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Peter Cawood Butler

Title(s)Professor, Medicine
SchoolMedicine
Address900 Weyburn Place North 24-130
Los Angeles CA 90024
Phone310-206-7312
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    Collapse Research 
    Collapse Research Activities and Funding
    Capacity and Mechanisms of Beta Cell Regeneration in Humans
    NIH/NIDDK R01DK077967Apr 1, 2007 - Jun 30, 2017
    Role: Principal Investigator
    Role of Pulsatile Insulin Secretion
    NIH/NIDDK R01DK061539Jul 1, 2002 - May 31, 2014
    Role: Principal Investigator
    Role of IAPP in Islet Dysfunction in Diabetes
    NIH/NIDDK R01DK059579Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    PULSATILE INSULIN SECRETION ON INSULIN ACTION
    NIH/NIDDK R29DK044341Sep 1, 1991 - Aug 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pancreatic alpha-cell mass across adult human lifespan. Eur J Endocrinol. 2020 Feb; 182(2):219-231. Moin ASM, Cory M, Gurlo T, Saisho Y, Rizza RA, Butler PC, Butler AE. PMID: 31821160.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes. Case Rep Endocrinol. 2019; 2019:5863569. Nomoto H, Gurlo T, Rosenberger M, Girgis MD, Dry S, Butler PC. PMID: 31949959.
      View in: PubMed   Mentions:
    3. Activation of the HIF1a/PFKFB3 stress response pathway in beta cells in type 1 diabetes. Diabetologia. 2020 01; 63(1):149-161. Nomoto H, Pei L, Montemurro C, Rosenberger M, Furterer A, Coppola G, Nadel B, Pellegrini M, Gurlo T, Butler PC, Tudzarova S. PMID: 31720731.
      View in: PubMed   Mentions:    Fields:    
    4. Publisher Correction: IAPP toxicity activates HIF1a/PFKFB3 signaling delaying ß-cell loss at the expense of ß-cell function. Nat Commun. 2019 Jul 31; 10(1):3507. Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31366929.
      View in: PubMed   Mentions: 1     Fields:    
    5. IAPP toxicity activates HIF1a/PFKFB3 signaling delaying ß-cell loss at the expense of ß-cell function. Nat Commun. 2019 06 18; 10(1):2679. Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31213603.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes. Diabetologia. 2019 06; 62(6):1000-1010. Gurlo T, Kim S, Butler AE, Liu C, Pei L, Rosenberger M, Butler PC. PMID: 30852627.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. An Increase in Chromogranin A-Positive, Hormone-Negative Endocrine Cells in Pancreas in Cystic Fibrosis. J Endocr Soc. 2018 Sep 01; 2(9):1058-1066. Cory M, Moin ASM, Moran A, Rizza RA, Butler PC, Dhawan S, Butler AE. PMID: 30202828.
      View in: PubMed   Mentions:
    8. In the setting of ß-cell stress, the pancreatic duct gland transcriptome shows characteristics of an activated regenerative response. Am J Physiol Gastrointest Liver Physiol. 2018 11 01; 315(5):G848-G854. Butler AE, Kirakossian D, Gurlo T, Gao F, Coppola G, Butler PC. PMID: 30095296.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Increased Chromogranin A-Positive Hormone-Negative Cells in Chronic Pancreatitis. J Clin Endocrinol Metab. 2018 06 01; 103(6):2126-2135. Moin ASM, Cory M, Choi J, Ong A, Dhawan S, Dry SM, Butler PC, Rizza RA, Butler AE. PMID: 29659906.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. Cell Death Dis. 2018 05 22; 9(6):600. Ruiz L, Gurlo T, Ravier MA, Wojtusciszyn A, Mathieu J, Brown MR, Broca C, Bertrand G, Butler PC, Matveyenko AV, Dalle S, Costes S. PMID: 29789539.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell Cycle. 2017; 16(21):2086-2099. Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler PC, Tudzarova S. PMID: 28820316.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight. 2017 Jul 06; 2(13). Schludi B, Moin ASM, Montemurro C, Gurlo T, Matveyenko AV, Kirakossian D, Dawson DW, Dry SM, Butler PC, Butler AE. PMID: 28679961.
      View in: PubMed   Mentions:    Fields:    
    13. Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes. J Endocr Soc. 2017 May 01; 1(5):385-395. Md Moin AS, Cory M, Ong A, Choi J, Dhawan S, Butler PC, Butler AE. PMID: 28782056.
      View in: PubMed   Mentions:
    14. Down Syndrome-Associated Diabetes Is Not Due To a Congenital Deficiency in ß Cells. J Endocr Soc. 2017 Jan 01; 1(1):39-45. Butler AE, Sacks W, Rizza RA, Butler PC. PMID: 28782055.
      View in: PubMed   Mentions:
    15. Increased Proliferation of the Pancreatic Duct Gland Compartment in Type 1 Diabetes. J Clin Endocrinol Metab. 2017 01 01; 102(1):200-209. Moin AS, Butler PC, Butler AE. PMID: 27813705.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. ß Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity. JCI Insight. 2016 11 03; 1(18):e89590. Gurlo T, Costes S, Hoang JD, Rivera JF, Butler AE, Butler PC. PMID: 27812546.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Glucagon-like Peptide 1 Drugs as Second-line Therapy for Type 2 Diabetes. JAMA Intern Med. 2016 10 01; 176(10):1-3. Butler PC. PMID: 27479247.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes. J Clin Endocrinol Metab. 2016 10; 101(10):3628-3636. Md Moin AS, Dhawan S, Cory M, Butler PC, Rizza RA, Butler AE. PMID: 27472443.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. Recovery of high-quality RNA from laser capture microdissected human and rodent pancreas. J Histotechnol. 2016; 39(2):59-65. Butler AE, Matveyenko AV, Kirakossian D, Park J, Gurlo T, Butler PC. PMID: 27231405.
      View in: PubMed   Mentions: 9     Fields:    
    20. Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue. J Histotechnol. 2016; 39(1):8-16. Gurlo T, Butler PC, Butler AE. PMID: 27182095.
      View in: PubMed   Mentions:    Fields:    
    21. CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced ß-Cell Apoptosis. Mol Endocrinol. 2016 Apr; 30(4):446-54. Gurlo T, Rivera JF, Butler AE, Cory M, Hoang J, Costes S, Butler PC. PMID: 26900721.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    22. ß-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of ß-Cell Dedifferentiation and Degranulation. J Clin Endocrinol Metab. 2016 Feb; 101(2):523-32. Butler AE, Dhawan S, Hoang J, Cory M, Zeng K, Fritsch H, Meier JJ, Rizza RA, Butler PC. PMID: 26700560.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    23. Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. J Biol Chem. 2015 Oct 23; 290(43):25782-93. Kegulian NC, Sankhagowit S, Apostolidou M, Jayasinghe SA, Malmstadt N, Butler PC, Langen R. PMID: 26283787.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    24. Type 2 diabetes as a protein misfolding disease. Trends Mol Med. 2015 Jul; 21(7):439-49. Mukherjee A, Morales-Scheihing D, Butler PC, Soto C. PMID: 25998900.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    25. Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med. 2015 Apr; 42:61-77. Satin LS, Butler PC, Ha J, Sherman AS. PMID: 25637831.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    26. Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes? Cell Metab. 2014 Aug 05; 20(2):201-3. Costes S, Butler PC. PMID: 25100059.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    27. Autophagy defends pancreatic ß cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest. 2014 Aug; 124(8):3489-500. Rivera JF, Costes S, Gurlo T, Glabe CG, Butler PC. PMID: 25036708.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    28. UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in ß-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy. 2014 Jun; 10(6):1004-14. Costes S, Gurlo T, Rivera JF, Butler PC. PMID: 24879150.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    29. Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604. Diabetes. 2013 Oct; 62(10):e19-22. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. PMID: 24065800.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. A critical analysis of the clinical use of incretin-based therapies: Are the GLP-1 therapies safe? Diabetes Care. 2013 Jul; 36(7):2118-25. Butler PC, Elashoff M, Elashoff R, Gale EA. PMID: 23645885.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimals
    31. Glucagonlike Peptide 1-based drugs and pancreatitis: clarity at last, but what about pancreatic cancer? JAMA Intern Med. 2013 Apr 08; 173(7):539-41. Gier B, Butler PC. PMID: 23463371.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    32. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes. 2013 Jul; 62(7):2595-604. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. PMID: 23524641.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCells
    33. ß-Cell failure in type 2 diabetes: a case of asking too much of too few? Diabetes. 2013 Feb; 62(2):327-35. Costes S, Langen R, Gurlo T, Matveyenko AV, Butler PC. PMID: 23349537.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    34. Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes. 2012 Sep; 61(9):2269-79. Matveyenko AV, Liuwantara D, Gurlo T, Kirakossian D, Dalla Man C, Cobelli C, White MF, Copps KD, Volpi E, Fujita S, Butler PC. PMID: 22688333.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    35. Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. Diabetes. 2012 May; 61(5):1250-62. Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler PC. PMID: 22266668.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    36. Farewell statement from Dr. Peter Butler as outgoing editor in chief of diabetes. Diabetes. 2011 Dec; 60(12):3099. Butler PC. PMID: 22110090.
      View in: PubMed   Mentions:    Fields:    
    37. Glucagon like peptide-1 receptor expression in the human thyroid gland. J Clin Endocrinol Metab. 2012 Jan; 97(1):121-31. Gier B, Butler PC, Lai CK, Kirakossian D, DeNicola MM, Yeh MW. PMID: 22031513.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    38. Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. J Cell Biol. 2011 Aug 08; 194(3):407-23. Sdek P, Zhao P, Wang Y, Huang CJ, Ko CY, Butler PC, Weiss JN, Maclellan WR. PMID: 21825075.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    39. Cyclin-dependent kinase 5 promotes pancreatic ß-cell survival via Fak-Akt signaling pathways. Diabetes. 2011 Apr; 60(4):1186-97. Daval M, Gurlo T, Costes S, Huang CJ, Butler PC. PMID: 21378178.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    40. Shortened {beta}-cell lifespan leads to {beta}-cell deficit in a rodent model of type 2 diabetes. Am J Physiol Endocrinol Metab. 2011 May; 300(5):E933-8. Manesso E, Toffolo GM, Butler AE, Butler PC, Cobelli C. PMID: 21343541.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    41. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology. 2011 Jul; 141(1):150-6. Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler PC. PMID: 21334333.
      View in: PubMed   Mentions: 179     Fields:    Translation:Humans
    42. Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011 Mar; 60(3):848-56. Saisho Y, Manesso E, Butler AE, Galasso R, Kavanagh K, Flynn M, Zhang L, Clark P, Gurlo T, Toffolo GM, Cobelli C, Wagner JD, Butler PC. PMID: 21270238.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    43. The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity. Amyloid. 2010 Sep; 17(3-4):118-28. Daval M, Bedrood S, Gurlo T, Huang CJ, Costes S, Butler PC, Langen R. PMID: 21067307.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    44. ß-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. Diabetes. 2011 Jan; 60(1):227-38. Costes S, Huang CJ, Gurlo T, Daval M, Matveyenko AV, Rizza RA, Butler AE, Butler PC. PMID: 20980462.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    45. Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity. Regul Pept. 2010 Dec 10; 165(2-3):158-62. Ritzel RA, Jayasinghe S, Hansen JB, Sturis J, Langen R, Butler PC. PMID: 20619299.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    46. Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E713-20. Matveyenko AV, Georgia S, Bhushan A, Butler PC. PMID: 20587750.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    47. GLP-1-based therapy for diabetes: what you do not know can hurt you. Diabetes Care. 2010 Feb; 33(2):453-5. Butler PC, Dry S, Elashoff R. PMID: 20103562.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    48. Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol. 2010 Feb; 176(2):861-9. Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe CG, Butler PC. PMID: 20042670.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    49. Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry. 2009 Nov 10; 48(44):10568-76. Bedrood S, Jayasinghe S, Sieburth D, Chen M, Erbel S, Butler PC, Langen R, Ritzel RA. PMID: 19810772.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    50. Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire? Diabetologia. 2010 Jan; 53(1):1-6. Butler PC, Matveyenko AV, Dry S, Bhushan A, Elashoff R. PMID: 19894028.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    51. Insulin glargine controversy: a tribute to the editorial team at Diabetologia. Diabetes. 2009 Nov; 58(11):2427-8. Butler PC. PMID: 19875618.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    52. Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. J Biol Chem. 2010 Jan 01; 285(1):339-48. Huang CJ, Gurlo T, Haataja L, Costes S, Daval M, Ryazantsev S, Wu X, Butler AE, Butler PC. PMID: 19861418.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    53. Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E323-30. Manesso E, Toffolo GM, Saisho Y, Butler AE, Matveyenko AV, Cobelli C, Butler PC. PMID: 19470833.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    54. Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. Diabetes. 2009 Jul; 58(7):1604-15. Matveyenko AV, Dry S, Cox HI, Moshtaghian A, Gurlo T, Galasso R, Butler AE, Butler PC. PMID: 19403868.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    55. Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress. Diabetes. 2009 Apr; 58(4):906-16. Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC. PMID: 19151199.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    56. Development of factors to convert frequency to rate for beta-cell replication and apoptosis quantified by time-lapse video microscopy and immunohistochemistry. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E89-96. Saisho Y, Manesso E, Gurlo T, Huang CJ, Toffolo GM, Cobelli C, Butler PC. PMID: 18940937.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    57. Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas. J Mol Histol. 2008 Oct; 39(5):543-51. Saisho Y, Harris PE, Butler AE, Galasso R, Gurlo T, Rizza RA, Butler PC. PMID: 18791800.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    58. Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and beta-cell mass to age-related insulin resistance in rats. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E832-41. Matveyenko AV, Veldhuis JD, Butler PC. PMID: 18664594.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    59. Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation. Cell Biochem Biophys. 2008; 51(2-3):105-7. Haataja L, Gurlo T, Huang CJ, Butler PC. PMID: 18651105.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    60. Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein. Am J Physiol Endocrinol Metab. 2008 Sep; 295(3):E569-74. Matveyenko AV, Veldhuis JD, Butler PC. PMID: 18577690.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    61. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes: response to Tushuizen et al. Diabetes Care. 2008 May; 31(5):e38; author reply e39. Saisho Y, Butler AE, Butler PC. PMID: 18445718.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    62. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes. 2008 Jun; 57(6):1584-94. Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC. PMID: 18334605.
      View in: PubMed   Mentions: 267     Fields:    Translation:HumansCells
    63. Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr Rev. 2008 May; 29(3):303-16. Haataja L, Gurlo T, Huang CJ, Butler PC. PMID: 18314421.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimals
    64. The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab. 2007 Nov; 3(11):758-68. Butler PC, Meier JJ, Butler AE, Bhushan A. PMID: 17955017.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    65. Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1656-62. Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC. PMID: 17911343.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    66. High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes. 2007 Aug; 56(8):2016-27. Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA, Butler PC. PMID: 17475933.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    67. Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans. Diabetes. 2007 Jul; 56(7):1810-6. Butler AE, Huang A, Rao PN, Bhushan A, Hogan WJ, Rizza RA, Butler PC. PMID: 17456852.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    68. Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes. 2007 May; 56(5):1324-32. Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC. PMID: 17353506.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    69. Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets. Diabetes. 2007 Jan; 56(1):65-71. Ritzel RA, Meier JJ, Lin CY, Veldhuis JD, Butler PC. PMID: 17192466.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    70. Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver. Diabetes. 2006 Aug; 55(8):2324-32. Meier JJ, Hong-McAtee I, Galasso R, Veldhuis JD, Moran A, Hering BJ, Butler PC. PMID: 16873697.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    71. Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy. Diabetes. 2006 Aug; 55(8):2347-56. Matveyenko AV, Veldhuis JD, Butler PC. PMID: 16873700.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    72. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1317-24. Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. PMID: 16849627.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    73. Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover. Diabetes Care. 2006 Jul; 29(7):1554-9. Meier JJ, Butler AE, Galasso R, Butler PC. PMID: 16801578.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    74. Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes. Diabetes. 2006 Jul; 55(7):2106-14. Matveyenko AV, Butler PC. PMID: 16804082.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    75. Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis. Diabetes. 2006 Apr; 55(4):1051-6. Meier JJ, Kjems LL, Veldhuis JD, Lefèbvre P, Butler PC. PMID: 16567528.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    76. The potential for stem cell therapy in diabetes. Pediatr Res. 2006 Apr; 59(4 Pt 2):65R-73R. Meier JJ, Bhushan A, Butler PC. PMID: 16549551.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    77. Relationship between beta-cell mass and fasting blood glucose concentration in humans. Diabetes Care. 2006 Mar; 29(3):717-8. Ritzel RA, Butler AE, Rizza RA, Veldhuis JD, Butler PC. PMID: 16505537.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    78. Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes. ILAR J. 2006; 47(3):225-33. Matveyenko AV, Butler PC. PMID: 16804197.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    79. Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec; 90(12):6678-86. Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC. PMID: 16204373.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    80. Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans. Diabetes. 2005 Jun; 54(6):1649-56. Meier JJ, Veldhuis JD, Butler PC. PMID: 15919785.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    81. Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes. 2004 Jun; 53(6):1509-16. Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC. PMID: 15161755.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    82. Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab. 2004 Feb; 89(2):795-805. Ritzel RA, Hansen JB, Veldhuis JD, Butler PC. PMID: 14764798.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    83. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes. 2004 Feb; 53(2):474-81. Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC. PMID: 14747300.
      View in: PubMed   Mentions: 221     Fields:    Translation:Humans
    84. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes. 2003 Sep; 52(9):2304-14. Butler AE, Janson J, Soeller WC, Butler PC. PMID: 12941770.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimals
    85. Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets. Endocrinology. 2003 Aug; 144(8):3399-405. Song SH, Rhodes CJ, Veldhuis JD, Butler PC. PMID: 12865318.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    86. Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis. Diabetes. 2003 Jul; 52(7):1701-8. Ritzel RA, Butler PC. PMID: 12829636.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    87. Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass: dose-response relationships. J Clin Endocrinol Metab. 2003 Feb; 88(2):742-7. Ritzel RA, Veldhuis JD, Butler PC. PMID: 12574208.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    88. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003 Jan; 52(1):102-10. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. PMID: 12502499.
      View in: PubMed   Mentions: 1092     Fields:    Translation:Humans
    89. Effects of fasting on physiologically pulsatile insulin release in healthy humans. Diabetes. 2002 Feb; 51 Suppl 1:S255-7. Juhl C, Grøfte T, Butler PC, Veldhuis JD, Schmitz O, Pørksen N. PMID: 11815488.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
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