Shakti Singh

Title(s)Assistant Professor-in-Residence, Medicine
ORCID ORCID Icon0000-0001-6521-0998 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Lundquist Institute for Biomedical Innovation, Torrance, CAPostdoctoral Research06/2022Fungal Immunology
    National Cancer Institute, Frederick, MarylandPostdoctoral Research01/2017Immunology
    University of Alberta, Edmonton, Alberta, CanadaPhD11/2015Experimental Surgery (Immunology)
    CCS University, Meerut, IndiaMSc06/2005Microbiology
    Collapse Awards and Honors
    Marine Biology Laboratory, University of Chicago, USA2019Lola Ellis Robertson Endowed Scholarship
    American Society for Microbiology, USA2018Travel Award
    Canadian Institute of Health Research, Canada2014Travel Award for Canadian Student Health Research Forum
    University of Alberta, AB, Canada2014Mary Louise Imrie Graduate Student Award
    University of Alberta, Canada2014Professional Development Grant
    University of Alberta, Canada2011  - 2015Dean’s Canadian Institute of Health Research Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Singh Singh is an expert immunologist and vaccinologist. Dr. Singh joined as an Assistant Professor at the David Geffen School of Medicine at UCLA in 2023 while continuing as an Investigator at The Lundquist Institute at Harbor-UCLA Medical Center. Dr. Singh's laboratory is pioneering research on novel Candida auris surface proteins, investigating their role in virulence and their potential application in developing vaccines and immunotherapies. Dr. Singh employs cutting-edge bioinformatics, immuno-proteomics, molecular biology techniques, and a range of animal models to achieve these goals.

    In his ~17 years of research career, Dr. Singh has significantly contributed to the scientific community. He has authored >30 peer-reviewed research articles, reviews, and editorials, edited two books, published multiple book chapters, and holds several patents. Dr. Singh is currently serving editorial roles for several high-impact journals including Nature Communications, and Frontiers in Immunology, Vaccines, etc.

    Collapse Research 
    Collapse Research Activities and Funding
    Mammalian cells associated expression of multi-drug resistant Candida auris cell wall Proteins
    UCLA Clinical and Translational Science Institute (CTSI) Core Voucher AwardAug 1, 2023 - Jun 30, 2023
    Role: Principal Investigator
    Identification of novel virulence factors on multi-drug resistant Candida auris for vaccine development strategies
    American Heart Association AHA# 938451Jul 1, 2022 - Jun 30, 2025
    Role: Principal Investigator
    Description: Investigate the role of Als3p orthologs and other unidentified cell wall proteins of multi-drug resistant Candida auris and test their potential for vaccine development.
    Identification of novel virulence factors on multi-drug resistant Candida auris for vaccine development strategies
    NIH/NCATS KL2TR001882Jul 1, 2022 - Jun 30, 2025
    Role: Principal Investigator
    Description: Investigate the role of Hyr1/Iff-like proteins and other unidentified cell wall proteins of multi-drug resistant Candida auris and test their potential for vaccine development using an innovative nucleic acid-based delivery platform.
    Self-amplifying mRNA-based vaccine targeting Candida infections
    UCLA Clinical and Translational Science Institute (CTSI) Core Voucher AwardJul 1, 2022 - Jun 30, 2023
    Role: Co-Investigator
    Development of therapeutic monoclonal antibodies against multi-drug resistant Candida auris
    UCLA Clinical and Translational Science Institute (CTSI) Core Voucher AwardJul 1, 2021 - Jun 30, 2022
    Role: Co-Investigator
    Evaluation of multi-drug resistant Candida auris cross-Reactive antibodies and T cells in humans vaccinated with NDV-3A vaccine
    UCLA Clinical and Translational Science Institute (CTSI) Core Voucher AwardJul 1, 2019 - Jun 30, 2020
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Candida auris-specific adhesin, Scf1, governs surface association, colonization, and virulence. Science. 2023 09 29; 381(6665):1461-1467. Santana DJ, Anku JAE, Zhao G, Zarnowski R, Johnson CJ, Hautau H, Visser ND, Ibrahim AS, Andes D, Nett JE, Singh S, O'Meara TR. PMID: 37769084.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    2. Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. PLoS Pathog. 2023 08; 19(8):e1011579. Phan QT, Solis NV, Cravener MV, Swidergall M, Lin J, Huang MY, Liu H, Singh S, Ibrahim AS, Mazzone M, Mitchell AP, Filler SG. PMID: 37611070; PMCID: PMC10479894.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. bioRxiv. 2023 Feb 23. Phan QT, Solis NV, Cravener MV, Swidergall M, Lin J, Huang MY, Liu H, Singh S, Ibrahim AS, Mazzone M, Mitchell AP, Filler SG. PMID: 36865306; PMCID: PMC9980113.
