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Yosuke Tanigawa

Title(s)Assistant Professor, Bioengineering
SchoolHenry Samueli School of Engineering and Applied Science
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience. Cell. 2025 Sep 04; 188(18):4980-5002.e29. Liu Z, Zhang S, James BT, Galani K, Mangan RJ, Fass SB, Liang C, Wagle MM, Boix CA, Tanigawa Y, Yun S, Sung Y, Xiong X, Sun N, Hou L, Wohlwend M, Qiu M, Han X, Xiong L, Preka E, Huang L, Li WF, Ho LL, Grayson A, Mantero J, Kozlenkov A, Mathys H, Chen T, Dracheva S, Bennett DA, Tsai LH, Kellis M. PMID: 40752494; PMCID: PMC12573303.
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    2. Cellular and Regional Vulnerability Shapes the Molecular Landscape of Psychosis in Alzheimer's Disease. bioRxiv. 2025 May 07. Victor MB, Sun N, Galani K, Leary N, Tanigawa Y, Scannail AN, Ho LL, Prosper S, Liu L, Kofler JK, Sweet RA, Tsai LH, Kellis M. PMID: 40654787; PMCID: PMC12247970.
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    3. Genetics of cardiometabolic disease progression. medRxiv. 2025 Feb 03. Justesen JM, Venkataraman G, Tanigawa Y, Li R, Hastie T, Tibshirani R, Knowles JW, Rivas MA. PMID: 39974115; PMCID: PMC11838626.
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    4. Hypometric genetics: Improved power in genetic discovery by incorporating quality control flags. Am J Hum Genet. 2024 Nov 07; 111(11):2478-2493. Tanigawa Y, Kellis M. PMID: 39442521; PMCID: PMC11568753.
      View in: PubMed   Mentions:
    5. A polygenic score method boosted by non-additive models. Nat Commun. 2024 May 29; 15(1):4433. Ohta R, Tanigawa Y, Suzuki Y, Kellis M, Morishita S. PMID: 38811555; PMCID: PMC11522481.
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    6. Power of inclusion: Enhancing polygenic prediction with admixed individuals. Am J Hum Genet. 2023 11 02; 110(11):1888-1902. Tanigawa Y, Kellis M. PMID: 37890495; PMCID: PMC10645553.
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    7. Human microglial state dynamics in Alzheimer's disease progression. Cell. 2023 09 28; 186(20):4386-4403.e29. Sun N, Victor MB, Park YP, Xiong X, Scannail AN, Leary N, Prosper S, Viswanathan S, Luna X, Boix CA, James BT, Tanigawa Y, Galani K, Mathys H, Jiang X, Ng AP, Bennett DA, Tsai LH, Kellis M. PMID: 37774678; PMCID: PMC10644954.
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    8. Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells. Cell Metab. 2022 10 04; 34(10):1578-1593.e6. Yang J, Vamvini M, Nigro P, Ho LL, Galani K, Alvarez M, Tanigawa Y, Renfro A, Carbone NP, Laakso M, Agudelo LZ, Pajukanta P, Hirshman MF, Middelbeek RJW, Grove K, Goodyear LJ, Kellis M. PMID: 36198295; PMCID: PMC9558082.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    9. WhichTF is functionally important in your open chromatin data? PLoS Comput Biol. 2022 08; 18(8):e1010378. Tanigawa Y, Dyer ES, Bejerano G. PMID: 36040971; PMCID: PMC9426921.
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    10. Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy. Nat Commun. 2022 08 30; 13(1):5107. Parikh VN, Ioannidis AG, Jimenez-Morales D, Gorzynski JE, De Jong HN, Liu X, Roque J, Cepeda-Espinoza VP, Osoegawa K, Hughes C, Sutton SC, Youlton N, Joshi R, Amar D, Tanigawa Y, Russo D, Wong J, Lauzon JT, Edelson J, Mas Montserrat D, Kwon Y, Rubinacci S, Delaneau O, Cappello L, Kim J, Shoura MJ, Raja AN, Watson N, Hammond N, Spiteri E, Mallempati KC, Montero-Martín G, Christle J, Kim J, Kirillova A, Seo K, Huang Y, Zhao C, Moreno-Grau S, Hershman SG, Dalton KP, Zhen J, Kamm J, Bhatt KD, Isakova A, Morri M, Ranganath T, Blish CA, Rogers AJ, Nadeau K, Yang S, Blomkalns A, O'Hara R, Neff NF, DeBoever C, Szalma S, Wheeler MT, Gates CM, Farh K, Schroth GP, Febbo P, deSouza F, Cornejo OE, Fernandez-Vina M, Kistler A, Palacios JA, Pinsky BA, Bustamante CD, Rivas MA, Ashley EA. PMID: 36042219; PMCID: PMC9426371.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    11. LARGE-SCALE MULTIVARIATE SPARSE REGRESSION WITH APPLICATIONS TO UK BIOBANK. Ann Appl Stat. 2022 Sep; 16(3):1891-1918. Qian J, Tanigawa Y, Li R, Tibshirani R, Rivas MA, Hastie T. PMID: 36091495; PMCID: PMC9454085.
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    12. Integration of rare expression outlier-associated variants improves polygenic risk prediction. Am J Hum Genet. 2022 06 02; 109(6):1055-1064. Smail C, Ferraro NM, Hui Q, Durrant MG, Aguirre M, Tanigawa Y, Keever-Keigher MR, Rao AS, Justesen JM, Li X, Gloudemans MJ, Assimes TL, Kooperberg C, Reiner AP, Huang J, O'Donnell CJ, Sun YV, Million Veteran Program, Rivas MA, Montgomery SB. PMID: 35588732; PMCID: PMC9247823.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    13. Fast Lasso method for large-scale and ultrahigh-dimensional Cox model with applications to UK Biobank. Biostatistics. 2022 04 13; 23(2):522-540. Li R, Chang C, Justesen JM, Tanigawa Y, Qian J, Hastie T, Rivas MA, Tibshirani R. PMID: 32989444; PMCID: PMC9007437.
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    14. Corrigendum to: Fast Lasso method for large-scale and ultrahigh-dimensional Cox model with applications to UK Biobank. Biostatistics. 2022 Apr 13; 23(2):683. Li R, Chang C, Justesen JM, Tanigawa Y, Qian J, Hastie T, Rivas MA, Tibshirani R. PMID: 34269393; PMCID: PMC9216480.
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    15. Significant sparse polygenic risk scores across 813 traits in UK Biobank. PLoS Genet. 2022 03; 18(3):e1010105. Tanigawa Y, Qian J, Venkataraman G, Justesen JM, Li R, Tibshirani R, Hastie T, Rivas MA. PMID: 35324888; PMCID: PMC8946745.
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    16. Survival analysis on rare events using group-regularized multi-response Cox regression. Bioinformatics. 2021 12 07; 37(23):4437-4443. Li R, Tanigawa Y, Justesen JM, Taylor J, Hastie T, Tibshirani R, Rivas MA. PMID: 33560296; PMCID: PMC8652035.
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    17. Bayesian model comparison for rare-variant association studies. Am J Hum Genet. 2021 12 02; 108(12):2354-2367. Venkataraman GR, DeBoever C, Tanigawa Y, Aguirre M, Ioannidis AG, Mostafavi H, Spencer CCA, Poterba T, Bustamante CD, Daly MJ, Pirinen M, Rivas MA. PMID: 34822764; PMCID: PMC8715195.
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    18. Fast numerical optimization for genome sequencing data in population biobanks. Bioinformatics. 2021 11 18; 37(22):4148-4155. Li R, Chang C, Tanigawa Y, Narasimhan B, Hastie T, Tibshirani R, Rivas MA. PMID: 34146108; PMCID: PMC9206591.
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    19. Author Correction: Genetics of 35 blood and urine biomarkers in the UK Biobank. Nat Genet. 2021 Nov; 53(11):1622. Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP, Qian J, Shcherbina A, FinnGen, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA. PMID: 34608296; PMCID: PMC12312872.
      View in: PubMed   Mentions: 5     Fields:    
    20. A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet. 2021 10; 53(10):1415-1424. Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, FinnGen, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y. PMID: 34594039; PMCID: PMC12208603.
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    21. APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups. Lipids Health Dis. 2021 Sep 21; 20(1):113. Goyal S, Tanigawa Y, Zhang W, Chai JF, Almeida M, Sim X, Lerner M, Chainakul J, Ramiu JG, Seraphin C, Apple B, Vaughan A, Muniu J, Peralta J, Lehman DM, Ralhan S, Wander GS, Singh JR, Mehra NK, Sidorov E, Peyton MD, Blackett PR, Curran JE, Tai ES, van Dam R, Cheng CY, Duggirala R, Blangero J, Chambers JC, Sabanayagam C, Kooner JS, Rivas MA, Aston CE, Sanghera DK. PMID: 34548093; PMCID: PMC8456544.
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    22. Polygenic risk modeling with latent trait-related genetic components. Eur J Hum Genet. 2021 07; 29(7):1071-1081. Aguirre M, Tanigawa Y, Venkataraman GR, Tibshirani R, Hastie T, Rivas MA. PMID: 33558700; PMCID: PMC8298449.
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    23. Genetics of 35 blood and urine biomarkers in the UK Biobank. Nat Genet. 2021 02; 53(2):185-194. Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP, Qian J, Shcherbina A, FinnGen, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA. PMID: 33462484; PMCID: PMC7867639.
      View in: PubMed   Mentions: 393     Fields:    Translation:Humans
    24. Cardiac Imaging of Aortic Valve Area From 34 287 UK Biobank Participants Reveals Novel Genetic Associations and Shared Genetic Comorbidity With Multiple Disease Phenotypes. Circ Genom Precis Med. 2020 12; 13(6):e003014. Córdova-Palomera A, Tcheandjieu C, Fries JA, Varma P, Chen VS, Fiterau M, Xiao K, Tejeda H, Keavney BD, Cordell HJ, Tanigawa Y, Venkataraman G, Rivas MA, Ré C, Ashley E, Priest JR. PMID: 33125279; PMCID: PMC12184884.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    25. A fast and scalable framework for large-scale and ultrahigh-dimensional sparse regression with application to the UK Biobank. PLoS Genet. 2020 10; 16(10):e1009141. Qian J, Tanigawa Y, Du W, Aguirre M, Chang C, Tibshirani R, Rivas MA, Hastie T. PMID: 33095761; PMCID: PMC7641476.
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    26. Sex-specific genetic effects across biomarkers. Eur J Hum Genet. 2021 01; 29(1):154-163. Flynn E, Tanigawa Y, Rodriguez F, Altman RB, Sinnott-Armstrong N, Rivas MA. PMID: 32873964; PMCID: PMC7794464.
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    27. High-throughput SARS-CoV-2 and host genome sequencing from single nasopharyngeal swabs. medRxiv. 2020 Sep 01. Gorzynski JE, De Jong HN, Amar D, Hughes CR, Ioannidis A, Bierman R, Liu D, Tanigawa Y, Kistler A, Kamm J, Kim J, Cappello L, Neff NF, Rubinacci S, Delaneau O, Shoura MJ, Seo K, Kirillova A, Raja A, Sutton S, Huang C, Sahoo MK, Mallempati KC, Montero-Martin G, Osoegawa K, Jimenez-Morales D, Watson N, Hammond N, Joshi R, Fernandez-Vina M, Christle JW, Wheeler MT, Febbo P, Farh K, Schroth G, Desouza F, Palacios J, Salzman J, Pinsky BA, Rivas MA, Bustamante CD, Ashley EA, Parikh VN. PMID: 32766602; PMCID: PMC7402057.
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    28. Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma. PLoS Genet. 2020 05; 16(5):e1008682. Tanigawa Y, Wainberg M, Karjalainen J, Kiiskinen T, Venkataraman G, Lemmelä S, Turunen JA, Graham RR, Havulinna AS, Perola M, Palotie A, FinnGen, Daly MJ, Rivas MA. PMID: 32369491; PMCID: PMC7199928.
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    29. Assessing Digital Phenotyping to Enhance Genetic Studies of Human Diseases. Am J Hum Genet. 2020 05 07; 106(5):611-622. DeBoever C, Tanigawa Y, Aguirre M, McInnes G, Lavertu A, Rivas MA. PMID: 32275883; PMCID: PMC7212271.
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    30. Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology. Nat Commun. 2019 09 06; 10(1):4064. Tanigawa Y, Li J, Justesen JM, Horn H, Aguirre M, DeBoever C, Chang C, Narasimhan B, Lage K, Hastie T, Park CY, Bejerano G, Ingelsson E, Rivas MA. PMID: 31492854; PMCID: PMC6731283.
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    31. Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics. Bioinformatics. 2019 07 15; 35(14):2495-2497. McInnes G, Tanigawa Y, DeBoever C, Lavertu A, Olivieri JE, Aguirre M, Rivas MA. PMID: 30520965; PMCID: PMC6612820.
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    32. Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide. Mol Psychiatry. 2020 10; 25(10):2422-2430. Ruderfer DM, Walsh CG, Aguirre MW, Tanigawa Y, Ribeiro JD, Franklin JC, Rivas MA. PMID: 30610202; PMCID: PMC6609505.
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    33. SNPs2ChIP: Latent Factors of ChIP-seq to infer functions of non-coding SNPs. Pac Symp Biocomput. 2019; 24:184-195. Anand S, Kalesinskas L, Smail C, Tanigawa Y. PMID: 30864321; PMCID: PMC6417821.
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    34. Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study. Nat Commun. 2018 04 24; 9(1):1612. DeBoever C, Tanigawa Y, Lindholm ME, McInnes G, Lavertu A, Ingelsson E, Chang C, Ashley EA, Bustamante CD, Daly MJ, Rivas MA. PMID: 29691392; PMCID: PMC5915386.
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    35. Collaborative environmental DNA sampling from petal surfaces of flowering cherry Cerasus × yedoensis 'Somei-yoshino' across the Japanese archipelago. J Plant Res. 2018 Jul; 131(4):709-717. Ohta T, Kawashima T, Shinozaki NO, Dobashi A, Hiraoka S, Hoshino T, Kanno K, Kataoka T, Kawashima S, Matsui M, Nemoto W, Nishijima S, Suganuma N, Suzuki H, Taguchi YH, Takenaka Y, Tanigawa Y, Tsuneyoshi M, Yoshitake K, Sato Y, Yamashita R, Arakawa K, Iwasaki W. PMID: 29460198.
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    36. Cloning of the gene gob-4, which is expressed in intestinal goblet cells in mice. Biochim Biophys Acta. 1999 Mar 19; 1444(3):434-8. Komiya T, Tanigawa Y, Hirohashi S. PMID: 10095068.
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    37. Cloning and identification of the gene gob-5, which is expressed in intestinal goblet cells in mice. Biochem Biophys Res Commun. 1999 Feb 16; 255(2):347-51. Komiya T, Tanigawa Y, Hirohashi S. PMID: 10049711.
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    38. Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice. Biochem Biophys Res Commun. 1998 Oct 29; 251(3):759-62. Komiya T, Tanigawa Y, Hirohashi S. PMID: 9790983.
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    39. Large-scale immunohistological staining using polyethylene glycol-embedded sections mounted on 96-well plates for monoclonal antibody screening. Anal Biochem. 1997 Sep 05; 251(2):158-62. Komiya T, Tanigawa Y, Oda S, Hirohashi S. PMID: 9299011.
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    40. [An autopsy case of chronic granulomatous disease diagnosed by biopsy]. Kansenshogaku Zasshi. 1997 Jul; 71(7):668-71. Gonda H, Noda Y, Ohishi T, Tanigawa Y, Yoshida N, Yoshida M, Yamamoto K, Mizuno H, Nishimura Y, Suitou H. PMID: 9283144.
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    41. Monoclonal nonspecific suppressor factor beta (MNSF beta) inhibits the production of TNF-alpha by lipopolysaccharide-activated macrophages. Immunobiology. 1996 Jul; 195(2):187-98. Suzuki K, Nakamura M, Nariai Y, Dekio S, Tanigawa Y. PMID: 8877395.
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    42. [Alpha fetoprotein-producing primary lung cancer]. Ryoikibetsu Shokogun Shirizu. 1994; (4):3-6. Matsumoto S, Tanigawa Y, Takahashi K, Oishi T. PMID: 7516441.
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    43. Cytological findings of 10 cases with i(Xq) and one with dic(X)(qter leads to cen leads to p22::p11 leads to qter). Hum Genet. 1977 Nov 10; 39(2):147-55. Fujita H, Tanigawa Y, Yoshida Y, Okada Y. PMID: 598825.
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    44. Proceedings: ADP-ribosylation of Ca 2+, Mg 2+-dependent endonuclease by poly(ADP-ribose) synthetase. J Biochem. 1975 Jan 01; 77(1?):10p. Yoshihara K, Tanigawa Y, Koide SS. PMID: 236992.
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    45. A survey of sex chromosome anomalies among normal children and mental defectives. Jinrui Idengaku Zasshi. 1972 Mar; 16(3):198-211. Fujita H, Yoshida Y, Tanigawa Y, Yamamoto K, Sakamoto Y. PMID: 5065760.
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    46. The effects of parental consanguinity and inbreeding in Hirado, Japan. 3. Vision and hearing. Hum Hered. 1970; 20(2):129-55. Neel JV, Schull WJ, Kimura T, Tanigawa Y, Yamamoto M, Nakajima A. PMID: 5489872.
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    47. [AN EPIPHARYNGEAL CANCER]. Jibiinkoka. 1965 Mar; 37:245-7. SUZUKI T, TANIGAWA Y, FUJIMORI K. PMID: 14304484.
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    48. [The effect of Metron-Kowa nasal drops in allergic rhinitis]. Jibiinkoka. 1961 Aug; 33:729-32. IBIHARA I, SAITO Y, SUZUKI T, TANIGAWA Y, FUJIMORI K. PMID: 13717344.
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