Zhefeng Guo

Title(s)Associate Professor-in-Residence, Neurology
ORCID ORCID Icon0000-0003-1992-7255 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, Los Angeles, Los Angeles, California, USAPh.D.12/2003Biochemistry and Molecular Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Structural studies of amyloid beta globulomers with EPR spectroscopy
    NIH R01AG050687Jul 15, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Structural biology of yeast prions.
    NIH R01GM110448May 1, 2014 - Apr 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. EPR Studies of Aβ42 Oligomers Indicate a Parallel In-Register β-Sheet Structure. ACS Chem Neurosci. 2024 Jan 03; 15(1):86-97. Jang C, Portugal Barron D, Duo L, Ma C, Seabaugh H, Guo Z. PMID: 38109787; PMCID: PMC10767747.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. The supersaturation perspective on the amyloid hypothesis. Chem Sci. 2023 Dec 20; 15(1):46-54. Portugal Barron D, Guo Z. PMID: 38131088; PMCID: PMC10731913.
      View in: PubMed   Mentions: 2  
    3. A protein aggregation platform that distinguishes oligomers from amyloid fibrils. Analyst. 2023 May 16; 148(10):2283-2294. Zhang A, Portugal Barron D, Chen EW, Guo Z. PMID: 37129054; PMCID: PMC10266934.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Preparation and Fractionation of Heterogeneous Aβ42 Oligomers with Different Aggregation Properties. Methods Mol Biol. 2023; 2551:29-39. Chen EW, Guo Z. PMID: 36310194.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Static and dynamic disorder in Aβ40 fibrils. Biochem Biophys Res Commun. 2022 06 25; 610:107-112. Xiao H, Duo L, Zhen J, Wang H, Guo Z. PMID: 35461071.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Amyloid hypothesis through the lens of Aβ supersaturation. Neural Regen Res. 2021 Aug; 16(8):1562-1563. Guo Z. PMID: 33433483; PMCID: PMC8323705.
      View in: PubMed   Mentions: 5  
    7. Lipid membranes induce structural conversion from amyloid oligomers to fibrils. Biochem Biophys Res Commun. 2021 06 11; 557:122-126. Gu L, Guo Z. PMID: 33862455; PMCID: PMC8116179.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Effect of spin labelling on the aggregation kinetics of yeast prion protein Ure2. R Soc Open Sci. 2021 Mar 03; 8(3):201747. Liu EN, Park G, Nohara J, Guo Z. PMID: 33959337; PMCID: PMC8074925.
      View in: PubMed   Mentions:
    9. Segmental structural dynamics in Aβ42 globulomers. Biochem Biophys Res Commun. 2021 03 19; 545:119-124. Yoon A, Zhen J, Guo Z. PMID: 33548624; PMCID: PMC7904658.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Alzheimer's Aβ42 and Aβ40 form mixed oligomers with direct molecular interactions. Biochem Biophys Res Commun. 2021 01 01; 534:292-296. Gu L, Guo Z. PMID: 33272573; PMCID: PMC7785691.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. Distinguishing the Effect on the Rate and Yield of Aβ42 Aggregation by Green Tea Polyphenol EGCG. ACS Omega. 2020 Sep 01; 5(34):21497-21505. Park G, Xue C, Wang H, Guo Z. PMID: 32905372; PMCID: PMC7469419.
      View in: PubMed   Mentions: 4  
    12. Polymorphic Aβ42 fibrils adopt similar secondary structure but differ in cross-strand side chain stacking interactions within the same β-sheet. Sci Rep. 2020 03 31; 10(1):5720. Wang H, Duo L, Hsu F, Xue C, Lee YK, Guo Z. PMID: 32235842; PMCID: PMC7109039.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    13. Spin Label Scanning Reveals Likely Locations of β-Strands in the Amyloid Fibrils of the Ure2 Prion Domain. ACS Omega. 2020 Mar 24; 5(11):5984-5993. Wang J, Park G, Lee YK, Nguyen M, San Fung T, Lin TY, Hsu F, Guo Z. PMID: 32226879; PMCID: PMC7098000.
      View in: PubMed   Mentions: 8  
    14. Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism. R Soc Open Sci. 2019 Jul; 6(7):190179. Xue C, Tran J, Wang H, Park G, Hsu F, Guo Z. PMID: 31417723; PMCID: PMC6689619.
      View in: PubMed   Mentions: 11  
    15. Key Residues for the Formation of Aβ42 Amyloid Fibrils. ACS Omega. 2018 Jul 31; 3(7):8401-8407. Hsu F, Park G, Guo Z. PMID: 30087945; PMCID: PMC6068601.
      View in: PubMed   Mentions: 10  
    16. Site-specific structural order in Alzheimer's Aβ42 fibrils. R Soc Open Sci. 2018 Jul; 5(7):180166. Wang H, Lee YK, Xue C, Guo Z. PMID: 30109072; PMCID: PMC6083707.
      View in: PubMed   Mentions: 9  
    17. A mix-and-click method to measure amyloid-β concentration with sub-micromolar sensitivity. R Soc Open Sci. 2017 Aug; 4(8):170325. Xue C, Lee YK, Tran J, Chang D, Guo Z. PMID: 28878984; PMCID: PMC5579099.
      View in: PubMed   Mentions: 9  
    18. Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation. R Soc Open Sci. 2017 Jan; 4(1):160696. Xue C, Lin TY, Chang D, Guo Z. PMID: 28280572; PMCID: PMC5319338.
      View in: PubMed   Mentions: 189  
    19. Cross-seeding between Aβ40 and Aβ42 in Alzheimer's disease. FEBS Lett. 2017 Jan; 591(1):177-185. Tran J, Chang D, Hsu F, Wang H, Guo Z. PMID: 27981583; PMCID: PMC5235972.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    20. A new structural model of Alzheimer's Aβ42 fibrils based on electron paramagnetic resonance data and Rosetta modeling. J Struct Biol. 2016 Apr; 194(1):61-7. Gu L, Tran J, Jiang L, Guo Z. PMID: 26827680; PMCID: PMC4764428.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    21. Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomers. J Biol Chem. 2014 Sep 26; 289(39):27300-27313. Gu L, Liu C, Stroud JC, Ngo S, Jiang L, Guo Z. PMID: 25118290; PMCID: PMC4175361.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    22. Structural insights into Aβ42 oligomers using site-directed spin labeling. J Biol Chem. 2013 Jun 28; 288(26):18673-83. Gu L, Liu C, Guo Z. PMID: 23687299; PMCID: PMC3696641.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    23. Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils. J Neurochem. 2013 Aug; 126(3):305-11. Gu L, Guo Z. PMID: 23406382; PMCID: PMC3716832.
      View in: PubMed   Mentions: 95     Fields:    Translation:Humans
    24. Prion domain of yeast Ure2 protein adopts a completely disordered structure: a solid-support EPR study. PLoS One. 2012; 7(10):e47248. Ngo S, Chiang V, Ho E, Le L, Guo Z. PMID: 23077577; PMCID: PMC3473064.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    25. Structural origin of polymorphism of Alzheimer's amyloid β-fibrils. Biochem J. 2012 Oct 01; 447(1):43-50. Agopian A, Guo Z. PMID: 22823461.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    26. Quantitative analysis of spin exchange interactions to identify β strand and turn regions in Ure2 prion domain fibrils with site-directed spin labeling. J Struct Biol. 2012 Nov; 180(2):374-81. Ngo S, Chiang V, Guo Z. PMID: 22967940.
      View in: PubMed   Mentions: 12     Fields:    
    27. Solid-support electron paramagnetic resonance (EPR) studies of Aβ40 monomers reveal a structured state with three ordered segments. J Biol Chem. 2012 Mar 16; 287(12):9081-9. Gu L, Ngo S, Guo Z. PMID: 22277652; PMCID: PMC3308762.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    28. Key residues for the oligomerization of Aβ42 protein in Alzheimer's disease. Biochem Biophys Res Commun. 2011 Oct 28; 414(3):512-6. Ngo S, Guo Z. PMID: 21986527.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Hierarchical organization in the amyloid core of yeast prion protein Ure2. J Biol Chem. 2011 Aug 26; 286(34):29691-9. Ngo S, Gu L, Guo Z. PMID: 21730048; PMCID: PMC3191010.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    30. Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins. Protein Sci. 2009 Aug; 18(8):1637-52. López CJ, Fleissner MR, Guo Z, Kusnetzow AK, Hubbell WL. PMID: 19585559; PMCID: PMC2776952.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    31. The structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold. Protein Sci. 2008 Sep; 17(9):1617-23. Guo Z, Eisenberg D. PMID: 18552127; PMCID: PMC2525518.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    32. Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme. Protein Sci. 2008 Feb; 17(2):228-39. Guo Z, Cascio D, Hideg K, Hubbell WL. PMID: 18096642; PMCID: PMC2222722.
      View in: PubMed   Mentions: 63     Fields:    Translation:Cells
    33. Structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme. Protein Sci. 2007 Jun; 16(6):1069-86. Guo Z, Cascio D, Hideg K, Kálái T, Hubbell WL. PMID: 17473014; PMCID: PMC2206656.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    34. The mechanism of the amyloidogenic conversion of T7 endonuclease I. J Biol Chem. 2007 May 18; 282(20):14968-74. Guo Z, Eisenberg D. PMID: 17360710.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    35. Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8042-7. Guo Z, Eisenberg D. PMID: 16698921; PMCID: PMC1472426.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
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