Frans J Walther

Title(s)Adjunct Professor, Pediatrics
ORCID ORCID Icon0000-0003-1931-159X Additional info
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    Collapse Biography 
    Collapse Education and Training
    Leiden University, Leiden, The Netherlands197209/1972Medicine
    Maastricht University, Maastricht, The Netherlands198210/1982Physiology

    Collapse Research 
    Collapse Research Activities and Funding
    Aerosol delivery of synthetic lung surfactant
    Bill & Melinda Gates Foundation INV-001227May 1, 2019 - Dec 31, 2020
    Role: Principal Investigator
    ME-101 treatment of preterm lambs
    Molecular Express Inc. 22053-01Sep 1, 2018 - Dec 31, 2020
    Role: Principal Investigator
    Aerosol delivery of synthetic lung surfactant
    Bill & Melinda Gates Foundation OPP1112090Nov 1, 2014 - Jun 30, 2018
    Role: Principal investigator
    Aerosol delivery of synthetic lung surfactant
    Bill & Melinda Gates Foundation OPP 1061325May 1, 2012 - Oct 31, 2013
    Role: Principal Investigator
    Bioengineering of novel synthetic lipid-peptide lung surfactants
    NIH BRP HL094641Aug 1, 2009 - Jul 31, 2015
    Role: Co-Investigator
    Synthetic surfactant and toxic chemical lung injury
    NIH R01ES015330Sep 1, 2008 - Aug 31, 2014
    Role: Principal Investigator
    Synthetic Lung Surfactant Optimized for Biomedical Application
    NIH R01HL092158Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aerosol, chemical and physical properties of dry powder synthetic lung surfactant for noninvasive treatment of neonatal respiratory distress syndrome. Sci Rep. 2021 Aug 12; 11(1):16439. Walther FJ, Chan H, Smith JR, Tauber M, Waring AJ. PMID: 34385559.
      View in: PubMed   Mentions:    Fields:    
    2. Aerosol delivery of dry powder synthetic lung surfactant to surfactant-deficient rabbits and preterm lambs on non-invasive respiratory support. Gates Open Res. 2019; 3:6. Walther FJ, Gupta M, Lipp MM, Chan H, Krzewick J, Gordon LM, Waring AJ. PMID: 31131369.
      View in: PubMed   Mentions:
    3. Advances in synthetic lung surfactant protein technology. Expert Rev Respir Med. 2019 06; 13(6):499-501. Walther FJ, Gordon LM, Waring AJ. PMID: 30817233.
      View in: PubMed   Mentions: 6     Fields:    
    4. A sulfur-free peptide mimic of surfactant protein B (B-YL) exhibits high in vitro and in vivo surface activities. Gates Open Res. 2018; 2:13. Walther FJ, Gupta M, Gordon LM, Waring AJ. PMID: 30234192.
      View in: PubMed   Mentions:
    5. A Combination of the Aerosolized PPAR-γ Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats. Neonatology. 2018; 113(4):296-304. Sakurai R, Lee C, Shen H, Waring AJ, Walther FJ, Rehan VK. PMID: 29428947.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. Adult Lysophosphatidic Acid Receptor 1-Deficient Rats with Hyperoxia-Induced Neonatal Chronic Lung Disease Are Protected against Lipopolysaccharide-Induced Acute Lung Injury. Front Physiol. 2017; 8:155. Chen X, Walther FJ, Laghmani EH, Hoogeboom AM, Hogen-Esch AC, van Ark I, Folkerts G, Wagenaar GT. PMID: 28382003.
      View in: PubMed   Mentions:
    7. Design of Surfactant Protein B Peptide Mimics Based on the Saposin Fold for Synthetic Lung Surfactants. Biomed Hub. 2016 Sep-Dec; 1(3). Walther FJ, Gordon LM, Waring AJ. PMID: 28503550.
      View in: PubMed   Mentions:
    8. Synthetic lung surfactants containing SP-B and SP-C peptides plus novel phospholipase-resistant lipids or glycerophospholipids. PeerJ. 2016; 4:e2635. Notter RH, Gupta R, Schwan AL, Wang Z, Shkoor MG, Walther FJ. PMID: 27812430.
      View in: PubMed   Mentions:
    9. Stability of an amphipathic helix-hairpin surfactant peptide in liposomes. Biochim Biophys Acta. 2016 12; 1858(12):3113-3119. Waring AJ, Gupta M, Gordon LM, Fujii G, Walther FJ. PMID: 27664499.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    10. Activity and biophysical inhibition resistance of a novel synthetic lung surfactant containing Super-Mini-B DATK peptide. PeerJ. 2016; 4:e1528. Notter RH, Wang Z, Walther FJ. PMID: 26793419.
      View in: PubMed   Mentions:
    11. Synthetic lung surfactant reduces alveolar-capillary protein leakage in surfactant-deficient rabbits. Exp Lung Res. 2015 Jun; 41(5):293-9. Gupta R, Hernández-Juviel JM, Waring AJ, Walther FJ. PMID: 26052829.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    12. Surfactant protein C peptides with salt-bridges ("ion-locks") promote high surfactant activities by mimicking the α-helix and membrane topography of the native protein. PeerJ. 2014; 2:e485. Walther FJ, Waring AJ, Hernández-Juviel JM, Ruchala P, Wang Z, Notter RH, Gordon LM. PMID: 25083348.
      View in: PubMed   Mentions:
    13. Aerosol delivery of synthetic lung surfactant. PeerJ. 2014; 2:e403. Walther FJ, Hernández-Juviel JM, Waring AJ. PMID: 24918030.
      View in: PubMed   Mentions:
    14. Synthetic surfactant containing SP-B and SP-C mimics is superior to single-peptide formulations in rabbits with chemical acute lung injury. PeerJ. 2014; 2:e393. Walther FJ, Hernández-Juviel JM, Gordon LM, Waring AJ. PMID: 24883253.
      View in: PubMed   Mentions:
    15. Role of the N-terminal seven residues of surfactant protein B (SP-B). PLoS One. 2013; 8(9):e72821. Sharifahmadian M, Sarker M, Palleboina D, Waring AJ, Walther FJ, Morrow MR, Booth V. PMID: 24023779.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    16. Is lung surfactant ready 'to protect and to serve' in necrotizing enterocolitis? Commentary on F.E. Canpolat et al.: Effects of enterally administered surfactant in a rat model of necrotizing enterocolitis (Neonatology 2012;102:53-58). Neonatology. 2012; 102(1):59-60. Walther FJ. PMID: 22508106.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. KL₄ peptide induces reversible collapse structures on multiple length scales in model lung surfactant. Biophys J. 2011 Dec 21; 101(12):2957-65. Holten-Andersen N, Michael Henderson J, Walther FJ, Waring AJ, Ruchala P, Notter RH, Lee KY. PMID: 22208194.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    18. Synthesis and activity of a novel diether phosphonoglycerol in phospholipase-resistant synthetic lipid:peptide lung surfactants(). Medchemcomm. 2011 Dec 01; 2(12):1167-1173. Schwan AL, Singh SP, Davy JA, Waring AJ, Gordon LM, Walther FJ, Wang Z, Notter RH. PMID: 22530092.
      View in: PubMed   Mentions:
    19. A ToF-SIMS study of the lateral organization of lipids and proteins in pulmonary surfactant systems. Biochim Biophys Acta. 2011 Mar; 1808(3):614-21. Keating E, Waring AJ, Walther FJ, Possmayer F, Veldhuizen RA, Petersen NO. PMID: 21110942.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    20. Synthetic surfactant based on analogues of SP-B and SP-C is superior to single-peptide surfactants in ventilated premature rabbits. Neonatology. 2010 Jun; 98(1):91-9. Almlén A, Walther FJ, Waring AJ, Robertson B, Johansson J, Curstedt T. PMID: 20110733.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    21. Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs. PLoS One. 2010 Jan 13; 5(1):e8672. Walther FJ, Waring AJ, Hernandez-Juviel JM, Gordon LM, Wang Z, Jung CL, Ruchala P, Clark AP, Smith WM, Sharma S, Notter RH. PMID: 20084172.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    22. Functional importance of the NH2-terminal insertion sequence of lung surfactant protein B. . 2010 Mar; 298(3):L335-47. Frey SL, Pocivavsek L, Waring AJ, Walther FJ, Hernandez-Juviel JM, Ruchala P, Lee KY. PMID: 20023175.
      View in: PubMed   Mentions:
    23. Lateral stress relaxation and collapse in lipid monolayers. Soft Matter. 2008 Jan 01; 4:2019-2029. Pocivavsek L, Frey SL, Krishan K, Gavrilov K, Ruchala P, Waring AJ, Walther FJ, Dennin M, Witten TA, Lee KY. PMID: 19657472.
      View in: PubMed   Mentions: 18     Fields:    
    24. Dynamic surface activity of a fully synthetic phospholipase-resistant lipid/peptide lung surfactant. PLoS One. 2007 Oct 17; 2(10):e1039. Walther FJ, Waring AJ, Hernandez-Juviel JM, Gordon LM, Schwan AL, Jung CL, Chang Y, Wang Z, Notter RH. PMID: 17940603.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    25. Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles. Biochemistry. 2007 Oct 02; 46(39):11047-56. Sarker M, Waring AJ, Walther FJ, Keough KM, Booth V. PMID: 17845058.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    26. Hydrophobic surfactant proteins and their analogues. Neonatology. 2007; 91(4):303-10. Walther FJ, Waring AJ, Sherman MA, Zasadzinski JA, Gordon LM. PMID: 17575474.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    27. Structure and conformation of the disulfide bond in dimeric lung surfactant peptides SP-B1-25 and SP-B8-25. Biochim Biophys Acta. 2007 May; 1768(5):1070-82. Biswas N, Waring AJ, Walther FJ, Dluhy RA. PMID: 17349612.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    28. Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury. BMC Pulm Med. 2006 Apr 18; 6:8. ter Horst SA, Fijlstra M, Sengupta S, Walther FJ, Wagenaar GT. PMID: 16620381.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    29. Comparison of three lipid formulations for synthetic surfactant with a surfactant protein B analog. Exp Lung Res. 2005 Jul-Aug; 31(6):563-79. Walther FJ, Hernández-Juviel JM, Gordon LM, Waring AJ, Stenger P, Zasadzinski JA. PMID: 16019988.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    30. Structure and properties of phospholipid-peptide monolayers containing monomeric SP-B(1-25) I. Phases and morphology by epifluorescence microscopy. Biophys Chem. 2005 Mar 01; 113(3):223-32. Biswas N, Shanmukh S, Waring AJ, Walther F, Wang Z, Chang Y, Notter RH, Dluhy RA. PMID: 15620507.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    31. Structure and properties of phospholipid-peptide monolayers containing monomeric SP-B(1-25) II. Peptide conformation by infrared spectroscopy. Biophys Chem. 2005 Mar 01; 113(3):233-44. Shanmukh S, Biswas N, Waring AJ, Walther FJ, Wang Z, Chang Y, Notter RH, Dluhy RA. PMID: 15620508.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    32. NMR structures of the C-terminal segment of surfactant protein B in detergent micelles and hexafluoro-2-propanol. Biochemistry. 2004 Dec 07; 43(48):15187-94. Booth V, Waring AJ, Walther FJ, Keough KM. PMID: 15568810.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. Adrenal suppression and extubation rate after moderately early low-dose dexamethasone therapy in very preterm infants. Early Hum Dev. 2003 Oct; 74(1):37-45. Walther FJ, Findlay RD, Durand M. PMID: 14512180.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    34. Dimeric surfactant protein B peptide sp-b(1-25) in neonatal and acute respiratory distress syndrome. Exp Lung Res. 2002 Dec; 28(8):623-40. Walther FJ, Hernandez-Juviel JM, Gordon LM, Sherman MA, Waring AJ. PMID: 12490037.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. Multilayer formation upon compression of surfactant monolayers depends on protein concentration as well as lipid composition. An atomic force microscopy study. J Biol Chem. 2002 Jun 14; 277(24):21179-88. Diemel RV, Snel MM, Waring AJ, Walther FJ, van Golde LM, Putz G, Haagsman HP, Batenburg JJ. PMID: 11923286.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    36. Surfactant with SP-B and SP-C analogues improves lung function in surfactant-deficient rats. Biol Neonate. 2002; 82(3):181-7. Walther FJ, Hernández-Juviel JM, Mercado PE, Gordon LM, Waring AJ. PMID: 12373069.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
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