Nagendra N Mishra

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Membrane Phenotypic, Metabolic and Genotypic Adaptations of Streptococcus oralis Strains Destined to Rapidly Develop Stable, High-Level Daptomycin Resistance during Daptomycin Exposures. Antibiotics (Basel). 2023 Jun 21; 12(7). Mishra NN, de Paula Baptista R, Tran TT, Lapitan CK, Garcia-de-la-Maria C, Miró JM, Proctor RA, Bayer AS. PMID: 37508179; PMCID: PMC10376253.
      View in: PubMed   Mentions:
    2. Combinations of Daptomycin plus Ceftriaxone, but Not Ascending Daptomycin Dose-Regimens, Are Effective in Experimental Endocarditis Caused by Streptococcus mitis-oralis Strains: Target Tissue Clearances and Prevention of Emergence of Daptomycin-Resistance. Antimicrob Agents Chemother. 2023 04 18; 67(4):e0147222. Mishra NN, Abdelhady W, Elsayed AM, Lapitan C, Proctor RA, Rybak MJ, Miro JM, Bayer AS. PMID: 36877026; PMCID: PMC10112159.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Activity of the Lactate Dehydrogenase Inhibitor Oxamic Acid against the Fermentative Bacterium Streptococcus mitis/oralis: Bactericidal Effects and Prevention of Daptomycin Resistance In Vitro and in an Ex Vivo Model. Antibiotics (Basel). 2022 Oct 13; 11(10). Kebriaei R, Bayer AS, Lapitan CK, Rybak MJ, Somerville GA, Mishra NN. PMID: 36290066; PMCID: PMC9598551.
      View in: PubMed   Mentions: 3  
    4. Synergy Mechanisms of Daptomycin-Fosfomycin Combinations in Daptomycin-Susceptible and -Resistant Methicillin-Resistant Staphylococcus aureus: In Vitro, Ex Vivo, and In Vivo Metrics. Antimicrob Agents Chemother. 2022 01 18; 66(1):e0164921. Mishra NN, Lew C, Abdelhady W, Lapitan CK, Proctor RA, Rose WE, Bayer AS. PMID: 34694870; PMCID: PMC8765261.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. β-Lactam-Induced Cell Envelope Adaptations, Not Solely Enhanced Daptomycin Binding, Underlie Daptomycin-β-Lactam Synergy in Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2021 07 16; 65(8):e0035621. Lew C, Mishra NN, Bayer AS, Rose WE. PMID: 34097478; PMCID: PMC8284448.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    6. Cell Membrane Adaptations Mediate β-Lactam-Induced Resensitization of Daptomycin-Resistant (DAP-R) Staphylococcus aureus In Vitro. Microorganisms. 2021 May 11; 9(5). Mishra NN, Bayer AS, Baines SL, Hayes AS, Howden BP, Lapitan CK, Lew C, Rose WE. PMID: 34064631; PMCID: PMC8150363.
      View in: PubMed   Mentions: 5  
    7. Mechanistic Fingerprinting Reveals Kinetic Signatures of Resistance to Daptomycin and Host Defense Peptides in Streptococcus mitis-oralis. Antibiotics (Basel). 2021 Apr 08; 10(4). Yeaman MR, Chan LC, Mishra NN, Bayer AS. PMID: 33918000; PMCID: PMC8068394.
      View in: PubMed   Mentions: 1  
    8. Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant Staphylococcus aureus (MRSA). Antimicrob Agents Chemother. 2023 05 01; 65(5). Ersoy SC, Chambers HF, Proctor RA, Rosato AE, Mishra NN, Xiong YQ, Bayer AS. PMID: 33649115; PMCID: PMC8092911.
      View in: PubMed   Mentions: 9     Fields:    
    9. Prolonged Exposure to β-Lactam Antibiotics Reestablishes Susceptibility of Daptomycin-Nonsusceptible Staphylococcus aureus to Daptomycin. Antimicrob Agents Chemother. 2020 08 20; 64(9). Jenson RE, Baines SL, Howden BP, Mishra NN, Farah S, Lew C, Berti AD, Shukla SK, Bayer AS, Rose WE. PMID: 32601160; PMCID: PMC7449200.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    10. Strain-Specific Adaptations of Streptococcus mitis-oralis to Serial In Vitro Passage in Daptomycin (DAP): Genotypic and Phenotypic Characteristics. Antibiotics (Basel). 2020 Aug 15; 9(8). Mishra NN, Tran TT, Arias CA, Seepersaud R, Sullam PM, Bayer AS. PMID: 32824132; PMCID: PMC7460094.
