Riccardo Olcese

Title(s)Professor, Anesthesiology
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    Title(s)Professor, Physiology

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    The Molecular Transitions that Initiate EC Coupling in Skeletal Muscle
    NIH R35GM131896Jun 1, 2019 - Mar 31, 2024
    Role: Principal Investigator
    The Late L-type Ca Current as the Target for a New Class of Antiarrhythmics
    NIH R01HL134346Jul 1, 2017 - Mar 31, 2021
    Role: Principal Investigator
    DRVCF, a new optical method for real-time, high resolution, intramolecular distance measurements in conducting ion channels
    NIH R21NS101734Mar 15, 2017 - Feb 28, 2021
    Role: Principal Investigator
    Voltage-driven Structural Transitions in Voltage-Gated Calcium Channels
    NIH R01GM110276Dec 1, 2014 - Sep 30, 2020
    Role: Principal Investigator
    BK(Ca) channel in heart mitochondria
    NIH R01HL107418Apr 15, 2012 - Feb 29, 2016
    Role: Principal Investigator
    Structural Changes in BKCa Channels During Gating
    NIH R01GM082289Dec 1, 2002 - Feb 28, 2013
    Role: Principal Investigator
    Structural Changes in BKCa Channels During Gating
    NIH R01NS043240Dec 1, 2002 - Nov 30, 2007
    Role: Principal Investigator
    Regulation of calcium-activated potassium channels by lipid messengers
    NIH R01GM057654May 1, 1998 - May 31, 2016
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. R-on-T and the initiation of reentry revisited: Integrating old and new concepts. Heart Rhythm. 2022 Aug; 19(8):1369-1383. Qu Z, Liu MB, Olcese R, Karagueuzian H, Garfinkel A, Chen PS, Weiss JN. PMID: 35364332.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current. J Gen Physiol. 2021 12 06; 153(12). Angelini M, Pezhouman A, Savalli N, Chang MG, Steccanella F, Scranton K, Calmettes G, Ottolia M, Pantazis A, Karagueuzian HS, Weiss JN, Olcese R. PMID: 34698805; PMCID: PMC8552156.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation. J Gen Physiol. 2021 11 01; 153(11). Savalli N, Angelini M, Steccanella F, Wier J, Wu F, Quinonez M, DiFranco M, Neely A, Cannon SC, Olcese R. PMID: 34546289; PMCID: PMC8460119.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    4. BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells. Am J Respir Cell Mol Biol. 2021 02; 64(2):224-234. Zyrianova T, Lopez B, Liao A, Gu C, Wong L, Ottolia M, Olcese R, Schwingshackl A. PMID: 33217242; PMCID: PMC7874395.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. K2P2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury. Sci Rep. 2020 12 15; 10(1):22011. Zyrianova T, Lopez B, Olcese R, Belperio J, Waters CM, Wong L, Nguyen V, Talapaneni S, Schwingshackl A. PMID: 33319831; PMCID: PMC7738539.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Tracking the motion of the KV 1.2 voltage sensor reveals the molecular perturbations caused by a de novo mutation in a case of epilepsy. J Physiol. 2020 11; 598(22):5245-5269. Pantazis A, Kaneko M, Angelini M, Steccanella F, Westerlund AM, Lindström SH, Nilsson M, Delemotte L, Saitta SC, Olcese R. PMID: 32833227; PMCID: PMC8923147.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Small-conductance Ca2+-activated K+ channels promote J-wave syndrome and phase 2 reentry. Heart Rhythm. 2020 09; 17(9):1582-1590. Landaw J, Zhang Z, Song Z, Liu MB, Olcese R, Chen PS, Weiss JN, Qu Z. PMID: 32333974; PMCID: PMC7483665.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1G93A Mouse Model for ALS. J Neurosci. 2019 10 30; 39(44):8798-8815. Seki S, Yamamoto T, Quinn K, Spigelman I, Pantazis A, Olcese R, Wiedau-Pazos M, Chandler SH, Venugopal S. PMID: 31530644; PMCID: PMC6820216.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    9. MitoBKCa channel is functionally associated with its regulatory β1 subunit in cardiac mitochondria. J Physiol. 2019 08; 597(15):3817-3832. Balderas E, Torres NS, Rosa-Garrido M, Chaudhuri D, Toro L, Stefani E, Olcese R. PMID: 31173379; PMCID: PMC6690848.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons. PLoS Comput Biol. 2019 06; 15(6):e1007154. Venugopal S, Seki S, Terman DH, Pantazis A, Olcese R, Wiedau-Pazos M, Chandler SH. PMID: 31226124; PMCID: PMC6608983.