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A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling. J Biol Chem. 2024 Jun; 300(6):107393.
Zhuang C, Yang S, Gonzalez CG, Ainsworth RI, Li S, Kobayashi MT, Wierzbicki I, Rossitto LM, Wen Y, Peti W, Stanford SM, Gonzalez DJ, Murali R, Santelli E, Bottini N. PMID: 38777143; PMCID: PMC11237943.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Laser Capture Microscopy RNA Sequencing for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis. Arthritis Rheumatol. 2024 Aug; 76(8):1243-1251.
Van Espen B, Prideaux EB, Wilson AR, Machado CRL, Sendo S, Parker J, Seumois G, Sacchetti C, Belongia AC, Perumal NB, Vijayanand P, Linnik MD, Benschop RJ, Wang W, Bottini N, Firestein GS, Stanford SM. PMID: 38556917.
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Translation:
HumansCells
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ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis. Biomater Sci. 2024 Apr 16; 12(8):2041-2056.
McBride DA, Wang JS, Johnson WT, Bottini N, Shah NJ. PMID: 38349277.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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The therapeutic potential of immunoengineering for systemic autoimmunity. Nat Rev Rheumatol. 2024 Apr; 20(4):203-215.
McBride DA, Jones RM, Bottini N, Shah NJ. PMID: 38383732.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. Sci Adv. 2024 Feb 02; 10(5):eadg7887.
Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, Paindelli C, Parietti V, Mikos AG, Lodi A, Bagrodia A, Elliott A, McKay RR, Murali R, Tiziani S, Kettenbach AN, Bottini N. PMID: 38295166; PMCID: PMC10830117.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Inhibiting the Inhibitor in Synovial Macrophages and Cancer Immunotherapy-Associated Inflammatory Arthritis. Arthritis Rheumatol. 2024 Apr; 76(4):505-506.
Shah NJ, Bottini N. PMID: 37909274; PMCID: PMC10965387.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Immunomodulatory Nanoparticles for Modulating Arthritis Flares. ACS Nano. 2024 Jan 23; 18(3):1892-1906.
Johnson WT, McBride D, Kerr M, Nguyen A, Zoccheddu M, Bollmann M, Wei X, Jones RM, Wang W, Svensson MND, Bottini N, Shah NJ. PMID: 38016062.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Revisiting VH1 phosphatase at the time of monkeypox: back to the spotlight. Biochem Soc Trans. 2023 08 31; 51(4):1419-1427.
Bottini A, Pacheco DRDCG, Forti FL, Bottini N. PMID: 37409507.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts. Sci Signal. 2023 07 04; 16(792):eabn8668.
Sendo S, Kiosses WB, Yang S, Wu DJ, Lee DWK, Liu L, Aschner Y, Vela AJ, Downey GP, Santelli E, Bottini N. PMID: 37402225; PMCID: PMC10544828.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis. Adv Sci (Weinh). 2023 04; 10(11):e2202720.
McBride DA, Kerr MD, Johnson WT, Nguyen A, Zoccheddu M, Yao M, Prideaux EB, Dorn NC, Wang W, Svensson MND, Bottini N, Shah NJ. PMID: 36890657; PMCID: PMC10104670.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders. Nat Rev Drug Discov. 2023 04; 22(4):273-294.
Stanford SM, Bottini N. PMID: 36693907; PMCID: PMC9872771.
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PubMed Mentions:
30 Fields:
Translation:
Humans
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Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro. Drug Deliv Transl Res. 2023 07; 13(7):1912-1924.
McBride DA, Dorn NC, Yao M, Johnson WT, Wang W, Bottini N, Shah NJ. PMID: 36566262; PMCID: PMC10695156.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Macromolecular crowding amplifies allosteric regulation of T-cell protein tyrosine phosphatase. J Biol Chem. 2022 12; 298(12):102655.
Tun MT, Yang S, Forti FL, Santelli E, Bottini N. PMID: 36328244; PMCID: PMC9720572.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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T-helper cell regulation of CD45 phosphatase activity by galectin-1 and CD43 governs chronic lymphocytic leukaemia proliferation. Br J Haematol. 2022 08; 198(3):556-573.