      View in: PubMed   Mentions: 5  
    11. Metabolic changes associated with adaptive resistance to daptomycin in Streptococcus mitis-oralis. BMC Microbiol. 2020 06 15; 20(1):162. Parrett A, Reed JM, Gardner SG, Mishra NN, Bayer AS, Powers R, Somerville GA. PMID: 32539684; PMCID: PMC7296729.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    12. Proteomic and Membrane Lipid Correlates of Reduced Host Defense Peptide. Antibiotics (Basel). 2019 Sep 28; 8(4). Kohler C, Proctor RA, Bayer AS, Yeaman MR, Lalk M, Engelmann S, Mishra NN. PMID: 31569354; PMCID: PMC6963496.
      View in: PubMed   Mentions: 3  
    13. Metabolic interventions for the prevention and treatment of daptomycin non-susceptibility in Staphylococcus aureus. J Antimicrob Chemother. 2019 08 01; 74(8):2274-2283. Reed JM, Gardner SG, Mishra NN, Bayer AS, Somerville GA. PMID: 31074482.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. Daptomycin Dose-Ranging Evaluation with Single-Dose versus Multidose Ceftriaxone Combinations against Streptococcus mitis/oralis in an Ex Vivo Simulated Endocarditis Vegetation Model. Antimicrob Agents Chemother. 2019 06; 63(6). Kebriaei R, Rice SA, Stamper KC, Seepersaud R, Garcia-de-la-Maria C, Mishra NN, Miro JM, Arias CA, Tran TT, Sullam PM, Bayer AS, Rybak MJ. PMID: 30962347; PMCID: PMC6535512.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    15. Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia. Front Med (Lausanne). 2019; 6:31. Abdelhady W, Mishra NN. PMID: 30842947; PMCID: PMC6391330.
      View in: PubMed   Mentions: 3  
    16. Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. oralis. Antimicrob Agents Chemother. 2019 02; 63(2). Tran TT, Mishra NN, Seepersaud R, Diaz L, Rios R, Dinh AQ, Garcia-de-la-Maria C, Rybak MJ, Miro JM, Shelburne SA, Sullam PM, Bayer AS, Arias CA. PMID: 30509945; PMCID: PMC6355606.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    17. Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance. mBio. 2018 12 18; 9(6). Ernst CM, Slavetinsky CJ, Kuhn S, Hauser JN, Nega M, Mishra NN, Gekeler C, Bayer AS, Peschel A. PMID: 30563904; PMCID: PMC6299216.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    18. Membrane trafficking of the bacterial adhesin GspB and the accessory Sec transport machinery. J Biol Chem. 2019 02 01; 294(5):1502-1515. Spencer C, Bensing BA, Mishra NN, Sullam PM. PMID: 30514759; PMCID: PMC6364773.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    19. Prevention of High-Level Daptomycin-Resistance Emergence In Vitro in Streptococcus mitis-oralis by Using Combination Antimicrobial Strategies. Curr Microbiol. 2018 Aug; 75(8):1062-1067. Zapata B, Alvarez DN, Farah S, Garcia-de-la-Maria C, Miro JM, Sakoulas G, Bayer AS, Mishra NN. PMID: 29651552.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Impact of Multiple Single-Nucleotide Polymorphisms Within mprF on Daptomycin Resistance in Staphylococcus aureus. Microb Drug Resist. 2018 Oct; 24(8):1075-1081. Yang SJ, Mishra NN, Kang KM, Lee GY, Park JH, Bayer AS. PMID: 29381428; PMCID: PMC6200021.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    21. Evaluation of daptomycin combinations with cephalosporins or gentamicin against Streptococcus mitis group strains in an in vitro model of simulated endocardial vegetations (SEVs). J Antimicrob Chemother. 2017 08 01; 72(8):2290-2296. Yim J, Smith JR, Singh NB, Rice S, Stamper K, Garcia de la Maria C, Bayer AS, Mishra NN, Miró JM, Tran TT, Arias CA, Sullam P, Rybak MJ. PMID: 28475731; PMCID: PMC5890769.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis/oralis by a Novel Mechanism. Antimicrob Agents Chemother. 2017 04; 61(4). Mishra NN, Tran TT, Seepersaud R, Garcia-de-la-Maria C, Faull K, Yoon A, Proctor R, Miro JM, Rybak MJ, Bayer AS, Arias CA, Sullam PM. PMID: 28115347; PMCID: PMC5365703.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    23. Phenotypic and genotypic correlates of daptomycin-resistant methicillin-susceptible Staphylococcus aureus clinical isolates. J Microbiol. 2017 Feb; 55(2):153-159. Kang KM, Mishra NN, Park KT, Lee GY, Park YH, Bayer AS, Yang SJ. PMID: 28120188; PMCID: PMC6218394.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    24. Dysregulation of mprF and dltABCD expression among daptomycin-non-susceptible MRSA clinical isolates. J Antimicrob Chemother. 2016 08; 71(8):2100-4. Bayer AS, Mishra NN, Cheung AL, Rubio A, Yang SJ. PMID: 27121398; PMCID: PMC4954926.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    25. The role of Staphylococcal carotenogenesis in resistance to host defense peptides and in vivo virulence in experimental endocarditis model. Pathog Dis. 2015 Oct; 73(7). Xiong YQ, Yang SJ, Tong SY, Alvarez DN, Mishra NN. PMID: 26242278; PMCID: PMC4607738.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Frequency and Distribution of Single-Nucleotide Polymorphisms within mprF in Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial Peptides. Antimicrob Agents Chemother. 2015 Aug; 59(8):4930-7. Bayer AS, Mishra NN, Chen L, Kreiswirth BN, Rubio A, Yang SJ. PMID: 26055370; PMCID: PMC4505294.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    27. A liaR deletion restores susceptibility to daptomycin and antimicrobial peptides in multidrug-resistant Enterococcus faecalis. J Infect Dis. 2015 Apr 15; 211(8):1317-25. Reyes J, Panesso D, Tran TT, Mishra NN, Cruz MR, Munita JM, Singh KV, Yeaman MR, Murray BE, Shamoo Y, Garsin D, Bayer AS, Arias CA. PMID: 25362197; PMCID: PMC4402337.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    28. Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides. Antimicrob Agents Chemother. 2014 Dec; 58(12):7462-7. Bayer AS, Mishra NN, Sakoulas G, Nonejuie P, Nast CC, Pogliano J, Chen KT, Ellison SN, Yeaman MR, Yang SJ. PMID: 25288091; PMCID: PMC4249560.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    29. Phenotypic and genotypic characterization of daptomycin-resistant methicillin-resistant Staphylococcus aureus strains: relative roles of mprF and dlt operons. PLoS One. 2014; 9(9):e107426. Mishra NN, Bayer AS, Weidenmaier C, Grau T, Wanner S, Stefani S, Cafiso V, Bertuccio T, Yeaman MR, Nast CC, Yang SJ. PMID: 25226591; PMCID: PMC4166420.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    30. Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible Enterococcus faecium harboring LiaSR substitutions. Clin Infect Dis. 2014 Nov 01; 59(9):1277-80. Munita JM, Mishra NN, Alvarez D, Tran TT, Diaz L, Panesso D, Reyes J, Murray BE, Adachi JA, Bayer AS, Arias CA. PMID: 25107294; PMCID: PMC4271039.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    31. Causal role of single nucleotide polymorphisms within the mprF gene of Staphylococcus aureus in daptomycin resistance. Antimicrob Agents Chemother. 2013 Nov; 57(11):5658-64. Yang SJ, Mishra NN, Rubio A, Bayer AS. PMID: 24002096; PMCID: PMC3811309.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    32. Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms. PLoS One. 2013; 8(8):e71151. Mishra NN, Yang SJ, Chen L, Muller C, Saleh-Mghir A, Kuhn S, Peschel A, Yeaman MR, Nast CC, Kreiswirth BN, Crémieux AC, Bayer AS. PMID: 23990934; PMCID: PMC3747195.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    33. Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids. mBio. 2013 Jul 23; 4(4). Tran TT, Panesso D, Mishra NN, Mileykovskaya E, Guan Z, Munita JM, Reyes J, Diaz L, Weinstock GM, Murray BE, Shamoo Y, Dowhan W, Bayer AS, Arias CA. PMID: 23882013; PMCID: PMC3735187.
