Zhefeng Guo

Title(s)Associate Professor-in-Residence, Neurology
Address710 Westwood Plaza C109
Los Angeles CA 90024
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    Structural studies of amyloid beta globulomers with EPR spectroscopy
    NIH/NIA R01AG050687Jul 15, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Structural biology of yeast prions.
    NIH/NIGMS R01GM110448May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Polymorphic Aß42 fibrils adopt similar secondary structure but differ in cross-strand side chain stacking interactions within the same ß-sheet. Sci Rep. 2020 Mar 31; 10(1):5720. Wang H, Duo L, Hsu F, Xue C, Lee YK, Guo Z. PMID: 32235842.
      View in: PubMed   Mentions: 1     Fields:    
    2. Spin Label Scanning Reveals Likely Locations of ß-Strands in the Amyloid Fibrils of the Ure2 Prion Domain. ACS Omega. 2020 Mar 24; 5(11):5984-5993. Wang J, Park G, Lee YK, Nguyen M, San Fung T, Lin TY, Hsu F, Guo Z. PMID: 32226879.
      View in: PubMed   Mentions:
    3. Aß42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism. R Soc Open Sci. 2019 Jul; 6(7):190179. Xue C, Tran J, Wang H, Park G, Hsu F, Guo Z. PMID: 31417723.
      View in: PubMed   Mentions:
    4. Key Residues for the Formation of Aß42 Amyloid Fibrils. ACS Omega. 2018 Jul 31; 3(7):8401-8407. Hsu F, Park G, Guo Z. PMID: 30087945.
      View in: PubMed   Mentions:
    5. Site-specific structural order in Alzheimer's Aß42 fibrils. R Soc Open Sci. 2018 Jul; 5(7):180166. Wang H, Lee YK, Xue C, Guo Z. PMID: 30109072.
      View in: PubMed   Mentions:
    6. A mix-and-click method to measure amyloid-ß concentration with sub-micromolar sensitivity. R Soc Open Sci. 2017 Aug; 4(8):170325. Xue C, Lee YK, Tran J, Chang D, Guo Z. PMID: 28878984.
      View in: PubMed   Mentions:
    7. Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation. R Soc Open Sci. 2017 Jan; 4(1):160696. Xue C, Lin TY, Chang D, Guo Z. PMID: 28280572.
      View in: PubMed   Mentions:
    8. Cross-seeding between Aß40 and Aß42 in Alzheimer's disease. FEBS Lett. 2017 Jan; 591(1):177-185. Tran J, Chang D, Hsu F, Wang H, Guo Z. PMID: 27981583.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    9. A new structural model of Alzheimer's Aß42 fibrils based on electron paramagnetic resonance data and Rosetta modeling. J Struct Biol. 2016 Apr; 194(1):61-7. Gu L, Tran J, Jiang L, Guo Z. PMID: 26827680.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    10. Antiparallel triple-strand architecture for prefibrillar Aß42 oligomers. J Biol Chem. 2014 Sep 26; 289(39):27300-13. Gu L, Liu C, Stroud JC, Ngo S, Jiang L, Guo Z. PMID: 25118290.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    11. Structural insights into Aß42 oligomers using site-directed spin labeling. J Biol Chem. 2013 Jun 28; 288(26):18673-83. Gu L, Liu C, Guo Z. PMID: 23687299.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    12. Alzheimer's Aß42 and Aß40 peptides form interlaced amyloid fibrils. J Neurochem. 2013 Aug; 126(3):305-11. Gu L, Guo Z. PMID: 23406382.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    13. Prion domain of yeast Ure2 protein adopts a completely disordered structure: a solid-support EPR study. PLoS One. 2012; 7(10):e47248. Ngo S, Chiang V, Ho E, Le L, Guo Z. PMID: 23077577.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Structural origin of polymorphism of Alzheimer's amyloid ß-fibrils. Biochem J. 2012 Oct 01; 447(1):43-50. Agopian A, Guo Z. PMID: 22823461.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    15. Quantitative analysis of spin exchange interactions to identify ß strand and turn regions in Ure2 prion domain fibrils with site-directed spin labeling. J Struct Biol. 2012 Nov; 180(2):374-81. Ngo S, Chiang V, Guo Z. PMID: 22967940.
      View in: PubMed   Mentions: 8     Fields:    
    16. Solid-support electron paramagnetic resonance (EPR) studies of Aß40 monomers reveal a structured state with three ordered segments. J Biol Chem. 2012 Mar 16; 287(12):9081-9. Gu L, Ngo S, Guo Z. PMID: 22277652.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Key residues for the oligomerization of Aß42 protein in Alzheimer's disease. Biochem Biophys Res Commun. 2011 Oct 28; 414(3):512-6. Ngo S, Guo Z. PMID: 21986527.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. Hierarchical organization in the amyloid core of yeast prion protein Ure2. J Biol Chem. 2011 Aug 26; 286(34):29691-9. Ngo S, Gu L, Guo Z. PMID: 21730048.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    19. Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins. Protein Sci. 2009 Aug; 18(8):1637-52. López CJ, Fleissner MR, Guo Z, Kusnetzow AK, Hubbell WL. PMID: 19585559.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    20. The structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold. Protein Sci. 2008 Sep; 17(9):1617-23. Guo Z, Eisenberg D. PMID: 18552127.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    21. Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme. Protein Sci. 2008 Feb; 17(2):228-39. Guo Z, Cascio D, Hideg K, Hubbell WL. PMID: 18096642.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    22. Structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme. Protein Sci. 2007 Jun; 16(6):1069-86. Guo Z, Cascio D, Hideg K, Kálái T, Hubbell WL. PMID: 17473014.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    23. The mechanism of the amyloidogenic conversion of T7 endonuclease I. J Biol Chem. 2007 May 18; 282(20):14968-74. Guo Z, Eisenberg D. PMID: 17360710.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8042-7. Guo Z, Eisenberg D. PMID: 16698921.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
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