Patrick G Harran

Title(s)Professor, Chemistry and Biochemistry
SchoolCollege of Letters and Science
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    Collapse Research 
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    Designed Small Molecule Inhibitors of Ghrelin O-Acyl Transferase
    NIH R01DK100627Jul 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Fully Synthetic Prodiginines as Probes of Protein-Protein Interactions Regulating
    NIH R01CA184772Apr 16, 2014 - Feb 28, 2020
    Role: Principal Investigator
    Synthesis and Properties of Nitrogen-Rich Polycycles
    NIH R01GM060591Mar 1, 2000 - Aug 31, 2010
    Role: Principal Investigator
    ASYMMETRIC SYNTHESIS OF BRYOSTATINS
    NIH F32CA066246Jul 31, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Indolizinylalanine Regioisomers: Tryptophan Isosteres with Bathochromic Fluorescence Emission. J Org Chem. 2024 Oct 18; 89(20):14665-14672. Cooper GID, Saha I, Newman J, Shin RH, Harran PG. PMID: 39307984.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Origin of Octafluorocyclopentene Polyelectrophilicity. J Am Chem Soc. 2024 Feb 28; 146(8):5375-5382. Tian H, Lee W, Li Y, Dweck MJ, Mendoza A, Harran PG, Houk KN. PMID: 38354320.
      View in: PubMed   Mentions:    Fields:    
    3. Cascade Synthesis of Fluorinated Spiroheterocyclic Scaffolding for Peptidic Macrobicycles. J Am Chem Soc. 2023 07 26; 145(29):15888-15895. Mendoza A, Bernardino SJ, Dweck MJ, Valencia I, Evans D, Tian H, Lee W, Li Y, Houk KN, Harran PG. PMID: 37441722.
      View in: PubMed   Mentions: 1     Fields:    
    4. Asymmetric Organocatalysis Enables Rapid Assembly of Portimine Precursor Chains. Org Lett. 2022 04 15; 24(14):2607-2612. Li L, El Khoury A, Clement BO, Wu C, Harran PG. PMID: 35377667.
      View in: PubMed   Mentions: 1     Fields:    
    5. In Search of Small Molecules That Selectively Inhibit MBOAT4. Molecules. 2021 Dec 15; 26(24). Murzinski ES, Saha I, Ding H, Strugatsky D, Hollibaugh RA, Liu H, Tontonoz P, Harran PG. PMID: 34946685; PMCID: PMC8709388.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Photorearrangement of [8]-2,6-Pyridinophane N-Oxide. J Am Chem Soc. 2020 12 09; 142(49):20717-20724. Hurlow EE, Lin JB, Dweck MJ, Nuryyeva S, Feng Z, Allred TK, Houk KN, Harran PG. PMID: 33226803.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    7. Callyspongiolide Is a Potent Inhibitor of the Vacuolar ATPase. J Nat Prod. 2020 11 25; 83(11):3381-3386. Fogarty S, Ouyang Y, Li L, Chen YC, Rane H, Manoni F, Parra KJ, Rutter J, Harran PG. PMID: 33151675.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Computational generation of an annotated gigalibrary of synthesizable, composite peptidic macrocycles. Proc Natl Acad Sci U S A. 2020 10 06; 117(40):24679-24690. Saha I, Dang EK, Svatunek D, Houk KN, Harran PG. PMID: 32948694; PMCID: PMC7547232.
      View in: PubMed   Mentions: 2     Fields:    
    9. Syntheses of Atypically Fluorinated Peptidyl Macrocycles through Sequential Vinylic Substitutions. Angew Chem Int Ed Engl. 2020 01 07; 59(2):674-678. Tsunemi T, Bernardino SJ, Mendoza A, Jones CG, Harran PG. PMID: 31693283.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Anomalous Chromophore Disruption Enables an Eight-Step Synthesis and Stereochemical Reassignment of (+)-Marineosin A. J Am Chem Soc. 2019 02 13; 141(6):2274-2278. Feng Z, Allred TK, Hurlow EE, Harran PG. PMID: 30691264.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    11. Cascading Auto-oxidative Biproline Guanylations Form Optically Active Dispacamide Dimers and Permit an Eight-Step Synthesis of (-)-Ageliferin. J Org Chem. 2018 07 06; 83(13):7231-7238. Ding H, Roberts AG, Chiang R, Harran PG. PMID: 29708748.
