Ke Shuai

Title(s)Professor, Medicine
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of ARID2 in the Regulation of Immune Checkpoint
    NIH R21CA228400Apr 1, 2018 - Mar 31, 2020
    Role: Principal Investigator
    TET2 in Host Defense Against Infection
    NIH R21AI128728Dec 13, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Signaling to PIAS1 to Regulate Immune Responses
    NIH R01GM085797Aug 1, 2008 - May 31, 2013
    Role: Principal Investigator
    The Role of PIAS1 in Immune Regulation
    NIH R01AI063286Dec 1, 2004 - Jul 31, 2018
    Role: Principal Investigator
    Regulation of STAT Activity by Tyrosine Phosphatases
    NIH R01GM066168Jul 1, 2002 - Jun 30, 2006
    Role: Principal Investigator
    Regulation of Cytokine Signaling by PIAS Protein
    NIH R21AI043438Jul 1, 1998 - May 31, 2006
    Role: Principal Investigator
    INHIBITION OF CYTOKINE SIGNALING BY PIS PROTEINS
    NIH R01AI043438Jul 1, 1998 - Jun 30, 2003
    Role: Principal Investigator
    TYROSINE DEPHOSPHORYLATION OF STATS IN IFN SIGNALING
    NIH R01AI039612Jun 1, 1996 - May 31, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing. PLoS One. 2014; 9(2):e89464. Liu B, Tahk S, Yee KM, Yang R, Yang Y, Mackie R, Hsu C, Chernishof V, O'Brien N, Jin Y, Fan G, Lane TF, Rao J, Slamon D, Shuai K. PMID: 24586797; PMCID: PMC3933565.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    2. PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells. EMBO J. 2014 Jan 13; 33(2):101-13. Liu B, Yee KM, Tahk S, Mackie R, Hsu C, Shuai K. PMID: 24357619; PMCID: PMC3989605.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    3. The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression. Science. 2010 Oct 22; 330(6003):521-5. Liu B, Tahk S, Yee KM, Fan G, Shuai K. PMID: 20966256; PMCID: PMC3043201.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    4. Summon SUMO to wrestle with inflammation. Mol Cell. 2009 Sep 24; 35(6):731-2. Liu B, Shuai K. PMID: 19782020.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Targeting the PIAS1 SUMO ligase pathway to control inflammation. Trends Pharmacol Sci. 2008 Oct; 29(10):505-9. Liu B, Shuai K. PMID: 18755518; PMCID: PMC2701905.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    6. Regulation of the sumoylation system in gene expression. Curr Opin Cell Biol. 2008 Jun; 20(3):288-93. Liu B, Shuai K. PMID: 18468876; PMCID: PMC2495007.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    7. Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell. 2008 Apr 04; 133(1):103-15. Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM. PMID: 18394993; PMCID: PMC2693193.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    8. PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. J Neurosci. 2007 Sep 12; 27(37):10037-46. Shalizi A, Bilimoria PM, Stegmüller J, Gaudillière B, Yang Y, Shuai K, Bonni A. PMID: 17855618; PMCID: PMC6672631.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    9. Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11643-8. Tahk S, Liu B, Chernishof V, Wong KA, Wu H, Shuai K. PMID: 17606919; PMCID: PMC1913887.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    10. Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity. Cell. 2007 Jun 01; 129(5):903-14. Liu B, Yang Y, Chernishof V, Loo RR, Jang H, Tahk S, Yang R, Mink S, Shultz D, Bellone CJ, Loo JA, Shuai K. PMID: 17540171.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    11. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol. 2007 Jan; 9(1):80-5. Dadke S, Cotteret S, Yip SC, Jaffer ZM, Haj F, Ivanov A, Rauscher F, Shuai K, Ng T, Neel BG, Chernoff J. PMID: 17159996.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    12. UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J. 2006 Jun 07; 25(11):2358-67. Malakhova OA, Kim KI, Luo JK, Zou W, Kumar KG, Fuchs SY, Shuai K, Zhang DE. PMID: 16710296; PMCID: PMC1478183.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    13. Regulation of cytokine signaling pathways by PIAS proteins. Cell Res. 2006 Feb; 16(2):196-202. Shuai K. PMID: 16474434.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    14. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat Rev Immunol. 2005 Aug; 5(8):593-605. Shuai K, Liu B. PMID: 16056253.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansAnimalsCells
    15. DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development. 2005 Aug; 132(15):3345-56. Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE. PMID: 16014513.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    16. Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):3966-71. Zhong M, Henriksen MA, Takeuchi K, Schaefer O, Liu B, ten Hoeve J, Ren Z, Mao X, Chen X, Shuai K, Darnell JE. PMID: 15753310; PMCID: PMC554839.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    17. Negative regulation of NF-kappaB signaling by PIAS1. Mol Cell Biol. 2005 Feb; 25(3):1113-23. Liu B, Yang R, Wong KA, Getman C, Stein N, Teitell MA, Cheng G, Wu H, Shuai K. PMID: 15657437; PMCID: PMC544018.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    18. PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004 Sep; 5(9):891-8. Liu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K. PMID: 15311277.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    19. PIASy-mediated repression of the androgen receptor is independent of sumoylation. Oncogene. 2004 Apr 15; 23(17):3059-66. Gross M, Yang R, Top I, Gasper C, Shuai K. PMID: 14981544.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    20. Serine phosphorylation: arming Stat1 against infection. Immunity. 2003 Dec; 19(6):771-2. Shuai K. PMID: 14670293.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    21. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol. 2003 Nov; 3(11):900-11. Shuai K, Liu B. PMID: 14668806.
      View in: PubMed   Mentions: 416     Fields:    Translation:HumansAnimalsCells
    22. Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9791-6. Long J, Matsuura I, He D, Wang G, Shuai K, Liu F. PMID: 12904571; PMCID: PMC187844.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    23. PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. J Biol Chem. 2003 Jun 13; 278(24):21327-30. Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K. PMID: 12716907.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    24. Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev. 2003 Feb 15; 17(4):455-60. Malakhova OA, Yan M, Malakhov MP, Yuan Y, Ritchie KJ, Kim KI, Peterson LF, Shuai K, Zhang DE. PMID: 12600939; PMCID: PMC195994.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    25. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol. 2002 Aug; 22(16):5662-8. ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, Zhu W, Tremblay M, David M, Shuai K. PMID: 12138178; PMCID: PMC133976.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    26. The STAT family of proteins in cytokine signaling. Prog Biophys Mol Biol. 1999; 71(3-4):405-22. Shuai K. PMID: 10354707.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells