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Stelzner, Matthias G

Title(s)Professor, Surgery
SchoolGeneral Surgery
Phone3102683457
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    Collapse Research 
    Collapse Research Activities and Funding
    Intestinal Stem Cell Culture and Entero-Endocrine Lineage Development
    NIH/NIDDK U01DK085535Sep 30, 2009 - Aug 31, 2019
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Solorzano-Vargas RS, Bjerknes M, Wu SV, Wang J, Stelzner M, Dunn JCY, Dhawan S, Cheng H, Georgia S, Martín MG. The cellular regulators PTEN and BMI1 help mediate NEUROGENIN-3-induced cell cycle arrest. J Biol Chem. 2019 Oct 11; 294(41):15182-15192. PMID: 31341016.
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    2. Khalil HA, Hong SN, Rouch JD, Scott A, Cho Y, Wang J, Lewis MS, Martin MG, Dunn JCY, Stelzner MG. Intestinal epithelial replacement by transplantation of cultured murine and human cells into the small intestine. PLoS One. 2019; 14(5):e0216326. PMID: 31150401.
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    3. Huynh N, Dubrovsky G, Rouch JD, Scott A, Stelzner M, Shekherdimian S, Dunn JCY. Feasibility and scalability of spring parameters in distraction enterogenesis in a murine model. J Surg Res. 2017 07; 215:219-224. PMID: 28688651.
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    4. Hong SN, Dunn JC, Stelzner M, Martín MG. Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients with Intestinal Failure. Stem Cells Transl Med. 2017 02; 6(2):666-676. PMID: 28191783.
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    5. Scott A, Rouch JD, Jabaji Z, Khalil HA, Solorzano S, Lewis M, Martín MG, Stelzner MG, Dunn JC. Long-term renewable human intestinal epithelial stem cells as monolayers: A potential for clinical use. J Pediatr Surg. 2016 Jun; 51(6):995-1000. PMID: 26995514.
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    6. Khalil HA, Lei NY, Brinkley G, Scott A, Wang J, Kar UK, Jabaji ZB, Lewis M, Martín MG, Dunn JC, Stelzner MG. A novel culture system for adult porcine intestinal crypts. Cell Tissue Res. 2016 07; 365(1):123-34. PMID: 26928041.
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    7. Singh S, Rejai S, Antongiorgi Z, Gonzalez N, Stelzner M. Misconnections in the Critically Ill: Injection of High-Dose Gadolinium into an External Ventricular Drain. A A Case Rep. 2016 Mar 01; 6(5):121-3. PMID: 26462163.
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    8. Rouch JD, Scott A, Lei NY, Solorzano-Vargas RS, Wang J, Hanson EM, Kobayashi M, Lewis M, Stelzner MG, Dunn JC, Eckmann L, Martín MG. Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids. PLoS One. 2016; 11(1):e0148216. PMID: 26820624.
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    9. Khalil HA, Lei NY, Nie W, Lewis MS, Stelzner MG, Martín MG, Dunn JC, Yoo J. Primary Myofibroblasts Maintain Short-Term Viability following Submucosal Injection in Syngeneic, Immune-Competent Mice Utilizing Murine Colonoscopy. PLoS One. 2015; 10(5):e0127258. PMID: 26016485.
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    10. Wang X, Wei L, Cramer JM, Leibowitz BJ, Judge C, Epperly M, Greenberger J, Wang F, Li L, Stelzner MG, Dunn JCY, Martin MG, Lagasse E, Zhang L, Yu J. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10; 5:8566. PMID: 25858503.
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    11. Ristow O, Koerdt S, Stelzner R, Stelzner M, Johannes C, Ristow M, Hohlweg-Majert B, Pautke C. A dental myth bites the dust--no observable relation between the incidence of dental abscess and the weather and lunar phase: an ecological study. BMC Oral Health. 2015 Feb 11; 15:21. PMID: 25888138.
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    12. Jabaji Z, Brinkley GJ, Khalil HA, Sears CM, Lei NY, Lewis M, Stelzner M, Martín MG, Dunn JC. Type I collagen as an extracellular matrix for the in vitro growth of human small intestinal epithelium. PLoS One. 2014; 9(9):e107814. PMID: 25222024.
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    13. Lei NY, Jabaji Z, Wang J, Joshi VS, Brinkley GJ, Khalil H, Wang F, Jaroszewicz A, Pellegrini M, Li L, Lewis M, Stelzner M, Dunn JC, Martín MG. Intestinal subepithelial myofibroblasts support the growth of intestinal epithelial stem cells. PLoS One. 2014; 9(1):e84651. PMID: 24400106.
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    14. Gracz AD, Fuller MK, Wang F, Li L, Stelzner M, Dunn JC, Martin MG, Magness ST. Brief report: CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells. Stem Cells. 2013 Sep; 31(9):2024-30. PMID: 23553902.
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    15. Magness ST, Puthoff BJ, Crissey MA, Dunn J, Henning SJ, Houchen C, Kaddis JS, Kuo CJ, Li L, Lynch J, Martin MG, May R, Niland JC, Olack B, Qian D, Stelzner M, Swain JR, Wang F, Wang J, Wang X, Yan K, Yu J, Wong MH. A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G542-51. PMID: 23928185.
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    16. Jabaji Z, Sears CM, Brinkley GJ, Lei NY, Joshi VS, Wang J, Lewis M, Stelzner M, Martín MG, Dunn JC. Use of collagen gel as an alternative extracellular matrix for the in vitro and in vivo growth of murine small intestinal epithelium. Tissue Eng Part C Methods. 2013 Dec; 19(12):961-9. PMID: 23566043.
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    17. Wang F, Scoville D, He XC, Mahe MM, Box A, Perry JM, Smith NR, Lei NY, Davies PS, Fuller MK, Haug JS, McClain M, Gracz AD, Ding S, Stelzner M, Dunn JC, Magness ST, Wong MH, Martin MG, Helmrath M, Li L. Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology. 2013 Aug; 145(2):383-95.e1-21. PMID: 23644405.
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    18. Vazirani S, Lankarani-Fard A, Liang LJ, Stelzner M, Asch SM. Perioperative processes and outcomes after implementation of a hospitalist-run preoperative clinic. J Hosp Med. 2012 Nov-Dec; 7(9):697-701. PMID: 22961756.
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    19. Stelzner M, Helmrath M, Dunn JC, Henning SJ, Houchen CW, Kuo C, Lynch J, Li L, Magness ST, Martin MG, Wong MH, Yu J. A nomenclature for intestinal in vitro cultures. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15; 302(12):G1359-63. PMID: 22461030.
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    20. Lahar N, Lei NY, Wang J, Jabaji Z, Tung SC, Joshi V, Lewis M, Stelzner M, Martín MG, Dunn JC. Intestinal subepithelial myofibroblasts support in vitro and in vivo growth of human small intestinal epithelium. PLoS One. 2011; 6(11):e26898. PMID: 22125602.
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    21. Stelzner F, Stelzner M. Manometry data support a novel concept of the lower esophageal sphincter system. Langenbecks Arch Surg. 2010 Nov; 395(8):1083-91. PMID: 20614132.
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    22. Wulkersdorfer B, Kao KK, Agopian VG, Dunn JC, Wu BM, Stelzner M. Growth factors adsorbed on polyglycolic acid mesh augment growth of bioengineered intestinal neomucosa. J Surg Res. 2011 Aug; 169(2):169-78. PMID: 20444471.
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    23. Agopian VG, Chen DC, Avansino JR, Stelzner M. Intestinal stem cell organoid transplantation generates neomucosa in dogs. J Gastrointest Surg. 2009 May; 13(5):971-82. PMID: 19165549.
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    24. Lee M, Wu BM, Stelzner M, Reichardt HM, Dunn JC. Intestinal smooth muscle cell maintenance by basic fibroblast growth factor. Tissue Eng Part A. 2008 Aug; 14(8):1395-402. PMID: 18680389.
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    25. Avansino JR, Chen DC, Hoagland VD, Woolman JD, Stelzner M. Orthotopic transplantation of intestinal mucosal organoids in rodents. Surgery. 2006 Sep; 140(3):423-34. PMID: 16934605.
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    26. Stelzner M. Loud and clear now-advocacy and academic surgery. J Surg Res. 2006 May 15; 132(2):147-52. PMID: 16647944.
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    27. Chen DC, Agopian VG, Avansino JR, Lee JK, Farley SM, Stelzner M. Optical tissue window: a novel model for optimizing engraftment of intestinal stem cell organoids. J Surg Res. 2006 Jul; 134(1):52-60. PMID: 16697415.
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    28. Stelzner M, Gittes G. First Annual Academic Surgical Congress, February 7-11, 2006, San Diego, California, USA. Abstracts. J Surg Res. 2006 Feb; 130(2):159. PMID: 16443006.
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    29. Chen DC, Avansino JR, Agopian VG, Hoagland VD, Woolman JD, Pan S, Ratner BD, Stelzner M. Comparison of polyester scaffolds for bioengineered intestinal mucosa. Cells Tissues Organs. 2006; 184(3-4):154-65. PMID: 17409741.
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    30. Stelzner M, Chen DC. To make a new intestinal mucosa. Rejuvenation Res. 2006; 9(1):20-5. PMID: 16608391.
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    31. Avansino JR, Chen DC, Woolman JD, Hoagland VD, Stelzner M. Engraftment of mucosal stem cells into murine jejunum is dependent on optimal dose of cells. J Surg Res. 2006 May; 132(1):74-9. PMID: 16297408.
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    32. Avansino JR, Chen DC, Hoagland VD, Woolman JD, Haigh WG, Stelzner M. Treatment of bile acid malabsorption using ileal stem cell transplantation. J Am Coll Surg. 2005 Nov; 201(5):710-20. PMID: 16256913.
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    33. Mauchley DC, Lynge DC, Langdale LA, Stelzner MG, Mock CN, Billingsley KG. Clinical utility and cost-effectiveness of routine preoperative computed tomography scanning in patients with colon cancer. Am J Surg. 2005 May; 189(5):512-7; discussion 517. PMID: 15862487.
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    34. Stelzner M. 2003 SSAT-AGA-ASGE Workshop on "Palliative Therapy of Rectal Cancer". Summary statement. J Gastrointest Surg. 2004 Mar-Apr; 8(3):253-8. PMID: 15019917.
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    35. Stelzner M. Achieving balance in academic surgery. J Surg Res. 2004 Feb; 116(2):350-4. PMID: 15013375.
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    36. Avansino JR, Bjerke S, Hendrickson M, Stelzner M, Sawin R. Clinical features and treatment outcome of intussusception in premature neonates. J Pediatr Surg. 2003 Dec; 38(12):1818-21. PMID: 14666476.
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    37. McFadden DW, Ferguson MK, Weigel RJ, Garrison NR, Stelzner MG, Brophy CM, Dionne D, Souba WW. The Journal of Surgical Research increases its science citation index: what's the impact? J Surg Res. 2003 Oct; 114(2):107-9. PMID: 14559433.
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    38. Stelzner M, Hoagland VD, Woolman JD. Identification of optimal harvest sites of ileal stem cells for treatment of bile acid malabsorption in a dog model. J Gastrointest Surg. 2003 May-Jun; 7(4):516-522. PMID: 12763409.
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    39. Barton JB, Langdale LA, Cummins JS, Stelzner M, Lynge DC, Mock CN, Nason KS, Billingsley KG. The utility of routine preoperative computed tomography scanning in the management of veterans with colon cancer. Am J Surg. 2002 May; 183(5):499-503. PMID: 12034380.
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    40. Bayón JE, Pascolo L, Gonzalo-Orden JM, Altonaga JR, González-Gallego J, Webster C, Haigh WG, Stelzner M, Pekow C, Tiribelli C, Ostrow JD. Pitfalls in preparation of (3)H-unconjugated bilirubin by biosynthetic labeling from precursor (3)H-5-aminolevulinic acid in the dog. J Lab Clin Med. 2001 Nov; 138(5):313-21. PMID: 11709655.
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    41. Stelzner M, Somasundaram S, Lee SP, Kuver R. Ileal mucosal bile acid absorption is increased in Cftr knockout mice. BMC Gastroenterol. 2001; 1:10. PMID: 11696242.
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    42. Stelzner M, Somasundaram S, Khakberdiev T. Systemic effects of acute terminal ileitis on uninflamed gut aggravate bile acid malabsorption. J Surg Res. 2001 Aug; 99(2):359-64. PMID: 11469911.
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    43. Stelzner M, Somasundaram S, Kearney D. A simple method for measuring of intestinal solute transport in mucosal biopsy specimens. Dig Dis Sci. 2001 Mar; 46(3):451-6. PMID: 11318514.
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    44. Chang L, Moonka R, Stelzner M. Percutaneous cholecystostomy for acute cholecystitis in veteran patients. Am J Surg. 2000 Sep; 180(3):198-202. PMID: 11084129.
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    45. Moonka R, Stiens SA, Stelzner M. Atypical gastrointestinal symptoms are not associated with gallstones in patients with spinal cord injury. Arch Phys Med Rehabil. 2000 Aug; 81(8):1085-9. PMID: 10943760.
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    46. Stelzner M, Hoagland V, Somasundaram S. Distribution of bile acid absorption and bile acid transporter gene message in the hamster ileum. Pflugers Arch. 2000 May; 440(1):157-62. PMID: 10864010.
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    47. Moonka R, Stiens SA, Resnick WJ, McDonald JM, Eubank WB, Dominitz JA, Stelzner MG. The prevalence and natural history of gallstones in spinal cord injured patients. J Am Coll Surg. 1999 Sep; 189(3):274-81. PMID: 10472928.
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    48. Moonka R, Stiens SA, Eubank WB, Stelzner M. The presentation of gallstones and results of biliary surgery in a spinal cord injured population. Am J Surg. 1999 Sep; 178(3):246-50. PMID: 10527448.
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    49. Stelzner M, Lynge DC. [Telesurgery--experiences from the USA]. Langenbecks Arch Chir Suppl Kongressbd. 1998; 115:897-9. PMID: 9931749.
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    50. Stelzner M. [Specializing in surgery. A contribution from the American viewpoint]. Chirurg. 1997 Sep; 68(9):888-91. PMID: 9410676.
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    51. Stelzner M, Vlahakos DV, Milford EL, Tilney NL. Colonic perforations after renal transplantation. J Am Coll Surg. 1997 Jan; 184(1):63-9. PMID: 8989302.
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    52. Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert SC, Smith CP, Hediger MA. The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport. J Biol Chem. 1994 Aug 12; 269(32):20599-606. PMID: 7914198.
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    53. Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA. Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders. Genomics. 1994 Mar 15; 20(2):335-6. PMID: 8020993.
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    54. You G, Smith CP, Kanai Y, Lee WS, Stelzner M, Hediger MA. Cloning and characterization of the vasopressin-regulated urea transporter. Nature. 1993 Oct 28; 365(6449):844-7. PMID: 8413669.
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    55. Stelzner M, Fonkalsrud EW. Functional changes associated with short and long lateral ileal reservoirs in a canine model. Dis Colon Rectum. 1993 Mar; 36(3):266-72. PMID: 8449131.
