-
Effect of Jardiance on glucose uptake into astrocytomas. J Neurooncol. 2024 Sep; 169(2):437-444.
Ghezzi C, Ellingson BM, Lai A, Liu J, Barrio JR, Wright EM. PMID: 39037688; PMCID: PMC11341586.
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PubMed Mentions: Fields:
Translation:
Humans
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Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT. Nat Commun. 2023 11 18; 14(1):7511.
Khan F, Elgeti M, Grandfield S, Paz A, Naughton FB, Marcoline FV, Althoff T, Ermolova N, Wright EM, Hubbell WL, Grabe M, Abramson J. PMID: 37980423; PMCID: PMC10657379.
View in:
PubMed Mentions:
1 Fields:
Translation:
Cells
-
Correction to: SGLT2 and cancer. Pflugers Arch. 2021 Nov; 473(11):1807.
Wright EM. PMID: 34546423; PMCID: PMC9172870.
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PubMed Mentions: Fields:
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SGLT2 Inhibitors: Physiology and Pharmacology. Kidney360. 2021 12 30; 2(12):2027-2037.
Wright EM. PMID: 35419546; PMCID: PMC8986039.
View in:
PubMed Mentions:
31 Fields:
Translation:
Humans
-
Regulation of Neutral Amino Acid Transport By the SARS-CoV-2 Receptor ACE2. Function (Oxf). 2021; 2(5):zqab048.
Loo DDF, Wright EM. PMID: 34642665; PMCID: PMC8499944.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
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The Molecular Basis of Glucose Galactose Malabsorption in a Large Swedish Pedigree. Function (Oxf). 2021; 2(5):zqab040.
Lostao MP, Loo DD, Hernell O, Meeuwisse G, Martin MG, Wright EM. PMID: 34485913; PMCID: PMC8410129.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Function Trumps Form in Two Sugar Symporters, LacY and vSGLT. Int J Mol Sci. 2021 Mar 30; 22(7).
Abramson J, Wright EM. PMID: 33808202; PMCID: PMC8037263.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
-
Active Glucose Transport 2020 and Beyond. Function (Oxf). 2021; 2(1):zqaa047.
Wright EM, Loo DDF. PMID: 33511351; PMCID: PMC7812037.
View in:
PubMed Mentions:
2 Fields:
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SGLT2 and cancer. Pflugers Arch. 2020 09; 472(9):1407-1414.
Wright EM. PMID: 32820343; PMCID: PMC7462911.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimals
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Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245.
Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032; PMCID: PMC6286348.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. Diabetologia. 2018 10; 61(10):2087-2097.
Ghezzi C, Loo DDF, Wright EM. PMID: 30132032; PMCID: PMC6133168.
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PubMed Mentions:
119 Fields:
Translation:
HumansAnimalsCells
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Intestinal absorption of glucose in mice as determined by positron emission tomography. J Physiol. 2018 07; 596(13):2473-2489.
Sala-Rabanal M, Ghezzi C, Hirayama BA, Kepe V, Liu J, Barrio JR, Wright EM. PMID: 29707805; PMCID: PMC6023830.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
-
Positron emission tomography of sodium glucose cotransport activity in high grade astrocytomas. J Neurooncol. 2018 Jul; 138(3):557-569.
Kepe V, Scafoglio C, Liu J, Yong WH, Bergsneider M, Huang SC, Barrio JR, Wright EM. PMID: 29525972; PMCID: PMC5999166.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Conformational transitions of the sodium-dependent sugar transporter, vSGLT. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2742-E2751.
Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. PMID: 29507231; PMCID: PMC5866573.
View in:
PubMed Mentions:
25 Fields:
Translation:
Cells
-
Novel and Unexpected Functions of SGLTs. Physiology (Bethesda). 2017 11; 32(6):435-443.
Wright EM, Ghezzi C, Loo DDF. PMID: 29021363; PMCID: PMC5817162.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
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Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9980-E9988.
Gorraitz E, Hirayama BA, Paz A, Wright EM, Loo DDF. PMID: 29087341; PMCID: PMC5699082.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Structural and functional significance of water permeation through cotransporters. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):E6887-E6894.
Zeuthen T, Gorraitz E, Her K, Wright EM, Loo DD. PMID: 27791155; PMCID: PMC5098644.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule. J Am Soc Nephrol. 2017 Mar; 28(3):802-810.
Ghezzi C, Yu AS, Hirayama BA, Kepe V, Liu J, Scafoglio C, Powell DR, Huang SC, Satyamurthy N, Barrio JR, Wright EM. PMID: 27620988; PMCID: PMC5328165.
View in:
PubMed Mentions:
27 Fields:
Translation:
Animals
-
Stochastic steps in secondary active sugar transport. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3960-6.
Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. PMID: 27325773; PMCID: PMC4941443.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice. J Physiol. 2016 08 01; 594(15):4425-38.
Sala-Rabanal M, Hirayama BA, Ghezzi C, Liu J, Huang SC, Kepe V, Koepsell H, Yu A, Powell DR, Thorens B, Wright EM, Barrio JR. PMID: 27018980; PMCID: PMC4967756.
View in:
PubMed Mentions:
41 Fields:
Translation:
Animals
-
Functional expression of sodium-glucose transporters in cancer. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4111-9.
Scafoglio C, Hirayama BA, Kepe V, Liu J, Ghezzi C, Satyamurthy N, Moatamed NA, Huang J, Koepsell H, Barrio JR, Wright EM. PMID: 26170283; PMCID: PMC4522748.
View in:
PubMed Mentions:
138 Fields:
Translation:
HumansAnimals
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Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences. Diab Vasc Dis Res. 2015 Mar; 12(2):78-89.
Gallo LA, Wright EM, Vallon V. PMID: 25616707; PMCID: PMC5886707.
View in:
PubMed Mentions:
164 Fields:
Translation:
HumansAnimals
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SGLT2 inhibitors act from the extracellular surface of the cell membrane. Physiol Rep. 2014 Jun 01; 2(6).
Ghezzi C, Hirayama BA, Gorraitz E, Loo DD, Liang Y, Wright EM. PMID: 24973332; PMCID: PMC4208661.
View in:
PubMed Mentions:
30 Fields:
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Structural determinants of water permeation through the sodium-galactose transporter vSGLT. Biophys J. 2014 Mar 18; 106(6):1280-9.
Adelman JL, Sheng Y, Choe S, Abramson J, Wright EM, Rosenberg JM, Grabe M. PMID: 24655503; PMCID: PMC3984995.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Fingerprints of hSGLT5 sugar and cation selectivity. Am J Physiol Cell Physiol. 2014 May 01; 306(9):C864-70.
Ghezzi C, Gorraitz E, Hirayama BA, Loo DD, Grempler R, Mayoux E, Wright EM. PMID: 24573086.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Functional identification and characterization of sodium binding sites in Na symporters. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4557-66.
Loo DD, Jiang X, Gorraitz E, Hirayama BA, Wright EM. PMID: 24191006; PMCID: PMC3839715.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Glucose transport families SLC5 and SLC50. Mol Aspects Med. 2013 Apr-Jun; 34(2-3):183-96.
Wright EM. PMID: 23506865.
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PubMed Mentions:
110 Fields:
Translation:
HumansCells
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Regional distribution of SGLT activity in rat brain in vivo. Am J Physiol Cell Physiol. 2013 Feb 01; 304(3):C240-7.
Yu AS, Hirayama BA, Timbol G, Liu J, Diez-Sampedro A, Kepe V, Satyamurthy N, Huang SC, Wright EM, Barrio JR. PMID: 23151803; PMCID: PMC3566441.
View in:
PubMed Mentions:
60 Fields:
Translation:
Animals
-
The importance of being aromatic: π interactions in sodium symporters. Biochemistry. 2012 Nov 27; 51(47):9480-7.
Jiang X, Loo DD, Hirayama BA, Wright EM. PMID: 23116249; PMCID: PMC3523751.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Regulation of the human Na+-dependent glucose cotransporter hSGLT2. Am J Physiol Cell Physiol. 2012 Aug 01; 303(3):C348-54.
Ghezzi C, Wright EM. PMID: 22673616; PMCID: PMC3423026.
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PubMed Mentions:
54 Fields:
Translation:
HumansCells
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Bridging the gap between structure and kinetics of human SGLT1. Am J Physiol Cell Physiol. 2012 May 01; 302(9):C1293-305.
Sala-Rabanal M, Hirayama BA, Loo DD, Chaptal V, Abramson J, Wright EM. PMID: 22159082; PMCID: PMC3361952.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Structural selectivity of human SGLT inhibitors. Am J Physiol Cell Physiol. 2012 Jan 15; 302(2):C373-82.
Hummel CS, Lu C, Liu J, Ghezzi C, Hirayama BA, Loo DD, Kepe V, Barrio JR, Wright EM. PMID: 21940664; PMCID: PMC3328840.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Biology of human sodium glucose transporters. Physiol Rev. 2011 Apr; 91(2):733-94.
Wright EM, Loo DD, Hirayama BA. PMID: 21527736.
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PubMed Mentions:
557 Fields:
Translation:
HumansAnimalsCells
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Conical tomography of a ribbon synapse: structural evidence for vesicle fusion. PLoS One. 2011 Mar 01; 6(3):e16944.
Zampighi GA, Schietroma C, Zampighi LM, Woodruff M, Wright EM, Brecha NC. PMID: 21390245; PMCID: PMC3046965.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
-
The mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature. 2010 Dec 16; 468(7326):988-91.
Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. PMID: 21131949; PMCID: PMC3736980.
View in:
PubMed Mentions:
113 Fields:
Translation:
Cells
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Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C14-21.
Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, Wright EM. PMID: 20980548; PMCID: PMC3023189.
View in:
PubMed Mentions:
114 Fields:
Translation:
HumansCells
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Water permeation through the sodium-dependent galactose cotransporter vSGLT. Biophys J. 2010 Oct 06; 99(7):L56-8.
Choe S, Rosenberg JM, Abramson J, Wright EM, Grabe M. PMID: 20923633; PMCID: PMC3042592.
View in:
PubMed Mentions:
26 Fields:
Translation:
Cells
-
Functional expression of SGLTs in rat brain. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1277-84.
Yu AS, Hirayama BA, Timbol G, Liu J, Basarah E, Kepe V, Satyamurthy N, Huang SC, Wright EM, Barrio JR. PMID: 20826762; PMCID: PMC3006325.
View in:
PubMed Mentions:
65 Fields:
Translation:
Animals
-
Structure and function of Na(+)-symporters with inverted repeats. Curr Opin Struct Biol. 2009 Aug; 19(4):425-32.
Abramson J, Wright EM. PMID: 19631523; PMCID: PMC3496787.
View in:
PubMed Mentions:
100 Fields:
Translation:
HumansCells
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Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Kidney Int. 2009 Jun; 75(12):1272-1277.
Bakris GL, Fonseca VA, Sharma K, Wright EM. PMID: 19357717.
View in:
PubMed Mentions:
118 Fields:
Translation:
HumansAnimals
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The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science. 2008 Aug 08; 321(5890):810-4.
Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J. PMID: 18599740; PMCID: PMC3654663.
View in:
PubMed Mentions:
266 Fields:
Translation:
Cells
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How drugs interact with transporters: SGLT1 as a model. J Membr Biol. 2008 May; 223(2):87-106.
Loo DD, Hirayama BA, Sala-Rabanal M, Wright EM. PMID: 18592293.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Conical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone. J Neurosci. 2008 Apr 16; 28(16):4151-60.
Zampighi GA, Fain N, Zampighi LM, Cantele F, Lanzavecchia S, Wright EM. PMID: 18417694; PMCID: PMC3844767.
View in:
PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
-
Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2. Am J Physiol Renal Physiol. 2008 Jun; 294(6):F1422-32.
Sala-Rabanal M, Loo DD, Hirayama BA, Wright EM. PMID: 18367661.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Sodium-dependent reorganization of the sugar-binding site of SGLT1. Biochemistry. 2007 Nov 20; 46(46):13391-406.
Hirayama BA, Loo DD, Díez-Sampedro A, Leung DW, Meinild AK, Lai-Bing M, Turk E, Wright EM. PMID: 17960916.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Active sugar transport in health and disease. J Intern Med. 2007 Jan; 261(1):32-43.
Wright EM, Hirayama BA, Loo DF. PMID: 17222166.
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PubMed Mentions:
194 Fields:
Translation:
HumansCells
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Conformational dynamics of hSGLT1 during Na+/glucose cotransport. J Gen Physiol. 2006 Dec; 128(6):701-20.
Loo DD, Hirayama BA, Karakossian MH, Meinild AK, Wright EM. PMID: 17130520; PMCID: PMC2151600.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Imino sugars are potent agonists of the human glucose sensor SGLT3. Mol Pharmacol. 2007 Feb; 71(2):628-34.
Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM. PMID: 17110502.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 01; 574(Pt 1):149-66.
Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM. PMID: 16627568; PMCID: PMC1817799.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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A reinvestigation of the secondary structure of functionally active vSGLT, the vibrio sodium/galactose cotransporter. Biochemistry. 2006 Feb 07; 45(5):1470-9.
Turk E, Gasymov OK, Lanza S, Horwitz J, Wright EM. PMID: 16445289.
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PubMed Mentions:
9 Fields:
Translation:
Cells
-
Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter. J Gen Physiol. 2005 Jan; 125(1):13-36.
Loo DD, Hirayama BA, Cha A, Bezanilla F, Wright EM. PMID: 15596535; PMCID: PMC2217483.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Surprising versatility of Na+-glucose cotransporters: SLC5. Physiology (Bethesda). 2004 Dec; 19:370-6.
Wright EM, Loo DD, Hirayama BA, Turk E. PMID: 15546855.
View in:
PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Coupled sodium/glucose cotransport by SGLT1 requires a negative charge at position 454. Biochemistry. 2004 Oct 19; 43(41):13175-84.
Díez-Sampedro A, Loo DD, Wright EM, Zampighi GA, Hirayama BA. PMID: 15476411.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Local conformational changes in the Vibrio Na+/galactose cotransporter. Biochemistry. 2004 Mar 30; 43(12):3620-7.
Veenstra M, Lanza S, Hirayama BA, Turk E, Wright EM. PMID: 15035632.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Intestinal absorption in health and disease--sugars. Best Pract Res Clin Gastroenterol. 2003 Dec; 17(6):943-56.
Wright EM, Martín MG, Turk E. PMID: 14642859.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11753-8.
Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H. PMID: 13130073; PMCID: PMC208830.
View in:
PubMed Mentions:
103 Fields:
Translation:
HumansAnimalsCells
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Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles. Biochemistry. 2003 Aug 05; 42(30):9147-52.
Quick M, Tomasevic J, Wright EM. PMID: 12885248.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb; 447(5):510-8.
Wright EM, Turk E. PMID: 12748858.
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PubMed Mentions:
173 Fields:
Translation:
HumansCells
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Structure of functional single AQP0 channels in phospholipid membranes. J Mol Biol. 2003 Jan 03; 325(1):201-10.
Zampighi GA, Kreman M, Lanzavecchia S, Turk E, Eskandari S, Zampighi L, Wright EM. PMID: 12473462.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Electrophysiological properties of the mouse Na+/Cl(-)-dependent taurine transporter (mTauT-1): steady-state kinetics: stoichiometry of taurine transport. Adv Exp Med Biol. 2003; 526:197-204.
Sarkar HK, Wright EM, Boorer KJ, Loo DD. PMID: 12908601.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Water pumps. J Physiol. 2002 Jul 01; 542(Pt 1):53-60.
Loo DD, Wright EM, Zeuthen T. PMID: 12096049; PMCID: PMC2290409.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Ligand-induced differences in secondary structure of the Vibrio parahaemolyticus Na+/galactose cotransporter. Biochemistry. 2002 Jun 25; 41(25):8082-6.
le Coutre J, Turk E, Kaback HR, Wright EM. PMID: 12069600.
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PubMed Mentions:
3 Fields:
Translation:
Cells
-
Employing Escherichia coli to functionally express, purify, and characterize a human transporter. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8597-601.
Quick M, Wright EM. PMID: 12077304; PMCID: PMC124325.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids. Plant J. 2002 Mar; 29(6):717-31.
Fischer WN, Loo DD, Koch W, Ludewig U, Boorer KJ, Tegeder M, Rentsch D, Wright EM, Frommer WB. PMID: 12148530.
View in:
PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
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Fluorescence studies of ligand-induced conformational changes of the Na(+)/glucose cotransporter. Biochemistry. 2002 Jan 29; 41(4):1250-8.
Meinild AK, Hirayama BA, Wright EM, Loo DD. PMID: 11802724.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Molecular basis for glucose-galactose malabsorption. Cell Biochem Biophys. 2002; 36(2-3):115-21.
Wright EM, Turk E, Martin MG. PMID: 12139397.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Renal Na(+)-glucose cotransporters. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F10-8.
Wright EM. PMID: 11133510.
View in:
PubMed Mentions:
157 Fields:
Translation:
HumansAnimalsCells
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Coupling between Na+, sugar, and water transport across the intestine. Ann N Y Acad Sci. 2000; 915:54-66.
Wright EM, Loo DD. PMID: 11193601.
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PubMed Mentions:
24 Fields:
Translation:
Animals
-
Commentary on "Epithelial Fluid Transport--A Century of Investigation" News Physiol Sci. 1999 Jun; 14:98-100.
Loo DD, Wright EM, Meinild AK, Klaerke DA, Zeuthen T. PMID: 11390830.
View in:
PubMed Mentions:
1 Fields: