Peter Cawood Butler

Title(s)Professor, Medicine
Address900 Weyburn Place North 24-130
Los Angeles CA 90024
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    Collapse Research 
    Collapse Research Activities and Funding
    Capacity and Mechanisms of Beta Cell Regeneration in Humans
    NIH R01DK077967Jan 15, 2008 - Jun 30, 2017
    Role: Principal Investigator
    Role of Pulsatile Insulin Secretion
    NIH R01DK061539Jul 1, 2002 - Jun 30, 2006
    Role: Principal Investigator
    Role of IAPP in Islet Dysfunction in Diabetes
    NIH R01DK059579Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    NIH R29DK044341Sep 1, 1991 - Aug 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Visualizing insulin vesicle neighborhoods in ß cells by cryo-electron tomography. Sci Adv. 2020 Dec; 6(50). Zhang X, Carter SD, Singla J, White KL, Butler PC, Stevens RC, Jensen GJ. PMID: 33298442.
      View in: PubMed   Mentions:    Fields:    
    2. Pancreatic alpha-cell mass across adult human lifespan. Eur J Endocrinol. 2020 Feb; 182(2):219-231. Moin ASM, Cory M, Gurlo T, Saisho Y, Rizza RA, Butler PC, Butler AE. PMID: 31821160.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes. Case Rep Endocrinol. 2019; 2019:5863569. Nomoto H, Gurlo T, Rosenberger M, Girgis MD, Dry S, Butler PC. PMID: 31949959.
      View in: PubMed   Mentions:
    4. Activation of the HIF1a/PFKFB3 stress response pathway in beta cells in type 1 diabetes. Diabetologia. 2020 01; 63(1):149-161. Nomoto H, Pei L, Montemurro C, Rosenberger M, Furterer A, Coppola G, Nadel B, Pellegrini M, Gurlo T, Butler PC, Tudzarova S. PMID: 31720731.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Publisher Correction: IAPP toxicity activates HIF1a/PFKFB3 signaling delaying ß-cell loss at the expense of ß-cell function. Nat Commun. 2019 Jul 31; 10(1):3507. Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31366929.
      View in: PubMed   Mentions: 1     Fields:    
    6. IAPP toxicity activates HIF1a/PFKFB3 signaling delaying ß-cell loss at the expense of ß-cell function. Nat Commun. 2019 06 18; 10(1):2679. Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. PMID: 31213603.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes. Diabetologia. 2019 06; 62(6):1000-1010. Gurlo T, Kim S, Butler AE, Liu C, Pei L, Rosenberger M, Butler PC. PMID: 30852627.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. An Increase in Chromogranin A-Positive, Hormone-Negative Endocrine Cells in Pancreas in Cystic Fibrosis. J Endocr Soc. 2018 Sep 01; 2(9):1058-1066. Cory M, Moin ASM, Moran A, Rizza RA, Butler PC, Dhawan S, Butler AE. PMID: 30202828.
      View in: PubMed   Mentions:
    9. In the setting of ß-cell stress, the pancreatic duct gland transcriptome shows characteristics of an activated regenerative response. Am J Physiol Gastrointest Liver Physiol. 2018 11 01; 315(5):G848-G854. Butler AE, Kirakossian D, Gurlo T, Gao F, Coppola G, Butler PC. PMID: 30095296.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Increased Chromogranin A-Positive Hormone-Negative Cells in Chronic Pancreatitis. J Clin Endocrinol Metab. 2018 06 01; 103(6):2126-2135. PMID: 29659906.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. Cell Death Dis. 2018 05 22; 9(6):600. Ruiz L, Gurlo T, Ravier MA, Wojtusciszyn A, Mathieu J, Brown MR, Broca C, Bertrand G, Butler PC, Matveyenko AV, Dalle S, Costes S. PMID: 29789539.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. . 2017; 16(21):2086-2099. Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler PC, Tudzarova S. PMID: 28820316.
      View in: PubMed   Mentions:
    13. Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight. 2017 Jul 06; 2(13). PMID: 28679961.
      View in: PubMed   Mentions: 1     Fields:    
    14. Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes. J Endocr Soc. 2017 May 01; 1(5):385-395. PMID: 28782056.
      View in: PubMed   Mentions:
    15. Down Syndrome-Associated Diabetes Is Not Due To a Congenital Deficiency in ß Cells. J Endocr Soc. 2017 Jan 01; 1(1):39-45. Butler AE, Sacks W, Rizza RA, Butler PC. PMID: 28782055.
      View in: PubMed   Mentions:
    16. Increased Proliferation of the Pancreatic Duct Gland Compartment in Type 1 Diabetes. J Clin Endocrinol Metab. 2017 01 01; 102(1):200-209. PMID: 27813705.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. ß Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity. JCI Insight. 2016 11 03; 1(18):e89590. PMID: 27812546.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Glucagon-like Peptide 1 Drugs as Second-line Therapy for Type 2 Diabetes. JAMA Intern Med. 2016 10 01; 176(10):1-3. PMID: 27479247.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes. J Clin Endocrinol Metab. 2016 10; 101(10):3628-3636. PMID: 27472443.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. Recovery of high-quality RNA from laser capture microdissected human and rodent pancreas. J Histotechnol. 2016; 39(2):59-65. PMID: 27231405.
      View in: PubMed   Mentions: 11     Fields:    
    21. Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue. J Histotechnol. 2016; 39(1):8-16. PMID: 27182095.
      View in: PubMed   Mentions: 1     Fields:    
    22. CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced ß-Cell Apoptosis. Mol Endocrinol. 2016 Apr; 30(4):446-54. PMID: 26900721.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    23. ß-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of ß-Cell Dedifferentiation and Degranulation. J Clin Endocrinol Metab. 2016 Feb; 101(2):523-32. PMID: 26700560.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    24. Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. J Biol Chem. 2015 Oct 23; 290(43):25782-93. PMID: 26283787.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. Type 2 diabetes as a protein misfolding disease. Trends Mol Med. 2015 Jul; 21(7):439-49. PMID: 25998900.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    26. Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med. 2015 Apr; 42:61-77. PMID: 25637831.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    27. Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes? Cell Metab. 2014 Aug 05; 20(2):201-3. PMID: 25100059.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    28. Autophagy defends pancreatic ß cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest. 2014 Aug; 124(8):3489-500. PMID: 25036708.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    29. UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in ß-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy. 2014 Jun; 10(6):1004-14. PMID: 24879150.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    30. Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604. Diabetes. 2013 Oct; 62(10):e19-22. PMID: 24065800.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. A critical analysis of the clinical use of incretin-based therapies: Are the GLP-1 therapies safe? Diabetes Care. 2013 Jul; 36(7):2118-25. PMID: 23645885.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    32. Glucagonlike Peptide 1-based drugs and pancreatitis: clarity at last, but what about pancreatic cancer? JAMA Intern Med. 2013 Apr 08; 173(7):539-41. PMID: 23463371.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    33. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes. 2013 Jul; 62(7):2595-604. PMID: 23524641.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    34. ß-Cell failure in type 2 diabetes: a case of asking too much of too few? Diabetes. 2013 Feb; 62(2):327-35. PMID: 23349537.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    35. Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes. 2012 Sep; 61(9):2269-79. PMID: 22688333.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    36. Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. Diabetes. 2012 May; 61(5):1250-62. PMID: 22266668.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    37. Farewell statement from Dr. Peter Butler as outgoing editor in chief of diabetes. Diabetes. 2011 Dec; 60(12):3099. PMID: 22110090.
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    38. Glucagon like peptide-1 receptor expression in the human thyroid gland. J Clin Endocrinol Metab. 2012 Jan; 97(1):121-31. PMID: 22031513.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    39. Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. J Cell Biol. 2011 Aug 08; 194(3):407-23. PMID: 21825075.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    40. Cyclin-dependent kinase 5 promotes pancreatic ß-cell survival via Fak-Akt signaling pathways. Diabetes. 2011 Apr; 60(4):1186-97. Daval M, Gurlo T, Costes S, Huang CJ, Butler PC. PMID: 21378178.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    41. Shortened {beta}-cell lifespan leads to {beta}-cell deficit in a rodent model of type 2 diabetes. Am J Physiol Endocrinol Metab. 2011 May; 300(5):E933-8. Manesso E, Toffolo GM, Butler AE, Butler PC, Cobelli C. PMID: 21343541.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    42. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology. 2011 Jul; 141(1):150-6. PMID: 21334333.
      View in: PubMed   Mentions: 190     Fields:    Translation:Humans
    43. Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011 Mar; 60(3):848-56. PMID: 21270238.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    44. The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity. Amyloid. 2010 Sep; 17(3-4):118-28. Daval M, Bedrood S, Gurlo T, Huang CJ, Costes S, Butler PC, Langen R. PMID: 21067307.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    45. ß-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. Diabetes. 2011 Jan; 60(1):227-38. Costes S, Huang CJ, Gurlo T, Daval M, Matveyenko AV, Rizza RA, Butler AE, Butler PC. PMID: 20980462.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    46. Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity. Regul Pept. 2010 Dec 10; 165(2-3):158-62. Ritzel RA, Jayasinghe S, Hansen JB, Sturis J, Langen R, Butler PC. PMID: 20619299.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    47. Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E713-20. Matveyenko AV, Georgia S, Bhushan A, Butler PC. PMID: 20587750.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    48. GLP-1-based therapy for diabetes: what you do not know can hurt you. Diabetes Care. 2010 Feb; 33(2):453-5. Butler PC, Dry S, Elashoff R. PMID: 20103562.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    49. Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol. 2010 Feb; 176(2):861-9. Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe CG, Butler PC. PMID: 20042670.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    50. Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry. 2009 Nov 10; 48(44):10568-76. Bedrood S, Jayasinghe S, Sieburth D, Chen M, Erbel S, Butler PC, Langen R, Ritzel RA. PMID: 19810772.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    51. Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire? Diabetologia. 2010 Jan; 53(1):1-6. Butler PC, Matveyenko AV, Dry S, Bhushan A, Elashoff R. PMID: 19894028.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    52. Insulin glargine controversy: a tribute to the editorial team at Diabetologia. Diabetes. 2009 Nov; 58(11):2427-8. Butler PC. PMID: 19875618.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    53. Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. J Biol Chem. 2010 Jan 01; 285(1):339-48. Huang CJ, Gurlo T, Haataja L, Costes S, Daval M, Ryazantsev S, Wu X, Butler AE, Butler PC. PMID: 19861418.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    54. Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E323-30. Manesso E, Toffolo GM, Saisho Y, Butler AE, Matveyenko AV, Cobelli C, Butler PC. PMID: 19470833.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    55. Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. Diabetes. 2009 Jul; 58(7):1604-15. Matveyenko AV, Dry S, Cox HI, Moshtaghian A, Gurlo T, Galasso R, Butler AE, Butler PC. PMID: 19403868.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    56. Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress. Diabetes. 2009 Apr; 58(4):906-16. Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC. PMID: 19151199.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    57. Development of factors to convert frequency to rate for beta-cell replication and apoptosis quantified by time-lapse video microscopy and immunohistochemistry. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E89-96. Saisho Y, Manesso E, Gurlo T, Huang CJ, Toffolo GM, Cobelli C, Butler PC. PMID: 18940937.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    58. Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas. J Mol Histol. 2008 Oct; 39(5):543-51. Saisho Y, Harris PE, Butler AE, Galasso R, Gurlo T, Rizza RA, Butler PC. PMID: 18791800.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    59. Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and beta-cell mass to age-related insulin resistance in rats. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E832-41. Matveyenko AV, Veldhuis JD, Butler PC. PMID: 18664594.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    60. Many commercially available antibodies for detection of CHOP expression as a marker of endoplasmic reticulum stress fail specificity evaluation. Cell Biochem Biophys. 2008; 51(2-3):105-7. Haataja L, Gurlo T, Huang CJ, Butler PC. PMID: 18651105.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    61. Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein. Am J Physiol Endocrinol Metab. 2008 Sep; 295(3):E569-74. Matveyenko AV, Veldhuis JD, Butler PC. PMID: 18577690.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    62. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes: response to Tushuizen et al. Diabetes Care. 2008 May; 31(5):e38; author reply e39. Saisho Y, Butler AE, Butler PC. PMID: 18445718.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    63. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes. 2008 Jun; 57(6):1584-94. Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC. PMID: 18334605.
      View in: PubMed   Mentions: 279     Fields:    Translation:HumansCells
    64. Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr Rev. 2008 May; 29(3):303-16. Haataja L, Gurlo T, Huang CJ, Butler PC. PMID: 18314421.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansAnimals
    65. The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab. 2007 Nov; 3(11):758-68. Butler PC, Meier JJ, Butler AE, Bhushan A. PMID: 17955017.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    66. Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1656-62. Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC. PMID: 17911343.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    67. High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes. 2007 Aug; 56(8):2016-27. Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA, Butler PC. PMID: 17475933.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    68. Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans. Diabetes. 2007 Jul; 56(7):1810-6. Butler AE, Huang A, Rao PN, Bhushan A, Hogan WJ, Rizza RA, Butler PC. PMID: 17456852.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    69. Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes. 2007 May; 56(5):1324-32. Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC. PMID: 17353506.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    70. Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets. Diabetes. 2007 Jan; 56(1):65-71. Ritzel RA, Meier JJ, Lin CY, Veldhuis JD, Butler PC. PMID: 17192466.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    71. Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver. Diabetes. 2006 Aug; 55(8):2324-32. Meier JJ, Hong-McAtee I, Galasso R, Veldhuis JD, Moran A, Hering BJ, Butler PC. PMID: 16873697.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    72. Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy. Diabetes. 2006 Aug; 55(8):2347-56. Matveyenko AV, Veldhuis JD, Butler PC. PMID: 16873700.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    73. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1317-24. Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. PMID: 16849627.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    74. Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover. Diabetes Care. 2006 Jul; 29(7):1554-9. Meier JJ, Butler AE, Galasso R, Butler PC. PMID: 16801578.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    75. Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes. Diabetes. 2006 Jul; 55(7):2106-14. Matveyenko AV, Butler PC. PMID: 16804082.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    76. Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis. Diabetes. 2006 Apr; 55(4):1051-6. Meier JJ, Kjems LL, Veldhuis JD, Lefèbvre P, Butler PC. PMID: 16567528.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    77. The potential for stem cell therapy in diabetes. Pediatr Res. 2006 Apr; 59(4 Pt 2):65R-73R. Meier JJ, Bhushan A, Butler PC. PMID: 16549551.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    78. Relationship between beta-cell mass and fasting blood glucose concentration in humans. Diabetes Care. 2006 Mar; 29(3):717-8. Ritzel RA, Butler AE, Rizza RA, Veldhuis JD, Butler PC. PMID: 16505537.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    79. Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes. ILAR J. 2006; 47(3):225-33. Matveyenko AV, Butler PC. PMID: 16804197.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    80. Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec; 90(12):6678-86. Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC. PMID: 16204373.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    81. Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans. Diabetes. 2005 Jun; 54(6):1649-56. Meier JJ, Veldhuis JD, Butler PC. PMID: 15919785.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    82. Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes. 2004 Jun; 53(6):1509-16. Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC. PMID: 15161755.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimals
    83. Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab. 2004 Feb; 89(2):795-805. Ritzel RA, Hansen JB, Veldhuis JD, Butler PC. PMID: 14764798.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    84. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes. 2004 Feb; 53(2):474-81. Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC. PMID: 14747300.
      View in: PubMed   Mentions: 240     Fields:    Translation:Humans
    85. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes. 2003 Sep; 52(9):2304-14. Butler AE, Janson J, Soeller WC, Butler PC. PMID: 12941770.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimals
    86. Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets. Endocrinology. 2003 Aug; 144(8):3399-405. Song SH, Rhodes CJ, Veldhuis JD, Butler PC. PMID: 12865318.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    87. Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis. Diabetes. 2003 Jul; 52(7):1701-8. Ritzel RA, Butler PC. PMID: 12829636.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    88. Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass: dose-response relationships. J Clin Endocrinol Metab. 2003 Feb; 88(2):742-7. Ritzel RA, Veldhuis JD, Butler PC. PMID: 12574208.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    89. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003 Jan; 52(1):102-10. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. PMID: 12502499.
      View in: PubMed   Mentions: 1169     Fields:    Translation:Humans
    90. Effects of fasting on physiologically pulsatile insulin release in healthy humans. Diabetes. 2002 Feb; 51 Suppl 1:S255-7. Juhl C, Grøfte T, Butler PC, Veldhuis JD, Schmitz O, Pørksen N. PMID: 11815488.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
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