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Riccardo Olcese

Title(s)Professor, Anesthesiology
SchoolMedicine
Address760 Westwood Plaza BH-509B
Los Angeles CA 90024
Phone3102062214
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    Other Positions
    Title(s)Professor, Physiology


    Collapse Research 
    Collapse Research Activities and Funding
    The Molecular Transitions that Initiate EC Coupling in Skeletal Muscle
    NIH/NIGMS R35GM131896Jun 1, 2019 - Mar 31, 2024
    Role: Principal Investigator
    The Late L-type Ca Current as the Target for a New Class of Antiarrhythmics
    NIH/NHLBI R01HL134346Jul 1, 2017 - Mar 31, 2021
    Role: Principal Investigator
    DRVCF, a new optical method for real-time, high resolution, intramolecular distance measurements in conducting ion channels
    NIH/NINDS R21NS101734Mar 15, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Voltage-driven Structural Transitions in Voltage-Gated Calcium Channels
    NIH/NIGMS R01GM110276Dec 1, 2014 - Nov 30, 2018
    Role: Principal Investigator
    BK(Ca) channel in heart mitochondria
    NIH/NHLBI R01HL107418Apr 15, 2012 - Feb 29, 2016
    Role: Principal Investigator
    Structural Changes in BKCa Channels During Gating
    NIH/NIGMS R01GM082289Dec 1, 2002 - Feb 29, 2012
    Role: Principal Investigator
    Structural Changes in BKCa Channels During Gating
    NIH/NINDS R01NS043240Dec 1, 2002 - Nov 30, 2007
    Role: Principal Investigator
    Regulation of calcium-activated potassium channels by lipid messengers
    NIH/NIGMS R01GM057654May 1, 1998 - Sep 19, 2011
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tracking the motion of KV 1.2 voltage sensor reveals the molecular perturbations caused by a de novo mutation in a case of epilepsy. J Physiol. 2020 Aug 24. Pantazis A, Kaneko M, Angelini M, Steccanella F, Westerlund AM, Lindström SH, Nilsson M, Delemotte L, Saitta SC, Olcese R. PMID: 32833227.
      View in: PubMed   Mentions:    Fields:    
    2. Small-conductance Ca2+-activated K+ channels promote J-wave syndrome and phase 2 reentry. Heart Rhythm. 2020 Sep; 17(9):1582-1590. Landaw J, Zhang Z, Song Z, Liu MB, Olcese R, Chen PS, Weiss JN, Qu Z. PMID: 32333974.
      View in: PubMed   Mentions:    Fields:    
    3. MitoBKCa channel is functionally associated with its regulatory ß1 subunit in cardiac mitochondria. J Physiol. 2019 08; 597(15):3817-3832. Balderas E, Torres NS, Rosa-Garrido M, Chaudhuri D, Toro L, Stefani E, Olcese R. PMID: 31173379.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons. PLoS Comput Biol. 2019 06; 15(6):e1007154. Venugopal S, Seki S, Terman DH, Pantazis A, Olcese R, Wiedau-Pazos M, Chandler SH. PMID: 31226124.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Harnessing photoinduced electron transfer to optically determine protein sub-nanoscale atomic distances. Nat Commun. 2018 11 09; 9(1):4738. Pantazis A, Westerberg K, Althoff T, Abramson J, Olcese R. PMID: 30413716.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. J Gen Physiol. 2018 02 05; 150(2):245-257. John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. PMID: 29301861.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets. Front Pharmacol. 2017; 8:36. Karagueuzian HS, Pezhouman A, Angelini M, Olcese R. PMID: 28220073.
