Eiji Yoshihara

Title(s)Assistant Professor-in-Residence, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0001-6324-6495 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Yamaguchi University, JapanB.S03/2006Physics/Informatics/Biology
    Kyoto University, JapanPh.D.03/2011Molecular Biology
    Salk Institute, La JollaPostdoc10/2016Genomics/Stem Cell/Physiology
    Collapse Awards and Honors
    Kyoto University2011Kyoto University President Award

    Collapse Overview 
    Collapse Overview
    Dr. Eiji Yoshihara is a principal investigator in the Lundquist Institute at Harbor-UCLA Medicine Center and an assistant professor in the David Geffen School of Medicine at UCLA. The overall goal of his research is to understand how tissue specific transcriptional networks regulate whole body metabolism and organogenesis. Dr. Yoshihara's research follows three major scientific directions: (1) the role of spatiotemporal transcriptome and epigenetic regulation in human organogenesis modeled by human pluripotent stem cells. (2) environmental adaptation during prenatal and postnatal development and metabolic homeostasis (3) engineering cell products for regeneration and cell replacement therapy in diabetes. As an undergraduate student, Dr.Yoshihara majored in computer science and physics and minored in developmental biology using Xenopus laevis as experimental model at Yamaguchi University in Japan. As a graduate student at Kyoto University, Dr.Yoshihara studied the function of thioredoxin interacting protein (Txnip) in the feeding-fasting metabolic transition with pancreatic islet physiology, and identified and characterized novel players in the glucose and lipid homeostasis in a mouse model of diabetes. During postdoctoral training in the Salk Institute, Dr.Yoshihara pioneered the study of nuclear receptors and gene regulation, and the organogenesis using human pluripotent stem cell technology. Dr.Yoshihara's lab is seeking the spatiotemporal gene regulation in development and physiology and aiming to engineer the cell products for the better solution to cure both type 1 and type 2 diabetes.
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Insulin-producing cells derived from expandable stem cell-derived endoderm are effective for the treatment of type 2 diabetes. Ann Transl Med. 2024 Dec 24; 12(6):121. Yoshihara E. PMID: 39817230; PMCID: PMC11729811.
      View in: PubMed   Mentions:
    2. Insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in INS-1 pancreatic β-cells. Physiol Rep. 2024 Jun; 12(12):e16106. Murata N, Nishimura K, Harada N, Kitakaze T, Yoshihara E, Inui H, Yamaji R. PMID: 38884322; PMCID: PMC11181300.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Scaling Insulin-Producing Cells by Multiple Strategies. Endocrinol Metab (Seoul). 2024 Apr; 39(2):191-205. Choi J, Cayabyab F, Perez H, Yoshihara E. PMID: 38572534; PMCID: PMC11066437.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Redoxisome Update: TRX and TXNIP/TBP2-Dependent Regulation of NLRP-1/NLRP-3 Inflammasome. Antioxid Redox Signal. 2024 04; 40(10-12):595-597. Yoshihara E, Matsuo Y, Masaki S, Chen Z, Tian H, Masutani H, Yamauchi A, Hirota K, Yodoi J. PMID: 38386512.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. A guide from the stomach to β cells. Nat Cell Biol. 2023 05; 25(5):637-638. Choi J, Cayabyab F, Yoshihara E. PMID: 37106061.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Stem Cell-Derived Islets for Type 2 Diabetes. Int J Mol Sci. 2022 May 04; 23(9). Salib A, Cayabyab F, Yoshihara E. PMID: 35563490; PMCID: PMC9105352.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. Adapting Physiology in Functional Human Islet Organogenesis. Front Cell Dev Biol. 2022; 10:854604. Yoshihara E. PMID: 35557947; PMCID: PMC9086403.
      View in: PubMed   Mentions: 3  
    8. Estrogen-Related Receptor γ Maintains Pancreatic Acinar Cell Function and Identity by Regulating Cellular Metabolism. Gastroenterology. 2022 07; 163(1):239-256. Choi J, Oh TG, Jung HW, Park KY, Shin H, Jo T, Kang DS, Chanda D, Hong S, Kim J, Hwang H, Ji M, Jung M, Shoji T, Matsushima A, Kim P, Mun JY, Paik MJ, Cho SJ, Lee IK, Whitcomb DC, Greer P, Blobner B, Goodarzi MO, Pandol SJ, Rotter JI, North American Pancreatitis Study 2 (NAPS2) Consortium, Fan W, Bapat SP, Zheng Y, Liddle C, Yu RT, Atkins AR, Downes M, Yoshihara E, Evans RM, Suh JM. PMID: 35461826; PMCID: PMC9233018.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    9. Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes. 2021 11 13. Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND, Symposium planning committee, moderators, and speakers:, Rosenblum N, Cefalu W, Andersen DK, Arreaza-Rubín G, Dhara C, James SP, Makarchuk MJ, Pin CL, Sato S, Verchere B, Woo M, Powers A, Estall J, Hoesli C, Millman J, Linnemann A, Johnson J, Pin CL, Hawkins M, Woo M, Gloyn A, Cefalu W, Rosenblum N, Huising MO, Benninger RKP, Almaça J, Hull-Meichle RL, MacDonald P, Lynn F, Melero-Martin J, Yoshihara E, Stabler C, Sander M, Evans-Molina C, Engin F, Thompson P, Shalev A, Redondo MJ, Nadeau K, Bellin M, Udler MS, Dennis J, Dash S, Zhou W, Snyder M, Booth G, Butte A, Florez J. PMID: 34957490.
