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A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation. Elife. 2021 11 01; 10.
Perez H, Abdallah MF, Chavira JI, Norris AS, Egeland MT, Vo KL, Buechsenschuetz CL, Sanghez V, Kim JL, Pind M, Nakamura K, Hicks GG, Gatti RA, Madrenas J, Iacovino M, McKinnon PJ, Mathews PJ. PMID: 34723800; PMCID: PMC8601662.
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6 Fields:
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AnimalsCells
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Intranasal Application of Lactococcus lactis W136 Is Safe in Chronic Rhinosinusitis Patients With Previous Sinus Surgery. Front Cell Infect Microbiol. 2020; 10:440.
Endam LM, Alromaih S, Gonzalez E, Madrenas J, Cousineau B, Renteria AE, Desrosiers M. PMID: 33154953; PMCID: PMC7586919.
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15 Fields:
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HumansCells
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Correction to: Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016. Demography. 2019 Oct 28.
Acosta E, Hallman SA, Dillon LY, Ouellette N, Bourbeau R, Herring DA, Inwood K, Earn DJD, Madrenas J, Miller MS, Gagnon A. PMID: 31659681.
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Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016. Demography. 2019 10; 56(5):1723-1746.
Acosta E, Hallman SA, Dillon LY, Ouellette N, Bourbeau R, Herring DA, Inwood K, Earn DJD, Madrenas J, Miller MS, Gagnon A. PMID: 31502229; PMCID: PMC6797638.
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7 Fields:
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HumansCells
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TAOK3, a Regulator of LCK-SHP-1 Crosstalk during TCR Signaling. Crit Rev Immunol. 2019; 39(1):59-81.
Ormonde JVS, Nie Y, Madrenas J. PMID: 31679194.
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3 Fields:
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HumansAnimalsCells
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Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic. mBio. 2018 01 16; 9(1).
Gagnon A, Acosta E, Hallman S, Bourbeau R, Dillon LY, Ouellette N, Earn DJD, Herring DA, Inwood K, Madrenas J, Miller MS. PMID: 29339427; PMCID: PMC5770550.
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23 Fields:
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HumansCells
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Bacterial immune evasion via an IL-10 mediated host response, a novel pathophysiologic mechanism for chronic rhinosinusitis. Rhinology. 2017 Sep 01; 55(3):227-233.
Schwartz JS, Al-Mot S, Endam MF, Alromaih S, Madrenas J, Desrosiers M. PMID: 28315920.
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2 Fields:
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HumansCells
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Topical probiotics as a therapeutic alternative for chronic rhinosinusitis: A preclinical proof of concept. Am J Rhinol Allergy. 2016 Nov 01; 30(6):202-205.
Schwartz JS, Peres AG, Mfuna Endam L, Cousineau B, Madrenas J, Desrosiers M. PMID: 28124641.
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20 Fields:
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HumansCells
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The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 2016 12; 17(12):1844-1856.
Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T. PMID: 27737933; PMCID: PMC5283581.
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84 Fields:
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HumansCells
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Is antigenic sin always "original?" Re-examining the evidence regarding circulation of a human H1 influenza virus immediately prior to the 1918 Spanish flu. PLoS Pathog. 2015 Mar; 11(3):e1004615.
Gagnon A, Acosta JE, Madrenas J, Miller MS. PMID: 25742615; PMCID: PMC4351064.
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19 Fields:
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HumansCells
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Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell. 2009 Aug 04; 16(2):161-71.
Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, Kimura A, Kubagawa H, Bertoli LF, Davis RS, Chau LA, Madrenas J, Hsia CC, Xenocostas A, Kipps TJ, Hennighausen L, Iwama A, Nakauchi H, Kawakami T. PMID: 19647226; PMCID: PMC2744338.
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46 Fields:
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AnimalsCells
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Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin. Clin Exp Immunol. 2009 Jul; 157(1):60-70.
Hayworth JL, Kasper KJ, Leon-Ponte M, Herfst CA, Yue D, Brintnell WC, Mazzuca DM, Heinrichs DE, Cairns E, Madrenas J, Hoskin DW, McCormick JK, Haeryfar SM. PMID: 19659771; PMCID: PMC2710593.
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14 Fields:
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HumansAnimalsCells
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Dendritic cell differentiation induced by a self-peptide derived from apolipoprotein E. J Immunol. 2008 Nov 15; 181(10):6859-71.
Stephens TA, Nikoopour E, Rider BJ, Leon-Ponte M, Chau TA, Mikolajczak S, Chaturvedi P, Lee-Chan E, Flavell RA, Haeryfar SM, Madrenas J, Singh B. PMID: 18981105.
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PubMed Mentions:
9 Fields:
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HumansAnimalsCells
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RIP2 is required for NOD signaling but not for Th1 cell differentiation and cellular allograft rejection. Am J Transplant. 2008 Jun; 8(6):1143-50.
Fairhead T, Lian D, McCully ML, Garcia B, Zhong R, Madrenas J. PMID: 18522545.
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PubMed Mentions:
7 Fields:
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AnimalsCells
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Receptor-interacting protein 2 is a marker for resolution of peritoneal dialysis-associated peritonitis. Kidney Int. 2007 Nov; 72(10):1273-81.
McCully ML, Baroja ML, Chau TA, Jain AK, Barra L, Salgado A, Blake PG, Madrenas J. PMID: 17851464.
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PubMed Mentions:
1 Fields:
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HumansCells
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Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. Circ Res. 2006 Dec 08; 99(12):1338-46.
Small TW, Bolender Z, Bueno C, O'Neil C, Nong Z, Rushlow W, Rajakumar N, Kandel C, Strong J, Madrenas J, Pickering JG. PMID: 17095724.
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PubMed Mentions:
27 Fields:
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HumansAnimalsCells
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The immunological synapse as a novel therapeutic target. Curr Opin Investig Drugs. 2006 Nov; 7(11):1008-13.
Teft WA, Madrenas J. PMID: 17117590.
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6 Fields:
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HumansCells
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FcR gamma presence in TCR complex of double-negative T cells is critical for their regulatory function. J Immunol. 2006 Aug 15; 177(4):2250-7.
Thomson CW, Teft WA, Chen W, Lee BP, Madrenas J, Zhang L. PMID: 16887985.
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9 Fields:
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AnimalsCells
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Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway. Immunity. 2006 Jul; 25(1):67-78.
Bueno C, Lemke CD, Criado G, Baroja ML, Ferguson SS, Rahman AK, Tsoukas CD, McCormick JK, Madrenas J. PMID: 16860758.
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PubMed Mentions:
46 Fields:
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HumansCells
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Characterization of human peritoneal dendritic cell precursors and their involvement in peritonitis. Clin Exp Immunol. 2005 Mar; 139(3):513-25.
McCully ML, Chau TA, Luke P, Blake PG, Madrenas J. PMID: 15730398; PMCID: PMC1809323.
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PubMed Mentions:
6 Fields:
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HumansCells
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Lck is required for activation-induced T cell death after TCR ligation with partial agonists. J Immunol. 2004 Feb 01; 172(3):1437-43.
Yu XZ, Levin SD, Madrenas J, Anasetti C. PMID: 14734719.
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PubMed Mentions:
7 Fields:
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AnimalsCells
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Human embryonic stem cells possess immune-privileged properties. Stem Cells. 2004; 22(4):448-56.
Li L, Baroja ML, Majumdar A, Chadwick K, Rouleau A, Gallacher L, Ferber I, Lebkowski J, Martin T, Madrenas J, Bhatia M. PMID: 15277692.
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121 Fields:
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HumansAnimalsCells
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Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. J Biol Chem. 2003 Apr 04; 278(14):11985-94.
DeVries ME, Cao H, Wang J, Xu L, Kelvin AA, Ran L, Chau LA, Madrenas J, Hegele RA, Kelvin DJ. PMID: 12551893.
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PubMed Mentions:
9 Fields:
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HumansAnimalsCells
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Thymic re-entry of mature activated T cells and increased negative selection in vascularized allograft recipients. Clin Exp Immunol. 2002 Jan; 127(1):43-52.
Chau LA, Rohekar S, Wang JJ, Lian D, Chakrabarti S, Zhang L, Zhong R, Madrenas J. PMID: 11882031; PMCID: PMC1906281.
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PubMed Mentions:
10 Fields:
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AnimalsCells
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Zap-70-independent Ca(2+) mobilization and Erk activation in Jurkat T cells in response to T-cell antigen receptor ligation. Mol Cell Biol. 2001 Nov; 21(21):7137-49.
Shan X, Balakir R, Criado G, Wood JS, Seminario MC, Madrenas J, Wange RL. PMID: 11585897; PMCID: PMC99889.
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PubMed Mentions:
16 Fields:
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HumansCells
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Inhibition of cytokine production and interference in IL-2 receptor-mediated Jak-Stat signaling by the hydroxylamine metabolite of sulfamethoxazole. FASEB J. 2001 Aug; 15(10):1855-7.
Hess DA, O'Leary EF, Lee JT, Almawi WY, Madrenas J, Rieder MJ. PMID: 11481253.
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PubMed Mentions:
1 Fields:
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HumansCells
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HuM291(Nuvion), a humanized Fc receptor-nonbinding antibody against CD3, anergizes peripheral blood T cells as partial agonist of the T cell receptor. Transplantation. 2001 Apr 15; 71(7):941-50.
Chau LA, Tso JY, Melrose J, Madrenas J. PMID: 11349730.
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PubMed Mentions:
1 Fields:
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HumansCells
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The role of ezrin in T-cell receptor-dependent signaling. Transplant Proc. 2001 Feb-Mar; 33(1-2):207-8.
Tomas EM, Darlington PJ, Chau LA, Madrenas J. PMID: 11266781.
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PubMed Mentions:
2 Fields:
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HumansAnimalsCells
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Generation of partial agonist ligands of the T-cell receptor by engineering of antibodies against CD3. Transplant Proc. 2001 Feb-Mar; 33(1-2):528-9.
Chau LA, Tso JY, Madrenas J. PMID: 11266941.
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HumansCells
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CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression. J Immunol. 2000 Aug 01; 165(3):1352-6.
Carreno BM, Bennett F, Chau TA, Ling V, Luxenberg D, Jussif J, Baroja ML, Madrenas J. PMID: 10903737.
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PubMed Mentions:
92 Fields:
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HumansCells
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Identification of a novel mechanism for endotoxin-mediated down-modulation of CC chemokine receptor expression. Eur J Immunol. 2000 Jan; 30(1):227-35.
Xu L, Khandaker MH, Barlic J, Ran L, Borja ML, Madrenas J, Rahimpour R, Chen K, Mitchell G, Tan CM, DeVries M, Feldman RD, Kelvin DJ. PMID: 10602045.
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PubMed Mentions:
10 Fields:
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HumansCells
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The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. J Immunol. 2000 Jan 01; 164(1):49-55.
Baroja ML, Luxenberg D, Chau T, Ling V, Strathdee CA, Carreno BM, Madrenas J. PMID: 10604992.
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PubMed Mentions:
16 Fields:
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HumansCells
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Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8(+) cells by the hydroxylamine of sulfamethoxazole. FASEB J. 1999 Oct; 13(13):1688-98.
Hess DA, Sisson ME, Suria H, Wijsman J, Puvanesasingham R, Madrenas J, Rieder MJ. PMID: 10506572.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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CD40-deficient dendritic cells producing interleukin-10, but not interleukin-12, induce T-cell hyporesponsiveness in vitro and prevent acute allograft rejection. Immunology. 1999 Oct; 98(2):159-70.
Gao JX, Madrenas J, Zeng W, Cameron MJ, Zhang Z, Wang JJ, Zhong R, Grant D. PMID: 10540214; PMCID: PMC2326930.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Phospho-LAT-independent activation of the ras-mitogen-activated protein kinase pathway: a differential recruitment model of TCR partial agonist signaling. J Immunol. 1999 Aug 15; 163(4):1853-8.
Chau LA, Madrenas J. PMID: 10438919.
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PubMed Mentions:
11 Fields:
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AnimalsCells
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CD45 modulation of CXCR1 and CXCR2 in human polymorphonuclear leukocytes. Eur J Immunol. 1999 05; 29(5):1467-76.
Mitchell GB, Khandaker MH, Rahimpour R, Xu L, Lazarovits AI, Pickering JG, Suria H, Madrenas J, Pomerantz DK, Feldman RD, Kelvin DJ. PMID: 10359100.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Metalloproteinases are involved in lipopolysaccharide- and tumor necrosis factor-alpha-mediated regulation of CXCR1 and CXCR2 chemokine receptor expression. Blood. 1999 Apr 01; 93(7):2173-85.
Khandaker MH, Mitchell G, Xu L, Andrews JD, Singh R, Leung H, Madrenas J, Ferguson SS, Feldman RD, Kelvin DJ. PMID: 10090924.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Specific CD3 epsilon association of a phosphodiesterase 4B isoform determines its selective tyrosine phosphorylation after CD3 ligation. J Immunol. 1999 Feb 15; 162(4):2016-23.
Baroja ML, Cieslinski LB, Torphy TJ, Wange RL, Madrenas J. PMID: 9973473.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Differential signalling by variant ligands of the T cell receptor and the kinetic model of T cell activation. Life Sci. 1999; 64(9):717-31.
Madrenas J. PMID: 10075104.
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PubMed Mentions:
3 Fields:
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HumansCells
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Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism. Life Sci. 1999; 65(25):2697-707.
Suria H, Chau LA, Negrou E, Kelvin DJ, Madrenas J. PMID: 10622279.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease. Immunol Today. 1998 Oct; 19(10):468-73.
Salojin KV, Zhang J, Madrenas J, Delovitch TL. PMID: 9785671.
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PubMed Mentions:
13 Fields:
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HumansAnimalsCells
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Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. J Exp Med. 1998 May 18; 187(10):1699-709.
Chau LA, Bluestone JA, Madrenas J. PMID: 9584148; PMCID: PMC2212283.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Development of an I-Ag7-expressing antigen-presenting cell line: intrinsic molecular defect in compact I-Ag7 dimer generation. J Autoimmun. 1998 Feb; 11(1):63-71.
Nabavieh A, Chou H, Volokhov I, Lee JE, Purdy LE, Elliott JF, Singh B, Madrenas J. PMID: 9480724.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance. Histol Histopathol. 1998 01; 13(1):221-9.
Madrenas J, Lazarovits AI. PMID: 9476651.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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Inactivation of lck and loss of TCR-mediated signaling upon persistent engagement with complexes of peptide:MHC molecules. J Immunol. 1997 Jul 01; 159(1):61-9.
Lee JE, Cossoy MB, Chau LA, Singh B, Madrenas J. PMID: 9200439.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Generation of dendritic cell-like antigen-presenting cells in long-term mixed leucocyte culture: phenotypic and functional studies. Immunology. 1997 May; 91(1):135-44.
Gao JX, Madrenas J, Zeng W, Zhong R, Grant D. PMID: 9203977; PMCID: PMC1364046.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J Exp Med. 1997 Jan 20; 185(2):219-29.
Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. PMID: 9016871; PMCID: PMC2196122.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9736-41.
Madrenas J, Schwartz RH, Germain RN. PMID: 8790400; PMCID: PMC38498.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. Semin Immunol. 1996 Apr; 8(2):83-101.
Madrenas J, Germain RN. PMID: 8920243.
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PubMed Mentions:
24 Fields:
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HumansAnimalsCells
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Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science. 1995 Jan 27; 267(5197):515-8.
Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. PMID: 7824949.
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PubMed Mentions:
114 Fields:
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AnimalsCells
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Ly-6 in kidney is widely expressed on tubular epithelium and vascular endothelium and is up-regulated by interferon gamma. J Am Soc Nephrol. 1993 Nov; 4(5):1140-50.
Blake PG, Madrenas J, Halloran PF. PMID: 8305641.
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PubMed Mentions:
10 Fields:
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HumansAnimalsCells
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The molecular immunology of acute rejection: an overview. Transpl Immunol. 1993; 1(1):3-27.
Halloran PF, Broski AP, Batiuk TD, Madrenas J. PMID: 8081760.
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PubMed Mentions:
2 Fields:
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HumansAnimalsCells
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Thymus-independent expression of a truncated T cell receptor-alpha mRNA in murine kidney. J Immunol. 1992 Jan 15; 148(2):612-9.
Madrenas J, Pazderka F, Parfrey NA, Halloran PF. PMID: 1530865.
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PubMed Mentions:
1 Fields:
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AnimalsCells
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[Systemic vasculitis with predominant renal involvement]. Med Clin (Barc). 1987 Mar 07; 88(9):356-62.
Vallés M, Galicia M, Madrenas J, Carrera M, Morlans M, Fort J, Ferrer E, Piera L. PMID: 3573853.
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PubMed Mentions:
1 Fields:
Translation:
Humans