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James S Economou

Title(s)Professor, Surgery
SchoolMedicine
Address760 Westwood Plaza 54-134
Los Angeles CA 90024
Phone52644
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    Other Positions
    Title(s)Professor, MIMG

    Title(s)Professor, Molecular and Medical Pharmacology


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    PET IMAGING OF MART TCR-ENGINEERED CD8 T CELL IMMUNOTHERAPY IN MAN
    NIH/NCI R01CA129816Aug 13, 2007 - Jul 31, 2013
    Role: Principal Investigator
    Dendritic Cell-Based Genetic Immunotherapy for Melanoma
    NIH/NCI R01CA079976Jan 1, 1999 - Jan 31, 2008
    Role: Principal Investigator
    Genetic Immunotherapy for Hepatocellular Cancer
    NIH/NCI R01CA077623Apr 1, 1998 - Mar 31, 2006
    Role: Principal Investigator
    UCLA Clinical Scientist Training in Cancer Gene Medicine
    NIH/NCI K12CA076905Sep 30, 1997 - Jun 30, 2008
    Role: Principal Investigator
    UCLA CANCER GENE MEDICINE TRAINING PROGRAM
    NIH/NCI T32CA075956Sep 30, 1997 - Jun 30, 2007
    Role: Principal Investigator
    GENE THERAPY FOR CANCER
    NIH/NCI P01CA059326Sep 30, 1992 - Sep 29, 1994
    Role: Principal Investigator
    THERAPEUTIC REGULATION OF TNF IN IL-2 IMMUNOTHERAPY
    NIH/NCI R29CA050780Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    REGULATION OF MACROPHAGE FUNCTION BY INTERLEUKIN-2
    NIH/NCI K08CA001360Jul 1, 1988 - Jun 30, 1991
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Interleukin 32 expression in human melanoma. J Transl Med. 2019 04 05; 17(1):113. Paz H, Tsoi J, Kalbasi A, Grasso CS, McBride WH, Schaue D, Butterfield LH, Maurer DM, Ribas A, Graeber TG, Economou JS. PMID: 30953519.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Engines of Discovery and Innovation. Ann Surg. 2016 09; 264(3):405-12. Economou JS. PMID: 27464615.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Gender bias in biomedical research. Surgery. 2014 Nov; 156(5):1061-5. Economou JS. PMID: 25262221.
      View in: PubMed   Mentions: 1     Fields:    
    4. Histone deacetylase inhibitor sensitizes apoptosis-resistant melanomas to cytotoxic human T lymphocytes through regulation of TRAIL/DR5 pathway. J Immunol. 2014 Apr 15; 192(8):3981-9. Jazirehi AR, Kurdistani SK, Economou JS. PMID: 24639349.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    5. A society in transition: presidential remarks at the 65th Annual SSO Cancer Symposium. Ann Surg Oncol. 2012 Oct; 19(11):3293-7. Economou JS. PMID: 22805856.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFß) signaling mediate superior tumor regression in an animal model of adoptive cell therapy. J Transl Med. 2012 Jun 19; 10:127. Quatromoni JG, Wang Y, Vo DD, Morris LF, Jazirehi AR, McBride W, Chatila T, Koya RC, Economou JS. PMID: 22713761.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    7. Proteasome inhibition blocks NF-?B and ERK1/2 pathways, restores antigen expression, and sensitizes resistant human melanoma to TCR-engineered CTLs. Mol Cancer Ther. 2012 Jun; 11(6):1332-41. Jazirehi AR, Economou JS. PMID: 22532603.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    8. T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3. J Hematol Oncol. 2011 Nov 23; 4:48. Quatromoni JG, Morris LF, Donahue TR, Wang Y, McBride W, Chatila T, Economou JS. PMID: 22112546.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Immunomodulation by imiquimod in patients with high-risk primary melanoma. J Invest Dermatol. 2012 Jan; 132(1):163-9. Narayan R, Nguyen H, Bentow JJ, Moy L, Lee DK, Greger S, Haskell J, Vanchinathan V, Chang PL, Tsui S, Konishi T, Comin-Anduix B, Dauphine C, Vargas HI, Economou JS, Ribas A, Bruhn KW, Craft N. PMID: 21850019.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    10. CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans. Clin Cancer Res. 2011 Jun 15; 17(12):4101-9. Huang RR, Jalil J, Economou JS, Chmielowski B, Koya RC, Mok S, Sazegar H, Seja E, Villanueva A, Gomez-Navarro J, Glaspy JA, Cochran AJ, Ribas A. PMID: 21558401.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCellsCTClinical Trials
    11. Radiation enhances regulatory T cell representation. Int J Radiat Oncol Biol Phys. 2011 Nov 15; 81(4):1128-35. Kachikwu EL, Iwamoto KS, Liao YP, DeMarco JJ, Agazaryan N, Economou JS, McBride WH, Schaue D. PMID: 21093169.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    12. Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824. Cancer Res. 2009 Nov 15; 69(22):8693-9. Vo DD, Prins RM, Begley JL, Donahue TR, Morris LF, Bruhn KW, de la Rocha P, Yang MY, Mok S, Garban HJ, Craft N, Economou JS, Marincola FM, Wang E, Ribas A. PMID: 19861533.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    13. Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin Cancer Res. 2009 Oct 01; 15(19):6267-76. Ribas A, Comin-Anduix B, Chmielowski B, Jalil J, de la Rocha P, McCannel TA, Ochoa MT, Seja E, Villanueva A, Oseguera DK, Straatsma BR, Cochran AJ, Glaspy JA, Hui L, Marincola FM, Wang E, Economou JS, Gomez-Navarro J. PMID: 19789309.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCellsCTClinical Trials
    14. Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockade. Clin Cancer Res. 2009 Jan 01; 15(1):390-9. Ribas A, Comin-Anduix B, Economou JS, Donahue TR, de la Rocha P, Morris LF, Jalil J, Dissette VB, Shintaku IP, Glaspy JA, Gomez-Navarro J, Cochran AJ. PMID: 19118070.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    15. Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma. J Transl Med. 2008 May 01; 6:22. Comin-Anduix B, Lee Y, Jalil J, Algazi A, de la Rocha P, Camacho LH, Bozon VA, Bulanhagui CA, Seja E, Villanueva A, Straatsma BR, Gualberto A, Economou JS, Glaspy JA, Gomez-Navarro J, Ribas A. PMID: 18452610.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCellsCTClinical Trials
    16. NK and CD4 cells collaborate to protect against melanoma tumor formation in the brain. J Immunol. 2006 Dec 15; 177(12):8448-55. Prins RM, Vo DD, Khan-Farooqi H, Yang MY, Soto H, Economou JS, Liau LM, Ribas A. PMID: 17142742.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    17. Immunosensitization of tumor cells to dendritic cell-activated immune responses with the proteasome inhibitor bortezomib (PS-341, Velcade). J Immunol. 2006 Apr 15; 176(8):4757-65. Schumacher LY, Vo DD, Garban HJ, Comin-Anduix B, Owens SK, Dissette VB, Glaspy JA, McBride WH, Bonavida B, Economou JS, Ribas A. PMID: 16585569.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCellsPHPublic Health
    18. Definition of an immunologic response using the major histocompatibility complex tetramer and enzyme-linked immunospot assays. Clin Cancer Res. 2006 Jan 01; 12(1):107-16. Comin-Anduix B, Gualberto A, Glaspy JA, Seja E, Ontiveros M, Reardon DL, Renteria R, Englahner B, Economou JS, Gomez-Navarro J, Ribas A. PMID: 16397031.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    19. Broad antitumor protection by dendritic cells administered to CD8alpha knock out mice. Cancer Immunol Immunother. 2006 Jun; 55(6):663-71. Ribas A, Vo DD, Weeks DL, Comin-Anduix B, Schumacher LY, Garban HJ, McLean C, Yang J, Dissette VB, Peraza P, Owens SK, McBride WH, Glaspy JA, Economou JS. PMID: 16133107.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. Natural killer cells play a critical role in the immune response following immunization with melanoma-antigen-engineered dendritic cells. Cancer Gene Ther. 2005 Jun; 12(6):516-27. Wargo JA, Schumacher LY, Comin-Anduix B, Dissette VB, Glaspy JA, McBride WH, Butterfield LH, Economou JS, Ribas A. PMID: 15775996.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. Role of dendritic cell phenotype, determinant spreading, and negative costimulatory blockade in dendritic cell-based melanoma immunotherapy. J Immunother. 2004 Sep-Oct; 27(5):354-67. Ribas A, Glaspy JA, Lee Y, Dissette VB, Seja E, Vu HT, Tchekmedyian NS, Oseguera D, Comin-Anduix B, Wargo JA, Amarnani SN, McBride WH, Economou JS, Butterfield LH. PMID: 15314544.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCellsCTClinical Trials
    22. Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells. J Immunol. 2004 Aug 15; 173(4):2462-9. Liao YP, Wang CC, Butterfield LH, Economou JS, Ribas A, Meng WS, Iwamoto KS, McBride WH. PMID: 15294960.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    23. Surveillance of the eye and vision in a clinical trial of MART1-transformed dendritic cells for metastatic melanoma. Control Clin Trials. 2004 Aug; 25(4):400-7. Gordon LK, Ribas A, Nusinowitz S, Butterfield LH, Glaspy JA, Economou JS, Straatsma BR. PMID: 15296814.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    24. Human dendritic cell maturation by adenovirus transduction enhances tumor antigen-specific T-cell responses. J Immunother. 2004 May-Jun; 27(3):191-200. Schumacher L, Ribas A, Dissette VB, McBride WH, Mukherji B, Economou JS, Butterfield LH. PMID: 15076136.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    25. Enhanced tumor responses to dendritic cells in the absence of CD8-positive cells. J Immunol. 2004 Apr 15; 172(8):4762-9. Ribas A, Wargo JA, Comin-Anduix B, Sanetti S, Schumacher LY, McLean C, Dissette VB, Glaspy JA, McBride WH, Butterfield LH, Economou JS. PMID: 15067052.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. T-cell responses to HLA-A*0201 immunodominant peptides derived from alpha-fetoprotein in patients with hepatocellular cancer. Clin Cancer Res. 2003 Dec 01; 9(16 Pt 1):5902-8. Butterfield LH, Ribas A, Meng WS, Dissette VB, Amarnani S, Vu HT, Seja E, Todd K, Glaspy JA, McBride WH, Economou JS. PMID: 14676113.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCellsCTClinical Trials
    27. Current developments in cancer vaccines and cellular immunotherapy. J Clin Oncol. 2003 Jun 15; 21(12):2415-32. Ribas A, Butterfield LH, Glaspy JA, Economou JS. PMID: 12805342.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    28. Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma. Clin Cancer Res. 2003 Mar; 9(3):998-1008. Butterfield LH, Ribas A, Dissette VB, Amarnani SN, Vu HT, Oseguera D, Wang HJ, Elashoff RM, McBride WH, Mukherji B, Cochran AJ, Glaspy JA, Economou JS. PMID: 12631598.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCellsCTClinical Trials
    29. Cancer immunotherapy using gene-modified dendritic cells. Curr Gene Ther. 2002 Feb; 2(1):57-78. Ribas A, Butterfield LH, Glaspy JA, Economou JS. PMID: 12108974.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    30. The status of gene therapy for surgical disease. Adv Surg. 2002; 36:223-57. Wargo JA, Economou JS. PMID: 12465553.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
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