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Fregoso, Oliver I

Title(s)Assistant Professor, Mimg
Phone3107941424
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    Collapse Research 
    Collapse Research Activities and Funding
    Defining the regulation of double-strand DNA break repair by HIV Vpr
    NIH/NIAID R01AI147837May 21, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Regulation of HIV-1 and related lentiviruses by the DNA damage response
    NIH/NIAID K22AI122824Aug 2, 2016 - Jul 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Aznarez I, Nomakuchi TT, Tetenbaum-Novatt J, Rahman MA, Fregoso O, Rees H, Krainer AR. Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1. Cell Rep. 2018 05 15; 23(7):2186-2198. PMID: 29768215.
      View in: PubMed
    2. Fregoso OI. Mind Your Cs and Gs. Cell Host Microbe. 2017 11 08; 22(5):575-576. PMID: 29120736.
      View in: PubMed
    3. Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT. Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):2729-2734. PMID: 28228523.
      View in: PubMed
    4. Fregoso OI, Emerman M. Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment. mBio. 2016 09 13; 7(5). PMID: 27624129.
      View in: PubMed
    5. Akerman M, Fregoso OI, Das S, Ruse C, Jensen MA, Pappin DJ, Zhang MQ, Krainer AR. Differential connectivity of splicing activators and repressors to the human spliceosome. Genome Biol. 2015 Jun 06; 16:119. PMID: 26047612.
      View in: PubMed
    6. Fregoso OI, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M. Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. PLoS Pathog. 2013; 9(7):e1003496. PMID: 23874202.
      View in: PubMed
    7. Das S, Fregoso OI, Krainer AR. A new path to oncogene-induced senescence: at the crossroads of splicing and translation. Cell Cycle. 2013 May 15; 12(10):1477-9. PMID: 23624837.
      View in: PubMed
    8. Fregoso OI, Das S, Akerman M, Krainer AR. Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. Mol Cell. 2013 Apr 11; 50(1):56-66. PMID: 23478443.
      View in: PubMed
    9. Bueno MT, Reyes D, Valdes L, Saheba A, Urias E, Mendoza C, Fregoso OI, Llano M. Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses. J Virol. 2013 Mar; 87(5):2496-507. PMID: 23255787.
      View in: PubMed
    10. Lim ES, Fregoso OI, McCoy CO, Matsen FA, Malik HS, Emerman M. The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe. 2012 Feb 16; 11(2):194-204. PMID: 22284954.
      View in: PubMed
    11. Sun S, Zhang Z, Fregoso O, Krainer AR. Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. RNA. 2012 Feb; 18(2):274-83. PMID: 22184459.
      View in: PubMed
    12. Bish RA, Fregoso OI, Piccini A, Myers MP. Conjugation of complex polyubiquitin chains to WRNIP1. J Proteome Res. 2008 Aug; 7(8):3481-9. PMID: 18613717.
      View in: PubMed
    13. Llano M, Vanegas M, Fregoso O, Saenz D, Chung S, Peretz M, Poeschla EM. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol. 2004 Sep; 78(17):9524-37. PMID: 15308744.
      View in: PubMed