      View in: PubMed   Mentions:
    8. The mitochondrial BKCa channel cardiac interactome reveals BKCa association with the mitochondrial import receptor subunit Tom22, and the adenine nucleotide translocator. Mitochondrion. 2017 03; 33:84-101. Zhang J, Li M, Zhang Z, Zhu R, Olcese R, Stefani E, Toro L. PMID: 27592226.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. The a2d-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentials. J Gen Physiol. 2016 08; 148(2):147-59. Savalli N, Pantazis A, Sigg D, Weiss JN, Neely A, Olcese R. PMID: 27481713.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    10. Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics. J Physiol. 2016 05 01; 594(9):2537-53. Prudat Y, Madhvani RV, Angelini M, Borgstom NP, Garfinkel A, Karagueuzian HS, Weiss JN, de Lange E, Olcese R, Kucera JP. PMID: 26563830.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    11. Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations. J Gen Physiol. 2015 May; 145(5):395-404. Madhvani RV, Angelini M, Xie Y, Pantazis A, Suriany S, Borgstrom NP, Garfinkel A, Qu Z, Weiss JN, Olcese R. PMID: 25918358.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    12. Perspective: a dynamics-based classification of ventricular arrhythmias. J Mol Cell Cardiol. 2015 May; 82:136-52. Weiss JN, Garfinkel A, Karagueuzian HS, Nguyen TP, Olcese R, Chen PS, Qu Z. PMID: 25769672.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    13. Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve. Cardiovasc Res. 2013 Jul 01; 99(1):6-15. Qu Z, Xie LH, Olcese R, Karagueuzian HS, Chen PS, Garfinkel A, Weiss JN. PMID: 23619423.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    14. Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing. J Gen Physiol. 2012 Aug; 140(2):207-18. Pantazis A, Olcese R. PMID: 22802360.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    15. The contribution of RCK domains to human BK channel allosteric activation. J Biol Chem. 2012 Jun 22; 287(26):21741-50. Savalli N, Pantazis A, Yusifov T, Sigg D, Olcese R. PMID: 22556415.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    16. Shaping a new Ca²? conductance to suppress early afterdepolarizations in cardiac myocytes. J Physiol. 2011 Dec 15; 589(Pt 24):6081-92. Madhvani RV, Xie Y, Pantazis A, Garfinkel A, Qu Z, Weiss JN, Olcese R. PMID: 22025660.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    17. I(KACh) at the whim of a capricious M2R. J Physiol. 2011 Apr 15; 589(Pt 8):1869-70. Olcese R. PMID: 21498381.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus. J Biol Chem. 2011 Jun 10; 286(23):20701-9. Javaherian AD, Yusifov T, Pantazis A, Franklin S, Gandhi CS, Olcese R. PMID: 21471215.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    19. Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel. J Gen Physiol. 2010 Dec; 136(6):645-57. Pantazis A, Kohanteb AP, Olcese R. PMID: 21078868.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements. J Gen Physiol. 2010 Aug; 136(2):189-202. Yusifov T, Javaherian AD, Pantazis A, Gandhi CS, Olcese R. PMID: 20624858.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    21. It's spring-time for slow inactivation. J Gen Physiol. 2009 Dec; 134(6):457-9. Olcese R. PMID: 19917731.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    22. A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J. 2008 Jan 15; 94(2):392-410. Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN. PMID: 18160660.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    23. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophys J. 2008 Jan 15; 94(2):411-23. Mahajan A, Sato D, Shiferaw Y, Baher A, Xie LH, Peralta R, Olcese R, Garfinkel A, Qu Z, Weiss JN. PMID: 18160661.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    24. The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):376-81. Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. PMID: 18162557.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    25. Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol. 2007 Jul; 130(1):117-31. Savalli N, Kondratiev A, de Quintana SB, Toro L, Olcese R. PMID: 17591990.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    26. Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1805-15. Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss JN, Olcese R. PMID: 17545475.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    27. And yet it moves: conformational States of the Ca2+ channel pore. J Gen Physiol. 2007 Jun; 129(6):457-9. Olcese R. PMID: 17535958.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    28. Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12619-24. Savalli N, Kondratiev A, Toro L, Olcese R. PMID: 16895996.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    29. GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes. Mol Pharmacol. 2005 Jul; 68(1):152-9. Chen ZW, Chang CS, Leil TA, Olcese R, Olsen RW. PMID: 15814572.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    30. Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect. J Gen Physiol. 2004 Aug; 124(2):173-84. Haug T, Sigg D, Ciani S, Toro L, Stefani E, Olcese R. PMID: 15277578.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    31. Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component. J Gen Physiol. 2004 Aug; 124(2):185-97. Haug T, Olcese R, Toro L, Stefani E. PMID: 15277579.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1. J Gen Physiol. 2003 Oct; 122(4):459-69. Latorre R, Olcese R, Basso C, Gonzalez C, Munoz F, Cosmelli D, Alvarez O. PMID: 14517271.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    33. A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation. J Biol Chem. 2003 Oct 31; 278(44):42821-8. Chang CS, Olcese R, Olsen RW. PMID: 12939268.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    34. Tissue-specific regulation of Ca(2+) channel protein expression by sex hormones. Biochim Biophys Acta. 2002 Jan 15; 1569(1-3):59-66. Helguera G, Olcese R, Song M, Toro L, Stefani E. PMID: 11853958.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
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