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Walther, Frans J

Title(s)Adjunct Professor, Pediatrics
Phone(310) 222-8150
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    Collapse Research 
    Collapse Research Activities and Funding
    Synthetic surfactant and toxic chemical lung injury
    NIH/NIEHS R01ES015330Sep 1, 2008 - Aug 31, 2014
    Role: Principal Investigator
    Synthetic Lung Surfactant Optimized for Biomedical Application
    NIH/NHLBI R01HL092158Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator
    MECHANISMS OF SURFACTANT INHIBITION
    NIH/NHLBI R01HL055534Feb 1, 1996 - Jan 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Walther FJ, Gupta M, Lipp MM, Chan H, Krzewick J, Gordon LM, Waring AJ. Aerosol delivery of dry powder synthetic lung surfactant to surfactant-deficient rabbits and preterm lambs on non-invasive respiratory support. Gates Open Res. 2019; 3:6. PMID: 31131369.
      View in: PubMed
    2. Walther FJ, Gordon LM, Waring AJ. Advances in synthetic lung surfactant protein technology. Expert Rev Respir Med. 2019 Jun; 13(6):499-501. PMID: 30817233.
      View in: PubMed
    3. Walther FJ, Gupta M, Gordon LM, Waring AJ. A sulfur-free peptide mimic of surfactant protein B (B-YL) exhibits high in vitro and in vivo surface activities. Gates Open Res. 2018 Jul 10; 2:13. PMID: 30234192.
      View in: PubMed
    4. Sakurai R, Lee C, Shen H, Waring AJ, Walther FJ, Rehan VK. A Combination of the Aerosolized PPAR-? Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats. Neonatology. 2018; 113(4):296-304. PMID: 29428947.
      View in: PubMed
    5. Chen X, Walther FJ, Laghmani EH, Hoogeboom AM, Hogen-Esch AC, van Ark I, Folkerts G, Wagenaar GT. Adult Lysophosphatidic Acid Receptor 1-Deficient Rats with Hyperoxia-Induced Neonatal Chronic Lung Disease Are Protected against Lipopolysaccharide-Induced Acute Lung Injury. Front Physiol. 2017; 8:155. PMID: 28382003.
      View in: PubMed
    6. Walther FJ, Gordon LM, Waring AJ. Design of Surfactant Protein B Peptide Mimics Based on the Saposin Fold for Synthetic Lung Surfactants. Biomed Hub. 2016 Sep-Dec; 1(3). PMID: 28503550.
      View in: PubMed
    7. Notter RH, Gupta R, Schwan AL, Wang Z, Shkoor MG, Walther FJ. Synthetic lung surfactants containing SP-B and SP-C peptides plus novel phospholipase-resistant lipids or glycerophospholipids. PeerJ. 2016; 4:e2635. PMID: 27812430.
      View in: PubMed
    8. Waring AJ, Gupta M, Gordon LM, Fujii G, Walther FJ. Stability of an amphipathic helix-hairpin surfactant peptide in liposomes. Biochim Biophys Acta. 2016 12; 1858(12):3113-3119. PMID: 27664499.
      View in: PubMed
    9. Notter RH, Wang Z, Walther FJ. Activity and biophysical inhibition resistance of a novel synthetic lung surfactant containing Super-Mini-B DATK peptide. PeerJ. 2016; 4:e1528. PMID: 26793419.
      View in: PubMed
    10. Gupta R, Hernández-Juviel JM, Waring AJ, Walther FJ. Synthetic lung surfactant reduces alveolar-capillary protein leakage in surfactant-deficient rabbits. Exp Lung Res. 2015 Jun; 41(5):293-9. PMID: 26052829.
      View in: PubMed
    11. Walther FJ, Waring AJ, Hernández-Juviel JM, Ruchala P, Wang Z, Notter RH, Gordon LM. Surfactant protein C peptides with salt-bridges ("ion-locks") promote high surfactant activities by mimicking the a-helix and membrane topography of the native protein. PeerJ. 2014; 2:e485. PMID: 25083348.
      View in: PubMed
    12. Walther FJ, Hernández-Juviel JM, Waring AJ. Aerosol delivery of synthetic lung surfactant. PeerJ. 2014; 2:e403. PMID: 24918030.
      View in: PubMed
    13. Walther FJ, Hernández-Juviel JM, Gordon LM, Waring AJ. Synthetic surfactant containing SP-B and SP-C mimics is superior to single-peptide formulations in rabbits with chemical acute lung injury. PeerJ. 2014; 2:e393. PMID: 24883253.
      View in: PubMed
    14. Sharifahmadian M, Sarker M, Palleboina D, Waring AJ, Walther FJ, Morrow MR, Booth V. Role of the N-terminal seven residues of surfactant protein B (SP-B). PLoS One. 2013; 8(9):e72821. PMID: 24023779.
      View in: PubMed
    15. Walther FJ. Is lung surfactant ready 'to protect and to serve' in necrotizing enterocolitis? Commentary on F.E. Canpolat et al.: Effects of enterally administered surfactant in a rat model of necrotizing enterocolitis (Neonatology 2012;102:53-58). Neonatology. 2012; 102(1):59-60. PMID: 22508106.
      View in: PubMed
    16. Holten-Andersen N, Michael Henderson J, Walther FJ, Waring AJ, Ruchala P, Notter RH, Lee KY. KL4 peptide induces reversible collapse structures on multiple length scales in model lung surfactant. Biophys J. 2011 Dec 21; 101(12):2957-65. PMID: 22208194.
      View in: PubMed
    17. Schwan AL, Singh SP, Davy JA, Waring AJ, Gordon LM, Walther FJ, Wang Z, Notter RH. Synthesis and activity of a novel diether phosphonoglycerol in phospholipase-resistant synthetic lipid:peptide lung surfactants(). Medchemcomm. 2011 Dec 01; 2(12):1167-1173. PMID: 22530092.
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    18. Keating E, Waring AJ, Walther FJ, Possmayer F, Veldhuizen RA, Petersen NO. A ToF-SIMS study of the lateral organization of lipids and proteins in pulmonary surfactant systems. Biochim Biophys Acta. 2011 Mar; 1808(3):614-21. PMID: 21110942.
      View in: PubMed
    19. Almlén A, Walther FJ, Waring AJ, Robertson B, Johansson J, Curstedt T. Synthetic surfactant based on analogues of SP-B and SP-C is superior to single-peptide surfactants in ventilated premature rabbits. Neonatology. 2010 Jun; 98(1):91-9. PMID: 20110733.
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    20. Walther FJ, Waring AJ, Hernandez-Juviel JM, Gordon LM, Wang Z, Jung CL, Ruchala P, Clark AP, Smith WM, Sharma S, Notter RH. Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs. PLoS One. 2010 Jan 13; 5(1):e8672. PMID: 20084172.
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    21. Frey SL, Pocivavsek L, Waring AJ, Walther FJ, Hernandez-Juviel JM, Ruchala P, Lee KY. Functional importance of the NH2-terminal insertion sequence of lung surfactant protein B. Am J Physiol Lung Cell Mol Physiol. 2010 Mar; 298(3):L335-47. PMID: 20023175.
      View in: PubMed
    22. Pocivavsek L, Frey SL, Krishan K, Gavrilov K, Ruchala P, Waring AJ, Walther FJ, Dennin M, Witten TA, Lee KY. Lateral stress relaxation and collapse in lipid monolayers. Soft Matter. 2008 Jan 01; 4:2019-2029. PMID: 19657472.