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    56. Kanai Y, Stelzner MG, Lee WS, Wells RG, Brown D, Hediger MA. Expression of mRNA (D2) encoding a protein involved in amino acid transport in S3 proximal tubule. Am J Physiol. 1992 Dec; 263(6 Pt 2):F1087-92. PMID: 1481885.
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    57. Phillips JD, Stelzner M, Zeng H, Kelly RE, Fonkalsrud EW. Alterations in gastrointestinal motility during postoperative acute corticosteroid withdrawal. Am J Surg. 1991 Sep; 162(3):251-5. PMID: 1928586.
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    58. Stelzner M, Krug B. [Gastrointestinal amyloidosis: differential diagnosis and indications for surgical therapy]. Chirurg. 1991 Jun; 62(6):493-9. PMID: 1914648.
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    59. Stelzner M, Buddington RK, Phillips JD, Diamond JM, Fonkalsrud EW. Changes in mucosal nutrient transport in small and large ileal reservoirs after endorectal ileal pullthrough. J Surg Res. 1990 Oct; 49(4):344-9. PMID: 2214744.
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    60. Stelzner M, Phillips JD, Fonkalsrud EW. Acute ileus from steroid withdrawal simulating intestinal obstruction after surgery for ulcerative colitis. Arch Surg. 1990 Jul; 125(7):914-7. PMID: 2369317.
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    61. Stelzner M, Phillips JD, Saleh S, Fonkalsrud EW. Nephrolithiasis and urine ion changes in ulcerative colitis patients undergoing colectomy and endorectal ileal pullthrough. J Surg Res. 1990 Jun; 48(6):552-6. PMID: 2362415.
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    62. Stelzner M, Fonkalsrud EW, Buddington RK, Phillips JD, Diamond JM. Adaptive changes in ileal mucosal nutrient transport following colectomy and endorectal ileal pull-through with ileal reservoir. Arch Surg. 1990 May; 125(5):586-90. PMID: 2331214.
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    63. Stelzner M, Fonkalsrud EW. Assessment of anorectal function after mucosal proctectomy and endorectal ileal pullthrough for ulcerative colitis. Surgery. 1990 Feb; 107(2):201-8. PMID: 2300899.
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    64. Stelzner M, Fonkalsrud EW. The endorectal ileal pullthrough procedure in patients with ulcerative colitis and familial polyposis with carcinoma. Surg Gynecol Obstet. 1989 Sep; 169(3):187-94. PMID: 2549648.
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    65. Fonkalsrud EW, Stelzner M. [Experiences with the endorectal ileal pull-through operation with lateral ileal reservoir following colectomy in ulcerative colitis and colonic polyps]. Chirurg. 1989 Sep; 60(9):573-7. PMID: 2553348.
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    66. Stelzner M, Fonkalsrud EW, Lichtenstein G. Significance of reservoir length in the endorectal ileal pullthrough with ileal reservoir. Arch Surg. 1988 Oct; 123(10):1265-8. PMID: 2845887.
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    67. Fonkalsrud EW, Stelzner M, McDonald N. Experience with the endorectal ileal pullthrough with lateral reservoir for ulcerative colitis and polyposis. Arch Surg. 1988 Sep; 123(9):1053-8. PMID: 2843144.
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    68. Fonkalsrud EW, Stelzner M, McDonald N. Construction of an ileal reservoir in patients with a previous straight endorectal ileal pull-through. Ann Surg. 1988 Jul; 208(1):50-5. PMID: 2839124.
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    69. Stelzner M, Hutterer FG, Fornacon D. [A method for measuring the function of the organ of continence]. Chirurg. 1988 Mar; 59(3):155-8. PMID: 3371128.
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    70. Müller JM, Herzig S, Halber M, Stelzner M, Thul P. [The acute physiology score as a stratification and prognostic criterion in patients in a surgical intensive care ward]. Chirurg. 1987 May; 58(5):334-40. PMID: 3608686.
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