Oliver I Fregoso

Title(s)Assistant Professor, MIMG
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    Integrative Modeling of HIV-Associated Neurocognitive Disorder in Human Brain Organoids
    NIH R01DA051897Aug 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Defining the regulation of double-strand DNA break repair by HIV Vpr
    NIH R01AI147837May 21, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Regulation of HIV-1 and related lentiviruses by the DNA damage response
    NIH K22AI122824Aug 2, 2016 - Jul 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Distinct evolutionary trajectories of SARS-CoV-2-interacting proteins in bats and primates identify important host determinants of COVID-19. Proc Natl Acad Sci U S A. 2022 08 30; 119(35):e2206610119. Cariou M, Picard L, Gu?guen L, Jacquet S, Cimarelli A, Fregoso OI, Molaro A, Navratil V, Etienne L. PMID: 35947637; PMCID: PMC9436378.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    2. Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling. Cell Rep. 2022 04 12; 39(2):110690. Johnson JR, Crosby DC, Hultquist JF, Kurland AP, Adhikary P, Li D, Marlett J, Swann J, H?ttenhain R, Verschueren E, Johnson TL, Newton BW, Shales M, Simon VA, Beltrao P, Frankel AD, Marson A, Cox JS, Fregoso OI, Young JAT, Krogan NJ. PMID: 35417684; PMCID: PMC9429972.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Viral Modulation of the DNA Damage Response and Innate Immunity: Two Sides of the Same Coin. J Mol Biol. 2022 03 30; 434(6):167327. Lopez A, Nichols Doyle R, Sandoval C, Nisson K, Yang V, Fregoso OI. PMID: 34695379; PMCID: PMC9119581.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair. mBio. 2020 08 04; 11(4). Li D, Lopez A, Sandoval C, Nichols Doyle R, Fregoso OI. PMID: 32753492; PMCID: PMC7407082.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1. Cell Rep. 2018 05 15; 23(7):2186-2198. Aznarez I, Nomakuchi TT, Tetenbaum-Novatt J, Rahman MA, Fregoso O, Rees H, Krainer AR. PMID: 29768215; PMCID: PMC5999336.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    6. Mind Your Cs and Gs. Cell Host Microbe. 2017 11 08; 22(5):575-576. Fregoso OI. PMID: 29120736.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):2729-2734. Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, K?nig R, Kim B, Emerman M, Fackler OT, Keppler OT. PMID: 28228523; PMCID: PMC5347584.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    8. Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment. mBio. 2016 09 13; 7(5). Fregoso OI, Emerman M. PMID: 27624129; PMCID: PMC5021806.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    9. Differential connectivity of splicing activators and repressors to the human spliceosome. Genome Biol. 2015 Jun 06; 16:119. Akerman M, Fregoso OI, Das S, Ruse C, Jensen MA, Pappin DJ, Zhang MQ, Krainer AR. PMID: 26047612; PMCID: PMC4502471.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    10. Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. PLoS Pathog. 2013; 9(7):e1003496. Fregoso OI, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M. PMID: 23874202; PMCID: PMC3715410.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    11. A new path to oncogene-induced senescence: at the crossroads of splicing and translation. Cell Cycle. 2013 May 15; 12(10):1477-9. Das S, Fregoso OI, Krainer AR. PMID: 23624837; PMCID: PMC3680522.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. Mol Cell. 2013 Apr 11; 50(1):56-66. Fregoso OI, Das S, Akerman M, Krainer AR. PMID: 23478443; PMCID: PMC3628402.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    13. Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses. J Virol. 2013 Mar; 87(5):2496-507. Bueno MT, Reyes D, Valdes L, Saheba A, Urias E, Mendoza C, Fregoso OI, Llano M. PMID: 23255787; PMCID: PMC3571415.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    14. The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe. 2012 Feb 16; 11(2):194-204. Lim ES, Fregoso OI, McCoy CO, Matsen FA, Malik HS, Emerman M. PMID: 22284954; PMCID: PMC3288607.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    15. Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. RNA. 2012 Feb; 18(2):274-83. Sun S, Zhang Z, Fregoso O, Krainer AR. PMID: 22184459; PMCID: PMC3264914.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    16. Conjugation of complex polyubiquitin chains to WRNIP1. J Proteome Res. 2008 Aug; 7(8):3481-9. Bish RA, Fregoso OI, Piccini A, Myers MP. PMID: 18613717.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol. 2004 Sep; 78(17):9524-37. Llano M, Vanegas M, Fregoso O, Saenz D, Chung S, Peretz M, Poeschla EM. PMID: 15308744; PMCID: PMC506940.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansCells
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