Joaquin Madrenas

Title(s)Assoc Dean, Deans Office-School Of Medicin
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    Title(s)Professor-in-residence, Medicine

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation. Elife. 2021 11 01; 10. Perez H, Abdallah MF, Chavira JI, Norris AS, Egeland MT, Vo KL, Buechsenschuetz CL, Sanghez V, Kim JL, Pind M, Nakamura K, Hicks GG, Gatti RA, Madrenas J, Iacovino M, McKinnon PJ, Mathews PJ. PMID: 34723800; PMCID: PMC8601662.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    2. Intranasal Application of Lactococcus lactis W136 Is Safe in Chronic Rhinosinusitis Patients With Previous Sinus Surgery. Front Cell Infect Microbiol. 2020; 10:440. Endam LM, Alromaih S, Gonzalez E, Madrenas J, Cousineau B, Renteria AE, Desrosiers M. PMID: 33154953; PMCID: PMC7586919.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    3. Correction to: Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016. Demography. 2019 Oct 28. Acosta E, Hallman SA, Dillon LY, Ouellette N, Bourbeau R, Herring DA, Inwood K, Earn DJD, Madrenas J, Miller MS, Gagnon A. PMID: 31659681.
      View in: PubMed   Mentions:    Fields:    
    4. Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959-2016. Demography. 2019 10; 56(5):1723-1746. Acosta E, Hallman SA, Dillon LY, Ouellette N, Bourbeau R, Herring DA, Inwood K, Earn DJD, Madrenas J, Miller MS, Gagnon A. PMID: 31502229; PMCID: PMC6797638.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. TAOK3, a Regulator of LCK-SHP-1 Crosstalk during TCR Signaling. Crit Rev Immunol. 2019; 39(1):59-81. Ormonde JVS, Nie Y, Madrenas J. PMID: 31679194.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    6. Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic. mBio. 2018 01 16; 9(1). Gagnon A, Acosta E, Hallman S, Bourbeau R, Dillon LY, Ouellette N, Earn DJD, Herring DA, Inwood K, Madrenas J, Miller MS. PMID: 29339427; PMCID: PMC5770550.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    7. Bacterial immune evasion via an IL-10 mediated host response, a novel pathophysiologic mechanism for chronic rhinosinusitis. Rhinology. 2017 Sep 01; 55(3):227-233. Schwartz JS, Al-Mot S, Endam MF, Alromaih S, Madrenas J, Desrosiers M. PMID: 28315920.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Topical probiotics as a therapeutic alternative for chronic rhinosinusitis: A preclinical proof of concept. Am J Rhinol Allergy. 2016 Nov 01; 30(6):202-205. Schwartz JS, Peres AG, Mfuna Endam L, Cousineau B, Madrenas J, Desrosiers M. PMID: 28124641.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    9. The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 2016 12; 17(12):1844-1856. Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T. PMID: 27737933; PMCID: PMC5283581.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    10. Is antigenic sin always "original?" Re-examining the evidence regarding circulation of a human H1 influenza virus immediately prior to the 1918 Spanish flu. PLoS Pathog. 2015 Mar; 11(3):e1004615. Gagnon A, Acosta JE, Madrenas J, Miller MS. PMID: 25742615; PMCID: PMC4351064.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    11. Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell. 2009 Aug 04; 16(2):161-71. Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, Kimura A, Kubagawa H, Bertoli LF, Davis RS, Chau LA, Madrenas J, Hsia CC, Xenocostas A, Kipps TJ, Hennighausen L, Iwama A, Nakauchi H, Kawakami T. PMID: 19647226; PMCID: PMC2744338.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    12. Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin. Clin Exp Immunol. 2009 Jul; 157(1):60-70. Hayworth JL, Kasper KJ, Leon-Ponte M, Herfst CA, Yue D, Brintnell WC, Mazzuca DM, Heinrichs DE, Cairns E, Madrenas J, Hoskin DW, McCormick JK, Haeryfar SM. PMID: 19659771; PMCID: PMC2710593.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    13. Dendritic cell differentiation induced by a self-peptide derived from apolipoprotein E. J Immunol. 2008 Nov 15; 181(10):6859-71. Stephens TA, Nikoopour E, Rider BJ, Leon-Ponte M, Chau TA, Mikolajczak S, Chaturvedi P, Lee-Chan E, Flavell RA, Haeryfar SM, Madrenas J, Singh B. PMID: 18981105.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. RIP2 is required for NOD signaling but not for Th1 cell differentiation and cellular allograft rejection. Am J Transplant. 2008 Jun; 8(6):1143-50. Fairhead T, Lian D, McCully ML, Garcia B, Zhong R, Madrenas J. PMID: 18522545.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Receptor-interacting protein 2 is a marker for resolution of peritoneal dialysis-associated peritonitis. Kidney Int. 2007 Nov; 72(10):1273-81. McCully ML, Baroja ML, Chau TA, Jain AK, Barra L, Salgado A, Blake PG, Madrenas J. PMID: 17851464.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. Circ Res. 2006 Dec 08; 99(12):1338-46. Small TW, Bolender Z, Bueno C, O'Neil C, Nong Z, Rushlow W, Rajakumar N, Kandel C, Strong J, Madrenas J, Pickering JG. PMID: 17095724.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    17. The immunological synapse as a novel therapeutic target. Curr Opin Investig Drugs. 2006 Nov; 7(11):1008-13. Teft WA, Madrenas J. PMID: 17117590.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. FcR gamma presence in TCR complex of double-negative T cells is critical for their regulatory function. J Immunol. 2006 Aug 15; 177(4):2250-7. Thomson CW, Teft WA, Chen W, Lee BP, Madrenas J, Zhang L. PMID: 16887985.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway. Immunity. 2006 Jul; 25(1):67-78. Bueno C, Lemke CD, Criado G, Baroja ML, Ferguson SS, Rahman AK, Tsoukas CD, McCormick JK, Madrenas J. PMID: 16860758.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    20. Characterization of human peritoneal dendritic cell precursors and their involvement in peritonitis. Clin Exp Immunol. 2005 Mar; 139(3):513-25. McCully ML, Chau TA, Luke P, Blake PG, Madrenas J. PMID: 15730398; PMCID: PMC1809323.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Lck is required for activation-induced T cell death after TCR ligation with partial agonists. J Immunol. 2004 Feb 01; 172(3):1437-43. Yu XZ, Levin SD, Madrenas J, Anasetti C. PMID: 14734719.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    22. Human embryonic stem cells possess immune-privileged properties. Stem Cells. 2004; 22(4):448-56. Li L, Baroja ML, Majumdar A, Chadwick K, Rouleau A, Gallacher L, Ferber I, Lebkowski J, Martin T, Madrenas J, Bhatia M. PMID: 15277692.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    23. Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. J Biol Chem. 2003 Apr 04; 278(14):11985-94. DeVries ME, Cao H, Wang J, Xu L, Kelvin AA, Ran L, Chau LA, Madrenas J, Hegele RA, Kelvin DJ. PMID: 12551893.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Thymic re-entry of mature activated T cells and increased negative selection in vascularized allograft recipients. Clin Exp Immunol. 2002 Jan; 127(1):43-52. Chau LA, Rohekar S, Wang JJ, Lian D, Chakrabarti S, Zhang L, Zhong R, Madrenas J. PMID: 11882031; PMCID: PMC1906281.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. HuM291(Nuvion), a humanized Fc receptor-nonbinding antibody against CD3, anergizes peripheral blood T cells as partial agonist of the T cell receptor. Transplantation. 2001 Apr 15; 71(7):941-50. Chau LA, Tso JY, Melrose J, Madrenas J. PMID: 11349730.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    26. The role of ezrin in T-cell receptor-dependent signaling. Transplant Proc. 2001 Feb-Mar; 33(1-2):207-8. Tomas EM, Darlington PJ, Chau LA, Madrenas J. PMID: 11266781.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Generation of partial agonist ligands of the T-cell receptor by engineering of antibodies against CD3. Transplant Proc. 2001 Feb-Mar; 33(1-2):528-9. Chau LA, Tso JY, Madrenas J. PMID: 11266941.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    28. CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression. J Immunol. 2000 Aug 01; 165(3):1352-6. Carreno BM, Bennett F, Chau TA, Ling V, Luxenberg D, Jussif J, Baroja ML, Madrenas J. PMID: 10903737.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    29. Identification of a novel mechanism for endotoxin-mediated down-modulation of CC chemokine receptor expression. Eur J Immunol. 2000 Jan; 30(1):227-35. Xu L, Khandaker MH, Barlic J, Ran L, Borja ML, Madrenas J, Rahimpour R, Chen K, Mitchell G, Tan CM, DeVries M, Feldman RD, Kelvin DJ. PMID: 10602045.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. J Immunol. 2000 Jan 01; 164(1):49-55. Baroja ML, Luxenberg D, Chau T, Ling V, Strathdee CA, Carreno BM, Madrenas J. PMID: 10604992.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    31. Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8(+) cells by the hydroxylamine of sulfamethoxazole. FASEB J. 1999 Oct; 13(13):1688-98. Hess DA, Sisson ME, Suria H, Wijsman J, Puvanesasingham R, Madrenas J, Rieder MJ. PMID: 10506572.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    32. CD40-deficient dendritic cells producing interleukin-10, but not interleukin-12, induce T-cell hyporesponsiveness in vitro and prevent acute allograft rejection. Immunology. 1999 Oct; 98(2):159-70. Gao JX, Madrenas J, Zeng W, Cameron MJ, Zhang Z, Wang JJ, Zhong R, Grant D. PMID: 10540214; PMCID: PMC2326930.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. Phospho-LAT-independent activation of the ras-mitogen-activated protein kinase pathway: a differential recruitment model of TCR partial agonist signaling. J Immunol. 1999 Aug 15; 163(4):1853-8. Chau LA, Madrenas J. PMID: 10438919.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    34. CD45 modulation of CXCR1 and CXCR2 in human polymorphonuclear leukocytes. Eur J Immunol. 1999 05; 29(5):1467-76. Mitchell GB, Khandaker MH, Rahimpour R, Xu L, Lazarovits AI, Pickering JG, Suria H, Madrenas J, Pomerantz DK, Feldman RD, Kelvin DJ. PMID: 10359100.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. Metalloproteinases are involved in lipopolysaccharide- and tumor necrosis factor-alpha-mediated regulation of CXCR1 and CXCR2 chemokine receptor expression. Blood. 1999 Apr 01; 93(7):2173-85. Khandaker MH, Mitchell G, Xu L, Andrews JD, Singh R, Leung H, Madrenas J, Ferguson SS, Feldman RD, Kelvin DJ. PMID: 10090924.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    36. Specific CD3 epsilon association of a phosphodiesterase 4B isoform determines its selective tyrosine phosphorylation after CD3 ligation. J Immunol. 1999 Feb 15; 162(4):2016-23. Baroja ML, Cieslinski LB, Torphy TJ, Wange RL, Madrenas J. PMID: 9973473.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    37. Differential signalling by variant ligands of the T cell receptor and the kinetic model of T cell activation. Life Sci. 1999; 64(9):717-31. Madrenas J. PMID: 10075104.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    38. Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism. Life Sci. 1999; 65(25):2697-707. Suria H, Chau LA, Negrou E, Kelvin DJ, Madrenas J. PMID: 10622279.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease. Immunol Today. 1998 Oct; 19(10):468-73. Salojin KV, Zhang J, Madrenas J, Delovitch TL. PMID: 9785671.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    40. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. J Exp Med. 1998 May 18; 187(10):1699-709. Chau LA, Bluestone JA, Madrenas J. PMID: 9584148; PMCID: PMC2212283.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    41. Development of an I-Ag7-expressing antigen-presenting cell line: intrinsic molecular defect in compact I-Ag7 dimer generation. J Autoimmun. 1998 Feb; 11(1):63-71. Nabavieh A, Chou H, Volokhov I, Lee JE, Purdy LE, Elliott JF, Singh B, Madrenas J. PMID: 9480724.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    42. Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance. Histol Histopathol. 1998 01; 13(1):221-9. Madrenas J, Lazarovits AI. PMID: 9476651.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    43. Inactivation of lck and loss of TCR-mediated signaling upon persistent engagement with complexes of peptide:MHC molecules. J Immunol. 1997 Jul 01; 159(1):61-9. Lee JE, Cossoy MB, Chau LA, Singh B, Madrenas J. PMID: 9200439.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    44. Generation of dendritic cell-like antigen-presenting cells in long-term mixed leucocyte culture: phenotypic and functional studies. Immunology. 1997 May; 91(1):135-44. Gao JX, Madrenas J, Zeng W, Zhong R, Grant D. PMID: 9203977; PMCID: PMC1364046.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J Exp Med. 1997 Jan 20; 185(2):219-29. Madrenas J, Chau LA, Smith J, Bluestone JA, Germain RN. PMID: 9016871; PMCID: PMC2196122.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    46. Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9736-41. Madrenas J, Schwartz RH, Germain RN. PMID: 8790400; PMCID: PMC38498.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    47. Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. Semin Immunol. 1996 Apr; 8(2):83-101. Madrenas J, Germain RN. PMID: 8920243.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    48. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science. 1995 Jan 27; 267(5197):515-8. Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. PMID: 7824949.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    49. Ly-6 in kidney is widely expressed on tubular epithelium and vascular endothelium and is up-regulated by interferon gamma. J Am Soc Nephrol. 1993 Nov; 4(5):1140-50. Blake PG, Madrenas J, Halloran PF. PMID: 8305641.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    50. The molecular immunology of acute rejection: an overview. Transpl Immunol. 1993; 1(1):3-27. Halloran PF, Broski AP, Batiuk TD, Madrenas J. PMID: 8081760.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    51. Thymus-independent expression of a truncated T cell receptor-alpha mRNA in murine kidney. J Immunol. 1992 Jan 15; 148(2):612-9. Madrenas J, Pazderka F, Parfrey NA, Halloran PF. PMID: 1530865.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    52. [Systemic vasculitis with predominant renal involvement]. Med Clin (Barc). 1987 Mar 07; 88(9):356-62. Vallés M, Galicia M, Madrenas J, Carrera M, Morlans M, Fort J, Ferrer E, Piera L. PMID: 3573853.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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