Yong Wu

Title(s)Associate Adjunct Professor, Medicine
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    Yong Wu, M.D., Ph.D., holds faculty positions at David Geffen School of Medicine at the University of California, Los Angeles (UCLA). He is also an Associate Professor and Core Director for the Drug Discovery Program in Charles Drew University of Medicine and Science. Dr. Wu has a broad background in pharmacology, molecular and cellular biology of diabetes and cancer, and has experiences in anti-cancer drug design and discovery. He is a member of the American Association for Cancer Research and American Heart Association, among others.
    Currently, He is engaged in investigating the links between metabolic syndrome and cancer, specifically focusing on the fundamental mechanisms by which elevated blood glucose and fatty acids increase breast cancer risk and progression. This is a key area of interest in the Division of Cancer Research and Training. His current research has also been focused on (1) elucidating a safe and effective therapeutic strategy to preferentially kill the malignant cells that are dependent on glycolytic pathway with a minor effect on normal cells; (2) Design, synthesis, modification, and biological evaluation of small molecule anti-cancer compounds for breast cancer therapeutic development.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Brief Intervention With Instant Messaging or Regular Text Messaging Support in Reducing Alcohol Use: A Randomized Clinical Trial. JAMA Intern Med. 2024 Apr 08. Chau SL, Luk TT, Wong BYC, Wu YS, Cheung YTD, Ho SY, Kim JH, Lo HHM, Lam TH, Wang MP. PMID: 38587827; PMCID: PMC11002763.
      View in: PubMed   Mentions:
    2. Perception of heated tobacco products and support for regulations: a cross-sectional study in Hong Kong. Tob Control. 2024 Mar 19; 33(e1):e132-e135. Wu YS, Cheung YTD, Ho SY, Tong HSC, Lai VWY, Lam TH, Wang MP. PMID: 36344255.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Association between tobacco industry denormalisation beliefs and support for tobacco endgame policies: a population-based study in Hong Kong. Tob Control. 2024 Mar 08. Yao Y, Cheung YTD, Wu YS, Guo Z, Chan SK, Zhao SZ, Tong HSC, Lai VWY, Lam TH, Ho SY, Wang MP. PMID: 38458757.
      View in: PubMed   Mentions:    Fields:    
    4. Perceptions of and responses of young adults who use e-cigarettes to flavour bans in China: a qualitative study. Tob Control. 2024 Jan 24. Weng X, Song CY, Liu K, Wu YS, Lee JJ, Guo N, Wang MP. PMID: 38267214.
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    5. Impact of mandatory masking amid the COVID-19 pandemic on outdoor smoking: an interrupted time-series analysis of a 33-month unobtrusive observational study. Front Public Health. 2023; 11:1136621. Sun Y, Wu YS, Cheung YTD, Wang MP, Chen J, Leung LT, Zhang X, Chak KY, Lam TH, Ho SY. PMID: 37521998; PMCID: PMC10372439.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    6. Associations of the perceived benefits and harms of COVID-19 with confidence in coping with the pandemic and mental health symptoms: a population-based survey in Hong Kong. Front Public Health. 2023; 11:1175085. Yao Y, Gong WJ, Lai AYK, Wu YS, Sit SMM, Wang MP, Ho SY, Lam TH. PMID: 37408744; PMCID: PMC10318160.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    7. Effect of smoking-related COVID-19 risk messaging on smoking cessation in community smokers: A pragmatic randomized controlled trial. Tob Induc Dis. 2023; 21:77. Weng X, Luk TT, Wu YS, Zhao SZ, Cheung DYT, Tong HSC, Lai VWY, Lam TH, Wang MP. PMID: 37323509; PMCID: PMC10266330.
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    8. Perceived increased susceptibility to COVID-19 due to smoking was associated with reduced smoking at home but not on the streets amid the pandemic: A population-based cross-sectional study. Tob Induc Dis. 2023; 21:56. Yao Y, Cheung DYT, Luk TT, Lam TH, Wu YS, Wang MP. PMID: 37153726; PMCID: PMC10161687.
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    9. Effect of mobile interventions with nicotine replacement therapy sampling on long-term smoking cessation in community smokers: A pragmatic randomized clinical trial. Tob Induc Dis. 2023; 21:44. Guo N, Luk TT, Wu YS, Guo Z, Chu JCL, Cheung YTD, Chan CHH, Kwok TTO, Wong VYL, Wong CKH, Lee JJ, Kwok YK, Viswanath K, Lam TH, Wang MP. PMID: 36969982; PMCID: PMC10037427.
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    10. Cigarettes, heated tobacco products and dual use: exhaled carbon monoxide, saliva cotinine and total tobacco consumed by Hong Kong tobacco users. Tob Control. 2023 Jan 24. Zhang X, Sun Y, Cheung YTD, Wang MP, Wu YS, Chak KY, Chen J, Leung LT, Lam TH, Ho SY. PMID: 36693724.
      View in: PubMed   Mentions: 1     Fields:    
    11. Workplace cessation support is associated with more abstinence in a workplace program in Hong Kong: A mixed-methods study. Tob Induc Dis. 2022; 20:114. Guo Z, Weng X, Lau AOS, Ng MCH, Wu YS, Lam TH, Wang MP. PMID: 36588924; PMCID: PMC9782256.
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    12. Associations of changes in smoking-related practices with quit attempt and smoking consumption during the COVID-19 pandemic: A mixed-methods study. Tob Induc Dis. 2022; 20:20. Zeng Y, Luk TT, Wu YS, Tong SC?, Lai WYV, Lam TH, Wang MP. PMID: 36588925; PMCID: PMC9782258.
      View in: PubMed   Mentions: 1  
    13. A content analysis of heated tobacco product business in Hong Kong on Facebook. Health Soc Care Community. 2022 Sep 05. Wu YS, Chan HL, Ho SY, Zhao SZ, Luk TT, Lam TH, Wang MP. PMID: 36062525.
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    14. Changes in tobacco use at the early stage of the COVID-19 pandemic: Results of four cross-sectional surveys in Hong Kong. Tob Induc Dis. 2022; 20:26. Sun Y, Wang MP, Cheung YTD, Ho SY, Luk TT, Zhao S, Wu YS, Wong BY, Weng X, Chen J, Zhang X, Leung LT, Chak KY, Lam TH. PMID: 35342385; PMCID: PMC8895477.
      View in: PubMed   Mentions: 7  
    15. Brief Advice, Nicotine Replacement Therapy Sampling, and Active Referral for Expectant Fathers Who Smoke Cigarettes: A Randomized Clinical Trial. JAMA Intern Med. 2021 08 01; 181(8):1081-1089. Luk TT, Lam TH, Leung WC, Leung KY, Cheung KW, Kwa C, Siong KH, Tang KK, Lee KW, Hsieh CJ, Wu YS, Li WH, Wang MP. PMID: 34125135; PMCID: PMC8204256.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Wild-Type TP53 Predicts Poor Prognosis in Patients with Gastric Cancer. Journal of Cancer Science and Clinical Therapeutics 5 (2021): 134-153. 2021. Wenhong Deng, Qiongyu Hao, Jaydutt Vadgama, Yong Wu. .
    17. Basal-like breast cancer with low TGFβ and high TNFα pathway activity is rich in activated memory CD4 T cells and has a good prognosis. Int J Biol Sci. 2021 Jan 30;17(3):670-682. doi: 10.7150/ijbs.56128. eCollection 2021. 2021. Liu D, Vadgama J, Wu Y.
    18. Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA. Cell Death Dis. 2020 Dec 11;11(12):1052. doi: 10.1038/s41419-020-03235-w. PMID: 33311440; PMCID: PMC7733521. 2021. 4. Hao Q, Wang P, Dutta P, Chung S, Li Q, Wang K, Li J, Cao W, Deng W, Geng Q, Schrode K, Shaheen M, Wu K, Zhu D, Chen QH, Chen G, Elshimali Y, Vadgama J, Wu Y.
    19. Association of an anaplastic lymphoma kinase pathway signature with cell de-differentiation, neoadjuvant chemotherapy response, and recurrence risk in breast cancer. Cancer Commun (Lond). 2020 Sep;40(9):422-434. doi: 10.1002/cac2.12038. Epub 2020 Aug 21. PMID: 32822101; PMCID: PMC7494065. 2021. Liu D, Wu Y*.
    20. The role of PPM1D in cancer and advances in studies of its inhibitors. Biomed Pharmacother. 2020 Jan 29;125:109956. doi: 10.1016/j.biopha.2020.109956. [Epub ahead of print]. PMID: 32006900. 2021. Deng W, Li J, Dorrah K, Jimenez-Tapia D2 Arriaga B, Hao Q, Cao W, Gao Z, Vadgama J, Wu Y*.
    21. PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response. Sci Adv. 2019 Oct 16;5(10):eaaw8417. doi: 10.1126/sciadv.aaw8417. eCollection 2019 Oct. (PMCID: PMC6795508). 2021. Li Q, Hao Q, Cao W, Li J, Wu K, Elshimali Y, Zhu D, Chen Q, Chen G, Pollack J, Vadgama JV, and Wu Y*.
    22. AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer. Breast Cancer Res. 2019 Feb 21;21(1):29. doi: 10.1186/s13058-019-1107-2. (*corresponding author) (PMCID: PMC6385460). 2021. Cao W, Li J, Hao Q, Vadgama JV*, Wu Y*.
    23. Targeting of PP2cδ By A Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression In Vivo. Antioxid Redox Signal. 2019 Jun 10;30(17):1983-1998. (*corresponding author) (PMCID: PMC6486665). 2021. Wu K, Yu X, Huang Z, Zhu D, Yi X, Wu YL, Hao Q, Kemp KT 2nd, Elshimali Y, Iyer R, Nguyen KT, Zheng S, Chen G, Chen QH, Wang G, Vadgama JV, Wu Y*.
    24. Mobile chat-based support plus nicotine replacement therapy sampling to promote smoking cessation for community smokers: A randomized controlled trial. Tob Induc Dis. 2021; 19:32. Zhao SZ, Wu YS, Chau SL, Fong DYT, Lam TH, Wang MP. PMID: 33927586; PMCID: PMC8078100.
      View in: PubMed   Mentions: 2  
    25. Association of heated tobacco product use with smoking cessation in Chinese cigarette smokers in Hong Kong: a prospective study. Tob Control. 2021 11; 30(6):653-659. Luk TT, Weng X, Wu YS, Chan HL, Lau CY, Kwong AC, Lai VW, Lam TH, Wang MP. PMID: 32912861.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Exposure to health misinformation about COVID-19 and increased tobacco and alcohol use: a population-based survey in Hong Kong. Tob Control. 2021 11; 30(6):696-699. Luk TT, Zhao S, Weng X, Wong JY, Wu YS, Ho SY, Lam TH, Wang MP. PMID: 32855353.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    27. Positive perceptions of electronic cigarettes relative to combustible cigarettes are associated with weaker support for endgame policies on combustible cigarettes: A population-based cross-sectional study in Hong Kong. Tob Induc Dis. 2019; 17:61. Wu YS, Wang MP, Ho SY, Cheung YT, Kwong A, Lai V, Lam TH. PMID: 31582950; PMCID: PMC6770616.
      View in: PubMed   Mentions: 3  
    28. Heated tobacco products use in Chinese adults in Hong Kong: a population-based cross-sectional study. Tob Control. 2020 05; 29(3):277-281. Wu YS, Wang MP, Ho SY, Li HCW, Cheung YTD, Tabuchi T, Kwong AC, Lai V, Lam TH. PMID: 31005892.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    29. Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis. Cancer Res. 2017 03 15; 77(6):1383-1394. Wu Y, Yu X, Yi X, Wu K, Dwabe S, Atefi M, Elshimali Y, Kemp KT, Bhat K, Haro J, Sarkissyan M, Vadgama JV. PMID: 28115363; PMCID: PMC5354968.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    30. Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing. Breast Cancer Res Treat. 2015 Jun; 151(3):529-39. Wu Y, Sarkissyan M, Mcghee E, Lee S, Vadgama JV. PMID: 25975952; PMCID: PMC4668274.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
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