Imbery JF, Heinzelbecker J, Jebsen JK, McGowan M, Myklebust C, Bottini N, Stanford SM, Skånland SS, Tveita A, Tjønnfjord GE, Munthe LA, Szodoray P, Nakken B. PMID: 35655388; PMCID: PMC9329260.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Emerging proteoglycans and proteoglycan-targeted therapies in rheumatoid arthritis. Am J Physiol Cell Physiol. 2022 06 01; 322(6):C1061-C1067.
Hurysz B, Bottini N. PMID: 35476502; PMCID: PMC9169851.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex. JCI Insight. 2022 04 22; 7(8).
Zhang R, Kumar GS, Hansen U, Zoccheddu M, Sacchetti C, Holmes ZJ, Lee MC, Beckmann D, Wen Y, Mikulski Z, Yang S, Santelli E, Page R, Boin F, Peti W, Bottini N. PMID: 35451370; PMCID: PMC9089796.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Lipid-based regulators of immunity. Bioeng Transl Med. 2022 May; 7(2):e10288.
Johnson WT, Dorn NC, Ogbonna DA, Bottini N, Shah NJ. PMID: 35600637; PMCID: PMC9115682.
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PubMed Mentions:
5
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Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity. Cell Rep. 2021 08 10; 36(6):109525.
Szodoray P, Andersen TK, Heinzelbecker J, Imbery JF, Huszthy PC, Stanford SM, Bogen B, Landsverk OB, Bottini N, Tveita A, Munthe LA, Nakken B. PMID: 34380042; PMCID: PMC8435664.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. J Med Chem. 2021 05 13; 64(9):5645-5653.
Stanford SM, Diaz MA, Ardecky RJ, Zou J, Roosild T, Holmes ZJ, Nguyen TP, Hedrick MP, Rodiles S, Guan A, Grotegut S, Santelli E, Chung TDY, Jackson MR, Bottini N, Pinkerton AB. PMID: 33914534; PMCID: PMC8939909.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy. J Cell Physiol. 2021 09; 236(9):6630-6642.
Stanford SM, Collins M, Diaz MA, Holmes ZJ, Gries P, Bliss MR, Lodi A, Zhang V, Tiziani S, Bottini N. PMID: 33615467; PMCID: PMC8222063.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. JCI Insight. 2020 10 15; 5(20).
Hsieh WC, Svensson MN, Zoccheddu M, Tremblay ML, Sakaguchi S, Stanford SM, Bottini N. PMID: 33055428; PMCID: PMC7605542.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020 06; 6(26):eaba4353.
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N. PMID: 32637608; PMCID: PMC7319753.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling. Sci Signal. 2020 03 17; 13(623).
Yang S, Svensson MND, Harder NHO, Hsieh WC, Santelli E, Kiosses WB, Moresco JJ, Yates JR, King CC, Liu L, Stanford SM, Bottini N. PMID: 32184287; PMCID: PMC7263369.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. J Biol Chem. 2020 04 10; 295(15):4923-4936.
Wen Y, Yang S, Wakabayashi K, Svensson MND, Stanford SM, Santelli E, Bottini N. PMID: 32139509; PMCID: PMC7152759.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy. ACS Nano. 2019 05 28; 13(5):5036-5048.
Liu L, Hu F, Wang H, Wu X, Eltahan AS, Stanford S, Bottini N, Xiao H, Bottini M, Guo W, Liang XJ. PMID: 30978282.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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The Contribution of PTPN22 to Rheumatic Disease. Arthritis Rheumatol. 2019 04; 71(4):486-495.
Mustelin T, Bottini N, Stanford SM. PMID: 30507064; PMCID: PMC6438733.
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PubMed Mentions:
27 Fields:
Translation:
Humans
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PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes. Ann Rheum Dis. 2019 05; 78(5):600-609.
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, Liu L, Corr M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N. PMID: 30808624; PMCID: PMC7039277.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity. J Clin Invest. 2019 03 01; 129(3):1193-1210.
Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N. PMID: 30620725; PMCID: PMC6391091.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nat Commun. 2018 07 06; 9(1):2627.
Zhao M, Svensson MND, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M. PMID: 29980684; PMCID: PMC6035278.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery. Adv Healthc Mater. 2018 03; 7(6):e1700916.
Bhattacharya K, Sacchetti C, Costa PM, Sommertune J, Brandner BD, Magrini A, Rosato N, Bottini N, Bottini M, Fadeel B. PMID: 29334180.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. Nat Commun. 2017 10 20; 8(1):1060.
Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. PMID: 29057934; PMCID: PMC5651906.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets. Curr Rheumatol Rep. 2017 May; 19(5):28.
Sacchetti C, Bottini N. PMID: 28397126; PMCID: PMC6703857.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Targeting Tyrosine Phosphatases: Time to End the Stigma. Trends Pharmacol Sci. 2017 06; 38(6):524-540.
Stanford SM, Bottini N. PMID: 28412041; PMCID: PMC5494996.
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PubMed Mentions:
88 Fields:
Translation:
HumansAnimals
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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 06; 13(6):624-632.
Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N. PMID: 28346406; PMCID: PMC5435566.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes. Epigenomics. 2017 04; 9(4):479-492.
Doody KM, Bottini N, Firestein GS. PMID: 28322585; PMCID: PMC5549652.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells. Nat Commun. 2016 11 14; 7:13373.
Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J. PMID: 27841348; PMCID: PMC5114568.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7).
Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. PMID: 27275015; PMCID: PMC4889026.
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PubMed Mentions:
26 Fields:
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T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. J Allergy Clin Immunol. 2016 09; 138(3):839-851.e8.
Szodoray P, Stanford SM, Molberg Ø, Munthe LA, Bottini N, Nakken B. PMID: 27056269.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice. Arthritis Rheumatol. 2016 Feb; 68(2):359-69.
Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N. PMID: 26414708; PMCID: PMC4770259.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy. Nanomedicine. 2016 Feb; 12(2):255-68.
Bottini M, Bhattacharya K, Fadeel B, Magrini A, Bottini N, Rosato N. PMID: 26707894.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Chondrocyte clocks make cartilage time-sensitive material. J Clin Invest. 2016 Jan; 126(1):38-9.
Doody KM, Bottini N. PMID: 26657854; PMCID: PMC4701534.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015 Nov 15; 195(10):4841-52.
Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, Bottini N, Wicker LS. PMID: 26438525; PMCID: PMC4635565.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside. Nat Rev Rheumatol. 2015 Nov; 11(11):623-4.
Bottini N, Firestein GS. PMID: 26390844.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy. J Pathol. 2015 Dec; 237(4):482-94.
Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, Roos KP, Assiri A, Al-Habeeb W, Sussman M, Bottini N, Poizat C. PMID: 26213100; PMCID: PMC5049627.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays. PLoS One. 2015; 10(6):e0129264.
Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S. PMID: 26061731; PMCID: PMC4462581.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20; 7(288):288ra76.
Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. PMID: 25995222; PMCID: PMC4458332.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes. ACS Nano. 2014 Dec 23; 8(12):12280-91.
Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M. PMID: 25415768; PMCID: PMC4373402.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. Ann Rheum Dis. 2016 Jan; 75(1):295-302.
Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. PMID: 25378349; PMCID: PMC4422771.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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"PEST control": regulation of molecular barcodes by tyrosine phosphatases. Cell Res. 2014 Sep; 24(9):1027-8.
Doody KM, Bottini N. PMID: 25081059; PMCID: PMC4152731.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest. 2014 Sep; 124(9):3793-806.
de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E. PMID: 25083990; PMCID: PMC4151223.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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PTPN22: the archetypal non-HLA autoimmunity gene. Nat Rev Rheumatol. 2014 Oct; 10(10):602-11.
Stanford SM, Bottini N. PMID: 25003765; PMCID: PMC4375551.
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PubMed Mentions:
111 Fields:
Translation:
HumansAnimalsCells
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Cellular biochemistry methods for investigating protein tyrosine phosphatases. Antioxid Redox Signal. 2014 May 10; 20(14):2160-78.
Stanford SM, Ahmed V, Barrios AM, Bottini N. PMID: 24294920; PMCID: PMC3995294.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. PLoS One. 2014; 9(2):e86677.
Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N. PMID: 24498279; PMCID: PMC3911918.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Covalent inhibition of the lymphoid tyrosine phosphatase. ChemMedChem. 2014 Feb; 9(2):296-9.
Ahmed VF, Bottini N, Barrios AM. PMID: 24403103; PMCID: PMC4096870.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Targeted nanodrugs for cancer therapy: prospects and challenges. J Nanosci Nanotechnol. 2014 Jan; 14(1):98-114.
Bottini M, Sacchetti C, Pietroiusti A, Bellucci S, Magrini A, Rosato N, Bottini N. PMID: 24730253.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Annu Rev Immunol. 2014; 32:83-119.
Bottini N, Peterson EJ. PMID: 24364806; PMCID: PMC6402334.
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PubMed Mentions:
102 Fields:
Translation:
HumansAnimalsCells
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Epigenetics in rheumatoid arthritis: a primer for rheumatologists. Curr Rheumatol Rep. 2013 Nov; 15(11):372.
Bottini N, Firestein GS. PMID: 24072602.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors. Chembiochem. 2013 Sep 02; 14(13):1640-7.
Kulkarni RA, Vellore NA, Bliss MR, Stanford SM, Falk MD, Bottini N, Baron R, Barrios AM. PMID: 23956195; PMCID: PMC3874405.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. Methods. 2014 Jan 15; 65(2):165-74.
Stanford SM, Krishnamurthy D, Kulkarni RA, Karver CE, Bruenger E, Walker LM, Ma CT, Chung TD, Sergienko E, Bottini N, Barrios AM. PMID: 23886911; PMCID: PMC3899110.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase. ChemMedChem. 2013 Sep; 8(9):1561-8.
Kulkarni RA, Stanford SM, Vellore NA, Krishnamurthy D, Bliss MR, Baron R, Bottini N, Barrios AM. PMID: 23873737; PMCID: PMC3863632.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity. 2013 Jul 25; 39(1):111-22.
Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ. PMID: 23871208; PMCID: PMC3830738.
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PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
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A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. J Med Chem. 2013 Jun 27; 56(12):4990-5008.
He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY. PMID: 23713581; PMCID: PMC3711248.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes. Bioconjug Chem. 2013 Jun 19; 24(6):852-8.
Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M. PMID: 23682992.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis Rheum. 2013 May; 65(5):1171-80.
Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. PMID: 23335101; PMCID: PMC3636201.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Surface polyethylene glycol conformation influences the protein corona of polyethylene glycol-modified single-walled carbon nanotubes: potential implications on biological performance. ACS Nano. 2013 Mar 26; 7(3):1974-89.
Sacchetti C, Motamedchaboki K, Magrini A, Palmieri G, Mattei M, Bernardini S, Rosato N, Bottini N, Bottini M. PMID: 23413928.
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PubMed Mentions:
53 Fields:
Translation:
HumansCells
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Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol. 2013 Jan; 9(1):24-33.
Bottini N, Firestein GS. PMID: 23147896; PMCID: PMC3970924.
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PubMed Mentions:
411 Fields:
Translation:
HumansCells
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Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology. 2012 Sep; 137(1):1-19.
Stanford SM, Rapini N, Bottini N. PMID: 22862552; PMCID: PMC3449242.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):13972-7.
Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. PMID: 22891353; PMCID: PMC3435192.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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PTPN22 alters the development of regulatory T cells in the thymus. J Immunol. 2012 Jun 01; 188(11):5267-75.
Maine CJ, Hamilton-Williams EE, Cheung J, Stanford SM, Bottini N, Wicker LS, Sherman LA. PMID: 22539785; PMCID: PMC3358490.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
-
Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus. Hum Immunol. 2012 Jan; 73(1):107-10.
Teruel M, Martin JE, Ortego-Centeno N, Jiménez-Alonso J, Sánchez-Román J, de Ramón E, Gonzalez-Escribano MF, Pons-Estel BA, D'Alfonso S, Sebastiani GD, Witte T, Bottini N, González-Gay MA, Alarcón-Riquelme ME, Martin J. PMID: 22064183.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead. Biomacromolecules. 2011 Oct 10; 12(10):3381-93.
Bottini M, Rosato N, Bottini N. PMID: 21916410.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
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Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients. Arthritis Res Ther. 2011 Jul 18; 13(4):R116.
