Kaustabh Ghosh

Title(s)Associate Professor-in-Residence, Ophthalmology
SchoolMedicine
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    Collapse Biography 
    Collapse Education and Training
    Boston Children's Hospital & Harvard Medical SchoolPostdoctoral Fellowship2011Vascular Biology
    Stony Brook University (SUNY)Ph.D.2006Biomedical Engineering
    National Institute of Technology, Warangal, IndiaB.Tech2001Chemical Engineering
    Collapse Awards and Honors
    Research to Prevent Blindness/IRRF2022Catalyst Award for Innovative Research Approaches for AMD
    BrightFocus Foundation2017Featured Scientist
    University of California2017Regents Faculty Development Award
    Orange County Engineering Council, CA2016Outstanding Educator Award
    Hellman Foundation2014Hellman Fellowship
    University of California2013Regents Faculty Fellowship
    University of Wisconsin-Madison 2011Lindbergh Lecturer
    NIH2008T32 Postdoctoral Training Grant
    Stony Brook University (SUNY)2006President’s Award to Distinguished Doctoral Students
    New Jersey Center for Biomaterials2004Graduate Student Scholarship
    Siemens Foundation2004Outstanding Mentor Award
    National Institute of Technology, Warangal, INDIA2001Undergraduate Merit Scholarship

    Collapse Overview 
    Collapse Overview
    Research in our lab aims to understand the mechanobiology of vascular inflammation and degeneration in retinal diseases, specifically diabetic retinopathy (DR) and age-related macular degeneration (AMD). Currently, DR and AMD are clinically managed only in their advanced stages that are marked by excessive multiplication and leakiness of blood vessels in the inner and outer retina, respectively. However, there is growing recognition that more effective treatment of these conditions is possible by tackling them in the early stages when these blood vessels degenerate. We are taking a multidisciplinary approach to understand and prevent this early loss of blood vessels in diabetes and aging. Integrating the principles of vascular biology, mechanobiology, inflammation, and bioengineering, our work has introduced a new paradigm that implicates vascular 'stiffness' as a crucial determinant of vascular degeneration associated with early DR and AMD. Our ongoing studies aim to identify the factors that alter vascular stiffness in the eye and uncover the mechanobiological mechanisms by which altered stiffness causes vascular loss in diabetes and aging. These studies, funded by the National Eye Institute/NIH and private foundations, have the potential to identify new classes of drugs that restore normal vascular stiffness and function in the eye and thereby block DR and AMD progression in their early stages.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanobiology of choroidal vascular loss in early AMD
    Research to Prevent Blindness/International Retinal Research Foundation Catalyst Award for Innovative Research ApproachesJan 1, 2023 - Dec 31, 2025
    Role: PI
    Transcriptomic and proteomic analysis of choroidal vascular cells to identify a novel link between mechanobiology and inflammation in age-related macular degeneration
    UCLA Clinical and Translational Science Institute T1/T2 Accelerator Program Core Voucher AwardJul 22, 2022 - Jan 31, 2023
    Role: PI
    Vascular Degeneration Basic Research
    W.M. Keck Foundation The Stephen Ryan Initiative for Macular ResearchJan 1, 2021 - Jun 30, 2023
    Role: PI
    Role of retinal capillary stiffness in diabetic retinopathy
    National Eye Institute/NIH R01 EY028242Oct 1, 2017 - Jun 30, 2023
    Role: PI
    Discovery of Biomarkers for Age-Related Macular Degeneration
    NIH R01EY027440Sep 30, 2017 - Aug 31, 2021
    Role: Co-Investigator
    Micromechanical determinants of choriocapillaris dysfunction in AMD pathogenesis
    BrightFocus Foundation Macular Degeneration Grant-M2016161Jul 1, 2016 - Jun 30, 2019
    Role: PI
    SysCODE Interdisciplinary postdoctoral Training Grant (8 of 10)RL9
    NIH RL9EB008539Sep 30, 2007 - Jun 30, 2013
    Role: T32 Postdoctoral Trainee (2008-2010)

