Paul J Mathews

Title(s)Associate Professor-in-Residence, Neurology
ORCID ORCID Icon0000-0002-1991-0798 Additional info
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    University of Texas, Austin, TXPhD12/2008Neuroscience
    University of Oregon, Eugene, ORBS07/2001Biology

    Collapse Overview 
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    Dr. Mathews’ research program seeks to understand how neural communication between brain regions, in particular the cerebellum and forebrain gives rise to complex animal behavior. Our current research goals are to 1) define region-specific connectivity between the cerebellum and forebrain, 2) elucidate the neural influence the cerebellum has on downstream forebrain structures (e.g. basal ganglia and prefrontal cortex), and 3) to elucidate the neural information provided by the cerebellum to the forebrain in non-motor behaviors (e.g. reversal learning). The lab currently incorporates a multifaceted set of approaches to answer these questions including in vivo multi-electrode recordings, functional Magnetic Resonance Imaging (fMRI), function Ulrasound (fUS), and animal behavioral testing and anatomy. Furthermore, we are complementing these approaches with both directed (e.g. DREADD or optogenetic manipulation) and/or disease related (e.g. mouse models of autism) disruptions in cerebellar-forebrain communication to significantly advance our understanding of cerebellar-forebrain communication and its role in non-motor behavior.

    A second major component of our research program is to understand and devise potential treatments for the disease Ataxia-Telangiectasia (A-T). To do so, we have recently created a new mouse model of A-T that for the first time displays the phenotypical loss of motor control and contains a human related genetic mutation (i.e. nonsense mutation). With this new model we are elucidating the neuropathogenesis of the disease and testing a new small molecule therapeutic designed to read-through premature termination codons. In collaboration with others here at the Lundquist Intistute, we are further testing and developing the therapeutic potential of these small molecule read-through (SMRT) compounds along with combinatorial approaches to restore protein production in an array diseases caused by a premature stop codons.
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    Behavioral and brain network effects of dysfunction in the cognitive cerebellum
    NIMH R21MH126359Jul 1, 2022 - Jun 30, 2023
    Role: PI
    Optimizing Small Molecule Read-Through Compounds for Treating AtaxiaTelangiectasia
    NINDS R61NS119708Apr 19, 2022 - Mar 1, 2024
    Role: PI
    Ataxia Telangiectasia: Elucidating Disease Pathogenesis and Testing New Treatments
    NIH R21NS108117Jun 15, 2018 - May 31, 2021
    Role: Principal Investigator
    A New Mouse Model of Ataxia-Telangiectasia for Testing Therapeutic Read-Through Compounds
    NIH R03NS103066Jan 15, 2018 - Dec 31, 2019
    Role: Principal Investigator
    An optogenetic approach to exploring climbing fiber connections in the cerebellum
    NIH F32NS074719Aug 28, 2011 - Aug 27, 2014
    Role: Principal Investigator
    Synaptic Integration in the Medial Superior Olive
    NIH F31DC008030Apr 28, 2006 - Apr 27, 2009
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correlated signatures of social behavior in cerebellum and anterior cingulate cortex. Elife. 2024 Feb 12; 12. Hur SW, Safaryan K, Yang L, Blair HT, Masmanidis SC, Mathews PJ, Aharoni D, Golshani P. PMID: 38345922; PMCID: PMC10942583.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Correlated signatures of social behavior in cerebellum and anterior cingulate cortex. bioRxiv. 2023 Oct 14. Hur SW, Safaryan K, Yang L, Blair HT, Masmanidis SC, Mathews PJ, Aharoni D, Golshani P. PMID: 37066345; PMCID: PMC10104017.
      View in: PubMed   Mentions:
    3. Editorial: Unravelling the complex and multifaceted role of the cerebellum in health and disease. Front Syst Neurosci. 2023; 17:1155939. Mathews PJ, Paradis AL, Cvetanovic M, Carlson ES, Parker KL. PMID: 37034016; PMCID: PMC10076819.
      View in: PubMed   Mentions: 1  
    4. A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation. Elife. 2021 11 01; 10. Perez H, Abdallah MF, Chavira JI, Norris AS, Egeland MT, Vo KL, Buechsenschuetz CL, Sanghez V, Kim JL, Pind M, Nakamura K, Hicks GG, Gatti RA, Madrenas J, Iacovino M, McKinnon PJ, Mathews PJ. PMID: 34723800; PMCID: PMC8601662.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Optogenetic fMRI and electrophysiological identification of region-specific connectivity between the cerebellar cortex and forebrain. Neuroimage. 2018 06; 173:370-383. Choe KY, Sanchez CF, Harris NG, Otis TS, Mathews PJ. PMID: 29496611; PMCID: PMC5911204.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    6. α7-Nicotinic acetylcholine receptor inhibition by indinavir: implications for cognitive dysfunction in treated HIV disease. AIDS. 2017 05 15; 31(8):1083-1089. Ekins S, Mathews P, Saito EK, Diaz N, Naylor D, Chung J, McMurtray AM. PMID: 28358738.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Enabling Anyone to Translate Clinically Relevant Ideas to Therapies. Pharm Res. 2017 01; 34(1):1-6. Ekins S, Diaz N, Chung J, Mathews P, McMurtray A. PMID: 27620174.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. Circuit mechanisms underlying motor memory formation in the cerebellum. Neuron. 2015 Apr 22; 86(2):529-40. Lee KH, Mathews PJ, Reeves AM, Choe KY, Jami SA, Serrano RE, Otis TS. PMID: 25843404; PMCID: PMC4417109.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    9. Effects of climbing fiber driven inhibition on Purkinje neuron spiking. J Neurosci. 2012 Dec 12; 32(50):17988-97. Mathews PJ, Lee KH, Peng Z, Houser CR, Otis TS. PMID: 23238715; PMCID: PMC3532857.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    10. How do climbing fibers teach? Front Neural Circuits. 2012; 6:95. Otis TS, Mathews PJ, Lee KH, Maiz J. PMID: 23226116; PMCID: PMC3510640.
      View in: PubMed   Mentions: 8     Fields:    
    11. Control of submillisecond synaptic timing in binaural coincidence detectors by K(v)1 channels. Nat Neurosci. 2010 May; 13(5):601-9. Mathews PJ, Jercog PE, Rinzel J, Scott LL, Golding NL. PMID: 20364143; PMCID: PMC3375691.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    12. Perisomatic voltage-gated sodium channels actively maintain linear synaptic integration in principal neurons of the medial superior olive. J Neurosci. 2010 Feb 10; 30(6):2039-50. Scott LL, Mathews PJ, Golding NL. PMID: 20147532; PMCID: PMC2827923.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    13. Posthearing developmental refinement of temporal processing in principal neurons of the medial superior olive. J Neurosci. 2005 Aug 31; 25(35):7887-95. Scott LL, Mathews PJ, Golding NL. PMID: 16135745; PMCID: PMC6725447.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
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