      View in: PubMed   Mentions: 86     Fields:    Translation:Cells
    34. Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. PLoS One. 2013; 8(6):e67398. Bertsche U, Yang SJ, Kuehner D, Wanner S, Mishra NN, Roth T, Nega M, Schneider A, Mayer C, Grau T, Bayer AS, Weidenmaier C. PMID: 23785522; PMCID: PMC3681945.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    35. Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin. J Infect Dis. 2013 Aug 01; 208(3):520-7. Tong SY, Sharma-Kuinkel BK, Thaden JT, Whitney AR, Yang SJ, Mishra NN, Rude T, Lilliebridge RA, Selim MA, Ahn SH, Holt DC, Giffard PM, Bayer AS, Deleo FR, Fowler VG. PMID: 23599317; PMCID: PMC3699000.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    36. Correlation of cell membrane lipid profiles with daptomycin resistance in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Feb; 57(2):1082-5. Mishra NN, Bayer AS. PMID: 23254419; PMCID: PMC3553710.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    37. Whole-genome analysis of a daptomycin-susceptible enterococcus faecium strain and its daptomycin-resistant variant arising during therapy. Antimicrob Agents Chemother. 2013 Jan; 57(1):261-8. Tran TT, Panesso D, Gao H, Roh JH, Munita JM, Reyes J, Diaz L, Lobos EA, Shamoo Y, Mishra NN, Bayer AS, Murray BE, Weinstock GM, Arias CA. PMID: 23114757; PMCID: PMC3535923.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    38. Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content. PLoS One. 2012; 7(8):e43958. Mishra NN, Bayer AS, Tran TT, Shamoo Y, Mileykovskaya E, Dowhan W, Guan Z, Arias CA. PMID: 22952824; PMCID: PMC3428275.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    39. Reduced susceptibility to host-defense cationic peptides and daptomycin coemerge in methicillin-resistant Staphylococcus aureus from daptomycin-naive bacteremic patients. J Infect Dis. 2012 Oct; 206(8):1160-7. Mishra NN, Bayer AS, Moise PA, Yeaman MR, Sakoulas G. PMID: 22904338; PMCID: PMC3448966.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    40. Differential Adaptations of Methicillin-Resistant Staphylococcus aureus to Serial In Vitro Passage in Daptomycin: Evolution of Daptomycin Resistance and Role of Membrane Carotenoid Content and Fluidity. Int J Microbiol. 2012; 2012:683450. Mishra NN, Rubio A, Nast CC, Bayer AS. PMID: 22956961; PMCID: PMC3431083.
      View in: PubMed   Mentions: 24  
    41. Ampicillin enhances daptomycin- and cationic host defense peptide-mediated killing of ampicillin- and vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother. 2012 Feb; 56(2):838-44. Sakoulas G, Bayer AS, Pogliano J, Tsuji BT, Yang SJ, Mishra NN, Nizet V, Yeaman MR, Moise PA. PMID: 22123698; PMCID: PMC3264218.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    42. The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides. Infect Immun. 2012 Jan; 80(1):74-81. Yang SJ, Bayer AS, Mishra NN, Meehl M, Ledala N, Yeaman MR, Xiong YQ, Cheung AL. PMID: 21986630; PMCID: PMC3255649.
      View in: PubMed   Mentions: 80     Fields:    Translation:Cells
    43. In vitro cross-resistance to daptomycin and host defense cationic antimicrobial peptides in clinical methicillin-resistant Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2011 Sep; 55(9):4012-8. Mishra NN, McKinnell J, Yeaman MR, Rubio A, Nast CC, Chen L, Kreiswirth BN, Bayer AS. PMID: 21709105; PMCID: PMC3165344.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    44. Carotenoid-related alteration of cell membrane fluidity impacts Staphylococcus aureus susceptibility to host defense peptides. Antimicrob Agents Chemother. 2011 Feb; 55(2):526-31. Mishra NN, Liu GY, Yeaman MR, Nast CC, Proctor RA, McKinnell J, Bayer AS. PMID: 21115796; PMCID: PMC3028772.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    45. Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms. Antimicrob Agents Chemother. 2010 Aug; 54(8):3079-85. Yang SJ, Nast CC, Mishra NN, Yeaman MR, Fey PD, Bayer AS. PMID: 20498310; PMCID: PMC2916340.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    46. The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion. PLoS Pathog. 2009 Nov; 5(11):e1000660. Ernst CM, Staubitz P, Mishra NN, Yang SJ, Hornig G, Kalbacher H, Bayer AS, Kraus D, Peschel A. PMID: 19915718; PMCID: PMC2774229.
      View in: PubMed   Mentions: 168     Fields:    Translation:Cells
    47. Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2009 Jun; 53(6):2312-8. Mishra NN, Yang SJ, Sawa A, Rubio A, Nast CC, Yeaman MR, Bayer AS. PMID: 19332678; PMCID: PMC2687258.
      View in: PubMed   Mentions: 120     Fields:    Translation:Cells
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