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mechanical Regulation of Retinal Vascular Inflammation and Degeneration in Diabetes. Diabetes. 2024 Feb 01; 73(2):280-291. Chandrakumar S, Santiago Tierno I, Agarwal M, Lessieur EM, Du Y, Tang J, Kiser J, Yang X, Rodriguez A, Kern TS, Ghosh K. PMID: 37986627; PMCID: PMC10796303.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Subendothelial Matrix Stiffening by Lysyl Oxidase Enhances RAGE-Mediated Retinal Endothelial Activation in Diabetes. Diabetes. 2023 07 01; 72(7):973-985. Chandrakumar S, Santiago Tierno I, Agarwal M, Matisioudis N, Kern TS, Ghosh K. PMID: 37058096; PMCID: PMC10281239.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    3. Increased cell stiffness contributes to complement-mediated injury of choroidal endothelial cells in a monkey model of early age-related macular degeneration. J Pathol. 2022 07; 257(3):314-326. Cabrera AP, Stoddard J, Santiago Tierno I, Matisioudis N, Agarwal M, Renner L, Palegar N, Neuringer M, McGill T, Ghosh K. PMID: 35239183; PMCID: PMC9337711.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Senescence Increases Choroidal Endothelial Stiffness and Susceptibility to Complement Injury: Implications for Choriocapillaris Loss in AMD. Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):5910-5918. Cabrera AP, Bhaskaran A, Xu J, Yang X, Scott HA, Mohideen U, Ghosh K. PMID: 27802521.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    5. Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. Mol Vis. 2016; 22:1280-1290. Mohan RR, Cabrera AP, Harrison RE, Gorham RD, Johnson LV, Ghosh K, Morikis D. PMID: 27829783; PMCID: PMC5082644.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Matrix stiffness exerts biphasic control over monocyte-endothelial adhesion via Rho-mediated ICAM-1 clustering. Integr Biol (Camb). 2016 08 08; 8(8):869-78. Scott HA, Quach B, Yang X, Ardekani S, Cabrera AP, Wilson R, Messaoudi-Powers I, Ghosh K. PMID: 27444067.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    7. Cathepsin D: an Mϕ-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy. FASEB J. 2016 Apr; 30(4):1670-82. Monickaraj F, McGuire PG, Nitta CF, Ghosh K, Das A. PMID: 26718887; PMCID: PMC4799507.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    8. Nanoliposomal Nitroglycerin Exerts Potent Anti-Inflammatory Effects. Sci Rep. 2015 Nov 20; 5:16258. Ardekani S, Scott HA, Gupta S, Eum S, Yang X, Brunelle AR, Wilson SM, Mohideen U, Ghosh K. PMID: 26584637; PMCID: PMC4653649.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Basement membrane stiffening promotes retinal endothelial activation associated with diabetes. FASEB J. 2016 Feb; 30(2):601-11. Yang X, Scott HA, Monickaraj F, Xu J, Ardekani S, Nitta CF, Cabrera A, McGuire PG, Mohideen U, Das A, Ghosh K. PMID: 26443820; PMCID: PMC6188223.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    10. Mouse Retinal Whole Mounts and Quantification of Vasculature Protocol. Bio Protoc. 2015 Aug 05; 5(15). Adini I, Ghosh K. PMID: 29552585; PMCID: PMC5856157.
      View in: PubMed   Mentions: 2  
    11. Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy. Oncogene. 2016 Jan 21; 35(3):314-22. Adapala RK, Thoppil RJ, Ghosh K, Cappelli HC, Dudley AC, Paruchuri S, Keshamouni V, Klagsbrun M, Meszaros JG, Chilian WM, Ingber DE, Thodeti CK. PMID: 25867067; PMCID: PMC4948740.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    12. Aberrant cell and basement membrane architecture contribute to sidestream smoke-induced choroidal endothelial dysfunction. Invest Ophthalmol Vis Sci. 2014 Apr 08; 55(5):3140-7. Yang X, Scott HA, Ardekani S, Williams M, Talbot P, Ghosh K. PMID: 24713480.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    13. Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment. J Clin Invest. 2014 Jan; 124(1):425-36. Adini I, Ghosh K, Adini A, Chi ZL, Yoshimura T, Benny O, Connor KM, Rogers MS, Bazinet L, Birsner AE, Bielenberg DR, D'Amato RJ. PMID: 24355922; PMCID: PMC3871226.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    14. Deformation gradients imprint the direction and speed of en masse fibroblast migration for fast healing. J Invest Dermatol. 2013 Oct; 133(10):2471-2479. Pan Z, Ghosh K, Hung V, Macri LK, Einhorn J, Bhatnagar D, Simon M, Clark RAF, Rafailovich MH. PMID: 23594599; PMCID: PMC3755030.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action. Angiogenesis. 2013 Apr; 16(2):405-16. Adini A, Adini I, Ghosh K, Benny O, Pravda E, Hu R, Luyindula D, D'Amato RJ. PMID: 23150059.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    16. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science. 2012 Aug 10; 337(6095):738-42. Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE. PMID: 22767894.
      View in: PubMed   Mentions: 139     Fields:    Translation:Animals
    17. Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix. Nano Lett. 2012 Jun 13; 12(6):3213-7. Kanapathipillai M, Mammoto A, Mammoto T, Kang JH, Jiang E, Ghosh K, Korin N, Gibbs A, Mannix R, Ingber DE. PMID: 22554317.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    18. Polymeric nanomaterials for islet targeting and immunotherapeutic delivery. Nano Lett. 2012 Jan 11; 12(1):203-8. Ghosh K, Kanapathipillai M, Korin N, McCarthy JR, Ingber DE. PMID: 22196766; PMCID: PMC3280082.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. Effects of fiber orientation and diameter on the behavior of human dermal fibroblasts on electrospun PMMA scaffolds. J Biomed Mater Res A. 2009 Sep 15; 90(4):1092-106. Liu Y, Ji Y, Ghosh K, Clark RA, Huang L, Rafailovich MH. PMID: 18671267.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    20. Traction stresses and translational distortion of the nucleus during fibroblast migration on a physiologically relevant ECM mimic. Biophys J. 2009 May 20; 96(10):4286-98. Pan Z, Ghosh K, Liu Y, Clark RA, Rafailovich MH. PMID: 19450499; PMCID: PMC2712144.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res. 2009 May 08; 104(9):1123-30. Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. PMID: 19359599; PMCID: PMC2754067.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimalsCells
    22. Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11305-10. Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. PMID: 18685096; PMCID: PMC2516246.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    23. Detecting cancer cells in normal tissue by scanning force modulation microscopy. Microscopy and Analysis . 2008; 22(2):5-8. Pernodet N, Jurukovski V, Fields J, Fields A, Ramek A, Tmironav T, Ghosh K, Bernheim T, Hall K, Ge S, Slutsky L, Dorst K, Simon M, Rafailovich M . View Publication.
    24. Micromechanical control of cell and tissue development: implications for tissue engineering. Adv Drug Deliv Rev. 2007 Nov 10; 59(13):1306-18. Ghosh K, Ingber DE. PMID: 17920155.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    25. Tissue engineering for cutaneous wounds. J Invest Dermatol. 2007 May; 127(5):1018-29. Clark RA, Ghosh K, Tonnesen MG. PMID: 17435787.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    26. Dual-syringe reactive electrospinning of cross-linked hyaluronic acid hydrogel nanofibers for tissue engineering applications. Macromol Biosci. 2006 Oct 20; 6(10):811-7. Ji Y, Ghosh K, Li B, Sokolov JC, Clark RA, Rafailovich MH. PMID: 17022092.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    27. Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties. Biomaterials. 2007 Feb; 28(4):671-9. Ghosh K, Pan Z, Guan E, Ge S, Liu Y, Nakamura T, Ren XD, Rafailovich M, Clark RA. PMID: 17049594; PMCID: PMC3625367.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    28. Molecular stenting with a crosslinked hyaluronan derivative inhibits collagen gel contraction. J Invest Dermatol. 2006 Oct; 126(10):2202-9. Mehra TD, Ghosh K, Shu XZ, Prestwich GD, Clark RA. PMID: 16741511.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    29. Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Biomaterials. 2006 Jul; 27(20):3782-92. Ji Y, Ghosh K, Shu XZ, Li B, Sokolov JC, Prestwich GD, Clark RA, Rafailovich MH. PMID: 16556462.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    30. Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing. Tissue Eng. 2006 Mar; 12(3):601-13. Ghosh K, Ren XD, Shu XZ, Prestwich GD, Clark RA. PMID: 16579693.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    31. Rheological characterization of in situ cross-linkable hyaluronan hydrogels. Biomacromolecules. 2005 Sep-Oct; 6(5):2857-65. Ghosh K, Shu XZ, Mou R, Lombardi J, Prestwich GD, Rafailovich MH, Clark RA. PMID: 16153128.
      View in: PubMed   Mentions: 51     Fields:    
    32. Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogel. J Biomed Mater Res A. 2004 Feb 01; 68(2):365-75. Shu XZ, Ghosh K, Liu Y, Palumbo FS, Luo Y, Clark RA, Prestwich GD. PMID: 14704979.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
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