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Combination Targeted Therapy with Pembrolizumab and Lenvatinib in Progressive, Radioiodine-Refractory Differentiated Thyroid Cancers. Clin Cancer Res. 2024 Sep 03; 30(17):3757-3767.
French JD, Haugen BR, Worden FP, Bowles DW, Gianoukakis AG, Konda B, Dadu R, Sherman EJ, McCue S, Foster NR, Nikiforov YE, Farias TDJ, Norman PJ, Wirth LJ. PMID: 38922338.
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PubMed Mentions: Fields:
Translation:
Humans
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Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA). J Clin Endocrinol Metab. 2024 Apr 30.
Petrovic I, LoPresti J, Fatemi S, Gianoukakis A, Burman K, Gomez-Lima CJ, Nguyen CT, Spencer CA. PMID: 38686504.
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PubMed Mentions: Fields:
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Real-world practice patterns and outcomes for RAI-refractory differentiated thyroid cancer. Eur Thyroid J. 2024 Feb 01; 13(1).
Gianoukakis AG, Choe JH, Bowles DW, Brose MS, Wirth LJ, Owonikoko T, Babajanyan S, Worden FP. PMID: 38096102; PMCID: PMC10831529.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Thyroglobulin Cutoff Values for Detecting Excellent Response to Therapy in Patients With Differentiated Thyroid Cancer. J Endocr Soc. 2023 Aug 01; 7(9):bvad102.
Sipos JA, Aloi J, Gianoukakis A, Lee SL, Klopper JP, Kung JT, Lupo MA, Morgenstern D, Prat-Knoll C, Schuetzenmeister A, Goldner WS. PMID: 37564885; PMCID: PMC10410295.
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PubMed Mentions:
2
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Health-related quality-of-life analyses from a multicenter, randomized, double-blind phase 2 study of patients with differentiated thyroid cancer treated with lenvatinib 18 or 24 mg/day. Cancer Med. 2023 02; 12(4):4332-4342.
Taylor MH, Leboulleux S, Panaseykin Y, Konda B, de La Fouchardiere C, Hughes BGM, Gianoukakis AG, Park YJ, Romanov I, Krzyzanowska MK, Garbinsky D, Sherif B, Pan JJ, Binder TA, Sauter N, Xie R, Brose MS. PMID: 36464853; PMCID: PMC9972135.
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PubMed Mentions:
4 Fields:
Translation:
HumansCTClinical Trials
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An Assessment of Diversity, Inclusion, and Health Equity Training in Endocrinology Fellowship Programs in the United States. Endocr Pract. 2022 Nov; 28(11):1159-1165.
Malek R, Shibli-Rahhal A, Correa R, Szmuilowicz ED, Morgan F, Luthra P, Sirisena I, Gianoukakis A, Smooke Praw S, Lieb DC, Haw JS, Mayson SE. PMID: 35985561.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Selumetinib Plus Adjuvant Radioactive Iodine in Patients With High-Risk Differentiated Thyroid Cancer: A Phase III, Randomized, Placebo-Controlled Trial (ASTRA). J Clin Oncol. 2022 06 10; 40(17):1870-1878.
Ho AL, Dedecjus M, Wirth LJ, Tuttle RM, Inabnet WB, Tennvall J, Vaisman F, Bastholt L, Gianoukakis AG, Rodien P, Paschke R, Elisei R, Viola D, So K, Carroll D, Hovey T, Thakre B, Fagin JA, ASTRA investigator group. PMID: 35192411; PMCID: PMC9851689.
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PubMed Mentions:
23 Fields:
Translation:
HumansCTClinical Trials
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A Randomized Study of Lenvatinib 18 mg vs 24 mg in Patients With Radioiodine-Refractory Differentiated Thyroid Cancer. J Clin Endocrinol Metab. 2022 02 17; 107(3):776-787.
Brose MS, Panaseykin Y, Konda B, de la Fouchardiere C, Hughes BGM, Gianoukakis AG, Joo Park Y, Romanov I, Krzyzanowska MK, Leboulleux S, Binder TA, Dutcus C, Xie R, Taylor MH. PMID: 34664662; PMCID: PMC8852210.
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PubMed Mentions:
26 Fields:
Translation:
HumansCTClinical Trials
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Ultrasensitive detection of BRAF V600E mutations in circulating tumor DNA of patients with metastatic thyroid cancer. Endocrine. 2022 05; 76(2):491-494.
Gouda MA, Ong E, Huang HJ, McPhaul LW, Yoon S, Janku F, Gianoukakis AG. PMID: 35152349.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Graves' disease patients with iron deficiency anemia: serologic evidence of co-existent autoimmune gastritis. Am J Blood Res. 2021; 11(3):238-247.
Gianoukakis AG, Gupta S, Tran TN, Richards P, Yehuda M, Tomassetti SE. PMID: 34322286; PMCID: PMC8303011.
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PubMed Mentions:
1
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Response to Rosário and Souza Côrtes re: "The De Novo Detection of Anti-Thyroglobulin Antibodies and Differentiated Thyroid Cancer Recurrence". Thyroid. 2020 11; 30(11):1686-1687.
Yin N, Sherman SI, Pak Y, Litofsky DR, Gianoukakis AG. PMID: 32484055.
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Humans
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The De Novo Detection of Anti-Thyroglobulin Antibodies and Differentiated Thyroid Cancer Recurrence. Thyroid. 2020 10; 30(10):1490-1495.
Yin N, Sherman SI, Pak Y, Litofsky DR, Gianoukakis AG, National Thyroid Cancer Treatment Cooperative Study Group. PMID: 32228151; PMCID: PMC7869880.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Voluntary Adoption of an All In Match Policy in the Medical Specialties Matching Program: Advantages and Disadvantages. J Grad Med Educ. 2019 08; 11(4):378-381.
McCartney CR, Gianoukakis AG, Gopalakrishnan G, McGill JB, Roach P, Siraj ES, True MW. PMID: 31440329; PMCID: PMC6699534.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Endothelial Cell Growth Promoting Activity in Graves' Disease Sera is Neutralized by Anti-Basic Fibroblast Growth Factor Antibodies in Patients with Fat Expansive but Not Infiltrative Orbitopathy. Endocrinol Diabetes Metab J. 2019 Feb; 3(1).
Zimering MB, Shin JJ, Zaitz JD, Nunez EA, Gianoukakis AG. PMID: 30854171; PMCID: PMC6407713.
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Impact of dose interruption on the efficacy of lenvatinib in a phase 3 study in patients with radioiodine-refractory differentiated thyroid cancer. Eur J Cancer. 2019 01; 106:61-68.
Tahara M, Brose MS, Wirth LJ, Suzuki T, Miyagishi H, Fujino K, Dutcus CE, Gianoukakis A. PMID: 30471649.
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PubMed Mentions:
34 Fields:
Translation:
HumansCTClinical Trials
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Prolonged duration of response in lenvatinib responders with thyroid cancer. Endocr Relat Cancer. 2018 06; 25(6):699-704.
Gianoukakis AG, Dutcus CE, Batty N, Guo M, Baig M. PMID: 29752332; PMCID: PMC5958278.
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PubMed Mentions:
29 Fields:
Translation:
HumansCTClinical Trials
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Parity and Risk of Thyroid Autoimmunity Based on the NHANES (2001-2002, 2007-2008, 2009-2010, and 2011-2012). J Clin Endocrinol Metab. 2017 09 01; 102(9):3437-3442.
Yehuda M, Wang CH, Pak Y, Chiu KC, Gianoukakis AG. PMID: 28911140.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm. Thyroid. 2017 08; 27(8):994-1000.
Haider U, Richards P, Gianoukakis AG. PMID: 28578595.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimals
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Incidence and timing of common adverse events in Lenvatinib-treated patients from the SELECT trial and their association with survival outcomes. Endocrine. 2017 Apr; 56(1):121-128.
Haddad RI, Schlumberger M, Wirth LJ, Sherman EJ, Shah MH, Robinson B, Dutcus CE, Teng A, Gianoukakis AG, Sherman SI. PMID: 28155175; PMCID: PMC5368192.
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PubMed Mentions:
43 Fields:
Translation:
HumansCTClinical Trials
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A Cervical Schwannoma Masquerading as a Thyroid Nodule. Eur Thyroid J. 2017 Jul; 6(4):216-220.
Nagavalli S, Yehuda M, McPhaul LW, Gianoukakis AG. PMID: 28868262; PMCID: PMC5566684.
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PubMed Mentions:
6 Fields:
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Treatment patterns, health state, and health care resource utilization of patients with radioactive iodine refractory differentiated thyroid cancer. Cancer Manag Res. 2016; 8:67-76.
Gianoukakis AG, Flores NM, Pelletier CL, Forsythe A, Wolfe GR, Taylor MH. PMID: 27313476; PMCID: PMC4892292.
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PubMed Mentions:
2
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Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med. 2015 Feb 12; 372(7):621-30.
Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, Habra MA, Newbold K, Shah MH, Hoff AO, Gianoukakis AG, Kiyota N, Taylor MH, Kim SB, Krzyzanowska MK, Dutcus CE, de las Heras B, Zhu J, Sherman SI. PMID: 25671254.
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PubMed Mentions:
762 Fields:
Translation:
HumansCTClinical Trials
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Thyroglobulin antibody status and differentiated thyroid cancer: what does it mean for prognosis and surveillance? Curr Opin Oncol. 2015 Jan; 27(1):26-32.
Gianoukakis AG. PMID: 25390556.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Treatment Patterns and Health Outcomes Among Patients with Radioiodine-Refractory Differentiated Thyroid Cancer in the United States and Western Europe. Value Health. 2014 Nov; 17(7):A614.
Gianoukakis AG, Flores NM, Pelletier CL, DiBonaventura M, Forsythe A, Wolfe G, Rege J, Taylor MH. PMID: 27202148.
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PubMed Mentions:
1 Fields:
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Computer modeling of a newly identified THRB gene mutation (S350L) associated with resistance to thyroid hormone in three unrelated patients. Thyroid. 2014 Sep; 24(9):1430-1.
Nagavalli S, Fletterick RJ, Ford G, Boston BA, Gianoukakis AG. PMID: 24906004; PMCID: PMC4361411.
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Translation:
Humans
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Familial adenomatous polyposis-associated, cribriform morular variant of papillary thyroid carcinoma harboring a K-RAS mutation: case presentation and review of molecular mechanisms. Thyroid. 2014 Jul; 24(7):1184-9.
Giannelli SM, McPhaul L, Nakamoto J, Gianoukakis AG. PMID: 24702198.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Elephantiatic dermopathy. Int J Dermatol. 2013 Aug; 52(8):987-9.
Madaj P, McPhaul L, Gianoukakis AG. PMID: 22417118; PMCID: PMC4334560.
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Translation:
Humans
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Visual vignette. Neurocysticercosis. Endocr Pract. 2011 Nov-Dec; 17(6):965.
Munir I, Qing X, Mlikotic A, Gianoukakis AG. PMID: 21803719.
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Translation:
Humans
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Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease. J Clin Endocrinol Metab. 2011 Dec; 96(12):3827-37.
Smith TJ, Padovani-Claudio DA, Lu Y, Raychaudhuri N, Fernando R, Atkins S, Gillespie EF, Gianoukakis AG, Miller BS, Gauger PG, Doherty GM, Douglas RS. PMID: 21956421; PMCID: PMC3232631.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Management of severe thyrotoxicosis when the gastrointestinal tract is compromised. Thyroid. 2011 Mar; 21(3):215-20.
Alfadhli E, Gianoukakis AG. PMID: 21254909.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Pancreatic neuroendocrine tumors. Endocr Res. 2011; 36(1):35-43.
Batcher E, Madaj P, Gianoukakis AG. PMID: 21226566.
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PubMed Mentions:
32 Fields:
Translation:
Humans
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Update in thyroidology 2010. J Clin Endocrinol Metab. 2011 Jan; 96(1):9-14.
Hershman JM, Cheng SY, Gianoukakis AG. PMID: 21209040.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Well differentiated follicular thyroid neoplasia: impact of molecular and technological advances on detection, monitoring and treatment. Mol Cell Endocrinol. 2011 Jan 30; 332(1-2):9-20.
Gianoukakis AG, Giannelli SM, Salameh WA, McPhaul LW. PMID: 21094678.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Visual vignette. Endocr Pract. 2010 Nov-Dec; 16(6):1081.
Madaj P, Tran T, Varma R, Gianoukakis AG. PMID: 20713335.
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Translation:
Humans
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Familial thyroid neoplasia: impact of technological advances on detection and monitoring. Curr Opin Endocrinol Diabetes Obes. 2010 Oct; 17(5):425-31.
Tran T, Gianoukakis AG. PMID: 20729730.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Increased generation of fibrocytes in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab. 2010 Jan; 95(1):430-8.
Douglas RS, Afifiyan NF, Hwang CJ, Chong K, Haider U, Richards P, Gianoukakis AG, Smith TJ. PMID: 19897675; PMCID: PMC2805489.
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PubMed Mentions:
94 Fields:
Translation:
HumansCells
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B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. J Immunol. 2008 Oct 15; 181(8):5768-74.
Douglas RS, Naik V, Hwang CJ, Afifiyan NF, Gianoukakis AG, Sand D, Kamat S, Smith TJ. PMID: 18832736; PMCID: PMC2562248.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells
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Recent insights into the pathogenesis and management of thyroid-associated ophthalmopathy. Curr Opin Endocrinol Diabetes Obes. 2008 Oct; 15(5):446-52.
Gianoukakis AG, Smith TJ. PMID: 18769218; PMCID: PMC3712753.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease. J Immunol. 2008 Sep 15; 181(6):4397-405.
Tsui S, Naik V, Hoa N, Hwang CJ, Afifiyan NF, Sinha Hikim A, Gianoukakis AG, Douglas RS, Smith TJ. PMID: 18768899; PMCID: PMC2775538.
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PubMed Mentions:
149 Fields:
Translation:
HumansCells
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Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy. Thyroid. 2008 Sep; 18(9):983-8.
Smith TJ, Tsai CC, Shih MJ, Tsui S, Chen B, Han R, Naik V, King CS, Press C, Kamat S, Goldberg RA, Phipps RP, Douglas RS, Gianoukakis AG. PMID: 18788919; PMCID: PMC2574420.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Cytokines, Graves' disease, and thyroid-associated ophthalmopathy. Thyroid. 2008 Sep; 18(9):953-8.
Gianoukakis AG, Khadavi N, Smith TJ. PMID: 18713026; PMCID: PMC2879490.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Characterization of the anaemia associated with Graves' disease. Clin Endocrinol (Oxf). 2009 May; 70(5):781-7.
Gianoukakis AG, Leigh MJ, Richards P, Christenson PD, Hakimian A, Fu P, Niihara Y, Smith TJ. PMID: 18710465; PMCID: PMC3712752.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Circulating mononuclear cells from euthyroid patients with thyroid-associated ophthalmopathy exhibit characteristic phenotypes. Clin Exp Immunol. 2007 Apr; 148(1):64-71.
Douglas RS, Gianoukakis AG, Goldberg RA, Kamat S, Smith TJ. PMID: 17349012; PMCID: PMC1868859.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis. J Immunol. 2007 Mar 01; 178(5):3281-7.
Douglas RS, Gianoukakis AG, Kamat S, Smith TJ. PMID: 17312178.
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PubMed Mentions:
70 Fields:
Translation:
HumansCellsCTClinical Trials
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Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts. Endocrinology. 2007 Jan; 148(1):54-62.
Gianoukakis AG, Jennings TA, King CS, Sheehan CE, Hoa N, Heldin P, Smith TJ. PMID: 17068136.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Monoclonal pathogenic antibodies to the thyroid-stimulating hormone receptor in Graves' disease with potent thyroid-stimulating activity but differential blocking activity activate multiple signaling pathways. J Immunol. 2006 Apr 15; 176(8):5084-92.
Gilbert JA, Gianoukakis AG, Salehi S, Moorhead J, Rao PV, Khan MZ, McGregor AM, Smith TJ, Banga JP. PMID: 16585606.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Immunoglobulin G from patients with Graves' disease induces interleukin-16 and RANTES expression in cultured human thyrocytes: a putative mechanism for T-cell infiltration of the thyroid in autoimmune disease. Endocrinology. 2006 Apr; 147(4):1941-9.
Gianoukakis AG, Douglas RS, King CS, Cruikshank WW, Smith TJ. PMID: 16410300.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Cytokine-induced lymphocyte chemoattraction from cultured human thyrocytes: evidence for interleukin-16 and regulated upon activation, normal T cell expressed, and secreted expression. Endocrinology. 2003 Jul; 144(7):2856-64.
Gianoukakis AG, Martino LJ, Horst N, Cruikshank WW, Smith TJ. PMID: 12810540.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Influence of diagnostic and therapeutic doses on thyroid remnant ablation rates. Nucl Med Commun. 2003 May; 24(5):489-95.
Karam M, Gianoukakis A, Feustel PJ, Cheema A, Postal ES, Cooper JA. PMID: 12717064.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Autonomous thyroid nodules visualized by positron emission tomography with 18F-fluorodeoxyglucose: a case report and review of the literature. Thyroid. 2003 Apr; 13(4):395-9.
Gianoukakis AG, Karam M, Cheema A, Cooper JA. PMID: 12804108.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Ritonavir-associated hyperparathyroidism, osteopenia and bone pain. AIDS. 2002 Jul 26; 16(11):1565-6.
Piliero PJ, Gianoukakis AG. PMID: 12131200.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Prostaglandin endoperoxide H synthase expression in human thyroid epithelial cells. Am J Physiol Cell Physiol. 2001 Mar; 280(3):C701-8.
Gianoukakis AG, Cao HJ, Jennings TA, Smith TJ. PMID: 11171589.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Comparison of diabetes care provided by an endocrinology clinic and a primary-care clinic. Endocr Pract. 2000 Sep-Oct; 6(5):361-6.
Leinung MC, Gianoukakis AG, Lee DW, Jeronis SL, Desemone J. PMID: 11141586.
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PubMed Mentions:
17 Fields:
Translation:
Humans