      View in: PubMed   Mentions: 1     Fields:    
    12. Assembly of Complex Macrocycles by Incrementally Amalgamating Unprotected Peptides with a Designed Four-Armed Insert. J Org Chem. 2018 03 16; 83(6):3090-3108. Curtin BH, Manoni F, Park J, Sisto LJ, Lam YH, Gravel M, Roulston A, Harran PG. PMID: 29494773.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    13. Unconventional Fragment Usage Enables a Concise Total Synthesis of (-)-Callyspongiolide. J Am Chem Soc. 2018 01 31; 140(4):1280-1284. Manoni F, Rumo C, Li L, Harran PG. PMID: 29332397.
      View in: PubMed   Mentions: 12     Fields:    
    14. Exploring the Boundaries of "Practical": De Novo Syntheses of Complex Natural Product-Based Drug Candidates. Chem Rev. 2017 Sep 27; 117(18):11994-12051. Allred TK, Manoni F, Harran PG. PMID: 28603978.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    15. The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Sci Transl Med. 2016 11 16; 8(365):365ra159. Wieczorek M, Tcherkezian J, Bernier C, Prota AE, Chaaban S, Rolland Y, Godbout C, Hancock MA, Arezzo JC, Ocal O, Rocha C, Olieric N, Hall A, Ding H, Bramoullé A, Annis MG, Zogopoulos G, Harran PG, Wilkie TM, Brekken RA, Siegel PM, Steinmetz MO, Shore GC, Brouhard GJ, Roulston A. PMID: 27856798; PMCID: PMC5291303.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan. Chem Sci. 2016 Jul 01; 7(7):4158-4166. Rose TE, Curtin BH, Lawson KV, Simon A, Houk KN, Harran PG. PMID: 30155060; PMCID: PMC6014094.
      View in: PubMed   Mentions: 2  
    17. Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro. Tetrahedron Lett. 2015 Jun 03; 56(23):3612-3616. Bracken JD, Carlson AD, Frederich JH, Nguyen M, Shore GC, Harran PG. PMID: 26019371; PMCID: PMC4442084.
      View in: PubMed   Mentions: 3     Fields:    
    18. Electrolytic macrocyclizations: scalable synthesis of a diazonamide-based drug development candidate. Angew Chem Int Ed Engl. 2015 Apr 13; 54(16):4818-22. Ding H, DeRoy PL, Perreault C, Larivée A, Siddiqui A, Caldwell CG, Harran S, Harran PG. PMID: 25729008.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    19. Large ring-forming alkylations provide facile access to composite macrocycles. Chem Sci. 2015 Apr 16; 6(4):2219-2223. Rose TE, Lawson KV, Harran PG. PMID: 28694951; PMCID: PMC5485560.
      View in: PubMed   Mentions: 5  
    20. Template-constrained macrocyclic peptides prepared from native, unprotected precursors. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):E3753-60. Lawson KV, Rose TE, Harran PG. PMID: 24043790; PMCID: PMC3791740.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    21. Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan. Tetrahedron. 2013 Sep 09; 69(36):7683-7691. Lawson KV, Rose TE, Harran PG. PMID: 23976797; PMCID: PMC3746997.
      View in: PubMed   Mentions: 6     Fields:    
    22. Substituted 2,2'-bipyrroles and pyrrolylfurans via intermediate isoxazolylpyrroles. Tetrahedron Lett. 2013 May 22; 54(21):2645-2647. Frederich JH, Matsui JK, Chang RO, Harran PG. PMID: 23814321; PMCID: PMC3691883.
      View in: PubMed   Mentions: 3     Fields:    
    23. Modular access to complex prodiginines: total synthesis of (+)-roseophilin via its 2-azafulvene prototropisomer. J Am Chem Soc. 2013 Mar 13; 135(10):3788-91. Frederich JH, Harran PG. PMID: 23452332; PMCID: PMC3675760.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    24. Total Synthesis of Ageliferin via Acyl N-amidinyliminium Ion Rearrangement. Chem Sci. 2013 Jan 01; 4(1):303-306. Ding H, Roberts AG, Harran PG. PMID: 23687567; PMCID: PMC3653441.
      View in: PubMed   Mentions: 7  
    25. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol. 2013 Feb; 9(2):84-9. Wang G, Wang X, Yu H, Wei S, Williams N, Holmes DL, Halfmann R, Naidoo J, Wang L, Li L, Chen S, Harran P, Lei X, Wang X. PMID: 23292651.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    26. Synthetic (±)-axinellamines deficient in halogen. Angew Chem Int Ed Engl. 2012 Apr 27; 51(18):4340-3. Ding H, Roberts AG, Harran PG. PMID: 22431425; PMCID: PMC3532944.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    27. SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner. Cancer Res. 2011 Dec 15; 71(24):7640-8. Greer RM, Peyton M, Larsen JE, Girard L, Xie Y, Gazdar AF, Harran P, Wang L, Brekken RA, Wang X, Minna JD. PMID: 22049529; PMCID: PMC3382117.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    28. Exploring symmetry-based logic for a synthesis of palau'amine. J Org Chem. 2009 Aug 21; 74(16):5909-19. Li Q, Hurley P, Ding H, Roberts AG, Akella R, Harran PG. PMID: 19603820; PMCID: PMC2888864.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    29. Acid promoted cinnamyl ion mobility within peptide derived macrocycles. J Am Chem Soc. 2008 Oct 22; 130(42):13864-6. Zhao H, Negash L, Wei Q, LaCour TG, Estill SJ, Capota E, Pieper AA, Harran PG. PMID: 18811162.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    30. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell. 2007 Nov; 12(5):445-56. Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, Harran P, Wang X. PMID: 17996648; PMCID: PMC3431210.
      View in: PubMed   Mentions: 312     Fields:    Translation:HumansAnimalsCells
    31. Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2074-9. Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL. PMID: 17287337; PMCID: PMC1794345.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    32. Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2068-73. Wang G, Shang L, Burgett AW, Harran PG, Wang X. PMID: 17287350; PMCID: PMC1894683.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    33. A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15523-8. Zubovych I, Doundoulakis T, Harran PG, Roth MG. PMID: 17032754; PMCID: PMC1622856.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    34. Spirocycloisomerization of tethered alkylidene glycocyamidines: synthesis of a base template common to the palau'amine family of alkaloids. Angew Chem Int Ed Engl. 2005 Jan 21; 44(5):765-9. Garrido-Hernandez H, Nakadai M, Vimolratana M, Li Q, Doundoulakis T, Harran PG. PMID: 15624220.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    35. A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science. 2004 Sep 03; 305(5689):1471-4. Li L, Thomas RM, Suzuki H, De Brabander JK, Wang X, Harran PG. PMID: 15353805.
      View in: PubMed   Mentions: 258     Fields:    Translation:HumansCells
    36. A concise and flexible total synthesis of (-)-diazonamide A. Angew Chem Int Ed Engl. 2003 Oct 20; 42(40):4961-6. Burgett AW, Li Q, Wei Q, Harran PG. PMID: 14579451.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    37. Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography. Eur J Biochem. 2003 Sep; 270(18):3822-8. Cruz-Monserrate Z, Mullaney JT, Harran PG, Pettit GR, Hamel E. PMID: 12950266.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Preview. Angew Chem Int Ed Engl. 2001 Dec 17; 40(24):4776. Li J, Burgett AW, Esser L, Amezcua C, Harran PG. PMID: 12404413.
      View in: PubMed   Mentions: 1     Fields:    
    39. Total Synthesis of Nominal Diazonamides-Part 2: On the True Structure and Origin of Natural Isolates Funding provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), the Robert A. Welch Foundation, and the Advanced Research Program of the Texas Higher Education Coordinating Board. We are grateful to Professor Michael Roth for his time, insight, and advice. Angew Chem Int Ed Engl. 2001 Dec 17; 40(24):4770-4773. Li J, Burgett AW, Esser L, Amezcua C, Harran PG. PMID: 12404412.
      View in: PubMed   Mentions: 31     Fields:    
    40. Total Synthesis of Nominal Diazonamides-Part 1: Convergent Preparation of the Structure Proposed for (-)-Diazonamide A Funding provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), the Robert A. Welch Foundation, and the Advanced Research Program of the Texas Higher Education Coordinating Board. Angew Chem Int Ed Engl. 2001 Dec 17; 40(24):4765-4769. Li J, Jeong S, Esser L, Harran PG. PMID: 12404411.
      View in: PubMed   Mentions: 18     Fields:    
    41. Synthetic seco Forms of (-)-Diazonamide A We thank Prof. Michael Roth for advice and insight and Ms. Susan Jeong for invaluable experimental assistance. Funding was provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), and the Robert A. Welch Foundation. Angew Chem Int Ed Engl. 2001 Jul 16; 40(14):2682-2685. Li J, Chen X, Burgett AW, Harran PG. PMID: 11458372.
      View in: PubMed   Mentions:    Fields:    
    42. Synthetic seco Forms of (-)-Diazonamide A. Angew Chem Int Ed Engl. 2001 Jul 16; 40(14):2682-2685. Li J, Chen X, Burgett AWG, Harran PG. PMID: 29712335.
      View in: PubMed   Mentions: 2     Fields:    
    43. The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):6624-9. Wender PA, DeBrabander J, Harran PG, Jimenez JM, Koehler MF, Lippa B, Park CM, Siedenbiedel C, Pettit GR. PMID: 9618462; PMCID: PMC22576.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
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