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Harnessing photoinduced electron transfer to optically determine protein sub-nanoscale atomic distances. Nat Commun. 2018 11 09; 9(1):4738. Pantazis A, Westerberg K, Althoff T, Abramson J, Olcese R. PMID: 30413716; PMCID: PMC6226468.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. J Gen Physiol. 2018 02 05; 150(2):245-257. John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. PMID: 29301861; PMCID: PMC5806679.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1030-L1046. Schwingshackl A, Lopez B, Teng B, Luellen C, Lesage F, Belperio J, Olcese R, Waters CM. PMID: 28839101; PMCID: PMC5814704.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    14. Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets. Front Pharmacol. 2017; 8:36. Karagueuzian HS, Pezhouman A, Angelini M, Olcese R. PMID: 28220073; PMCID: PMC5292429.
      View in: PubMed   Mentions: 16  
    15. The mitochondrial BKCa channel cardiac interactome reveals BKCa association with the mitochondrial import receptor subunit Tom22, and the adenine nucleotide translocator. Mitochondrion. 2017 03; 33:84-101. Zhang J, Li M, Zhang Z, Zhu R, Olcese R, Stefani E, Toro L. PMID: 27592226; PMCID: PMC5332438.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. The α2δ-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentials. J Gen Physiol. 2016 08; 148(2):147-59. Savalli N, Pantazis A, Sigg D, Weiss JN, Neely A, Olcese R. PMID: 27481713; PMCID: PMC4969795.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    17. Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics. J Physiol. 2016 05 01; 594(9):2537-53. Prudat Y, Madhvani RV, Angelini M, Borgstom NP, Garfinkel A, Karagueuzian HS, Weiss JN, de Lange E, Olcese R, Kucera JP. PMID: 26563830; PMCID: PMC4850193.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    18. Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations. J Gen Physiol. 2015 May; 145(5):395-404. Madhvani RV, Angelini M, Xie Y, Pantazis A, Suriany S, Borgstrom NP, Garfinkel A, Qu Z, Weiss JN, Olcese R. PMID: 25918358; PMCID: PMC4411259.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    19. Perspective: a dynamics-based classification of ventricular arrhythmias. J Mol Cell Cardiol. 2015 May; 82:136-52. Weiss JN, Garfinkel A, Karagueuzian HS, Nguyen TP, Olcese R, Chen PS, Qu Z. PMID: 25769672; PMCID: PMC4405495.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    20. Functional heterogeneity of the four voltage sensors of a human L-type calcium channel. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18381-6. Pantazis A, Savalli N, Sigg D, Neely A, Olcese R. PMID: 25489110; PMCID: PMC4280600.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    21. Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve. Cardiovasc Res. 2013 Jul 01; 99(1):6-15. Qu Z, Xie LH, Olcese R, Karagueuzian HS, Chen PS, Garfinkel A, Weiss JN. PMID: 23619423; PMCID: PMC3687754.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    22. Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing. J Gen Physiol. 2012 Aug; 140(2):207-18. Pantazis A, Olcese R. PMID: 22802360; PMCID: PMC3409098.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    23. The contribution of RCK domains to human BK channel allosteric activation. J Biol Chem. 2012 Jun 22; 287(26):21741-50. Savalli N, Pantazis A, Yusifov T, Sigg D, Olcese R. PMID: 22556415; PMCID: PMC3381136.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    24. Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes. J Physiol. 2011 Dec 15; 589(Pt 24):6081-92. Madhvani RV, Xie Y, Pantazis A, Garfinkel A, Qu Z, Weiss JN, Olcese R. PMID: 22025660; PMCID: PMC3286687.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    25. I(KACh) at the whim of a capricious M2R. J Physiol. 2011 Apr 15; 589(Pt 8):1869-70. Olcese R. PMID: 21498381; PMCID: PMC3090587.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus. J Biol Chem. 2011 Jun 10; 286(23):20701-9. Javaherian AD, Yusifov T, Pantazis A, Franklin S, Gandhi CS, Olcese R. PMID: 21471215; PMCID: PMC3121532.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    27. Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel. J Gen Physiol. 2010 Dec; 136(6):645-57. Pantazis A, Kohanteb AP, Olcese R. PMID: 21078868; PMCID: PMC2995153.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements. J Gen Physiol. 2010 Aug; 136(2):189-202. Yusifov T, Javaherian AD, Pantazis A, Gandhi CS, Olcese R. PMID: 20624858; PMCID: PMC2912072.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4459-64. Pantazis A, Gudzenko V, Savalli N, Sigg D, Olcese R. PMID: 20160086; PMCID: PMC2840143.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    30. It's spring-time for slow inactivation. J Gen Physiol. 2009 Dec; 134(6):457-9. Olcese R. PMID: 19917731; PMCID: PMC2806423.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    31. A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J. 2008 Jan 15; 94(2):392-410. Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN. PMID: 18160660; PMCID: PMC2157228.
      View in: PubMed   Mentions: 191     Fields:    Translation:AnimalsCells
    32. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophys J. 2008 Jan 15; 94(2):411-23. Mahajan A, Sato D, Shiferaw Y, Baher A, Xie LH, Peralta R, Olcese R, Garfinkel A, Qu Z, Weiss JN. PMID: 18160661; PMCID: PMC2157257.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    33. The voltage-clamp fluorometry technique. Methods Mol Biol. 2008; 491:213-31. Gandhi CS, Olcese R. PMID: 18998096.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    34. The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):376-81. Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. PMID: 18162557; PMCID: PMC2224220.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    35. Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol. 2007 Jul; 130(1):117-31. Savalli N, Kondratiev A, de Quintana SB, Toro L, Olcese R. PMID: 17591990; PMCID: PMC2154362.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    36. Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1805-15. Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss JN, Olcese R. PMID: 17545475.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    37. And yet it moves: conformational States of the Ca2+ channel pore. J Gen Physiol. 2007 Jun; 129(6):457-9. Olcese R. PMID: 17535958; PMCID: PMC2151624.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    38. Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12619-24. Savalli N, Kondratiev A, Toro L, Olcese R. PMID: 16895996; PMCID: PMC1567928.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    39. GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes. Mol Pharmacol. 2005 Jul; 68(1):152-9. Chen ZW, Chang CS, Leil TA, Olcese R, Olsen RW. PMID: 15814572.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    40. Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect. J Gen Physiol. 2004 Aug; 124(2):173-84. Haug T, Sigg D, Ciani S, Toro L, Stefani E, Olcese R. PMID: 15277578; PMCID: PMC2229624.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    41. Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component. J Gen Physiol. 2004 Aug; 124(2):185-97. Haug T, Olcese R, Toro L, Stefani E. PMID: 15277579; PMCID: PMC2229619.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    42. Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1. J Gen Physiol. 2003 Oct; 122(4):459-69. Latorre R, Olcese R, Basso C, Gonzalez C, Munoz F, Cosmelli D, Alvarez O. PMID: 14517271; PMCID: PMC2233774.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    43. A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation. J Biol Chem. 2003 Oct 31; 278(44):42821-8. Chang CS, Olcese R, Olsen RW. PMID: 12939268.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    44. Tissue-specific regulation of Ca(2+) channel protein expression by sex hormones. Biochim Biophys Acta. 2002 Jan 15; 1569(1-3):59-66. Helguera G, Olcese R, Song M, Toro L, Stefani E. PMID: 11853958.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals