Albert Lai

Title(s)Professor-in-Residence, Neurology
SchoolMedicine
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    Collapse Research 
    Collapse research activities and funding
    Investigation of tumor suppressive miR-148a in IDH mutant gliomas
    NIH R01CA179071May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Genome-wide promoter methylation profiling of glioma
    NIH K08CA124479Sep 1, 2008 - Aug 31, 2013
    Role: Principal Investigator
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Modeling gliomas with organoids: Classification, fidelity, and guidelines for translational neuro-oncology. Neuro Oncol. 2026 Aug 01; 28(8):1861-1876. Hubert CG, Read RD, Miller TE, Kim U, Wang X, Ishan M, Wang Z, Miller EZY, Sun Y, Lai A, Ming GL, Song H, Wang Z. PMID: 42015385; PMCID: PMC13437898.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. MGMT downregulation by CRISPR/Cas13 RNA-guided RNA targeting enhances glioma cell sensitivity to TMZ chemotherapy. J Neurooncol. 2026 Mar 12; 177(1). Prins TJ, Lai TJ, Li T, Fisher A, Eldred BSC, Mostafavi R, Liau LM, Chong RA, Nghiemphu PL, Cloughesy TF, Nathanson DA, Lai A. PMID: 41817895; PMCID: PMC12982228.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. A multifocal IDH-mutant glioma with differential response to IDH inhibition: Role of quantitative neuroimaging. Radiol Case Rep. 2026 May; 21(5):2095-2100. Ibrahim O, Cho NS, Le VL, Sanvito F, Yao J, Teraishi A, Lai A, Nghiemphu PL, Salamon N, Rodriguez FJ, Everson R, Cloughesy TF, Ellingson BM. PMID: 41769184; PMCID: PMC12936475.
      View in: PubMed   Mentions:
    4. Perfusion, diffusion, and anatomical MRI characteristics of pathologically confirmed malignant transformation in IDH-mutant gliomas. Neuro Oncol. 2025 Dec 01; 27(12):3306-3317. Cho NS, Le VL, Teraishi A, Liu V, Sanvito F, Telesca D, Nakajo M, Wang C, Oshima S, Eldred BSC, Yao J, Nghiemphu PL, Salamon N, Cloughesy TF, Lai A, Ellingson BM. PMID: 40888039; PMCID: PMC12916721.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Impact of corticosteroid administration on contrast-enhancing volume and diffusion MRI in treatment naïve glioblastoma. Neuro Oncol. 2025 Nov 01; 27(11):3016-3026. Sanvito F, Kim A, Raymond C, Teraishi A, Everson RG, Nghiemphu PL, Lai A, Chong RA, Nathanson DA, Salamon N, Cloughesy TF, Yao J, Ellingson BM. PMID: 40443040; PMCID: PMC12908483.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Advanced imaging characterization of post-chemoradiation glioblastoma stratified by diffusion MRI phenotypes known to predict favorable anti-VEGF response. J Neurooncol. 2025 Jul; 173(3):583-594. Sanvito F, Kryukov I, Yao J, Teraishi A, Raymond C, Gao J, Miller C, Nghiemphu PL, Lai A, Liau LM, Patel K, Everson RG, Eldred BSC, Prins RM, Nathanson DA, Salamon N, Cloughesy TF, Ellingson BM. PMID: 40227555; PMCID: PMC12170782.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. A comparative study of preclinical and clinical molecular imaging response to EGFR inhibition using osimertinib in glioblastoma. Neurooncol Adv. 2025 Jan-Dec; 7(1):vdaf022. Ellingson BM, Okobi Q, Chong R, Plawat R, Zhao E, Gafita A, Sonni I, Chun S, Filka E, Yao J, Telesca D, Li S, Li G, Lai A, Nghiemphu P, Czernin J, Nathanson DA, Cloughesy TF. PMID: 40051661; PMCID: PMC11883343.
      View in: PubMed   Mentions: 2  
    8. Environment scan of generative AI infrastructure for clinical and translational science. Npj Health Syst. 2025; 2(1):4. Idnay B, Xu Z, Adams WG, Adibuzzaman M, Anderson NR, Bahroos N, Bell DS, Bumgardner C, Campion T, Castro M, Cimino JJ, Cohen IG, Dorr D, Elkin PL, Fan JW, Ferris T, Foran DJ, Hanauer D, Hogarth M, Huang K, Kalpathy-Cramer J, Kandpal M, Karnik NS, Katoch A, Lai AM, Lambert CG, Li L, Lindsell C, Liu J, Lu Z, Luo Y, McGarvey P, Mendonca EA, Mirhaji P, Murphy S, Osborne JD, Paschalidis IC, Harris PA, Prior F, Shaheen NJ, Shara N, Sim I, Tachinardi U, Waitman LR, Wright RJ, Zai AH, Zheng K, Lee SS, Malin BA, Natarajan K, Price Ii WN, Zhang R, Zhang Y, Xu H, Bian J, Weng C, Peng Y. PMID: 39872195; PMCID: PMC11762411.
      View in: PubMed   Mentions: 6  
    9. Estimation of prevalence of autoimmune diseases in the United States using electronic health record data. J Clin Invest. 2024 Dec 12; 135(4). Abend AH, He I, Bahroos N, Christianakis S, Crew AB, Wise LM, Lipori GP, He X, Murphy SN, Herrick CD, Avasarala J, Weiner MG, Zelko JS, Matute-Arcos E, Abajian M, Payne PR, Lai AM, Davis HA, Hoberg AA, Ortman CE, Gode AD, Taylor BW, Osinski KI, Di Florio DN, Rose NR, Miller FW, Tsokos GC, Fairweather D. PMID: 39666393; PMCID: PMC11827834.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    10. Diffusion MRI is superior to quantitative T2-FLAIR mismatch in predicting molecular subtypes of human non-enhancing gliomas. Neuroradiology. 2024 Dec; 66(12):2153-2162. Cho NS, Sanvito F, Le VL, Oshima S, Teraishi A, Yao J, Telesca D, Raymond C, Pope WB, Nghiemphu PL, Lai A, Salamon N, Cloughesy TF, Ellingson BM. PMID: 39377927; PMCID: PMC11611930.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Digital "flipbooks" for enhanced visual assessment of simple and complex brain tumors. Neuro Oncol. 2024 Oct 03; 26(10):1823-1836. Cho NS, Le VL, Sanvito F, Oshima S, Harper J, Chun S, Raymond C, Lai A, Nghiemphu PL, Yao J, Everson R, Salamon N, Cloughesy TF, Ellingson BM. PMID: 38808755; PMCID: PMC11449060.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Environment Scan of Generative AI Infrastructure for Clinical and Translational Science. ArXiv. 2024 Sep 28. Idnay B, Xu Z, Adams WG, Adibuzzaman M, Anderson NR, Bahroos N, Bell DS, Bumgardner C, Campion T, Castro M, Cimino JJ, Cohen IG, Dorr D, Elkin PL, Fan JW, Ferris T, Foran DJ, Hanauer D, Hogarth M, Huang K, Kalpathy-Cramer J, Kandpal M, Karnik NS, Katoch A, Lai AM, Lambert CG, Li L, Lindsell C, Liu J, Lu Z, Luo Y, McGarvey P, Mendonca EA, Mirhaji P, Murphy S, Osborne JD, Paschalidis IC, Harris PA, Prior F, Shaheen NJ, Shara N, Sim I, Tachinardi U, Waitman LR, Wright RJ, Zai AH, Zheng K, Lee SS, Malin BA, Natarajan K, Price WN, Zhang R, Zhang Y, Xu H, Bian J, Weng C, Peng Y. PMID: 41031081; PMCID: PMC12478420.
      View in: PubMed   Mentions: 4  
    13. Mesenchymal Stromal Cell Implants for Chronic Motor Deficits After Traumatic Brain Injury: Post Hoc Analysis of a Randomized Trial. Neurology. 2024 Oct 08; 103(7):e209797. Okonkwo DO, McAllister P, Achrol AS, Karasawa Y, Kawabori M, Cramer SC, Lai A, Kesari S, Frishberg BM, Groysman LI, Kim AS, Schwartz NE, Chen JW, Imai H, Yasuhara T, Chida D, Nejadnik B, Bates D, Stonehouse AH, Richardson RM, Steinberg GK, Poggio EC, Weintraub AH. PMID: 39231380; PMCID: PMC11373674.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    14. Valproic acid targets IDH1 mutants through alteration of lipid metabolism. NPJ Metab Health Dis. 2024; 2(1):20. Elahi LS, Condro MC, Kawaguchi R, Qin Y, Alvarado AG, Gruender B, Qi H, Li T, Lai A, Castro MG, Lowenstein PR, Garrett MC, Kornblum HI. PMID: 39149696; PMCID: PMC11321993.
      View in: PubMed   Mentions: 1  
    15. Valproic acid targets IDH1 mutants through alteration of lipid metabolism. NPJ Metab Health Dis. 2024; 2(1):20. Elahi LS, Condro MC, Kawaguchi R, Qin Y, Alvarado AG, Gruender B, Qi H, Li T, Lai A, Castro MG, Lowenstein PR, Garrett MC, Kornblum HI. PMID: 39149696; PMCID: PMC11321993.
      View in: PubMed   Mentions: 1  
    16. Effect of Jardiance on glucose uptake into astrocytomas. J Neurooncol. 2024 Sep; 169(2):437-444. Ghezzi C, Ellingson BM, Lai A, Liu J, Barrio JR, Wright EM. PMID: 39037688; PMCID: PMC11341586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth. Mol Cancer Res. 2024 07 02; 22(7):656-667. Muthukrishnan SD, Qi H, Wang D, Elahi L, Pham A, Alvarado AG, Li T, Gao F, Kawaguchi R, Lai A, Kornblum HI. PMID: 38441553; PMCID: PMC11217726.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    18. Epigenetic Induction of Cancer-Testis Antigens and Endogenous Retroviruses at Single-Cell Level Enhances Immune Recognition and Response in Glioma. Cancer Res Commun. 2024 07 01; 4(7):1834-1849. Lai TJ, Sun L, Li K, Prins TJ, Treger J, Li T, Sun MZ, Nathanson DA, Liau LM, Lai A, Prins RM, Everson RG. PMID: 38856710; PMCID: PMC11275559.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation. Cancer Res Commun. 2024 03 22; 4(3):876-894. Pianka ST, Li T, Prins TJ, Eldred BSC, Kevan BM, Liang H, Zapanta Rinonos S, Kornblum HI, Nathanson DA, Pellegrini M, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. PMID: 38445960; PMCID: PMC10959073.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    20. Quantification of T2-FLAIR Mismatch in Nonenhancing Diffuse Gliomas Using Digital Subtraction. AJNR Am J Neuroradiol. 2024 02 07; 45(2):188-197. Cho NS, Sanvito F, Le VL, Oshima S, Teraishi A, Yao J, Telesca D, Raymond C, Pope WB, Nghiemphu PL, Lai A, Cloughesy TF, Salamon N, Ellingson BM. PMID: 38238098; PMCID: PMC11285991.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. dCas9/CRISPR-based methylation of O-6-methylguanine-DNA methyltransferase enhances chemosensitivity to temozolomide in malignant glioma. J Neurooncol. 2024 Jan; 166(1):129-142. Zapanta Rinonos S, Li T, Pianka ST, Prins TJ, Eldred BSC, Kevan BM, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. PMID: 38224404; PMCID: PMC10824881.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI. Eur Radiol. 2024 May; 34(5):3087-3101. Sanvito F, Raymond C, Cho NS, Yao J, Hagiwara A, Orpilla J, Liau LM, Everson RG, Nghiemphu PL, Lai A, Prins R, Salamon N, Cloughesy TF, Ellingson BM. PMID: 37882836; PMCID: PMC11045669.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    23. SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation. J Neurooncol. 2019 May; 142(3):423-434. Liu F, Cox CD, Chowdhury R, Dovek L, Nguyen H, Li T, Li S, Ozer B, Chou A, Nguyen N, Wei B, Antonios J, Soto H, Kornblum H, Liau L, Prins R, Nghiemphu PL, Yong W, Cloughesy T, Lai A. PMID: 30838489; PMCID: PMC6516751.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    24. D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation. Mol Cancer Res. 2018 06; 16(6):947-960. Li T, Cox CD, Ozer BH, Nguyen NT, Nguyen HN, Lai TJ, Li S, Liu F, Kornblum HI, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. PMID: 29545476; PMCID: PMC5984679.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    25. Phase 2 Study of Bortezomib Combined With Temozolomide and Regional Radiation Therapy for Upfront Treatment of Patients With Newly Diagnosed Glioblastoma Multiforme: Safety and Efficacy Assessment. Int J Radiat Oncol Biol Phys. 2018 04 01; 100(5):1195-1203. Kong XT, Nguyen NT, Choi YJ, Zhang G, Nguyen HN, Filka E, Green S, Yong WH, Liau LM, Green RM, Kaprealian T, Pope WB, Nghiemphu PL, Cloughesy T, Lassman A, Lai A. PMID: 29722661; PMCID: PMC6277207.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCTClinical Trials
    26. Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide. Mol Cancer. 2015 Nov 06; 14:189. Tso JL, Yang S, Menjivar JC, Yamada K, Zhang Y, Hong I, Bui Y, Stream A, McBride WH, Liau LM, Nelson SF, Cloughesy TF, Yong WH, Lai A, Tso CL. PMID: 26546412; PMCID: PMC4636799.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    27. Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas. Clin Cancer Res. 2014 Nov 15; 20(22):5808-22. Li S, Chowdhury R, Liu F, Chou AP, Li T, Mody RR, Lou JJ, Chen W, Reiss J, Soto H, Prins R, Liau LM, Mischel PS, Nghiemphu PL, Yong WH, Cloughesy TF, Lai A. PMID: 25224277; PMCID: PMC4233178.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    28. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol. 2011 Jan 10; 29(2):142-8. Lai A, Tran A, Nghiemphu PL, Pope WB, Solis OE, Selch M, Filka E, Yong WH, Mischel PS, Liau LM, Phuphanich S, Black K, Peak S, Green RM, Spier CE, Kolevska T, Polikoff J, Fehrenbacher L, Elashoff R, Cloughesy T. PMID: 21135282; PMCID: PMC3058273.
      View in: PubMed   Mentions: 238     Fields:    Translation:HumansCTClinical Trials
    29. Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int J Radiat Oncol Biol Phys. 2008 Aug 01; 71(5):1372-80. Lai A, Filka E, McGibbon B, Nghiemphu PL, Graham C, Yong WH, Mischel P, Liau LM, Bergsneider M, Pope W, Selch M, Cloughesy T. PMID: 18355978.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCTClinical Trials
    30. Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells. J Cell Sci. 2006 Feb 01; 119(Pt 3):532-41. Lai A, Le DN, Paznekas WA, Gifford WD, Jabs EW, Charles AC. PMID: 16418219.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
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