      View in: PubMed   Mentions:
    4. Protective Efficacy of Anti-Hyr1p Monoclonal Antibody against Systemic Candidiasis Due to Multi-Drug-Resistant Candida auris. J Fungi (Basel). 2023 Jan 12; 9(1). Singh S, Barbarino A, Youssef EG, Coleman D, Gebremariam T, Ibrahim AS. PMID: 36675924; PMCID: PMC9860579.
      View in: PubMed   Mentions: 4  
    5. Niclosamide-loaded nanoparticles disrupt Candida biofilms and protect mice from mucosal candidiasis. PLoS Biol. 2022 08; 20(8):e3001762. Sutar Y, Nabeela S, Singh S, Alqarihi A, Solis N, Ghebremariam T, Filler S, Ibrahim AS, Date A, Uppuluri P. PMID: 35976859; PMCID: PMC9385045.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. Antibodies targeting Candida albicans Als3 and Hyr1 antigens protect neonatal mice from candidiasis. Front Immunol. 2022; 13:925821. Singh S, Nabeela S, Barbarino A, Ibrahim AS, Uppuluri P. PMID: 35935947; PMCID: PMC9355692.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    7. Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells. PLoS Pathog. 2022 07; 18(7):e1010681. Phan QT, Solis NV, Lin J, Swidergall M, Singh S, Liu H, Sheppard DC, Ibrahim AS, Mitchell AP, Filler SG. PMID: 35797411; PMCID: PMC9295963.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Combination treatment of liposomal amphotericin B and isavuconazole is synergistic in treating experimental mucormycosis. J Antimicrob Chemother. 2021 09 15; 76(10):2636-2639. Gebremariam T, Gu Y, Singh S, Kitt TM, Ibrahim AS. PMID: 34263306; PMCID: PMC8446914.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    9. Adaptive immunity induces mutualism between commensal eukaryotes. Nature. 2021 08; 596(7870):114-118. Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. PMID: 34262174; PMCID: PMC8904204.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    10. An evolutionarily diverged mitochondrial protein controls biofilm growth and virulence in Candida albicans. PLoS Biol. 2021 03; 19(3):e3000957. Mamouei Z, Singh S, Lemire B, Gu Y, Alqarihi A, Nabeela S, Li D, Ibrahim A, Uppuluri P. PMID: 33720927; PMCID: PMC8007014.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    11. Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis. Nat Microbiol. 2021 03; 6(3):313-326. Soliman SSM, Baldin C, Gu Y, Singh S, Gebremariam T, Swidergall M, Alqarihi A, Youssef EG, Alkhazraji S, Pikoulas A, Perske C, Venkataramani V, Rich A, Bruno VM, Hotopp JD, Mantis NJ, Edwards JE, Filler SG, Chamilos G, Vitetta ES, Ibrahim AS. PMID: 33462434; PMCID: PMC7914224.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    12. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nat Commun. 2020 12 22; 11(1):6429. Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE. PMID: 33353950; PMCID: PMC7755909.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    13. Editorial: Heterologous Immunity: Implications and Applications in Vaccines and Immunotherapies. Front Immunol. 2020; 11:1408. Singh S, Yanow SK, Agrawal B. PMID: 32774334; PMCID: PMC7381340.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    14. Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis. Antimicrob Agents Chemother. 2020 02 21; 64(3). Alkhazraji S, Gebremariam T, Alqarihi A, Gu Y, Mamouei Z, Singh S, Wiederhold NP, Shaw KJ, Ibrahim AS. PMID: 31818813; PMCID: PMC7038288.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    15. Monoclonal IgM Antibodies Targeting Candida albicans Hyr1 Provide Cross-Kingdom Protection Against Gram-Negative Bacteria. Front Immunol. 2020; 11:76. Youssef EG, Zhang L, Alkhazraji S, Gebremariam T, Singh S, Yount NY, Yeaman MR, Uppuluri P, Ibrahim AS. PMID: 32153560; PMCID: PMC7045048.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2019 12 20; 64(1). Gebremariam T, Alkhazraji S, Gu Y, Singh S, Alqarihi A, Shaw KJ, Ibrahim AS. PMID: 31685475; PMCID: PMC7187618.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    17. The NDV-3A vaccine protects mice from multidrug resistant Candida auris infection. PLoS Pathog. 2019 08; 15(8):e1007460. Singh S, Uppuluri P, Mamouei Z, Alqarihi A, Elhassan H, French S, Lockhart SR, Chiller T, Edwards JE, Ibrahim AS. PMID: 31381597; PMCID: PMC6695204.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCellsPHPublic Health
    18. Heterologous Immunity between Adenoviruses and Hepatitis C Virus (HCV): Recombinant Adenovirus Vaccine Vectors Containing Antigens from Unrelated Pathogens Induce Cross-Reactive Immunity Against HCV Antigens. Cells. 2019 05 26; 8(5). Agrawal B, Gupta N, Vedi S, Singh S, Li W, Garg S, Li J, Kumar R. PMID: 31130710; PMCID: PMC6562520.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    19. NDV-3A vaccination prevents C. albicans colonization of jugular vein catheters in mice. Sci Rep. 2019 04 17; 9(1):6194. Alqarihi A, Singh S, Edwards JE, Ibrahim AS, Uppuluri P. PMID: 30996274; PMCID: PMC6470131.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsPHPublic Health
    20. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018 10 31; 3(5). Mamouei Z, Alqarihi A, Singh S, Xu S, Mansour MK, Ibrahim AS, Uppuluri P. PMID: 30381356; PMCID: PMC6211222.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    21. Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques. J Virol. 2018 08 01; 92(15). Singh S, Ramírez-Salazar EG, Doueiri R, Valentin A, Rosati M, Hu X, Keele BF, Shen X, Tomaras GD, Ferrari G, LaBranche C, Montefiori DC, Das J, Alter G, Trinh HV, Hamlin C, Rao M, Dayton F, Bear J, Chowdhury B, Alicea C, Lifson JD, Broderick KE, Sardesai NY, Sivananthan SJ, Fox CB, Reed SG, Venzon DJ, Hirsch VM, Pavlakis GN, Felber BK. PMID: 29793957; PMCID: PMC6052320.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    22. Human Anti-Als3p Antibodies Are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis. Front Immunol. 2018; 9:1349. Uppuluri P, Singh S, Alqarihi A, Schmidt CS, Hennessey JP, Yeaman MR, Filler SG, Edwards JE, Ibrahim AS. PMID: 29963049; PMCID: PMC6013566.
      View in: PubMed   Mentions: 18     Fields:    
    23. Unsolved Puzzles Surrounding HCV Immunity: Heterologous Immunity Adds Another Dimension. Int J Mol Sci. 2017 Jul 27; 18(8). Agrawal B, Singh S, Gupta N, Li W, Vedi S, Kumar R. PMID: 28749434; PMCID: PMC5578017.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    24. Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines. PLoS One. 2016; 11(1):e0146404. Singh S, Vedi S, Samrat SK, Li W, Kumar R, Agrawal B. PMID: 26751211; PMCID: PMC4709057.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    25. Editorial: Influenza Virus Vaccines and Immunotherapies. Front Immunol. 2015; 6:599. Kumar A, Singh S. PMID: 26635813; PMCID: PMC4657188.
      View in: PubMed   Mentions: 1     Fields:    
    26. Immunization with Recombinant Adenoviral Vectors Expressing HCV Core or F Proteins Leads to T Cells with Reduced Effector Molecules Granzyme B and IFN-γ: A Potential New Strategy for Immune Evasion in HCV Infection. Viral Immunol. 2015 Jul-Aug; 28(6):309-24. Samrat SK, Vedi S, Singh S, Li W, Kumar R, Agrawal B. PMID: 26133045.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. Recombinant adenoviral vector expressing HCV NS4 induces protective immune responses in a mouse model of Vaccinia-HCV virus infection: a dose and route conundrum. Vaccine. 2014 May 13; 32(23):2712-21. Singh S, Vedi S, Li W, Samrat SK, Kumar R, Agrawal B. PMID: 24631092.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Alternate reading frame protein (F protein) of hepatitis C virus: paradoxical effects of activation and apoptosis on human dendritic cells lead to stimulation of T cells. PLoS One. 2014; 9(1):e86567. Samrat SK, Li W, Singh S, Kumar R, Agrawal B. PMID: 24475147; PMCID: PMC3903568.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    29. Transplacental rotavirus IgG interferes with immune response to live oral rotavirus vaccine ORV-116E in Indian infants. Vaccine. 2014 Feb 03; 32(6):651-6. Appaiahgari MB, Glass R, Singh S, Taneja S, Rongsen-Chandola T, Bhandari N, Mishra S, Vrati S. PMID: 24374502.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    30. Descriptive epidemiology of rotavirus infection in a community in North India. Epidemiol Infect. 2013 Oct; 141(10):2094-100. Chandola TR, Taneja S, Goyal N, Rathore SS, Appaiahgari MB, Mishra A, Singh S, Vrati S, Bhandari N. PMID: 23298643; PMCID: PMC9151399.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    31. A dose-escalation safety and immunogenicity study of live attenuated oral rotavirus vaccine 116E in infants: a randomized, double-blind, placebo-controlled trial. J Infect Dis. 2009 Aug 01; 200(3):421-9. Bhandari N, Sharma P, Taneja S, Kumar T, Rongsen-Chandola T, Appaiahgari MB, Mishra A, Singh S, Vrati S, Rotavirus Vaccine Development Group. PMID: 19545211.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
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