Teruel M, Martin JE, González-Juanatey C, López-Mejias R, Miranda-Filloy JA, Blanco R, Balsa A, Pascual-Salcedo D, Rodriguez-Rodriguez L, Fernández-Gutierrez B, Ortiz AM, González-Alvaro I, Gómez-Vaquero C, Bottini N, Llorca J, González-Gay MA, Martin J. PMID: 21767392; PMCID: PMC3239354.
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PubMed Mentions:
13 Fields:
Translation:
Humans
-
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem. 2011 Mar 24; 54(6):1640-54.
Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, Neamati N, Bottini N. PMID: 21341673; PMCID: PMC3086468.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Arthritis Rheum. 2011 Feb; 63(2):365-72.
Rodríguez-Rodríguez L, Taib WR, Topless R, Steer S, González-Escribano MF, Balsa A, Pascual-Salcedo D, González-Gay MA, Raya E, Fernandez-Gutierrez B, González-Álvaro I, Bottini N, Witte T, Viken MK, Coenen MJ, van Riel PL, Franke B, den Heijer M, Radstake TR, Wordsworth P, Lie BA, Merriman TR, Martín J. PMID: 21279993.
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PubMed Mentions:
33 Fields:
Translation:
Humans
-
Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2011 Nov; 17(11):2287-94.
Diaz-Gallo LM, Espino-Paisán L, Fransen K, Gómez-García M, van Sommeren S, Cardeña C, Rodrigo L, Mendoza JL, Taxonera C, Nieto A, Alcain G, Cueto I, López-Nevot MA, Bottini N, Barclay ML, Crusius JB, van Bodegraven AA, Wijmenga C, Ponsioen CY, Gearry RB, Roberts RL, Weersma RK, Urcelay E, Merriman TR, Alizadeh BZ, Martin J. PMID: 21287672.
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PubMed Mentions:
40 Fields:
Translation:
Humans
-
Carbon nanotube-based nanocarriers: the importance of keeping it clean. J Nanosci Nanotechnol. 2010 Aug; 10(8):5293-301.
Delogu LG, Stanford SM, Santelli E, Magrini A, Bergamaschi A, Motamedchaboki K, Rosato N, Mustelin T, Bottini N, Bottini M. PMID: 21125885.
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PubMed Mentions:
10 Fields:
Translation:
HumansCellsPHPublic Health
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Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue. J Biol Chem. 2010 Aug 20; 285(34):26506-18.
Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N. PMID: 20538612; PMCID: PMC2924087.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Semin Immunopathol. 2010 Jun; 32(2):127-36.
Stanford SM, Mustelin TM, Bottini N. PMID: 20204370; PMCID: PMC2881161.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. J Inorg Biochem. 2010 Mar; 104(3):268-73.
Karver MR, Krishnamurthy D, Bottini N, Barrios AM. PMID: 20083307; PMCID: PMC2873867.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes. J Med Chem. 2009 Nov 12; 52(21):6912-8.
Karver MR, Krishnamurthy D, Kulkarni RA, Bottini N, Barrios AM. PMID: 19888762; PMCID: PMC2801581.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms. Med Sci Monit. 2009 Oct; 15(10):CR511-517.
Saccucci P, Manca Bitti ML, Bottini N, Rapini N, Piccinini S, D'Annibale F, Chiarelli F, Verrotti A, Bottini E, Gloria-Bottini F. PMID: 19789510.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Biochemistry. 2009 Aug 11; 48(31):7525-32.
Liu Y, Stanford SM, Jog SP, Fiorillo E, Orrú V, Comai L, Bottini N. PMID: 19586056; PMCID: PMC3113683.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans. J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102.
Shu YH, Hartiala J, Xiang AH, Trigo E, Lawrence JM, Allayee H, Buchanan TA, Bottini N, Watanabe RM. PMID: 19622628; PMCID: PMC2758733.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation . Biochemistry. 2009 Jun 09; 48(22):4838-45.
Tsai SJ, Sen U, Zhao L, Greenleaf WB, Dasgupta J, Fiorillo E, Orrú V, Bottini N, Chen XS. PMID: 19371084; PMCID: PMC2747803.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes. Bioconjug Chem. 2009 Mar 18; 20(3):427-31.
Delogu LG, Magrini A, Bergamaschi A, Rosato N, Dawson MI, Bottini N, Bottini M. PMID: 19243140.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children. Pediatrics. 2009 Mar; 123(3):1051-8.
Renzetti G, Silvestre G, D'Amario C, Bottini E, Gloria-Bottini F, Bottini N, Auais A, Perez MK, Piedimonte G. PMID: 19255039.
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PubMed Mentions:
16 Fields:
Translation:
HumansCellsPHPublic Health
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A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet. 2009 Feb 01; 18(3):569-79.
Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S, Italian Collaborative Group, Arnett FC, Wu H, Gonzalez-Gay MA, Tsao BP, Pons-Estel B, Alarcon-Riquelme ME, He Y, Zhang ZY, Allayee H, Chen XS, Martin J, Bottini N. PMID: 18981062; PMCID: PMC2722189.
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PubMed Mentions:
66 Fields:
Translation:
HumansCells
-
Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study. J Med Chem. 2008 Aug 14; 51(15):4790-5.
Krishnamurthy D, Karver MR, Fiorillo E, Orrú V, Stanford SM, Bottini N, Barrios AM. PMID: 18605719.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
-
Adenosine deaminase genetic polymorphism and coronary artery disease. Cardiology. 2009; 112(1):74-5.
Banci M, Saccucci P, D'Annibale F, Dofcaci A, Trionfera G, Magrini A, Bottini N, Bottini E, Gloria-Bottini F. PMID: 18560234.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies. J Nanosci Nanotechnol. 2008 May; 8(5):2259-69.
Cato MH, D'Annibale F, Mills DM, Cerignoli F, Dawson MI, Bergamaschi E, Bottini N, Magrini A, Bergamaschi A, Rosato N, Rickert RC, Mustelin T, Bottini M. PMID: 18572636.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Low birth weight and allergy: possible pleiotropic effect of ACP1. Hum Biol. 2008 Feb; 80(1):65-72.
Gloria-Bottini F, Bottini N, Magrini A, Renzetti G, Martinoli R, Bergamaschi A, Bottini E. PMID: 18505045.
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PubMed Mentions: Fields:
Translation:
HumansCTClinical Trials
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Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes. Diabetes. 2008 Jan; 57(1):229-34.
Zoledziewska M, Perra C, Orrù V, Moi L, Frongia P, Congia M, Bottini N, Cucca F. PMID: 17934143.
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PubMed Mentions:
19 Fields:
Translation:
Humans
-
Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity. 2007 Sep; 40(6):453-61.
Vang T, Miletic AV, Bottini N, Mustelin T. PMID: 17729039.
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PubMed Mentions:
62 Fields:
Translation:
Humans
-
The effects of genetic and seasonal factors on reproductive success. Fertil Steril. 2008 May; 89(5):1090-1094.
Gloria-Bottini F, Bottini N, La Torre M, Magrini A, Bergamaschi A, Bottini E. PMID: 17678914.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Association between PTPN22 and endometriosis. Fertil Steril. 2008 Apr; 89(4):993-4.
Ammendola M, Bottini N, Pietropolli A, Saccucci P, Gloria-Bottini F. PMID: 17624340.
View in:
PubMed Mentions:
10 Fields:
Translation:
Humans
-
Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Semin Immunol. 2006 Aug; 18(4):207-13.
Bottini N, Vang T, Cucca F, Mustelin T. PMID: 16697661.
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PubMed Mentions:
115 Fields:
Translation:
HumansAnimals
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Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation. Mol Cell Biol. 2006 Mar; 26(5):1806-16.
Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T. PMID: 16479000; PMCID: PMC1430257.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Adenosine deaminase polymorphism and the relationship of total immunoglobulin E with skin prick test: a study on school children. Allergy Asthma Proc. 2006 Mar-Apr; 27(2):115-8.
Gloria-Bottini F, Ronchetti F, Ammendola L, Bottini N. PMID: 16724628.
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PubMed Mentions: Fields:
Translation:
Humans
-
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 05; 202(11):1587-97.
Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. PMID: 16330817; PMCID: PMC2213338.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet. 2005 Dec; 37(12):1317-9.
Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N. PMID: 16273109.