      View in: PubMed   Mentions: 3     Fields:    
    10. Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes. Front Endocrinol (Lausanne). 2021; 12:732431. Cayabyab F, Nih LR, Yoshihara E. PMID: 34589059; PMCID: PMC8473744.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    11. Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β. J Biol Chem. 2021 11; 297(5):101173. Iwamoto M, Masuya T, Hosose M, Tagawa K, Ishibashi T, Suyama K, Nose T, Yoshihara E, Downes M, Evans RM, Matsushima A. PMID: 34499926; PMCID: PMC8551653.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Immune Protection of Stem Cell-Derived Islet Cell Therapy for Treating Diabetes. Front Endocrinol (Lausanne). 2021; 12:716625. Tahbaz M, Yoshihara E. PMID: 34447354; PMCID: PMC8382875.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    13. Publisher Correction: Immune-evasive human islet-like organoids ameliorate diabetes. Nature. 2021 Feb; 590(7844):E27. Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 33469222; PMCID: PMC11332361.
      View in: PubMed   Mentions:    Fields:    
    14. Immune-evasive human islet-like organoids ameliorate diabetes. Nature. 2020 10; 586(7830):606-611. Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 32814902; PMCID: PMC7872080.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    15. TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis. Antioxidants (Basel). 2020 Aug 18; 9(8). Yoshihara E. PMID: 32824669; PMCID: PMC7464905.
      View in: PubMed   Mentions: 39  
    16. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 2019 02 21; 176(5):1098-1112.e18. Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM. PMID: 30794774; PMCID: PMC6701863.
      View in: PubMed   Mentions: 199     Fields:    Translation:HumansAnimalsCells
    17. Vitamin D Switches BAF Complexes to Protect β Cells. Cell. 2018 May 17; 173(5):1135-1149.e15. Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AFM, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM. PMID: 29754817; PMCID: PMC5987229.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    18. ERRγ Preserves Brown Fat Innate Thermogenic Activity. Cell Rep. 2018 03 13; 22(11):2849-2859. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. PMID: 29539415; PMCID: PMC5884669.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    19. ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells. Cell Metab. 2016 Apr 12; 23(4):622-34. Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng T, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 27076077; PMCID: PMC4832237.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    20. ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. Cell Stem Cell. 2015 May 07; 16(5):547-55. Kida YS, Kawamura T, Wei Z, Sogo T, Jacinto S, Shigeno A, Kushige H, Yoshihara E, Liddle C, Ecker JR, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 25865501; PMCID: PMC4427539.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    21. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344; PMCID: PMC4320010.
      View in: PubMed   Mentions: 320     Fields:    Translation:Animals
    22. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014 Sep 18; 513(7518):436-9. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. PMID: 25043058; PMCID: PMC4184286.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimals
    23. Methylome, transcriptome, and PPAR(γ) cistrome analyses reveal two epigenetic transitions in fat cells. Epigenetics. 2014 Sep; 9(9):1195-206. Takada H, Saito Y, Mituyama T, Wei Z, Yoshihara E, Jacinto S, Downes M, Evans RM, Kida YS. PMID: 25093444; PMCID: PMC4169011.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition. PLoS One. 2012; 7(6):e39900. Masaki S, Masutani H, Yoshihara E, Yodoi J. PMID: 22768160; PMCID: PMC3387201.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    25. Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation. Leukemia. 2011 Mar; 25(3):440-8. Chen Z, Lopez-Ramos DA, Yoshihara E, Maeda Y, Masutani H, Sugie K, Maeda M, Yodoi J. PMID: 21151022; PMCID: PMC3072512.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    26. Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity. Nat Commun. 2010 Nov 23; 1:127. Yoshihara E, Fujimoto S, Inagaki N, Okawa K, Masaki S, Yodoi J, Masutani H. PMID: 21119640; PMCID: PMC3060604.
      View in: PubMed   Mentions: 60     Fields:    
    27. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol. 2010 Oct; 11(10):897-904. Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA. PMID: 20835230; PMCID: PMC3103663.
      View in: PubMed   Mentions: 622     Fields:    Translation:HumansAnimalsCells
    28. Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses. Eur J Immunol. 2008 May; 38(5):1358-67. Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J. PMID: 18425727.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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