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Jie Jay Zheng

Title(s)Professor-in-Residence, Ophthalmology
SchoolMedicine
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    Development of small-molecule Wnt mimetics for corneal epithelial cell regeneration
    NIH R01EY028557Sep 30, 2018 - Aug 31, 2022
    Role: Principal Investigator
    Structural investigation of focal adhesion formation and disassembly
    NIH R01GM100909May 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Mechanisms of Different Wnt Signals
    NIH R01GM081492Aug 1, 2007 - May 31, 2012
    Role: Principal Investigator
    STRUCTURAL INVESTIGATION OF FOCAL ADHESION MOLECULES
    NIH R01GM069916Feb 1, 2004 - Jan 31, 2009
    Role: Principal Investigator
    MOLECULAR BASIS OF THE WNT SIGNALING PATHWAY
    NIH R01GM061739Aug 1, 2000 - Jul 31, 2006
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Positive cooperativity in synergistic activation of Wnt proteins. Mol Biol Rep. 2024 Aug 18; 51(1):914. Bonnet C, Han CS, Deng SX, Zheng JJ. PMID: 39154310; PMCID: PMC11330945.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Wnt activation as a potential therapeutic approach to treat partial limbal stem cell deficiency. Sci Rep. 2023 09 21; 13(1):15670. Bonnet C, González S, Deng SX, Zheng JJ. PMID: 37735479; PMCID: PMC10514048.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Characterizing the metabolic profile of dexamethasone treated human trabecular meshwork cells. Exp Eye Res. 2022 01; 214:108888. Graybeal K, Sanchez L, Zhang C, Stiles L, Zheng JJ. PMID: 34896106; PMCID: PMC9272781.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    4. A Small-Molecule Wnt Mimic Improves Human Limbal Stem Cell Ex Vivo Expansion. iScience. 2020 May 22; 23(5):101075. Zhang C, Mei H, Robertson SYT, Lee HJ, Deng SX, Zheng JJ. PMID: 32361505; PMCID: PMC7200314.
      View in: PubMed   Mentions: 17  
    5. Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin. J Biol Chem. 2017 11 03; 292(44):18281-18289. Zhang C, Miller DJ, Guibao CD, Donato DM, Hanks SK, Zheng JJ. PMID: 28860193; PMCID: PMC5672050.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    6. Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells. Exp Cell Res. 2017 08 01; 357(1):116-123. Ahadome SD, Zhang C, Tannous E, Shen J, Zheng JJ. PMID: 28526237; PMCID: PMC5535738.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    7. Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. J Biol Chem. 2017 04 07; 292(14):5898-5908. Qi J, Lee HJ, Saquet A, Cheng XN, Shao M, Zheng JJ, Shi DL. PMID: 28223363; PMCID: PMC5392581.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    8. Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses. Angew Chem Int Ed Engl. 2016 Mar 01; 55(10):3438-41. Bao J, Marathe B, Govorkova EA, Zheng JJ. PMID: 26833677; PMCID: PMC4807618.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    9. Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. J Biol Chem. 2015 Dec 18; 290(51):30596-606. Lee HJ, Bao J, Miller A, Zhang C, Wu J, Baday YC, Guibao C, Li L, Wu D, Zheng JJ. PMID: 26504084; PMCID: PMC4683279.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
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