Thomas John Kremen

Title(s)Associate Professor-in-residence, Orthopaedic Surgery
ORCID ORCID Icon0000-0003-1643-4869 Additional info
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    Collapse Research Activities and Funding
    Enhanced Soft Tissue-to-Bone Healing via Treatment with Novel Growth Factor NELL-1: Targeted Delivery and Biomimetic Scaffolds
    US Department of Veterans Affairs IK2BX005199Jul 1, 2020 - Jun 30, 2025
    Role: Principle Investigator
    Regenerative Musculoskeletal Medicine Training Program
    NIH T32AR059033Apr 1, 2010 - Jul 31, 2026
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reverse total shoulder arthroplasty with proximal bone loss: a biomechanical comparison of partially vs. fully cemented humeral stems. J Shoulder Elbow Surg. 2024 Feb 27. Maturana C, Peterson B, Shi B, Mooney B, Clites T, Kremen TJ. PMID: 38417733.
      View in: PubMed   Mentions:    Fields:    
    2. Novel bisphosphonate-based cathepsin K-triggered compound targets the enthesis without impairing soft tissue-to-bone healing. Front Bioeng Biotechnol. 2024; 12:1308161. Shi BY, Sriram V, Wu SY, Huang D, Cheney A, Metzger MF, Sundberg O, Lyons KM, McKenna CE, Nishimura I, Kremen TJ. PMID: 38433822; PMCID: PMC10905384.
      View in: PubMed   Mentions:
    3. MELD score predicts short-term outcomes after surgical management of proximal humerus fractures: a matched analysis. OTA Int. 2023 Dec; 6(4):e289. Shi BY, Upfill-Brown A, Li A, Wu SY, Ahlquist S, Hart CM, Kremen TJ, Lee C, Stavrakis AI. PMID: 37901451; PMCID: PMC10611337.
      View in: PubMed   Mentions:
    4. Changes in the incidence of stress reactions and fractures among intercollegiate athletes after the COVID-19 pandemic. J Orthop Surg Res. 2023 Oct 20; 18(1):788. Shi BY, Castaneda C, Sriram V, Yamasaki S, Wu SY, Kremen TJ. PMID: 37864273; PMCID: PMC10588212.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    5. Short-Term Outcomes and Long-Term Implant Survival After Inpatient Surgical Management of Geriatric Proximal Humerus Fractures. J Shoulder Elb Arthroplast. 2023; 7:24715492231192068. Shi BY, Upfill-Brown A, Wu SY, Trikha R, Ahlquist S, Kremen TJ, Lee C, SooHoo NF. PMID: 37559885; PMCID: PMC10408354.
      View in: PubMed   Mentions:
    6. Impact of the COVID-19 Pandemic Hiatus From Sports Activities on Injuries Observed Among Division I NCAA Athletes. Orthop J Sports Med. 2023 May; 11(5):23259671231169188. Kremen TJ, Wu SY, Upfill-Brown A, Bugarin A, Huang J, Jones KJ, Shi BY. PMID: 37250744; PMCID: PMC10209719.
      View in: PubMed   Mentions: 1  
    7. Biologically-coupled bisphosphonate chaperones effectively deliver molecules to the site of soft tissue-bone healing. J Orthop Res. 2023 10; 41(10):2250-2260. Kremen TJ, Shi BY, Wu SY, Sundberg O, Sriram V, Kim W, Sheyn D, Lyons KM, Wang W, McKenna CE, Nishimura I. PMID: 37087676.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Multicenter Analysis of the Epidemiology of Injury Patterns and Return to Sport in Collegiate Gymnasts. Orthop J Sports Med. 2023 Feb; 11(2):23259671231154618. Trikha R, Greig DE, Shi BY, Schroeder GG, Chernoff DJ, Jones KJ, Kremen TJ. PMID: 36860774; PMCID: PMC9969444.
      View in: PubMed   Mentions:
    9. Increasing Rate of Shoulder Arthroplasty for Geriatric Proximal Humerus Fractures in the United States, 2010-2019. J Shoulder Elb Arthroplast. 2022; 6:24715492221137186. Shi BY, Upfill-Brown A, Kelley BV, Brodke DJ, Mayer EN, Devana SK, Kremen TJ, Lee C. PMID: 36419867; PMCID: PMC9677166.
      View in: PubMed   Mentions: 3  
    10. Reliability of MRI Detection of Kaplan Fiber Injury in Pediatric and Adolescent Patients with ACL Tears. Orthop J Sports Med. 2022 Oct; 10(10):23259671221128601. Shi BY, Levine B, Ghazikhanian V, Bugarin A, Schroeder G, Wu S, Kremen T, Jones K. PMID: 36324697; PMCID: PMC9618750.
      View in: PubMed   Mentions: 1  
    11. Combined Assessments of Patellar Tendon and Hamstring Tendon Parameters on Preoperative Magnetic Resonance Imaging Can Improve Predictability of Hamstring Tendon Autograft Diameter in the Setting of Anterior Cruciate Ligament Reconstruction. Arthrosc Sports Med Rehabil. 2022 Dec; 4(6):e1913-e1921. Kremen TJ, Arnold MT, Trivellas M, Shi BY, Jones KJ, Garcia-Mansilla I. PMID: 36579048; PMCID: PMC9791872.
      View in: PubMed   Mentions: 2  
    12. Injuries Affecting Intercollegiate Water Polo Athletes: A Descriptive Epidemiologic Study. Orthop J Sports Med. 2022 Jul; 10(7):23259671221110208. Schroeder GG, McClintick DJ, Trikha R, Kremen TJ. PMID: 35898203; PMCID: PMC9310270.
      View in: PubMed   Mentions: 2  
    13. Assessment of Characteristics and Methodological Quality of the Top 50 Most Cited Articles on Platelet-Rich Plasma in Musculoskeletal Medicine. Orthop J Sports Med. 2022 May; 10(5):23259671221093074. Bugarin A, Schroeder G, Shi BY, Jones KJ, Kremen TJ. PMID: 35656192; PMCID: PMC9152206.
      View in: PubMed   Mentions: 2  
    14. Characterizing Health Events and Return to Sport in Collegiate Swimmers. Orthop J Sports Med. 2022 Apr; 10(4):23259671221083588. Trikha R, Schroeder GG, Greig DE, Kremen TJ. PMID: 35400141; PMCID: PMC8988675.
      View in: PubMed   Mentions: 3  
    15. In Vitro Cellular Strain Models of Tendon Biology and Tenogenic Differentiation. Front Bioeng Biotechnol. 2022; 10:826748. Wu SY, Kim W, Kremen TJ. PMID: 35242750; PMCID: PMC8886160.
      View in: PubMed   Mentions: 4  
    16. The Reliability of 3-T Magnetic Resonance Imaging to Identify Arthroscopic Features of Meniscal Tears and Its Utility to Predict Meniscal Tear Reparability. Am J Sports Med. 2021 12; 49(14):3887-3897. Strawbridge JC, Schroeder GG, Garcia-Mansilla I, Singla A, Levine BD, Motamedi K, Jones KJ, Kremen TJ. PMID: 34726983.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Hybrid Bone-Grafting Technique for Staged Revision Anterior Cruciate Ligament Reconstruction. JBJS Essent Surg Tech. 2021 Oct-Dec; 11(4). Garcia-Mansilla I, Jones KJ, Kremen TJ. PMID: 35693133; PMCID: PMC9173559.
      View in: PubMed   Mentions:
    18. Characterization of Infraspinatus Tendon Anatomy: The Soft-Tissue Portion of Remplissage. Arthrosc Sports Med Rehabil. 2021 Jun; 3(3):e741-e748. Kremen TJ, Monfiston CH, Garlich JM, Little MTM, Metzger MF. PMID: 34195640; PMCID: PMC8220603.
      View in: PubMed   Mentions:
    19. A Translational Porcine Model for Human Cell-Based Therapies in the Treatment of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Injury. Am J Sports Med. 2020 10; 48(12):3002-3012. Kremen TJ, Stefanovic T, Tawackoli W, Salehi K, Avalos P, Reichel D, Perez MJ, Glaeser JD, Sheyn D. PMID: 32924528; PMCID: PMC7945314.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    20. Microfracture for the Treatment of Symptomatic Cartilage Lesions of the Knee: A Survey of International Cartilage Regeneration & Joint Preservation Society. Cartilage. 2021 12; 13(1_suppl):1148S-1155S. Medina J, Garcia-Mansilla I, Fabricant PD, Kremen TJ, Sherman SL, Jones K. PMID: 32911974; PMCID: PMC8808788.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. A Comparison of 3 Fixation Strategies in the Treatment of Neer Type IIB Distal Clavicle Fractures. J Orthop Trauma. 2020 Aug; 34(8):e266-e271. Garlich J, Little MTM, Nelson TJ, Eberlein SA, Monfiston CH, Kremen T, Metzger MF. PMID: 32118623.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Comparative Analysis of Sagittal-Plane Radiographic Landmarks Used to Identify the Femoral Attachments of Lateral Knee Structures. Arthroscopy. 2020 11; 36(11):2888-2896. Kremen TJ, Haggerty E, Chahla J, Eberlein SA, Nelson TJ, Schroeder G, Metzger MF. PMID: 32738278.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Infraspinatus Tenotomy Improves Glenoid Visualization With the Modified Judet Approach. J Orthop Trauma. 2020 Mar; 34(3):158-162. Garlich JM, Samuel K, Nelson TJ, Monfiston C, Kremen T, Metzger MF, Little MTM. PMID: 31725084.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. In Vivo Imaging of Exogenous Progenitor Cells in Tendon Regeneration via Superparamagnetic Iron Oxide Particles. Am J Sports Med. 2019 09; 47(11):2737-2744. Kremen TJ, Bez M, Sheyn D, Ben-David S, Da X, Tawackoli W, Wagner S, Gazit D, Pelled G. PMID: 31336056.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Pulmonary Function Evaluation in Elite Swimmers: A Case Series of Environmental Considerations. Curr Sports Med Rep. 2019 Apr; 18(4):109-111. Robinson K, Kremen T, Olin JT, Wilber R. PMID: 30969233.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Association of Wearable Activity Monitors With Assessment of Daily Ambulation and Length of Stay Among Patients Undergoing Major Surgery. JAMA Netw Open. 2019 02 01; 2(2):e187673. Daskivich TJ, Houman J, Lopez M, Luu M, Fleshner P, Zaghiyan K, Cunneen S, Burch M, Walsh C, Paiement G, Kremen T, Soukiasian H, Spitzer A, Jackson T, Kim HL, Li A, Spiegel B. PMID: 30707226; PMCID: PMC6484591.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    27. Ultrasound-Mediated Gene Delivery Enhances Tendon Allograft Integration in Mini-Pig Ligament Reconstruction. Mol Ther. 2018 07 05; 26(7):1746-1755. Bez M, Kremen TJ, Tawackoli W, Avalos P, Sheyn D, Shapiro G, Giaconi JC, Ben David S, Snedeker JG, Gazit Z, Ferrara KW, Gazit D, Pelled G. PMID: 29784586; PMCID: PMC6035740.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    28. The Effect of Hamstring Tendon Autograft Harvest on the Restoration of Knee Stability in the Setting of Concurrent Anterior Cruciate Ligament and Medial Collateral Ligament Injuries. Am J Sports Med. 2018 01; 46(1):163-170. Kremen TJ, Polakof LS, Rajaee SS, Nelson TJ, Metzger MF. PMID: 29048929.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    29. In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs. Sci Transl Med. 2017 05 17; 9(390). Bez M, Sheyn D, Tawackoli W, Avalos P, Shapiro G, Giaconi JC, Da X, David SB, Gavrity J, Awad HA, Bae HW, Ley EJ, Kremen TJ, Gazit Z, Ferrara KW, Pelled G, Gazit D. PMID: 28515335; PMCID: PMC5524999.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    30. Interposition Dermal Matrix Xenografts: A Successful Alternative to Traditional Treatment of Massive Rotator Cuff Tears. Am J Sports Med. 2017 May; 45(6):1261-1268. Neumann JA, Zgonis MH, Rickert KD, Bradley KE, Kremen TJ, Boggess BR, Toth AP. PMID: 28141953.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    31. Death after closed adolescent knee injury and popliteal artery occlusion: a case report and clinical review. Sports Health. 2013 Nov; 5(6):558-61. Reid JJ, Kremen TJ, Oppenheim WL. PMID: 24427433; PMCID: PMC3806179.
      View in: PubMed   Mentions: 4     Fields:    
    32. Giant cell tumor of bone: are we stratifying results appropriately? Clin Orthop Relat Res. 2012 Mar; 470(3):677-83. Kremen TJ, Bernthal NM, Eckardt MA, Eckardt JJ. PMID: 22125240; PMCID: PMC3270191.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    33. Can the reparability of meniscal tears be predicted with magnetic resonance imaging? Am J Sports Med. 2011 Mar; 39(3):506-10. Bernthal NM, Seeger LL, Motamedi K, Stavrakis AI, Kremen TJ, McAllister DR, Motamedi AR. PMID: 21173193.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    34. A mouse model of post-arthroplasty Staphylococcus aureus joint infection to evaluate in vivo the efficacy of antimicrobial implant coatings. PLoS One. 2010 Sep 07; 5(9):e12580. Bernthal NM, Stavrakis AI, Billi F, Cho JS, Kremen TJ, Simon SI, Cheung AL, Finerman GA, Lieberman JR, Adams JS, Miller LS. PMID: 20830204; PMCID: PMC2935351.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    35. Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment. Clin Cancer Res. 2005 Aug 01; 11(15):5515-25. Liau LM, Prins RM, Kiertscher SM, Odesa SK, Kremen TJ, Giovannone AJ, Lin JW, Chute DJ, Mischel PS, Cloughesy TF, Roth MD. PMID: 16061868.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansCellsCTClinical Trials
    36. Robustness of gene expression profiling in glioma specimen samplings and derived cell lines. Brain Res Mol Brain Res. 2005 May 20; 136(1-2):99-103. Mehrian Shai R, Reichardt JK, Ya-Hsuan H, Kremen TJ, Liau LM, Cloughesy TF, Mischel PS, Nelson SF. PMID: 15893592.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    37. Modulation of major histocompatibility complex Class I molecules and major histocompatibility complex-bound immunogenic peptides induced by interferon-alpha and interferon-gamma treatment of human glioblastoma multiforme. J Neurosurg. 2004 Feb; 100(2):310-9. Yang I, Kremen TJ, Giovannone AJ, Paik E, Odesa SK, Prins RM, Liau LM. PMID: 15086239.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    38. MART-1 adenovirus-transduced dendritic cell immunization in a murine model of metastatic central nervous system tumor. J Neurooncol. 2003 Aug-Sep; 64(1-2):21-30. Broder H, Anderson A, Kremen TJ, Odesa SK, Liau LM. PMID: 12952283.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    39. Gene expression profiling identifies molecular subtypes of gliomas. Oncogene. 2003 Jul 31; 22(31):4918-23. Shai R, Shi T, Kremen TJ, Horvath S, Liau LM, Cloughesy TF, Mischel PS, Nelson SF. PMID: 12894235.
      View in: PubMed   Mentions: 135     Fields:    Translation:Humans
    40. Identification of molecular subtypes of glioblastoma by gene expression profiling. Oncogene. 2003 Apr 17; 22(15):2361-73. Mischel PS, Shai R, Shi T, Horvath S, Lu KV, Choe G, Seligson D, Kremen TJ, Palotie A, Liau LM, Cloughesy TF, Nelson SF. PMID: 12700671.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    41. Active matrix metalloproteinase 9 expression is associated with primary glioblastoma subtype. Clin Cancer Res. 2002 Sep; 8(9):2894-901. Choe G, Park JK, Jouben-Steele L, Kremen TJ, Liau LM, Vinters HV, Cloughesy TF, Mischel PS. PMID: 12231534.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    42. Tumor immunity within the central nervous system stimulated by recombinant Listeria monocytogenes vaccination. Cancer Res. 2002 Apr 15; 62(8):2287-93. Liau LM, Jensen ER, Kremen TJ, Odesa SK, Sykes SN, Soung MC, Miller JF, Bronstein JM. PMID: 11956085.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    43. Hamartin expression and interaction with tuberin in tumor cell lines and primary cultures. J Neurosci Res. 2001 Feb 01; 63(3):276-83. Catania MG, Johnson MW, Liau LM, Kremen TJ, deVellis JS, Vinters HV. PMID: 11170177.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    44. Recombinant adenovirus-transduced dendritic cell immunization in a murine model of central nervous system tumor. Neurosurg Focus. 2000 Dec 15; 9(6):e6. Broder H, Anderson A, Odesa SK, Kremen TJ, Liau LM. PMID: 16817689.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health