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Dumesic, Daniel Anthony

Title(s)Professor, Obstetrics And Gynecology
PhoneApt 47274, Adm 45542
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    Paracrine dysregulation of oocyte competence in PCOS
    NIH/NICHD U01HD044650Sep 1, 2003 - Dec 31, 2004
    Role: Principal Investigator
    OOCYTE COMPETENCY IN PRENATALLY ANDROGENIZED ANIMALS
    NIH/NCRR R21RR014093May 1, 1999 - Apr 30, 2002
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Dumesic DA, Hoyos LR, Chazenbalk GD, Naik R, Padmanabhan V, Abbott DH. Mechanisms of intergenerational transmission of polycystic ovary syndrome. Reproduction. 2020 Jan; 159(1):R1-R13. PMID: 31376813.
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    2. Abbott DH, Rogers J, Dumesic DA, Levine JE. Naturally Occurring and Experimentally Induced Rhesus Macaque Models for Polycystic Ovary Syndrome: Translational Gateways to Clinical Application. Med Sci (Basel). 2019 Nov 27; 7(12). PMID: 31783681.
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    3. Abbott DH, Kraynak M, Dumesic DA, Levine JE. In utero Androgen Excess: A Developmental Commonality Preceding Polycystic Ovary Syndrome? Front Horm Res. 2019; 53:1-17. PMID: 31499494.
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    4. Singh P, Agress A, Madrigal VK, Magyar C, Ostrzega N, Chazenbalk GD, Dumesic DA. Massive Ovarian Growth in a Woman With Severe Insulin-Resistant Polycystic Ovary Syndrome Receiving GnRH Analogue. J Clin Endocrinol Metab. 2019 Jul 01; 104(7):2796-2800. PMID: 30759233.
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    5. Dumesic DA, Phan JD, Leung KL, Grogan TR, Ding X, Li X, Hoyos LR, Abbott DH, Chazenbalk GD. Adipose Insulin Resistance in Normal-Weight Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2019 Jun 01; 104(6):2171-2183. PMID: 30649347.
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    6. Brennan KM, Kroener LL, Chazenbalk GD, Dumesic DA. Polycystic Ovary Syndrome: Impact of Lipotoxicity on Metabolic and Reproductive Health. Obstet Gynecol Surv. 2019 Apr; 74(4):223-231. PMID: 31344250.
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    7. Abbott DH, Dumesic DA, Levine JE. Hyperandrogenic origins of polycystic ovary syndrome - implications for pathophysiology and therapy. Expert Rev Endocrinol Metab. 2019 03; 14(2):131-143. PMID: 30767580.
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    8. Fisch SC, Nikou AF, Wright EA, Phan JD, Leung KL, Grogan TR, Abbott DH, Chazenbalk GD, Dumesic DA. Precocious subcutaneous abdominal stem cell development to adipocytes in normal-weight women with polycystic ovary syndrome. Fertil Steril. 2018 12; 110(7):1367-1376. PMID: 30503136.
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    9. Guedikian AA, Lee AY, Grogan TR, Abbott DH, Largaespada K, Chazenbalk GD, Dumesic DA. Reproductive and metabolic determinants of granulosa cell dysfunction in normal-weight women with polycystic ovary syndrome. Fertil Steril. 2018 03; 109(3):508-515. PMID: 29428312.
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    10. Fisch SC, Gimeno ML, Phan JD, Simerman AA, Dumesic DA, Perone MJ, Chazenbalk GD. Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective. Stem Cell Res Ther. 2017 10 18; 8(1):227. PMID: 29041955.
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    11. Kroener L, Dumesic D, Al-Safi Z. Use of fertility medications and cancer risk: a review and update. Curr Opin Obstet Gynecol. 2017 Aug; 29(4):195-201. PMID: 28538003.
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    12. Simerman AA, Phan JD, Dumesic DA, Chazenbalk GD. Muse Cells: Nontumorigenic Pluripotent Stem Cells Present in Adult Tissues-A Paradigm Shift in Tissue Regeneration and Evolution. Stem Cells Int. 2016; 2016:1463258. PMID: 28070194.
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    13. Dumesic DA, Akopians AL, Madrigal VK, Ramirez E, Margolis DJ, Sarma MK, Thomas AM, Grogan TR, Haykal R, Schooler TA, Okeya BL, Abbott DH, Chazenbalk GD. Hyperandrogenism Accompanies Increased Intra-Abdominal Fat Storage in Normal Weight Polycystic Ovary Syndrome Women. J Clin Endocrinol Metab. 2016 11; 101(11):4178-4188. PMID: 27571186.
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    14. Dumesic DA, Guedikian AA, Madrigal VK, Phan JD, Hill DL, Alvarez JP, Chazenbalk GD. Cumulus Cell Mitochondrial Resistance to Stress In Vitro Predicts Oocyte Development During Assisted Reproduction. J Clin Endocrinol Metab. 2016 05; 101(5):2235-45. PMID: 27003307.
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    15. Abbott DH, Levine JE, Dumesic DA. Translational Insight Into Polycystic Ovary Syndrome (PCOS) From Female Monkeys with PCOS-like Traits. Curr Pharm Des. 2016; 22(36):5625-5633. PMID: 27426126.
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    16. Cardoso RC, Veiga-Lopez A, Moeller J, Beckett E, Pease A, Keller E, Madrigal V, Chazenbalk G, Dumesic D, Padmanabhan V. Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep. Endocrinology. 2016 Feb; 157(2):522-35. PMID: 26650569.
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    17. Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocr Rev. 2015 Oct; 36(5):487-525. PMID: 26426951.
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    18. Chithiwala ZH, Lee HC, Hill DL, Jellerette-Nolan T, Fissore R, Grow D, Dumesic DA. Phospholipase C-zeta deficiency as a cause for repetitive oocyte fertilization failure during ovarian stimulation for in vitro fertilization with ICSI: a case report. J Assist Reprod Genet. 2015 Sep; 32(9):1415-9. PMID: 26174123.
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    19. Dumesic D. Inflammatory Factors in Reproductive Medicine. Semin Reprod Med. 2015 Jul; 33(4):237. PMID: 26132927.
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    20. Dumesic DA, Meldrum DR, Katz-Jaffe MG, Krisher RL, Schoolcraft WB. Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health. Fertil Steril. 2015 Feb; 103(2):303-16. PMID: 25497448.
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    21. Vagi SJ, Azziz-Baumgartner E, Sjödin A, Calafat AM, Dumesic D, Gonzalez L, Kato K, Silva MJ, Ye X, Azziz R. Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol A in polycystic ovary syndrome: a case-control study. BMC Endocr Disord. 2014 Oct 28; 14:86. PMID: 25348326.
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    22. Simerman AA, Hill DL, Grogan TR, Elashoff D, Clarke NJ, Goldstein EH, Manrriquez AN, Chazenbalk GD, Dumesic DA. Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization. Fertil Steril. 2015 Jan; 103(1):249-57. PMID: 25439840.
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    23. Simerman AA, Dumesic DA, Chazenbalk GD. Pluripotent muse cells derived from human adipose tissue: a new perspective on regenerative medicine and cell therapy. Clin Transl Med. 2014; 3:12. PMID: 24940477.
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    24. Simerman AA, Perone MJ, Gimeno ML, Dumesic DA, Chazenbalk GD. A mystery unraveled: nontumorigenic pluripotent stem cells in human adult tissues. Expert Opin Biol Ther. 2014 Jul; 14(7):917-29. PMID: 24745973.
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    25. Keller E, Chazenbalk GD, Aguilera P, Madrigal V, Grogan T, Elashoff D, Dumesic DA, Abbott DH. Impaired preadipocyte differentiation into adipocytes in subcutaneous abdominal adipose of PCOS-like female rhesus monkeys. Endocrinology. 2014 Jul; 155(7):2696-703. PMID: 24735327.
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    26. Dumesic DA, Goodarzi MO, Chazenbalk GD, Abbott DH. Intrauterine environment and polycystic ovary syndrome. Semin Reprod Med. 2014 May; 32(3):159-65. PMID: 24715510.
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    27. Amin M, Simerman A, Cho M, Singh P, Briton-Jones C, Hill D, Grogan T, Elashoff D, Clarke NJ, Chazenbalk GD, Dumesic DA. 21-Hydroxylase-derived steroids in follicles of nonobese women undergoing ovarian stimulation for in vitro fertilization (IVF) positively correlate with lipid content of luteinized granulosa cells (LGCs) as a source of cholesterol for steroid synthesis. J Clin Endocrinol Metab. 2014 Apr; 99(4):1299-306. PMID: 24423334.
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    28. Jumabay M, Abdmaulen R, Ly A, Cubberly MR, Shahmirian LJ, Heydarkhan-Hagvall S, Dumesic DA, Yao Y, Boström KI. Pluripotent stem cells derived from mouse and human white mature adipocytes. Stem Cells Transl Med. 2014 Feb; 3(2):161-71. PMID: 24396033.
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    29. Chazenbalk G, Singh P, Irge D, Shah A, Abbott DH, Dumesic DA. Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation. Steroids. 2013 Sep; 78(9):920-6. PMID: 23707571.
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    30. Carmina E, Dumesic D. Introduction to the special issue: 2012 AE-PCOS meeting. Steroids. 2013 Aug; 78(8):733. PMID: 23643846.
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    31. Dumesic DA, Lobo RA. Cancer risk and PCOS. Steroids. 2013 Aug; 78(8):782-5. PMID: 23624028.
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    32. Singh P, Amin M, Keller E, Simerman A, Aguilera P, Briton-Jones C, Hill DL, Abbott DH, Chazenbalk G, Dumesic DA. A novel approach to quantifying ovarian cell lipid content and lipid accumulation in vitro by confocal microscopy in lean women undergoing ovarian stimulation for in vitro fertilization (IVF). J Assist Reprod Genet. 2013 Jun; 30(5):733-40. PMID: 23512091.
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    33. Dumesic DA, Richards JS. Ontogeny of the ovary in polycystic ovary syndrome. Fertil Steril. 2013 Jul; 100(1):23-38. PMID: 23472949.
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    34. Mehta J, Kamdar V, Dumesic D. Phenotypic expression of polycystic ovary syndrome in South Asian women. Obstet Gynecol Surv. 2013 Mar; 68(3):228-34. PMID: 23945839.
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    35. Ezeh U, Pall M, Mathur R, Dey D, Berman D, Chen IY, Dumesic DA, Azziz R. Effects of endogenous androgens and abdominal fat distribution on the interrelationship between insulin and non-insulin-mediated glucose uptake in females. J Clin Endocrinol Metab. 2013 Apr; 98(4):1541-8. PMID: 23450052.
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    36. Abbott DH, Nicol LE, Levine JE, Xu N, Goodarzi MO, Dumesic DA. Nonhuman primate models of polycystic ovary syndrome. Mol Cell Endocrinol. 2013 Jul 05; 373(1-2):21-8. PMID: 23370180.
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    37. Abbott AD, Colman RJ, Tiefenthaler R, Dumesic DA, Abbott DH. Early-to-mid gestation fetal testosterone increases right hand 2D:4D finger length ratio in polycystic ovary syndrome-like monkeys. PLoS One. 2012; 7(8):e42372. PMID: 22927929.
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    38. Kroener L, Ambartsumyan G, Briton-Jones C, Dumesic D, Surrey M, Munné S, Hill D. The effect of timing of embryonic progression on chromosomal abnormality. Fertil Steril. 2012 Oct; 98(4):876-80. PMID: 22789142.
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    39. Carmina E, Dumesic D. Androgen disorders. Steroids. 2012 Mar 10; 77(4):289. PMID: 22178786.
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    40. Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, Carmina E, Chang J, Yildiz BO, Laven JS, Boivin J, Petraglia F, Wijeyeratne CN, Norman RJ, Dunaif A, Franks S, Wild RA, Dumesic D, Barnhart K. Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril. 2012 Jan; 97(1):28-38.e25. PMID: 22153789.
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    41. Xu N, Kwon S, Abbott DH, Geller DH, Dumesic DA, Azziz R, Guo X, Goodarzi MO. Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys. PLoS One. 2011; 6(11):e27286. PMID: 22076147.
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    42. Chazenbalk G, Bertolotto C, Heneidi S, Jumabay M, Trivax B, Aronowitz J, Yoshimura K, Simmons CF, Dumesic DA, Azziz R. Novel pathway of adipogenesis through cross-talk between adipose tissue macrophages, adipose stem cells and adipocytes: evidence of cell plasticity. PLoS One. 2011 Mar 31; 6(3):e17834. PMID: 21483855.
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    43. Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol. 2011 Apr; 7(4):219-31. PMID: 21263450.
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    44. Azziz R, Dumesic DA, Goodarzi MO. Polycystic ovary syndrome: an ancient disorder? Fertil Steril. 2011 Apr; 95(5):1544-8. PMID: 20979996.
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    45. Wild RA, Carmina E, Diamanti-Kandarakis E, Dokras A, Escobar-Morreale HF, Futterweit W, Lobo R, Norman RJ, Talbott E, Dumesic DA. Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society. J Clin Endocrinol Metab. 2010 May; 95(5):2038-49. PMID: 20375205.
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    46. Abbott DH, Tarantal AF, Dumesic DA. Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys. Am J Primatol. 2009 Sep; 71(9):776-84. PMID: 19367587.
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    47. Dumesic DA, Lesnick TG, Stassart JP, Ball GD, Wong A, Abbott DH. Intrafollicular antimüllerian hormone levels predict follicle responsiveness to follicle-stimulating hormone (FSH) in normoandrogenic ovulatory women undergoing gonadotropin releasing-hormone analog/recombinant human FSH therapy for in vitro fertilization and embryo transfer. Fertil Steril. 2009 Jul; 92(1):217-21. PMID: 18675414.
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    48. Steckler TL, Herkimer C, Dumesic DA, Padmanabhan V. Developmental programming: excess weight gain amplifies the effects of prenatal testosterone excess on reproductive cyclicity--implication for polycystic ovary syndrome. Endocrinology. 2009 Mar; 150(3):1456-65. PMID: 18974266.
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    49. Abbott DH, Barnett DK, Levine JE, Padmanabhan V, Dumesic DA, Jacoris S, Tarantal AF. Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys. Biol Reprod. 2008 Jul; 79(1):154-63. PMID: 18385445.
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    50. Abbott DH, Zhou R, Bird IM, Dumesic DA, Conley AJ. Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome. Endocr Dev. 2008; 13:145-158. PMID: 18493139.
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    51. Dumesic DA, Abbott DH. Implications of polycystic ovary syndrome on oocyte development. Semin Reprod Med. 2008 Jan; 26(1):53-61. PMID: 18181083.
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    52. Dumesic DA, Padmanabhan V, Abbott DH. Polycystic ovary syndrome and oocyte developmental competence. Obstet Gynecol Surv. 2008 Jan; 63(1):39-48. PMID: 18081939.
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    53. Dumesic DA, Abbott DH, Padmanabhan V. Polycystic ovary syndrome and its developmental origins. Rev Endocr Metab Disord. 2007 Jun; 8(2):127-41. PMID: 17659447.
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    54. Wood JR, Dumesic DA, Abbott DH, Strauss JF. Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab. 2007 Feb; 92(2):705-13. PMID: 17148555.
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    55. Foong SC, Abbott DH, Zschunke MA, Lesnick TG, Phy JL, Dumesic DA. Follicle luteinization in hyperandrogenic follicles of polycystic ovary syndrome patients undergoing gonadotropin therapy for in vitro fertilization. J Clin Endocrinol Metab. 2006 Jun; 91(6):2327-33. PMID: 16551732.
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    56. Allemand MC, Tummon IS, Phy JL, Foong SC, Dumesic DA, Session DR. Diagnosis of polycystic ovaries by three-dimensional transvaginal ultrasound. Fertil Steril. 2006 Jan; 85(1):214-9. PMID: 16412756.
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    57. Zhou R, Bird IM, Dumesic DA, Abbott DH. Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome. J Clin Endocrinol Metab. 2005 Dec; 90(12):6630-7. PMID: 16174719.
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    58. Foong SC, Abbott DH, Lesnick TG, Session DR, Walker DL, Dumesic DA. Diminished intrafollicular estradiol levels in in vitro fertilization cycles from women with reduced ovarian response to recombinant human follicle-stimulating hormone. Fertil Steril. 2005 May; 83(5):1377-83. PMID: 15866572.
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    59. Dumesic DA, Schramm RD, Abbott DH. Early origins of polycystic ovary syndrome. Reprod Fertil Dev. 2005; 17(3):349-60. PMID: 15745643.
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    60. Phy JL, Conover CA, Abbott DH, Zschunke MA, Walker DL, Session DR, Tummon IS, Thornhill AR, Lesnick TG, Dumesic DA. Insulin and messenger ribonucleic acid expression of insulin receptor isoforms in ovarian follicles from nonhirsute ovulatory women and polycystic ovary syndrome patients. J Clin Endocrinol Metab. 2004 Jul; 89(7):3561-6. PMID: 15240646.
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    61. Tummon IS, Contag SA, Thornhill AR, Session DR, Dumesic DA, Damario MA. Cumulative first live birth after elective cryopreservation of all embryos due to ovarian hyperresponsiveness. Fertil Steril. 2004 Feb; 81(2):309-14. PMID: 14967365.
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    62. Christian RC, Dumesic DA, Behrenbeck T, Oberg AL, Sheedy PF, Fitzpatrick LA. Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003 Jun; 88(6):2562-8. PMID: 12788855.
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    63. Dumesic DA, Schramm RD, Peterson E, Paprocki AM, Zhou R, Abbott DH. Impaired developmental competence of oocytes in adult prenatally androgenized female rhesus monkeys undergoing gonadotropin stimulation for in vitro fertilization. J Clin Endocrinol Metab. 2002 Mar; 87(3):1111-9. PMID: 11889174.
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    64. Eisner JR, Barnett MA, Dumesic DA, Abbott DH. Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess. Fertil Steril. 2002 Jan; 77(1):167-72. PMID: 11779609.
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