"ras Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
| Descriptor ID |
D018631
|
| MeSH Number(s) |
D08.811.277.040.330.300.400.500 D12.644.360.525.500 D12.776.157.325.515.500 D12.776.476.525.500
|
| Concept/Terms |
ras Proteins- ras Proteins
- ras GTPases
- GTPases, ras
- Gene Products, ras
- ras Gene Products
|
Below are MeSH descriptors whose meaning is more general than "ras Proteins".
Below are MeSH descriptors whose meaning is more specific than "ras Proteins".
This graph shows the total number of publications written about "ras Proteins" by people in this website by year, and whether "ras Proteins" was a major or minor topic of these publications.
View timeline visualization
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 11 | 6 | 17 |
| 1996 | 12 | 10 | 22 |
| 1997 | 15 | 4 | 19 |
| 1998 | 11 | 11 | 22 |
| 1999 | 16 | 13 | 29 |
| 2000 | 17 | 5 | 22 |
| 2001 | 14 | 6 | 20 |
| 2002 | 16 | 7 | 23 |
| 2003 | 17 | 12 | 29 |
| 2004 | 15 | 13 | 28 |
| 2005 | 22 | 15 | 37 |
| 2006 | 17 | 8 | 25 |
| 2007 | 19 | 13 | 32 |
| 2008 | 14 | 13 | 27 |
| 2009 | 13 | 13 | 26 |
| 2010 | 17 | 23 | 40 |
| 2011 | 21 | 12 | 33 |
| 2012 | 15 | 19 | 34 |
| 2013 | 26 | 17 | 43 |
| 2014 | 31 | 16 | 47 |
| 2015 | 27 | 16 | 43 |
| 2016 | 15 | 19 | 34 |
| 2017 | 15 | 10 | 25 |
| 2018 | 14 | 7 | 21 |
| 2019 | 11 | 12 | 23 |
| 2020 | 15 | 2 | 17 |
| 2021 | 10 | 6 | 16 |
| 2022 | 4 | 4 | 8 |
| 2023 | 3 | 2 | 5 |
| 2024 | 4 | 4 | 8 |
| 2025 | 2 | 2 | 4 |
Below are the most recent publications written about "ras Proteins" by people in Profiles.
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Targeting Hyperactive Ras Signaling in Pediatric Cancer. Cold Spring Harb Perspect Med. 2025 May 05; 15(5).
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Condensates as a Culprit in RAS Activation and Inhibitor Resistance. Cancer Res. 2025 Apr 15; 85(8):1349-1351.
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Galectin-1 Inhibition as a Strategy for Malignant Peripheral Nerve Sheath Tumor Treatment. Cells. 2025 03 31; 14(7).
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Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation. Nat Commun. 2025 Jan 09; 16(1):525.
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Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies. Clin Cancer Res. 2024 Nov 01; 30(21):4834-4843.
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First-Line Therapy in Metastatic, RAS Wild-Type, Left-Sided Colorectal Cancer: Should Everyone Receive Anti-EGFR Therapy? Curr Oncol Rep. 2024 Nov; 26(11):1489-1501.
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Direct RAS inhibitors turn 10. Nat Chem Biol. 2024 Oct; 20(10):1238-1241.
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Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell. 2024 Oct 31; 187(22):6379-6392.e17.
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Leep2A and Leep2B function as a RasGAP complex to regulate macropinosome formation. J Cell Biol. 2024 Sep 02; 223(9).
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RASopathies - what they reveal about RAS/MAPK signaling in skeletal muscle development. Dis Model Mech. 2024 Jun 01; 17(6).