      View in: PubMed
    23. Walther FJ, Waring AJ, Hernandez-Juviel JM, Gordon LM, Schwan AL, Jung CL, Chang Y, Wang Z, Notter RH. Dynamic surface activity of a fully synthetic phospholipase-resistant lipid/peptide lung surfactant. PLoS One. 2007 Oct 17; 2(10):e1039. PMID: 17940603.
      View in: PubMed
    24. Sarker M, Waring AJ, Walther FJ, Keough KM, Booth V. Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles. Biochemistry. 2007 Oct 02; 46(39):11047-56. PMID: 17845058.
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    25. Walther FJ, Waring AJ, Sherman MA, Zasadzinski JA, Gordon LM. Hydrophobic surfactant proteins and their analogues. Neonatology. 2007; 91(4):303-10. PMID: 17575474.
      View in: PubMed
    26. Biswas N, Waring AJ, Walther FJ, Dluhy RA. Structure and conformation of the disulfide bond in dimeric lung surfactant peptides SP-B1-25 and SP-B8-25. Biochim Biophys Acta. 2007 May; 1768(5):1070-82. PMID: 17349612.
      View in: PubMed
    27. ter Horst SA, Fijlstra M, Sengupta S, Walther FJ, Wagenaar GT. Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury. BMC Pulm Med. 2006 Apr 18; 6:8. PMID: 16620381.
      View in: PubMed
    28. Walther FJ, Hernández-Juviel JM, Gordon LM, Waring AJ, Stenger P, Zasadzinski JA. Comparison of three lipid formulations for synthetic surfactant with a surfactant protein B analog. Exp Lung Res. 2005 Jul-Aug; 31(6):563-79. PMID: 16019988.
      View in: PubMed
    29. Biswas N, Shanmukh S, Waring AJ, Walther F, Wang Z, Chang Y, Notter RH, Dluhy RA. Structure and properties of phospholipid-peptide monolayers containing monomeric SP-B(1-25) I. Phases and morphology by epifluorescence microscopy. Biophys Chem. 2005 Mar 01; 113(3):223-32. PMID: 15620507.
      View in: PubMed
    30. Shanmukh S, Biswas N, Waring AJ, Walther FJ, Wang Z, Chang Y, Notter RH, Dluhy RA. Structure and properties of phospholipid-peptide monolayers containing monomeric SP-B(1-25) II. Peptide conformation by infrared spectroscopy. Biophys Chem. 2005 Mar 01; 113(3):233-44. PMID: 15620508.
      View in: PubMed
    31. Booth V, Waring AJ, Walther FJ, Keough KM. NMR structures of the C-terminal segment of surfactant protein B in detergent micelles and hexafluoro-2-propanol. Biochemistry. 2004 Dec 07; 43(48):15187-94. PMID: 15568810.
      View in: PubMed
    32. Walther FJ, Findlay RD, Durand M. Adrenal suppression and extubation rate after moderately early low-dose dexamethasone therapy in very preterm infants. Early Hum Dev. 2003 Oct; 74(1):37-45. PMID: 14512180.
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    33. Walther FJ, Hernandez-Juviel JM, Gordon LM, Sherman MA, Waring AJ. Dimeric surfactant protein B peptide sp-b(1-25) in neonatal and acute respiratory distress syndrome. Exp Lung Res. 2002 Dec; 28(8):623-40. PMID: 12490037.
      View in: PubMed
    34. Diemel RV, Snel MM, Waring AJ, Walther FJ, van Golde LM, Putz G, Haagsman HP, Batenburg JJ. Multilayer formation upon compression of surfactant monolayers depends on protein concentration as well as lipid composition. An atomic force microscopy study. J Biol Chem. 2002 Jun 14; 277(24):21179-88. PMID: 11923286.
      View in: PubMed
    35. Walther FJ, Hernández-Juviel JM, Mercado PE, Gordon LM, Waring AJ. Surfactant with SP-B and SP-C analogues improves lung function in surfactant-deficient rats. Biol Neonate. 2002; 82(3):181-7. PMID: 12373069.
      View in: PubMed