focused on the study of fungal-host interactions and pathogenesis. Furthermore, he spearheaded the development of vaccines and immunotherapies targeting healthcare-associated infections, including Candida albicans, Candida auris, Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, and Carbapenem-resistant Klebsiella pneumoniae.

    In his ~17 years of research career, Dr. Singh has made significant contributions to the scientific community. He has authored >30 peer-reviewed research articles, reviews, and editorials, edited two books, published multiple book chapters, and holds several patents. Dr. Singh's work has been recognized through numerous grants, including funding from reputable institutions such as the American Heart Association and UCLA CTSI grants. Dr. Singh's expertise and reputation have led him to assume key editorial roles, serving as an Associate Editor for Frontiers in Immunology and as a reviewer for various prestigious scientific journals.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Candida auris-specific adhesin, Scf1, governs surface association, colonization, and virulence. Science. 2023 Sep 29; 381(6665):1461-1467. Santana DJ, Anku JAE, Zhao G, Zarnowski R, Johnson CJ, Hautau H, Visser ND, Ibrahim AS, Andes D, Nett JE, Singh S, O'Meara TR. PMID: 37769084.
      View in: PubMed   Mentions:
    2. Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. PLoS Pathog. 2023 Aug 23; 19(8):e1011579. Phan QT, Solis NV, Cravener MV, Swidergall M, Lin J, Huang MY, Liu H, Singh S, Ibrahim AS, Mazzone M, Mitchell AP, Filler SG. PMID: 37611070.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. bioRxiv. 2023 Feb 23. Phan QT, Solis NV, Cravener MV, Swidergall M, Lin J, Huang MY, Liu H, Singh S, Ibrahim AS, Mazzone M, Mitchell AP, Filler SG. PMID: 36865306; PMCID: PMC9980113.
      View in: PubMed   Mentions:
    4. Protective Efficacy of Anti-Hyr1p Monoclonal Antibody against Systemic Candidiasis Due to Multi-Drug-Resistant Candida auris. J Fungi (Basel). 2023 Jan 12; 9(1). Singh S, Barbarino A, Youssef EG, Coleman D, Gebremariam T, Ibrahim AS. PMID: 36675924; PMCID: PMC9860579.
      View in: PubMed   Mentions:
    5. Niclosamide-loaded nanoparticles disrupt Candida biofilms and protect mice from mucosal candidiasis. PLoS Biol. 2022 08; 20(8):e3001762. Sutar Y, Nabeela S, Singh S, Alqarihi A, Solis N, Ghebremariam T, Filler S, Ibrahim AS, Date A, Uppuluri P. PMID: 35976859; PMCID: PMC9385045.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. Antibodies targeting Candida albicans Als3 and Hyr1 antigens protect neonatal mice from candidiasis. Front Immunol. 2022; 13:925821. Singh S, Nabeela S, Barbarino A, Ibrahim AS, Uppuluri P. PMID: 35935947; PMCID: PMC9355692.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    7. Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells. PLoS Pathog. 2022 07; 18(7):e1010681. Phan QT, Solis NV, Lin J, Swidergall M, Singh S, Liu H, Sheppard DC, Ibrahim AS, Mitchell AP, Filler SG. PMID: 35797411; PMCID: PMC9295963.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Combination treatment of liposomal amphotericin B and isavuconazole is synergistic in treating experimental mucormycosis. J Antimicrob Chemother. 2021 09 15; 76(10):2636-2639. Gebremariam T, Gu Y, Singh S, Kitt TM, Ibrahim AS. PMID: 34263306; PMCID: PMC8446914.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    9. Adaptive immunity induces mutualism between commensal eukaryotes. Nature. 2021 08; 596(7870):114-118. Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. PMID: 34262174; PMCID: PMC8904204.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    10. An evolutionarily diverged mitochondrial protein controls biofilm growth and virulence in Candida albicans. PLoS Biol. 2021 03; 19(3):e3000957. Mamouei Z, Singh S, Lemire B, Gu Y, Alqarihi A, Nabeela S, Li D, Ibrahim A, Uppuluri P. PMID: 33720927; PMCID: PMC8007014.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    11. Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis. Nat Microbiol. 2021 03; 6(3):313-326. Soliman SSM, Baldin C, Gu Y, Singh S, Gebremariam T, Swidergall M, Alqarihi A, Youssef EG, Alkhazraji S, Pikoulas A, Perske C, Venkataramani V, Rich A, Bruno VM, Hotopp JD, Mantis NJ, Edwards JE, Filler SG, Chamilos G, Vitetta ES, Ibrahim AS. PMID: 33462434; PMCID: PMC7914224.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    12. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nat Commun. 2020 12 22; 11(1):6429. Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE. PMID: 33353950; PMCID: PMC7755909.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    13. Editorial: Heterologous Immunity: Implications and Applications in Vaccines and Immunotherapies. Front Immunol. 2020; 11:1408. Singh S, Yanow SK, Agrawal B. PMID: 32774334; PMCID: PMC7381340.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    14. Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis. Antimicrob Agents Chemother. 2020 02 21; 64(3). Alkhazraji S, Gebremariam T, Alqarihi A, Gu Y, Mamouei Z, Singh S, Wiederhold NP, Shaw KJ, Ibrahim AS. PMID: 31818813; PMCID: PMC7038288.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    15. Monoclonal IgM Antibodies Targeting Candida albicans Hyr1 Provide Cross-Kingdom Protection Against Gram-Negative Bacteria. Front Immunol. 2020; 11:76. Youssef EG, Zhang L, Alkhazraji S, Gebremariam T, Singh S, Yount NY, Yeaman MR, Uppuluri P, Ibrahim AS. PMID: 32153560; PMCID: PMC7045048.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2019 12 20; 64(1). Gebremariam T, Alkhazraji S, Gu Y, Singh S, Alqarihi A, Shaw KJ, Ibrahim AS. PMID: 31685475; PMCID: PMC7187618.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    17. The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection. PLoS Pathog. 2019 08; 15(8):e1007460. Singh S, Uppuluri P, Mamouei Z, Alqarihi A, Elhassan H, French S, Lockhart SR, Chiller T, Edwards JE, Ibrahim AS. PMID: 31381597; PMCID: PMC6695204.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCellsPHPublic Health
    18. Heterologous Immunity between Adenoviruses and Hepatitis C Virus (HCV): Recombinant Adenovirus Vaccine Vectors Containing Antigens from Unrelated Pathogens Induce Cross-Reactive Immunity Against HCV Antigens. Cells. 2019 May 26; 8(5). Agrawal B, Gupta N, Vedi S, Singh S, Li W, Garg S, Li J, Kumar R. PMID: 31130710; PMCID: PMC6562520.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    19. NDV-3A vaccination prevents C. albicans colonization of jugular vein catheters in mice. Sci Rep. 2019 04 17; 9(1):6194. Alqarihi A, Singh S, Edwards JE, Ibrahim AS, Uppuluri P. PMID: 30996274; PMCID: PMC6470131.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsPHPublic Health
    20. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018 10 31; 3(5). Mamouei Z, Alqarihi A, Singh S, Xu S, Mansour MK, Ibrahim AS, Uppuluri P. PMID: 30381356; PMCID: PMC6211222.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    21. Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques. J Virol. 2018 Aug 01; 92(15). Singh S, Ramírez-Salazar EG, Doueiri R, Valentin A, Rosati M, Hu X, Keele BF, Shen X, Tomaras GD, Ferrari G, LaBranche C, Montefiori DC, Das J, Alter G, Trinh HV, Hamlin C, Rao M, Dayton F, Bear J, Chowdhury B, Alicea C, Lifson JD, Broderick KE, Sardesai NY, Sivananthan SJ, Fox CB, Reed SG, Venzon DJ, Hirsch VM, Pavlakis GN, Felber BK. PMID: 29793957; PMCID: PMC6052320.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCellsPHPublic Health
    22. Human Anti-Als3p Antibodies Are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis. Front Immunol. 2018; 9:1349. Uppuluri P, Singh S, Alqarihi A, Schmidt CS, Hennessey JP, Yeaman MR, Filler SG, Edwards JE, Ibrahim AS. PMID: 29963049; PMCID: PMC6013566.
      View in: PubMed   Mentions: 16     Fields:    
    23. Unsolved Puzzles Surrounding HCV Immunity: Heterologous Immunity Adds Another Dimension. Int J Mol Sci. 2017 Jul 27; 18(8). Agrawal B, Singh S, Gupta N, Li W, Vedi S, Kumar R. PMID: 28749434; PMCID: PMC5578017.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    24. Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines. PLoS One. 2016; 11(1):e0146404. Singh S, Vedi S, Samrat SK, Li W, Kumar R, Agrawal B. PMID: 26751211; PMCID: PMC4709057.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    25. Editorial: Influenza Virus Vaccines and Immunotherapies. Front Immunol. 2015; 6:599. Kumar A, Singh S. PMID: 26635813; PMCID: PMC4657188.
      View in: PubMed   Mentions: 1     Fields:    
    26. Immunization with Recombinant Adenoviral Vectors Expressing HCV Core or F Proteins Leads to T Cells with Reduced Effector Molecules Granzyme B and IFN-?: A Potential New Strategy for Immune Evasion in HCV Infection. Viral Immunol. 2015; 28(6):309-24. Samrat SK, Vedi S, Singh S, Li W, Kumar R, Agrawal B. PMID: 26133045.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. Recombinant adenoviral vector expressing HCV NS4 induces protective immune responses in a mouse model of Vaccinia-HCV virus infection: a dose and route conundrum. Vaccine. 2014 May 13; 32(23):2712-21. Singh S, Vedi S, Li W, Samrat SK, Kumar R, Agrawal B. PMID: 24631092.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Alternate reading frame protein (F protein) of hepatitis C virus: paradoxical effects of activation and apoptosis on human dendritic cells lead to stimulation of T cells. PLoS One. 2014; 9(1):e86567. Samrat SK, Li W, Singh S, Kumar R, Agrawal B. PMID: 24475147; PMCID: PMC3903568.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    29. Transplacental rotavirus IgG interferes with immune response to live oral rotavirus vaccine ORV-116E in Indian infants. Vaccine. 2014 Feb 03; 32(6):651-6. Appaiahgari MB, Glass R, Singh S, Taneja S, Rongsen-Chandola T, Bhandari N, Mishra S, Vrati S. PMID: 24374502.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCTClinical Trials
    30. Descriptive epidemiology of rotavirus infection in a community in North India. Epidemiol Infect. 2013 Oct; 141(10):2094-100. Chandola TR, Taneja S, Goyal N, Rathore SS, Appaiahgari MB, Mishra A, Singh S, Vrati S, Bhandari N. PMID: 23298643; PMCID: PMC9151399.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    31. A dose-escalation safety and immunogenicity study of live attenuated oral rotavirus vaccine 116E in infants: a randomized, double-blind, placebo-controlled trial. J Infect Dis. 2009 Aug 01; 200(3):421-9. Bhandari N, Sharma P, Taneja S, Kumar T, Rongsen-Chandola T, Appaiahgari MB, Mishra A, Singh S, Vrati S, Rotavirus Vaccine Development Group. PMID: 19545211.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
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