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Guo, Zhefeng

Title(s)Associate Professor-in-Residence, Neurology
Phone68773
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    Collapse Research 
    Collapse Research Activities and Funding
    Structural studies of amyloid beta globulomers with EPR spectroscopy
    NIH/NIA R01AG050687Jul 15, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Structural biology of yeast prions.
    NIH/NIGMS R01GM110448May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xue C, Tran J, Wang H, Park G, Hsu F, Guo Z. Aß42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism. R Soc Open Sci. 2019 Jul; 6(7):190179. PMID: 31417723.
      View in: PubMed
    2. Hsu F, Park G, Guo Z. Key Residues for the Formation of Aß42 Amyloid Fibrils. ACS Omega. 2018 Jul 31; 3(7):8401-8407. PMID: 30087945.
      View in: PubMed
    3. Wang H, Lee YK, Xue C, Guo Z. Site-specific structural order in Alzheimer's Aß42 fibrils. R Soc Open Sci. 2018 Jul; 5(7):180166. PMID: 30109072.
      View in: PubMed
    4. Xue C, Lee YK, Tran J, Chang D, Guo Z. A mix-and-click method to measure amyloid-ß concentration with sub-micromolar sensitivity. R Soc Open Sci. 2017 Aug; 4(8):170325. PMID: 28878984.
      View in: PubMed
    5. Xue C, Lin TY, Chang D, Guo Z. Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation. R Soc Open Sci. 2017 Jan; 4(1):160696. PMID: 28280572.
      View in: PubMed
    6. Tran J, Chang D, Hsu F, Wang H, Guo Z. Cross-seeding between Aß40 and Aß42 in Alzheimer's disease. FEBS Lett. 2017 Jan; 591(1):177-185. PMID: 27981583.
      View in: PubMed
    7. Gu L, Tran J, Jiang L, Guo Z. A new structural model of Alzheimer's Aß42 fibrils based on electron paramagnetic resonance data and Rosetta modeling. J Struct Biol. 2016 Apr; 194(1):61-7. PMID: 26827680.
      View in: PubMed
    8. Gu L, Liu C, Stroud JC, Ngo S, Jiang L, Guo Z. Antiparallel triple-strand architecture for prefibrillar Aß42 oligomers. J Biol Chem. 2014 Sep 26; 289(39):27300-13. PMID: 25118290.
      View in: PubMed
    9. Gu L, Liu C, Guo Z. Structural insights into Aß42 oligomers using site-directed spin labeling. J Biol Chem. 2013 Jun 28; 288(26):18673-83. PMID: 23687299.
      View in: PubMed
    10. Gu L, Guo Z. Alzheimer's Aß42 and Aß40 peptides form interlaced amyloid fibrils. J Neurochem. 2013 Aug; 126(3):305-11. PMID: 23406382.
      View in: PubMed
    11. Ngo S, Chiang V, Ho E, Le L, Guo Z. Prion domain of yeast Ure2 protein adopts a completely disordered structure: a solid-support EPR study. PLoS One. 2012; 7(10):e47248. PMID: 23077577.
      View in: PubMed
    12. Agopian A, Guo Z. Structural origin of polymorphism of Alzheimer's amyloid ß-fibrils. Biochem J. 2012 Oct 01; 447(1):43-50. PMID: 22823461.
      View in: PubMed
    13. Ngo S, Chiang V, Guo Z. Quantitative analysis of spin exchange interactions to identify ß strand and turn regions in Ure2 prion domain fibrils with site-directed spin labeling. J Struct Biol. 2012 Nov; 180(2):374-81. PMID: 22967940.
      View in: PubMed
    14. Gu L, Ngo S, Guo Z. Solid-support electron paramagnetic resonance (EPR) studies of Aß40 monomers reveal a structured state with three ordered segments. J Biol Chem. 2012 Mar 16; 287(12):9081-9. PMID: 22277652.
      View in: PubMed
    15. Ngo S, Guo Z. Key residues for the oligomerization of Aß42 protein in Alzheimer's disease. Biochem Biophys Res Commun. 2011 Oct 28; 414(3):512-6. PMID: 21986527.
      View in: PubMed
    16. Ngo S, Gu L, Guo Z. Hierarchical organization in the amyloid core of yeast prion protein Ure2. J Biol Chem. 2011 Aug 26; 286(34):29691-9. PMID: 21730048.
      View in: PubMed
    17. López CJ, Fleissner MR, Guo Z, Kusnetzow AK, Hubbell WL. Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins. Protein Sci. 2009 Aug; 18(8):1637-52. PMID: 19585559.
      View in: PubMed
    18. Guo Z, Eisenberg D. The structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold. Protein Sci. 2008 Sep; 17(9):1617-23. PMID: 18552127.
      View in: PubMed
    19. Guo Z, Cascio D, Hideg K, Hubbell WL. Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme. Protein Sci. 2008 Feb; 17(2):228-39. PMID: 18096642.
      View in: PubMed
    20. Guo Z, Cascio D, Hideg K, Kálái T, Hubbell WL. Structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme. Protein Sci. 2007 Jun; 16(6):1069-86. PMID: 17473014.
      View in: PubMed
    21. Guo Z, Eisenberg D. The mechanism of the amyloidogenic conversion of T7 endonuclease I. J Biol Chem. 2007 May 18; 282(20):14968-74. PMID: 17360710.
      View in: PubMed
    22. Guo Z, Eisenberg D. Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8042-7. PMID: 16698921.
      View in: PubMed