Oliver I Fregoso

Title(s)Associate Professor, MIMG
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    Collapse Biography 
    Collapse Education and Training
    UC Santa CruzBA2003MCD Bio & Studio Art
    The Mayo ClinicPostbac2004
    Cold Spring Harbor LaboratoryPhD2011Molecular Biology
    Fred Hutchinson Cancer Research CenterPostdoc2016Viral Replication & Evolution

    Collapse Overview 
    Collapse Overview
    Dr. Oliver Fregoso is an assistant professor in the department of Microbiology, Immunology, and Molecular Genetics (MIMG). He was an undergrad at UC Santa Cruz, where he double majored in Molecular, Cellular, & Developmental Biology and Studio Art. He also played on the collegiate soccer team, but found his passion for research in the labs at UCSC. He received his PhD from Cold Spring Harbor Laboratory (New York) and did his postdoctoral work at Fred Hutch (Seattle, WA). As a grad student he worked in the lab of Dr. Adrian Krainer Lab where he used proteomics to understand roles of alternative splicing activators and repressors in splicing and other cellular processes, including cancer and senescence. For his postdoctoral studies at Fred Hutch, he worked in the lab of Dr. Michael Emerman. He worked to understand the evolution and emergence of the lentiviral accessory gene Vpx, and to understand how it overcomes antiviral restriction by innate immune proteins. While there, also started developing systems to study the interplay between the host DNA damage response and lentiviral replication.

    His lab studies the molecular mechanisms of viral replication, with a primary focus on HIV and related viruses. They are particularly interested in understanding how viruses usurp host proteins to facilitate replication and to overcome host antiviral mechanisms, and how these interactions influence the evolution of the virus and the host as well as viral cross-species transmission. In addition, the lab is investigating how HIV contributes to diseases not directly attributed to viral replication, such as disorders of the central and peripheral nervous systems. By using a unique combination of molecular biology, biochemistry, stem cell biology, and evolutionary biology, they hope to uncover novel aspects of viral replication that can lead to the development of antivirals and vaccines.

    In addition to his research, Dr. Fregoso is passionate about enhancing diversity, equity, and inclusion in the sciences. For his past and continued efforts in these areas, he was recruited to UCLA as a Mentor Professor, where he is at the forefront of UCLA’s mission to build inclusive excellence in science.
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    Collapse Research 
    Collapse Research Activities and Funding
    Integrative Modeling of HIV-Associated Neurocognitive Disorder in Human Brain Organoids
    NIH R01DA051897Aug 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Defining the regulation of double-strand DNA break repair by HIV Vpr
    NIH R01AI147837May 21, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Regulation of HIV-1 and related lentiviruses by the DNA damage response
    NIH K22AI122824Aug 2, 2016 - Jul 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chemoproteomics Identifies State-Dependent and Proteoform-Selective Caspase-2 Inhibitors. J Am Chem Soc. 2024 Jun 05; 146(22):14972-14988. Castellón JO, Ofori S, Burton NR, Julio AR, Turmon AC, Armenta E, Sandoval C, Boatner LM, Takayoshi EE, Faragalla M, Taylor C, Zhou AL, Tran K, Shek J, Yan T, Desai HS, Fregoso OI, Damoiseaux R, Backus KM. PMID: 38787738.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrest. bioRxiv. 2024 Jan 25. Sandoval C, Nisson K, Fregoso OI. PMID: 37292767; PMCID: PMC10245860.
      View in: PubMed   Mentions: 1  
    3. NSC95397 is a Novel HIV Latency Reversing Agent. bioRxiv. 2023 May 25. Nichols Doyle R, Yang V, Damoiseaux R, Fregoso OI. PMID: 37293110; PMCID: PMC10245985.
      View in: PubMed   Mentions:
    4. Distinct evolutionary trajectories of SARS-CoV-2-interacting proteins in bats and primates identify important host determinants of COVID-19. Proc Natl Acad Sci U S A. 2022 08 30; 119(35):e2206610119. Cariou M, Picard L, Guéguen L, Jacquet S, Cimarelli A, Fregoso OI, Molaro A, Navratil V, Etienne L. PMID: 35947637; PMCID: PMC9436378.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    5. Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling. Cell Rep. 2022 04 12; 39(2):110690. Johnson JR, Crosby DC, Hultquist JF, Kurland AP, Adhikary P, Li D, Marlett J, Swann J, Hüttenhain R, Verschueren E, Johnson TL, Newton BW, Shales M, Simon VA, Beltrao P, Frankel AD, Marson A, Cox JS, Fregoso OI, Young JAT, Krogan NJ. PMID: 35417684; PMCID: PMC9429972.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    6. Viral Modulation of the DNA Damage Response and Innate Immunity: Two Sides of the Same Coin. J Mol Biol. 2022 03 30; 434(6):167327. Lopez A, Nichols Doyle R, Sandoval C, Nisson K, Yang V, Fregoso OI. PMID: 34695379; PMCID: PMC9119581.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair. mBio. 2020 08 04; 11(4). Li D, Lopez A, Sandoval C, Nichols Doyle R, Fregoso OI. PMID: 32753492; PMCID: PMC7407082.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    8. Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1. Cell Rep. 2018 05 15; 23(7):2186-2198. Aznarez I, Nomakuchi TT, Tetenbaum-Novatt J, Rahman MA, Fregoso O, Rees H, Krainer AR. PMID: 29768215; PMCID: PMC5999336.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    9. Mind Your Cs and Gs. Cell Host Microbe. 2017 11 08; 22(5):575-576. Fregoso OI. PMID: 29120736.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):2729-2734. Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT. PMID: 28228523; PMCID: PMC5347584.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    11. Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment. mBio. 2016 09 13; 7(5). Fregoso OI, Emerman M. PMID: 27624129; PMCID: PMC5021806.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    12. Differential connectivity of splicing activators and repressors to the human spliceosome. Genome Biol. 2015 Jun 06; 16:119. Akerman M, Fregoso OI, Das S, Ruse C, Jensen MA, Pappin DJ, Zhang MQ, Krainer AR. PMID: 26047612; PMCID: PMC4502471.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    13. Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. PLoS Pathog. 2013; 9(7):e1003496. Fregoso OI, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M. PMID: 23874202; PMCID: PMC3715410.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    14. A new path to oncogene-induced senescence: at the crossroads of splicing and translation. Cell Cycle. 2013 May 15; 12(10):1477-9. Das S, Fregoso OI, Krainer AR. PMID: 23624837; PMCID: PMC3680522.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. Mol Cell. 2013 Apr 11; 50(1):56-66. Fregoso OI, Das S, Akerman M, Krainer AR. PMID: 23478443; PMCID: PMC3628402.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    16. Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses. J Virol. 2013 Mar; 87(5):2496-507. Bueno MT, Reyes D, Valdes L, Saheba A, Urias E, Mendoza C, Fregoso OI, Llano M. PMID: 23255787; PMCID: PMC3571415.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    17. The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe. 2012 Feb 16; 11(2):194-204. Lim ES, Fregoso OI, McCoy CO, Matsen FA, Malik HS, Emerman M. PMID: 22284954; PMCID: PMC3288607.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    18. Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. RNA. 2012 Feb; 18(2):274-83. Sun S, Zhang Z, Fregoso O, Krainer AR. PMID: 22184459; PMCID: PMC3264914.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    19. Conjugation of complex polyubiquitin chains to WRNIP1. J Proteome Res. 2008 Aug; 7(8):3481-9. Bish RA, Fregoso OI, Piccini A, Myers MP. PMID: 18613717.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol. 2004 Sep; 78(17):9524-37. Llano M, Vanegas M, Fregoso O, Saenz D, Chung S, Peretz M, Poeschla EM. PMID: 15308744; PMCID: PMC506940.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
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