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Dysregulation of cholesterol homeostasis is an early signal of β-cell proteotoxicity characteristic of type 2 diabetes. Physiol Genomics. 2024 Sep 01; 56(9):621-633.
Gurlo T, Liu R, Wang Z, Hoang J, Ryazantsev S, Daval M, Butler AE, Yang X, Blencowe M, Butler PC. PMID: 38949617.
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Translation:
HumansAnimalsCells
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Erratum. β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency. Diabetes 2011;60:227-238. Diabetes. 2023 Dec 01; 72(12):1881.
Costes S, Huang CJ, Gurlo T, Daval M, Matveyenko AV, Rizza RA, Butler AE, Butler PC. PMID: 37683136; PMCID: PMC10658060.
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PubMed Mentions: Fields:
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Application of fluorescence lifetime imaging microscopy to monitor glucose metabolism in pancreatic islets in vivo. Biomed Opt Express. 2023 Aug 01; 14(8):4170-4178.
Wang Z, Archang M, Gurlo T, Wong E, Fraser SE, Butler PC. PMID: 37799700; PMCID: PMC10549748.
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Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide. Front Mol Biosci. 2023; 10:1096286.
Gurlo T, Prakash TP, Wang Z, Archang M, Pei L, Rosenberger M, Pirie E, Lee RG, Butler PC. PMID: 36814640; PMCID: PMC9939749.
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PubMed Mentions:
2
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Reversing type 1 diabetes with stem cell-derived islets: a step closer to the dream? J Clin Invest. 2022 02 01; 132(3).
Butler PC, Gale EA. PMID: 35104802; PMCID: PMC8803316.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes. Diabetologia. 2022 01; 65(1):173-187.
Blencowe M, Furterer A, Wang Q, Gao F, Rosenberger M, Pei L, Nomoto H, Mawla AM, Huising MO, Coppola G, Yang X, Butler PC, Gurlo T. PMID: 34554282; PMCID: PMC8660728.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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The β-cell glucose toxicity hypothesis: Attractive but difficult to prove. Metabolism. 2021 11; 124:154870.
Weir GC, Butler PC, Bonner-Weir S. PMID: 34480921; PMCID: PMC8530963.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes. Commun Biol. 2021 05 19; 4(1):594.
Wang Z, Gurlo T, Matveyenko AV, Elashoff D, Wang P, Rosenberger M, Junge JA, Stevens RC, White KL, Fraser SE, Butler PC. PMID: 34012065; PMCID: PMC8134470.
View in:
PubMed Mentions:
18 Translation:
HumansAnimalsCells
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Supplying Insulin while Evading Immunity. N Engl J Med. 2021 03 11; 384(10):967-969.
Butler PC. PMID: 33704943.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Visualizing insulin vesicle neighborhoods in β cells by cryo-electron tomography. Sci Adv. 2020 12; 6(50).
Zhang X, Carter SD, Singla J, White KL, Butler PC, Stevens RC, Jensen GJ. PMID: 33298442; PMCID: PMC7725471.
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PubMed Mentions:
12 Fields:
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Pancreatic alpha-cell mass across adult human lifespan. Eur J Endocrinol. 2020 Feb; 182(2):219-231.
Moin ASM, Cory M, Gurlo T, Saisho Y, Rizza RA, Butler PC, Butler AE. PMID: 31821160; PMCID: PMC6944979.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes. Case Rep Endocrinol. 2019; 2019:5863569.
Nomoto H, Gurlo T, Rosenberger M, Girgis MD, Dry S, Butler PC. PMID: 31949959; PMCID: PMC6948281.
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PubMed Mentions:
4
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Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes. Diabetologia. 2020 01; 63(1):149-161.
Nomoto H, Pei L, Montemurro C, Rosenberger M, Furterer A, Coppola G, Nadel B, Pellegrini M, Gurlo T, Butler PC, Tudzarova S. PMID: 31720731; PMCID: PMC6945783.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Publisher Correction: IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function. Nat Commun. 2019 Jul 31; 10(1):3507.
Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31366929; PMCID: PMC6668385.
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PubMed Mentions:
3 Fields:
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IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function. Nat Commun. 2019 06 18; 10(1):2679.
Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31213603; PMCID: PMC6581914.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes. Diabetologia. 2019 06; 62(6):1000-1010.
Gurlo T, Kim S, Butler AE, Liu C, Pei L, Rosenberger M, Butler PC. PMID: 30852627; PMCID: PMC6544020.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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An Increase in Chromogranin A-Positive, Hormone-Negative Endocrine Cells in Pancreas in Cystic Fibrosis. J Endocr Soc. 2018 Sep 01; 2(9):1058-1066.
Cory M, Moin ASM, Moran A, Rizza RA, Butler PC, Dhawan S, Butler AE. PMID: 30202828; PMCID: PMC6125715.
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PubMed Mentions:
5
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In the setting of β-cell stress, the pancreatic duct gland transcriptome shows characteristics of an activated regenerative response. Am J Physiol Gastrointest Liver Physiol. 2018 11 01; 315(5):G848-G854.
Butler AE, Kirakossian D, Gurlo T, Gao F, Coppola G, Butler PC. PMID: 30095296; PMCID: PMC6293255.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Increased Chromogranin A-Positive Hormone-Negative Cells in Chronic Pancreatitis. J Clin Endocrinol Metab. 2018 06 01; 103(6):2126-2135.
Moin ASM, Cory M, Choi J, Ong A, Dhawan S, Dry SM, Butler PC, Rizza RA, Butler AE. PMID: 29659906; PMCID: PMC6456995.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Mechanotargeting: Mechanics-Dependent Cellular Uptake of Nanoparticles. Adv Mater. 2018 Jul; 30(27):e1707464.
Wei Q, Huang C, Zhang Y, Zhao T, Zhao P, Butler P, Zhang S. PMID: 29797358.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. Cell Death Dis. 2018 05 22; 9(6):600.
Ruiz L, Gurlo T, Ravier MA, Wojtusciszyn A, Mathieu J, Brown MR, Broca C, Bertrand G, Butler PC, Matveyenko AV, Dalle S, Costes S. PMID: 29789539; PMCID: PMC5964068.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell Cycle. 2017; 16(21):2086-2099.
Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler PC, Tudzarova S. PMID: 28820316; PMCID: PMC5731404.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight. 2017 Jul 06; 2(13).
Schludi B, Moin ASM, Montemurro C, Gurlo T, Matveyenko AV, Kirakossian D, Dawson DW, Dry SM, Butler PC, Butler AE. PMID: 28679961; PMCID: PMC5499368.
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PubMed Mentions:
13 Fields:
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Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes. J Endocr Soc. 2017 May 01; 1(5):385-395.
Md Moin AS, Cory M, Ong A, Choi J, Dhawan S, Butler PC, Butler AE. PMID: 28782056; PMCID: PMC5542010.
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PubMed Mentions:
7
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Down Syndrome-Associated Diabetes Is Not Due To a Congenital Deficiency in β Cells. J Endocr Soc. 2017 Jan 01; 1(1):39-45.
Butler AE, Sacks W, Rizza RA, Butler PC. PMID: 28782055; PMCID: PMC5542008.
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PubMed Mentions:
6
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Increased Proliferation of the Pancreatic Duct Gland Compartment in Type 1 Diabetes. J Clin Endocrinol Metab. 2017 01 01; 102(1):200-209.
Moin AS, Butler PC, Butler AE. PMID: 27813705; PMCID: PMC5413103.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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β Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity. JCI Insight. 2016 11 03; 1(18):e89590.
Gurlo T, Costes S, Hoang JD, Rivera JF, Butler AE, Butler PC. PMID: 27812546; PMCID: PMC5085608.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Glucagon-like Peptide 1 Drugs as Second-line Therapy for Type 2 Diabetes. JAMA Intern Med. 2016 10 01; 176(10):1-3.
Butler PC. PMID: 27479247; PMCID: PMC5118084.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes. J Clin Endocrinol Metab. 2016 10; 101(10):3628-3636.
Md Moin AS, Dhawan S, Cory M, Butler PC, Rizza RA, Butler AE. PMID: 27472443; PMCID: PMC5052343.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes. J Clin Endocrinol Metab. 2016 09; 101(9):3487-96.
Md Moin AS, Dhawan S, Shieh C, Butler PC, Cory M, Butler AE. PMID: 27300574; PMCID: PMC5010569.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Recovery of high-quality RNA from laser capture microdissected human and rodent pancreas. J Histotechnol. 2016; 39(2):59-65.
Butler AE, Matveyenko AV, Kirakossian D, Park J, Gurlo T, Butler PC. PMID: 27231405; PMCID: PMC4878453.
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PubMed Mentions:
16 Fields:
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Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue. J Histotechnol. 2016; 39(1):8-16.
Gurlo T, Butler PC, Butler AE. PMID: 27182095; PMCID: PMC4863713.
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PubMed Mentions:
1 Fields:
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CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell Apoptosis. Mol Endocrinol. 2016 Apr; 30(4):446-54.
Gurlo T, Rivera JF, Butler AE, Cory M, Hoang J, Costes S, Butler PC. PMID: 26900721; PMCID: PMC4814476.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation. J Clin Endocrinol Metab. 2016 Feb; 101(2):523-32.
Butler AE, Dhawan S, Hoang J, Cory M, Zeng K, Fritsch H, Meier JJ, Rizza RA, Butler PC. PMID: 26700560; PMCID: PMC4880126.
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PubMed Mentions:
64 Fields:
Translation:
HumansCells
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Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. J Biol Chem. 2015 Oct 23; 290(43):25782-93.
Kegulian NC, Sankhagowit S, Apostolidou M, Jayasinghe SA, Malmstadt N, Butler PC, Langen R. PMID: 26283787; PMCID: PMC4646232.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Type 2 diabetes as a protein misfolding disease. Trends Mol Med. 2015 Jul; 21(7):439-49.
Mukherjee A, Morales-Scheihing D, Butler PC, Soto C. PMID: 25998900; PMCID: PMC4492843.
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PubMed Mentions:
122 Fields:
Translation:
HumansCells
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Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med. 2015 Apr; 42:61-77.
Satin LS, Butler PC, Ha J, Sherman AS. PMID: 25637831; PMCID: PMC4696552.
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PubMed Mentions:
96 Fields:
Translation:
HumansAnimalsCells
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Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes? Cell Metab. 2014 Aug 05; 20(2):201-3.
Costes S, Butler PC. PMID: 25100059; PMCID: PMC4144405.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest. 2014 Aug; 124(8):3489-500.
Rivera JF, Costes S, Gurlo T, Glabe CG, Butler PC. PMID: 25036708; PMCID: PMC4109537.
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PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
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UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy. 2014 Jun; 10(6):1004-14.
Costes S, Gurlo T, Rivera JF, Butler PC. PMID: 24879150; PMCID: PMC4091165.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604. Diabetes. 2013 Oct; 62(10):e19-22.
Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. PMID: 24065800; PMCID: PMC3781463.
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Translation:
HumansCells
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Response to Comment on: Saisho et al. β-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care 2013;36:111-117. Diabetes Care. 2013 Jul; 36(7):e112.
Saisho Y, Butler AE, Manesso E, Butler PC. PMID: 23801813; PMCID: PMC3687307.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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A critical analysis of the clinical use of incretin-based therapies: Are the GLP-1 therapies safe? Diabetes Care. 2013 Jul; 36(7):2118-25.
Butler PC, Elashoff M, Elashoff R, Gale EA. PMID: 23645885; PMCID: PMC3687282.
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PubMed Mentions:
100 Fields:
Translation:
HumansAnimals
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Glucagonlike Peptide 1-based drugs and pancreatitis: clarity at last, but what about pancreatic cancer? JAMA Intern Med. 2013 Apr 08; 173(7):539-41.
Gier B, Butler PC. PMID: 23463371.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes. 2013 Jul; 62(7):2595-604.
Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. PMID: 23524641; PMCID: PMC3712065.
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PubMed Mentions:
157 Fields:
Translation:
HumansCells
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β-Cell failure in type 2 diabetes: a case of asking too much of too few? Diabetes. 2013 Feb; 62(2):327-35.
Costes S, Langen R, Gurlo T, Matveyenko AV, Butler PC. PMID: 23349537; PMCID: PMC3554362.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
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β-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care. 2013 Jan; 36(1):111-7.
Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler PC. PMID: 22875233; PMCID: PMC3526241.
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PubMed Mentions:
213 Fields:
Translation:
HumansCells
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Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes. 2012 Sep; 61(9):2269-79.
Matveyenko AV, Liuwantara D, Gurlo T, Kirakossian D, Dalla Man C, Cobelli C, White MF, Copps KD, Volpi E, Fujita S, Butler PC. PMID: 22688333; PMCID: PMC3425431.
View in:
PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
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Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. Diabetes. 2012 May; 61(5):1250-62.
Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler PC. PMID: 22266668; PMCID: PMC3331736.
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PubMed Mentions:
91 Fields:
Translation:
HumansAnimals
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Farewell statement from Dr. Peter Butler as outgoing editor in chief of diabetes. Diabetes. 2011 Dec; 60(12):3099.