View in:
PubMed Mentions:
283 Fields:
Translation:
HumansCells
-
Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett. 2006 Jan 05; 160(2):121-6.
Bottini M, Bruckner S, Nika K, Bottini N, Bellucci S, Magrini A, Bergamaschi A, Mustelin T. PMID: 16125885.
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PubMed Mentions:
98 Fields:
Translation:
HumansCells
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Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. Arthritis Rheum. 2005 Aug; 52(8):2396-402.
Wu H, Cantor RM, Graham DS, Lingren CM, Farwell L, Jager PL, Bottini N, Grossman JM, Wallace DJ, Hahn BH, Julkunen H, Hebert LA, Rovin BH, Birmingham DJ, Rioux JD, Yu CY, Kere J, Vyse TJ, Tsao BP. PMID: 16052563.
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PubMed Mentions:
25 Fields:
Translation:
Humans
-
Serum glucose concentration and ACP1 genotype in healthy adult subjects. Metabolism. 2005 Jul; 54(7):891-4.
Iannaccone U, Bergamaschi A, Magrini A, Marino G, Bottini N, Lucarelli P, Bottini E, Gloria-Bottini F. PMID: 15988697.
View in:
PubMed Mentions:
9 Fields:
Translation:
Humans
-
Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis. J Bacteriol. 2005 Jul; 187(14):4945-56.
Musumeci L, Bongiorni C, Tautz L, Edwards RA, Osterman A, Perego M, Mustelin T, Bottini N. PMID: 15995210; PMCID: PMC1169535.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE. J Bacteriol. 2005 May; 187(10):3384-90.
Mijakovic I, Musumeci L, Tautz L, Petranovic D, Edwards RA, Jensen PR, Mustelin T, Deutscher J, Bottini N. PMID: 15866923; PMCID: PMC1112022.
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PubMed Mentions:
18 Fields:
Translation:
Cells
-
Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Hum Immunol. 2005 Jan; 66(1):60-4.
Ladner MB, Bottini N, Valdes AM, Noble JA. PMID: 15620463.
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PubMed Mentions:
35 Fields:
Translation:
Humans
-
Protein tyrosine phosphatases and the immune response. Nat Rev Immunol. 2005 Jan; 5(1):43-57.
Mustelin T, Vang T, Bottini N. PMID: 15630428.
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PubMed Mentions:
137 Fields:
Translation:
HumansAnimalsCells
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Protein-tyrosine phosphorylation in Bacillus subtilis. J Mol Microbiol Biotechnol. 2005; 9(3-4):189-97.
Mijakovic I, Petranovic D, Bottini N, Deutscher J, Ruhdal Jensen P. PMID: 16415592.
View in:
PubMed Mentions:
16 Fields:
Translation:
Cells
-
Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. J Biol Chem. 2005 Mar 11; 280(10):9400-8.
Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T. PMID: 15615724.
View in:
PubMed Mentions:
24 Fields:
Translation:
Cells
-
Covalent decoration of multi-walled carbon nanotubes with silica nanoparticles. Chem Commun (Camb). 2005 Feb 14; (6):758-60.
Bottini M, Tautz L, Huynh H, Monosov E, Bottini N, Dawson MI, Bellucci S, Mustelin T. PMID: 15685328.
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PubMed Mentions:
16 Fields:
Translation:
Cells
-
Genetics of signal transduction and the effect of maternal smoking on sex ratio of offspring. Am J Hum Biol. 2004 Sep-Oct; 16(5):588-92.
Bottini N, Magrini A, Cosmi E, Gloria-Bottini F, Saccucci P, Di Iorio R, Bergamaschi A, Bottini E. PMID: 15368606.
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PubMed Mentions: Fields:
Translation:
HumansCells
-
Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol. 2004 Sep; 6(9):831-9.
Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T. PMID: 15322554.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
-
Protein tyrosine phosphatases in T cell physiology. Mol Immunol. 2004 Jul; 41(6-7):687-700.
Mustelin T, Alonso A, Bottini N, Huynh H, Rahmouni S, Nika K, Louis-dit-Sully C, Tautz L, Togo SH, Bruckner S, Mena-Duran AV, al-Khouri AM. PMID: 15220004.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
-
Protein tyrosine phosphatases in the human genome. Cell. 2004 Jun 11; 117(6):699-711.
Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. PMID: 15186772.
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PubMed Mentions:
698 Fields:
Translation:
HumansCells
-
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet. 2004 Apr; 36(4):337-8.
Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T. PMID: 15004560.
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PubMed Mentions:
488 Fields:
Translation:
Humans
-
Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. Biochem J. 2004 Mar 01; 378(Pt 2):335-42.
Nika K, Hyunh H, Williams S, Paul S, Bottini N, Taskén K, Lombroso PJ, Mustelin T. PMID: 14613483; PMCID: PMC1223964.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
-
Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. J Immunol. 2003 Dec 15; 171(12):6661-71.
Huynh H, Wang X, Li W, Bottini N, Williams S, Nika K, Ishihara H, Godzik A, Mustelin T. PMID: 14662869.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. J Biol Chem. 2004 Feb 06; 279(6):4922-8.
Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, Mustelin T. PMID: 14623872.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
-
Association study of autistic disorder and chromosome 16p. Am J Med Genet A. 2003 Jun 01; 119A(2):242-6.
Lucarelli P, Palminiello S, Saccucci P, Bottini N, De Luca D, Elia M, Fiumara A, Curatolo P. PMID: 12749074.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. Med Sci Monit. 2003 Mar; 9(3):CR105-8.
Meloni G, Bottini N, Borgiani P, Lucarelli P, Meloni T, Bottini E. PMID: 12640337.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
Role of protein tyrosine phosphatases in T cell activation. Immunol Rev. 2003 Feb; 191:139-47.
Mustelin T, Rahmouni S, Bottini N, Alonso A. PMID: 12614357.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Convulsive disorder and the genetics of signal transduction; a study of a low molecular weight protein tyrosine phosphatase in a pediatric sample. Neurosci Lett. 2002 Nov 29; 333(3):159-62.
Bottini N, Saccucci P, Piciullo A, Iannetti P, Lucarini N, Lucarelli P, Gloria-Bottini F, Curatolo P. PMID: 12429372.
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PubMed Mentions: Fields:
Translation:
HumansCells
-
Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women. Mol Genet Metab. 2002 Nov; 77(3):226-9.
Bottini N, MacMurray J, Peters W, Rostamkhani M, Comings DE. PMID: 12409270.
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PubMed Mentions:
15 Fields:
Translation:
Humans
-
Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome. Neurosci Lett. 2002 Sep 20; 330(2):198-200.
Bottini N, MacMurray J, Rostamkani M, McGue M, Iacono WG, Comings DE. PMID: 12231445.
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PubMed Mentions: Fields:
Translation:
HumansCells
-
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. J Immunol. 2002 Jul 01; 169(1):286-91.
Birle D, Bottini N, Williams S, Huynh H, deBelle I, Adamson E, Mustelin T. PMID: 12077256.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
-
Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). J Biol Chem. 2002 Jul 05; 277(27):24220-4.
Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham RT, Couture C, Mustelin T. PMID: 11976341.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Two-loci ADA haplotypes in autistic disorder. Am J Med Genet. 2002 Apr 01; 108(4):339-40.
Lucarelli P, Saccucci P, Bottini N, De Luca D, Fiumara A, Elia M, Bottini N, Porfirio MC, Curatolo P. PMID: 11920843.
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PubMed Mentions: Fields:
Translation:
Humans
-
Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms. Arch Immunol Ther Exp (Warsz). 2002; 50(2):95-104.
Bottini N, Bottini E, Gloria-Bottini F, Mustelin T. PMID: 12022706.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Low molecular weight PTP-IL-4RA interaction in atopy predisposition. Allergy. 2002; 57 Suppl 72:10-2.
Bottini N, Mao XQ, Borgiani P, Saccucci P, Stefanini L, Greco E, Fontana L, Shirakawa T, Hopkin JM. PMID: 12144546.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Acid phosphatase locus 1 (ACP1): Possible relationship of allelic variation to body size and human population adaptation to thermal stress-A theoretical perspective. Am J Hum Biol. 2000 Sep; 12(5):688-701.
Greene LS, Bottini N, Borgiani P, Gloria-Bottini F. PMID: 11534062.
View in:
PubMed Mentions:
5 Fields: