Elissa A Hallem

Title(s)Department Vice Chair, MIMG, MIMG
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    Title(s)Professor, MIMG

    Collapse Biography 
    Collapse Education and Training
    Williams College, Williamstown, MABA06/1999Biology and Chemistry
    Yale University, New Haven, CTPhD05/2005Neuroscience
    Collapse Awards and Honors
    2011Rita Allen Foundation Fellowship
    2011Alfred P. Sloan Research Fellowship
    2012Searle Scholar Award
    2012MacArthur Fellowship
    UCLA2013Dean's Recognition Award
    2013McKnight Scholar Award
    NIH2014NIH Director's New Innovator Award
    2015Burroughs-Wellcome Fund Investigators in the Pathogenesis of Disease Award
    David Geffen School of Medicine at UCLA2015John H. Walsh Young Investigator Research Prize
    2016HHMI Faculty Scholar Award
    UCLA2020Faculty Mentor Award

    Collapse Overview 
    Collapse Overview
    Our research focuses on sensory circuit function in parasitic and free-living animals, and lies at the interface of neurobiology and parasitology. Nearly all organisms respond to sensory stimuli, but how sensory circuits specify behavior is poorly understood. We are investigating the neural basis of sensory behaviors in the context of human parasitism. We use parasitic nematodes and the free-living nematode C. elegans as models. The goals of our research are to understand how parasitic worms use sensory cues to locate and infect hosts, how sensory circuits of parasitic animals differ from those of free-living animals to enable parasitic behaviors, and how sensory microcircuits generate flexible outputs. Our research addresses fundamental questions of sensory circuit function and evolution. In addition, human-parasitic worms are a major cause of morbidity worldwide, and a better understanding of their behaviors may enable the development of novel strategies for preventing infections.

    Collapse Research 
    Collapse Research Activities and Funding
    Thermosensation in skin-penetrating parasitic nematodes
    NIH R01AI136976Jul 22, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Chemosensation in skin-penetrating parasitic nematodes
    NIH R01DC017959Jun 1, 2019 - May 31, 2024
    Role: Principal Investigator
    The neural basis of odor-driven behavior in skin-penetrating parasitic nematodes.
    NIH DP2DC014596Sep 15, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Mechanisms of carbon dioxide response in nematodes
    NIH R00AI085107May 1, 2010 - Dec 31, 2012
    Role: Principal Investigator
    Mechanisms of carbon dioxide avoidance in parasitic nematodes
    NIH K99AI085107May 1, 2010 - Jan 2, 2011
    Role: Principal Investigator
    Functional Characterization of Drosophila Odor Receptors
    NIH F31DC006518Dec 1, 2003 - Nov 30, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Differential processing of a chemosensory cue across life stages sharing the same valence state in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2218023120. Banerjee N, Shih PY, Rojas Palato EJ, Sternberg PW, Hallem EA. PMID: 37126715; PMCID: PMC10175840.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Editorial - Strongyloides research in the post-genomics era. Mol Biochem Parasitol. 2022 Nov; 252:111522. Atkinson LE, Hallem EA. PMID: 36156285.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Making sense of sensory behaviors in vector-borne helminths. Trends Parasitol. 2022 10; 38(10):841-853. Wheeler NJ, Hallem EA, Zamanian M. PMID: 35931639; PMCID: PMC9481669.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsPHPublic Health
    4. Using newly optimized genetic tools to probe Strongyloides sensory behaviors. Mol Biochem Parasitol. 2022 07; 250:111491. Mendez P, Walsh B, Hallem EA. PMID: 35697205; PMCID: PMC9339661.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. The neural basis of heat seeking in a human-infective parasitic worm. Curr Biol. 2022 05 23; 32(10):2206-2221.e6. Bryant AS, Ruiz F, Lee JH, Hallem EA. PMID: 35483361; PMCID: PMC9158753.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Olfaction: One receptor drives opposite behaviors. Curr Biol. 2022 01 24; 32(2):R93-R96. Patel R, Hallem EA. PMID: 35077699.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. Generating Transgenics and Knockouts in Strongyloides Species by Microinjection. J Vis Exp. 2021 10 07; (176). Castelletto ML, Hallem EA. PMID: 34694289; PMCID: PMC9109651.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. Skin-penetrating nematodes exhibit life-stage-specific interactions with host-associated and environmental bacteria. BMC Biol. 2021 10 07; 19(1):221. Chavez IN, Brown TM, Assié A, Bryant AS, Samuel BS, Hallem EA. PMID: 34620172; PMCID: PMC8499433.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. The Wild Worm Codon Adapter: a web tool for automated codon adaptation of transgenes for expression in non-Caenorhabditis nematodes. G3 (Bethesda). 2021 07 14; 11(7). Bryant AS, Hallem EA. PMID: 33914084; PMCID: PMC8496300.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    10. Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in Pristionchus pacificus. Genetics. 2021 06 24; 218(2). Carstensen HR, Villalon RM, Banerjee N, Hallem EA, Hong RL. PMID: 33963848; PMCID: PMC8225345.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Strongyloides RNA-seq Browser: a web-based software platform for on-demand bioinformatics analyses of Strongyloides species. G3 (Bethesda). 2021 05 07; 11(5). Bryant AS, DeMarco SF, Hallem EA. PMID: 33823530; PMCID: PMC8104939.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. Chemosensory mechanisms of host seeking and infectivity in skin-penetrating nematodes. Proc Natl Acad Sci U S A. 2020 07 28; 117(30):17913-17923. Gang SS, Castelletto ML, Yang E, Ruiz F, Brown TM, Bryant AS, Grant WN, Hallem EA. PMID: 32651273; PMCID: PMC7395504.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    13. Recent advances in functional genomics for parasitic nematodes of mammals. J Exp Biol. 2020 02 07; 223(Pt Suppl 1). Castelletto ML, Gang SS, Hallem EA. PMID: 32034038; PMCID: PMC7790190.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    14. Decoding Inter-individual Variability in Experience-Dependent Behavioral Plasticity. Neuron. 2020 01 08; 105(1):7-9. Banerjee N, Hallem EA. PMID: 31951528.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. The role of carbon dioxide in nematode behaviour and physiology. Parasitology. 2020 07; 147(8):841-854. Banerjee N, Hallem EA. PMID: 31601281; PMCID: PMC7148182.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    16. Feeding state sculpts a circuit for sensory valence in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1776-1781. Rengarajan S, Yankura KA, Guillermin ML, Fung W, Hallem EA. PMID: 30651312; PMCID: PMC6358703.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    17. Terror in the dirt: Sensory determinants of host seeking in soil-transmitted mammalian-parasitic nematodes. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):496-510. Bryant AS, Hallem EA. PMID: 30396862; PMCID: PMC6287541.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    18. Temperature-dependent behaviors of parasitic helminths. Neurosci Lett. 2018 11 20; 687:290-303. Bryant AS, Hallem EA. PMID: 30336196; PMCID: PMC6240462.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    19. A Critical Role for Thermosensation in Host Seeking by Skin-Penetrating Nematodes. Curr Biol. 2018 07 23; 28(14):2338-2347.e6. Bryant AS, Ruiz F, Gang SS, Castelletto ML, Lopez JB, Hallem EA. PMID: 30017486; PMCID: PMC6091634.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    20. Sexual Dimorphisms: How Sex-Shared Neurons Generate Sex-Specific Behaviors. Curr Biol. 2018 03 19; 28(6):R254-R256. Banerjee N, Hallem E. PMID: 29558638.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    21. Experience-dependent olfactory behaviors of the parasitic nematode Heligmosomoides polygyrus. PLoS Pathog. 2017 Nov; 13(11):e1006709. Ruiz F, Castelletto ML, Gang SS, Hallem EA. PMID: 29190282; PMCID: PMC5708605.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    22. Targeted mutagenesis in a human-parasitic nematode. PLoS Pathog. 2017 Oct; 13(10):e1006675. Gang SS, Castelletto ML, Bryant AS, Yang E, Mancuso N, Lopez JB, Pellegrini M, Hallem EA. PMID: 29016680; PMCID: PMC5650185.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    23. A Single Set of Interneurons Drives Opposite Behaviors in C. elegans. Curr Biol. 2017 Sep 11; 27(17):2630-2639.e6. Guillermin ML, Carrillo MA, Hallem EA. PMID: 28823678; PMCID: PMC6193758.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    24. Olfactory Preferences of the Parasitic Nematode Howardula aoronymphium and its Insect Host Drosophila falleni. J Chem Ecol. 2017 Apr; 43(4):362-373. Cevallos JA, Okubo RP, Perlman SJ, Hallem EA. PMID: 28315996; PMCID: PMC5673469.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    25. Stilbene epoxidation and detoxification in a Photorhabdus luminescens-nematode symbiosis. J Biol Chem. 2017 04 21; 292(16):6680-6694. Park HB, Sampathkumar P, Perez CE, Lee JH, Tran J, Bonanno JB, Hallem EA, Almo SC, Crawford JM. PMID: 28246174; PMCID: PMC5399116.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    26. Olfactory circuits and behaviors of nematodes. Curr Opin Neurobiol. 2016 12; 41:136-148. Rengarajan S, Hallem EA. PMID: 27668755; PMCID: PMC5123917.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    27. Mechanisms of host seeking by parasitic nematodes. Mol Biochem Parasitol. 2016 07; 208(1):23-32. Gang SS, Hallem EA. PMID: 27211240; PMCID: PMC4993646.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    28. Temperature-dependent changes in the host-seeking behaviors of parasitic nematodes. BMC Biol. 2016 05 06; 14:36. Lee JH, Dillman AR, Hallem EA. PMID: 27154502; PMCID: PMC4858831.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsPHPublic Health
    29. Variation in the susceptibility of Drosophila to different entomopathogenic nematodes. Infect Immun. 2015 Mar; 83(3):1130-8. Peña JM, Carrillo MA, Hallem EA. PMID: 25561714; PMCID: PMC4333445.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    30. Diverse host-seeking behaviors of skin-penetrating nematodes. PLoS Pathog. 2014 Aug; 10(8):e1004305. Castelletto ML, Gang SS, Okubo RP, Tselikova AA, Nolan TJ, Platzer EG, Lok JB, Hallem EA. PMID: 25121736; PMCID: PMC4133384.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    31. O2-sensing neurons control CO2 response in C. elegans. J Neurosci. 2013 Jun 05; 33(23):9675-83. Carrillo MA, Guillermin ML, Rengarajan S, Okubo RP, Hallem EA. PMID: 23739964; PMCID: PMC3721734.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    32. Chemosensory behaviors of parasites. Trends Parasitol. 2012 Oct; 28(10):427-36. Chaisson KE, Hallem EA. PMID: 22921895; PMCID: PMC5663455.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    33. Olfaction shapes host-parasite interactions in parasitic nematodes. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):E2324-33. Dillman AR, Guillermin ML, Lee JH, Kim B, Sternberg PW, Hallem EA. PMID: 22851767; PMCID: PMC3435218.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    34. Differentiation of carbon dioxide-sensing neurons in Caenorhabditis elegans requires the ETS-5 transcription factor. Genetics. 2011 Dec; 189(4):1327-39. Guillermin ML, Castelletto ML, Hallem EA. PMID: 21954162; PMCID: PMC3241437.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    35. A sensory code for host seeking in parasitic nematodes. Curr Biol. 2011 Mar 08; 21(5):377-83. Hallem EA, Dillman AR, Hong AV, Zhang Y, Yano JM, DeMarco SF, Sternberg PW. PMID: 21353558; PMCID: PMC3152378.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    36. Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):254-9. Hallem EA, Spencer WC, McWhirter RD, Zeller G, Henz SR, Rätsch G, Miller DM, Horvitz HR, Sternberg PW, Ringstad N. PMID: 21173231; PMCID: PMC3017194.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    37. Acute carbon dioxide avoidance in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8038-43. Hallem EA, Sternberg PW. PMID: 18524955; PMCID: PMC2430355.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    38. Nematodes, bacteria, and flies: a tripartite model for nematode parasitism. Curr Biol. 2007 May 15; 17(10):898-904. Hallem EA, Rengarajan M, Ciche TA, Sternberg PW. PMID: 17475494.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    39. Coding of odors by a receptor repertoire. Cell. 2006 Apr 07; 125(1):143-60. Hallem EA, Carlson JR. PMID: 16615896.
      View in: PubMed   Mentions: 500     Fields:    Translation:Animals
    40. Insect odor and taste receptors. Annu Rev Entomol. 2006; 51:113-35. Hallem EA, Dahanukar A, Carlson JR. PMID: 16332206.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    41. Insect chemoreception. Curr Opin Neurobiol. 2005 Aug; 15(4):423-30. Dahanukar A, Hallem EA, Carlson JR. PMID: 16006118.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    42. The odor coding system of Drosophila. Trends Genet. 2004 Sep; 20(9):453-9. Hallem EA, Carlson JR. PMID: 15313555.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    43. The molecular basis of odor coding in the Drosophila antenna. Cell. 2004 Jun 25; 117(7):965-79. Hallem EA, Ho MG, Carlson JR. PMID: 15210116.
      View in: PubMed   Mentions: 350     Fields:    Translation:AnimalsCells
    44. The spatial code for odors is changed by conditioning. Neuron. 2004 May 13; 42(3):359-61. Hallem EA, Carlson JR. PMID: 15134632.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    45. Olfaction: mosquito receptor for human-sweat odorant. Nature. 2004 Jan 15; 427(6971):212-3. Hallem EA, Nicole Fox A, Zwiebel LJ, Carlson JR. PMID: 14724626.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
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