Butler PC. PMID: 22110090; PMCID: PMC3219941.
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PubMed Mentions: Fields:
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Glucagon like peptide-1 receptor expression in the human thyroid gland. J Clin Endocrinol Metab. 2012 Jan; 97(1):121-31.
Gier B, Butler PC, Lai CK, Kirakossian D, DeNicola MM, Yeh MW. PMID: 22031513; PMCID: PMC3412261.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. J Cell Biol. 2011 Aug 08; 194(3):407-23.
Sdek P, Zhao P, Wang Y, Huang CJ, Ko CY, Butler PC, Weiss JN, Maclellan WR. PMID: 21825075; PMCID: PMC3153646.
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PubMed Mentions:
88 Fields:
Translation:
AnimalsCells
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Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways. Diabetes. 2011 Apr; 60(4):1186-97.
Daval M, Gurlo T, Costes S, Huang CJ, Butler PC. PMID: 21378178; PMCID: PMC3064092.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Shortened {beta}-cell lifespan leads to {beta}-cell deficit in a rodent model of type 2 diabetes. Am J Physiol Endocrinol Metab. 2011 May; 300(5):E933-8.
Manesso E, Toffolo GM, Butler AE, Butler PC, Cobelli C. PMID: 21343541; PMCID: PMC3279301.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology. 2011 Jul; 141(1):150-6.
Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler PC. PMID: 21334333; PMCID: PMC4404515.
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PubMed Mentions:
260 Fields:
Translation:
Humans
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Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011 Mar; 60(3):848-56.
Saisho Y, Manesso E, Butler AE, Galasso R, Kavanagh K, Flynn M, Zhang L, Clark P, Gurlo T, Toffolo GM, Cobelli C, Wagner JD, Butler PC. PMID: 21270238; PMCID: PMC3046845.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity. Amyloid. 2010 Sep; 17(3-4):118-28.
Daval M, Bedrood S, Gurlo T, Huang CJ, Costes S, Butler PC, Langen R. PMID: 21067307; PMCID: PMC4394664.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. Diabetes. 2011 Jan; 60(1):227-38.
Costes S, Huang CJ, Gurlo T, Daval M, Matveyenko AV, Rizza RA, Butler AE, Butler PC. PMID: 20980462; PMCID: PMC3012175.
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PubMed Mentions:
64 Fields:
Translation:
HumansAnimalsCells
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Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity. Regul Pept. 2010 Dec 10; 165(2-3):158-62.
Ritzel RA, Jayasinghe S, Hansen JB, Sturis J, Langen R, Butler PC. PMID: 20619299; PMCID: PMC2995001.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E713-20.
Matveyenko AV, Georgia S, Bhushan A, Butler PC. PMID: 20587750; PMCID: PMC3774125.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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GLP-1-based therapy for diabetes: what you do not know can hurt you. Diabetes Care. 2010 Feb; 33(2):453-5.
Butler PC, Dry S, Elashoff R. PMID: 20103562; PMCID: PMC2809301.
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PubMed Mentions:
25 Fields:
Translation:
Humans
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Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol. 2010 Feb; 176(2):861-9.
Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe CG, Butler PC. PMID: 20042670; PMCID: PMC2808091.
View in:
PubMed Mentions:
105 Fields:
Translation:
HumansAnimalsCells
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Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry. 2009 Nov 10; 48(44):10568-76.
Bedrood S, Jayasinghe S, Sieburth D, Chen M, Erbel S, Butler PC, Langen R, Ritzel RA. PMID: 19810772; PMCID: PMC4394648.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire? Diabetologia. 2010 Jan; 53(1):1-6.
Butler PC, Matveyenko AV, Dry S, Bhushan A, Elashoff R. PMID: 19894028; PMCID: PMC2789933.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
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Insulin glargine controversy: a tribute to the editorial team at Diabetologia. Diabetes. 2009 Nov; 58(11):2427-8.
Butler PC. PMID: 19875618; PMCID: PMC2768168.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
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Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. J Biol Chem. 2010 Jan 01; 285(1):339-48.
Huang CJ, Gurlo T, Haataja L, Costes S, Daval M, Ryazantsev S, Wu X, Butler AE, Butler PC. PMID: 19861418; PMCID: PMC2804181.
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PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
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Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E323-30.
Manesso E, Toffolo GM, Saisho Y, Butler AE, Matveyenko AV, Cobelli C, Butler PC. PMID: 19470833; PMCID: PMC2724115.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. Diabetes. 2009 Jul; 58(7):1604-15.
Matveyenko AV, Dry S, Cox HI, Moshtaghian A, Gurlo T, Galasso R, Butler AE, Butler PC. PMID: 19403868; PMCID: PMC2699878.
View in:
PubMed Mentions:
86 Fields:
Translation:
HumansAnimals
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11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med. 2009 Mar; 50(3):382-9.
Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, Butler PC, Van Heertum R, Leibel RL, Ichise M, Harris PE. PMID: 19223416; PMCID: PMC3629294.
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PubMed Mentions:
56 Fields:
Translation:
HumansCells
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Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress. Diabetes. 2009 Apr; 58(4):906-16.
Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC. PMID: 19151199; PMCID: PMC2661593.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Development of factors to convert frequency to rate for beta-cell replication and apoptosis quantified by time-lapse video microscopy and immunohistochemistry. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E89-96.
Saisho Y, Manesso E, Gurlo T, Huang CJ, Toffolo GM, Cobelli C, Butler PC. PMID: 18940937; PMCID: PMC4043232.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas. J Mol Histol. 2008 Oct; 39(5):543-51.
Saisho Y, Harris PE, Butler AE, Galasso R, Gurlo T, Rizza RA, Butler PC. PMID: 18791800; PMCID: PMC2566800.
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PubMed Mentions:
52 Fields:
Translation:
HumansCells
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Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and beta-cell mass to age-related insulin resistance in rats. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E832-41.
Matveyenko AV, Veldhuis JD, Butler PC. PMID: 18664594; PMCID: PMC2575907.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation. Cell Biochem Biophys. 2008; 51(2-3):105-7.
Haataja L, Gurlo T, Huang CJ, Butler PC. PMID: 18651105; PMCID: PMC2527405.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein. Am J Physiol Endocrinol Metab. 2008 Sep; 295(3):E569-74.
Matveyenko AV, Veldhuis JD, Butler PC. PMID: 18577690; PMCID: PMC2536733.
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PubMed Mentions:
30 Fields:
Translation:
Animals
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Pancreatic fat content and beta-cell function in men with and without type 2 diabetes: response to Tushuizen et al. Diabetes Care. 2008 May; 31(5):e38; author reply e39.
Saisho Y, Butler AE, Butler PC. PMID: 18445718.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes. 2008 Jun; 57(6):1584-94.
Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC. PMID: 18334605; PMCID: PMC3697779.
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PubMed Mentions:
364 Fields:
Translation:
HumansCells
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Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr Rev. 2008 May; 29(3):303-16.
Haataja L, Gurlo T, Huang CJ, Butler PC. PMID: 18314421; PMCID: PMC2528855.
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PubMed Mentions:
246 Fields:
Translation:
HumansAnimals
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The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab. 2007 Nov; 3(11):758-68.
Butler PC, Meier JJ, Butler AE, Bhushan A. PMID: 17955017.
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PubMed Mentions:
133 Fields:
Translation:
HumansAnimalsCells
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Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1656-62.
Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC. PMID: 17911343.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007 Sep 26; 2:18.
Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. PMID: 17897471; PMCID: PMC2100048.
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PubMed Mentions:
366 Fields:
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High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes. 2007 Aug; 56(8):2016-27.
Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA, Butler PC. PMID: 17475933.
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PubMed Mentions:
204 Fields:
Translation:
HumansAnimalsCells
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Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans. Diabetes. 2007 Jul; 56(7):1810-6.
Butler AE, Huang A, Rao PN, Bhushan A, Hogan WJ, Rizza RA, Butler PC. PMID: 17456852.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes. 2007 May; 56(5):1324-32.
Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC. PMID: 17353506.
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PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
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Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E1-E15.
Cobelli C, Toffolo GM, Dalla Man C, Campioni M, Denti P, Caumo A, Butler P, Rizza R. PMID: 17341552.
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PubMed Mentions:
130 Fields:
Translation:
HumansCells
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Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets. Diabetes. 2007 Jan; 56(1):65-71.
Ritzel RA, Meier JJ, Lin CY, Veldhuis JD, Butler PC. PMID: 17192466.
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PubMed Mentions:
82 Fields:
Translation:
Humans
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Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver. Diabetes. 2006 Aug; 55(8):2324-32.
Meier JJ, Hong-McAtee I, Galasso R, Veldhuis JD, Moran A, Hering BJ, Butler PC. PMID: 16873697.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy. Diabetes. 2006 Aug; 55(8):2347-56.
Matveyenko AV, Veldhuis JD, Butler PC. PMID: 16873700.
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PubMed Mentions:
43 Fields:
Translation:
Animals
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Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1317-24.
Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. PMID: 16849627.
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PubMed Mentions:
70 Fields:
Translation:
HumansAnimalsCells
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Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover. Diabetes Care. 2006 Jul; 29(7):1554-9.
Meier JJ, Butler AE, Galasso R, Butler PC. PMID: 16801578.
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PubMed Mentions:
100 Fields:
Translation:
HumansCells
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Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes. Diabetes. 2006 Jul; 55(7):2106-14.
Matveyenko AV, Butler PC. PMID: 16804082.
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PubMed Mentions:
79 Fields:
Translation:
HumansAnimals
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Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis. Diabetes. 2006 Apr; 55(4):1051-6.
Meier JJ, Kjems LL, Veldhuis JD, Lefèbvre P, Butler PC. PMID: 16567528.
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PubMed Mentions:
53 Fields:
Translation:
Animals
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The potential for stem cell therapy in diabetes. Pediatr Res. 2006 Apr; 59(4 Pt 2):65R-73R.
Meier JJ, Bhushan A, Butler PC. PMID: 16549551.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Relationship between beta-cell mass and fasting blood glucose concentration in humans. Diabetes Care. 2006 Mar; 29(3):717-8.
Ritzel RA, Butler AE, Rizza RA, Veldhuis JD, Butler PC. PMID: 16505537.
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PubMed Mentions:
98 Fields:
Translation:
HumansCells
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Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes. ILAR J. 2006; 47(3):225-33.
Matveyenko AV, Butler PC. PMID: 16804197.
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PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
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Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec; 90(12):6678-86.
Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC. PMID: 16204373.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans. Diabetes. 2005 Jun; 54(6):1649-56.
Meier JJ, Veldhuis JD, Butler PC. PMID: 15919785.
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PubMed Mentions:
106 Fields:
Translation:
Humans
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Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes. 2004 Jun; 53(6):1509-16.
Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC. PMID: 15161755.
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PubMed Mentions:
105 Fields:
Translation:
HumansAnimals
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Increased risk of type 2 diabetes in Alzheimer disease. Diabetes. 2004 Feb; 53(2):474-81.
Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC. PMID: 14747300.
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PubMed Mentions:
371 Fields:
Translation:
Humans
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Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab. 2004 Feb; 89(2):795-805.
Ritzel RA, Hansen JB, Veldhuis JD, Butler PC. PMID: 14764798.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes. 2003 Sep; 52(9):2304-14.
Butler AE, Janson J, Soeller WC, Butler PC. PMID: 12941770.
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PubMed Mentions:
151 Fields:
Translation:
HumansAnimals
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Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets. Endocrinology. 2003 Aug; 144(8):3399-405.
Song SH, Rhodes CJ, Veldhuis JD, Butler PC. PMID: 12865318.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis. Diabetes. 2003 Jul; 52(7):1701-8.
Ritzel RA, Butler PC. PMID: 12829636.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass: dose-response relationships. J Clin Endocrinol Metab. 2003 Feb; 88(2):742-7.
Ritzel RA, Veldhuis JD, Butler PC. PMID: 12574208.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003 Jan; 52(1):102-10.
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. PMID: 12502499.
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PubMed Mentions:
1524 Fields:
Translation:
Humans
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Pulsatile insulin secretion: detection, regulation, and role in diabetes. Diabetes. 2002 Feb; 51 Suppl 1:S245-54.
Pørksen N, Hollingdal M, Juhl C, Butler P, Veldhuis JD, Schmitz O. PMID: 11815487.
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PubMed Mentions:
85 Fields:
Translation:
Humans
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Effects of fasting on physiologically pulsatile insulin release in healthy humans. Diabetes. 2002 Feb; 51 Suppl 1:S255-7.
Juhl C, Grøfte T, Butler PC, Veldhuis JD, Schmitz O, Pørksen N. PMID: 11815488.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Pulsatile insulin secretion by human pancreatic islets. J Clin Endocrinol Metab. 2002 Jan; 87(1):213-21.
Song SH, Kjems L, Ritzel R, McIntyre SM, Johnson ML, Veldhuis JD, Butler PC. PMID: 11788649.
View in:
PubMed Mentions:
27 Fields:
Translation:
Humans