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Ernest Marshall Wright

Title(s)Professor, Physiology
SchoolMedicine
Address760 Westwood Plaza 53-231
Los Angeles CA 90024
Phone3108256905
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    Role of SGLTs in Glucose Homeostasis and Tissue Metabolism
    NIH/NIDDK R01DK077133Apr 1, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Molecular Architecture of the Na+/Glucose Cotransporter
    NIH/NIDDK R01DK044602Sep 30, 1992 - Sep 29, 1997
    Role: Principal Investigator
    FAMILIAL GLUCOSE GALACTOSE MALABSORPTION
    NIH/NIDDK R01DK044582Sep 30, 1992 - Sep 29, 1996
    Role: Principal Investigator
    STRUCTURE AND FUNCTIONS OF NA/GLUCOSE COTRANSPORTERS
    NIH/NIDDK R01DK036700May 1, 1986 - Apr 30, 1991
    Role: Principal Investigator
    PHYSIOLOGY STUDY SECTION
    NIH/CSR R09RG010769Jul 1, 1983 - Jun 30, 1986
    Role: Principal Investigator
    THE SECRETION OF CEREBROSPINAL FLUID
    NIH/NINDS R01NS009666Mar 1, 1979 - Jun 30, 1994
    Role: Principal Investigator
    Molecular Mechanisms of Intestinal Transport
    NIH/NIDDK R01DK019567Dec 1, 1976 - Oct 31, 2010
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    NIH/NIADDK R01AM019567Dec 1, 1976 - Nov 30, 1988
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. SGLT2 and cancer. Pflugers Arch. 2020 Aug 20. Wright EM. PMID: 32820343.
      View in: PubMed   Mentions: 1     Fields:    
    2. George Sachs, MB, ChB, DSc (August 26, 1935 - November 12, 2019). Gastroenterology. 2020 Jun; 158(8):2015-2016. Marcus EA, Wright EM. PMID: 32423789.
      View in: PubMed   Mentions:    Fields:    
    3. Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nat Commun. 2018 12 07; 9(1):5245. Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. PMID: 30532032.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    4. Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. Diabetologia. 2018 10; 61(10):2087-2097. Ghezzi C, Loo DDF, Wright EM. PMID: 30132032.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    5. Intestinal absorption of glucose in mice as determined by positron emission tomography. J Physiol. 2018 07; 596(13):2473-2489. Sala-Rabanal M, Ghezzi C, Hirayama BA, Kepe V, Liu J, Barrio JR, Wright EM. PMID: 29707805.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. Positron emission tomography of sodium glucose cotransport activity in high grade astrocytomas. J Neurooncol. 2018 Jul; 138(3):557-569. Kepe V, Scafoglio C, Liu J, Yong WH, Bergsneider M, Huang SC, Barrio JR, Wright EM. PMID: 29525972.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. Conformational transitions of the sodium-dependent sugar transporter, vSGLT. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2742-E2751. Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. PMID: 29507231.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    8. Novel and Unexpected Functions of SGLTs. Physiology (Bethesda). 2017 11; 32(6):435-443. Wright EM, Ghezzi C, Loo DDF. PMID: 29021363.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    9. Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9980-E9988. Gorraitz E, Hirayama BA, Paz A, Wright EM, Loo DDF. PMID: 29087341.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Structural and functional significance of water permeation through cotransporters. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):E6887-E6894. Zeuthen T, Gorraitz E, Her K, Wright EM, Loo DD. PMID: 27791155.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule. J Am Soc Nephrol. 2017 Mar; 28(3):802-810. Ghezzi C, Yu AS, Hirayama BA, Kepe V, Liu J, Scafoglio C, Powell DR, Huang SC, Satyamurthy N, Barrio JR, Wright EM. PMID: 27620988.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    12. Stochastic steps in secondary active sugar transport. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3960-6. Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. PMID: 27325773.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    13. Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice. J Physiol. 2016 08 01; 594(15):4425-38. Sala-Rabanal M, Hirayama BA, Ghezzi C, Liu J, Huang SC, Kepe V, Koepsell H, Yu A, Powell DR, Thorens B, Wright EM, Barrio JR. PMID: 27018980.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    14. Functional expression of sodium-glucose transporters in cancer. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4111-9. Scafoglio C, Hirayama BA, Kepe V, Liu J, Ghezzi C, Satyamurthy N, Moatamed NA, Huang J, Koepsell H, Barrio JR, Wright EM. PMID: 26170283.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    15. Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences. Diab Vasc Dis Res. 2015 Mar; 12(2):78-89. Gallo LA, Wright EM, Vallon V. PMID: 25616707.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    16. SGLT2 inhibitors act from the extracellular surface of the cell membrane. Physiol Rep. 2014 Jun 01; 2(6). Ghezzi C, Hirayama BA, Gorraitz E, Loo DD, Liang Y, Wright EM. PMID: 24973332.
      View in: PubMed   Mentions: 16     Fields:    
    17. Structural determinants of water permeation through the sodium-galactose transporter vSGLT. Biophys J. 2014 Mar 18; 106(6):1280-9. Adelman JL, Sheng Y, Choe S, Abramson J, Wright EM, Rosenberg JM, Grabe M. PMID: 24655503.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    18. Fingerprints of hSGLT5 sugar and cation selectivity. Am J Physiol Cell Physiol. 2014 May 01; 306(9):C864-70. Ghezzi C, Gorraitz E, Hirayama BA, Loo DD, Grempler R, Mayoux E, Wright EM. PMID: 24573086.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    19. Functional identification and characterization of sodium binding sites in Na symporters. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4557-66. Loo DD, Jiang X, Gorraitz E, Hirayama BA, Wright EM. PMID: 24191006.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    20. Glucose transport families SLC5 and SLC50. Mol Aspects Med. 2013 Apr-Jun; 34(2-3):183-96. Wright EM. PMID: 23506865.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    21. Regional distribution of SGLT activity in rat brain in vivo. Am J Physiol Cell Physiol. 2013 Feb 01; 304(3):C240-7. Yu AS, Hirayama BA, Timbol G, Liu J, Diez-Sampedro A, Kepe V, Satyamurthy N, Huang SC, Wright EM, Barrio JR. PMID: 23151803.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    22. The importance of being aromatic: p interactions in sodium symporters. Biochemistry. 2012 Nov 27; 51(47):9480-7. Jiang X, Loo DD, Hirayama BA, Wright EM. PMID: 23116249.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    23. Regulation of the human Na+-dependent glucose cotransporter hSGLT2. Am J Physiol Cell Physiol. 2012 Aug 01; 303(3):C348-54. Ghezzi C, Wright EM. PMID: 22673616.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    24. Bridging the gap between structure and kinetics of human SGLT1. Am J Physiol Cell Physiol. 2012 May 01; 302(9):C1293-305. Sala-Rabanal M, Hirayama BA, Loo DD, Chaptal V, Abramson J, Wright EM. PMID: 22159082.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    25. Structural selectivity of human SGLT inhibitors. Am J Physiol Cell Physiol. 2012 Jan 15; 302(2):C373-82. Hummel CS, Lu C, Liu J, Ghezzi C, Hirayama BA, Loo DD, Kepe V, Barrio JR, Wright EM. PMID: 21940664.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    26. Biology of human sodium glucose transporters. Physiol Rev. 2011 Apr; 91(2):733-94. Wright EM, Loo DD, Hirayama BA. PMID: 21527736.
      View in: PubMed   Mentions: 251     Fields:    Translation:HumansAnimalsCells
    27. Conical tomography of a ribbon synapse: structural evidence for vesicle fusion. PLoS One. 2011 Mar 01; 6(3):e16944. Zampighi GA, Schietroma C, Zampighi LM, Woodruff M, Wright EM, Brecha NC. PMID: 21390245.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    28. The mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature. 2010 Dec 16; 468(7326):988-91. Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. PMID: 21131949.
      View in: PubMed   Mentions: 82     Fields:    Translation:Cells
    29. Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C14-21. Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, Wright EM. PMID: 20980548.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    30. Water permeation through the sodium-dependent galactose cotransporter vSGLT. Biophys J. 2010 Oct 06; 99(7):L56-8. Choe S, Rosenberg JM, Abramson J, Wright EM, Grabe M. PMID: 20923633.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    31. Functional expression of SGLTs in rat brain. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1277-84. Yu AS, Hirayama BA, Timbol G, Liu J, Basarah E, Kepe V, Satyamurthy N, Huang SC, Wright EM, Barrio JR. PMID: 20826762.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    32. Structure and function of Na(+)-symporters with inverted repeats. Curr Opin Struct Biol. 2009 Aug; 19(4):425-32. Abramson J, Wright EM. PMID: 19631523.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    33. Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Kidney Int. 2009 Jun; 75(12):1272-1277. Bakris GL, Fonseca VA, Sharma K, Wright EM. PMID: 19357717.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimals
    34. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science. 2008 Aug 08; 321(5890):810-4. Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J. PMID: 18599740.
      View in: PubMed   Mentions: 219     Fields:    Translation:Cells
    35. How drugs interact with transporters: SGLT1 as a model. J Membr Biol. 2008 May; 223(2):87-106. Loo DD, Hirayama BA, Sala-Rabanal M, Wright EM. PMID: 18592293.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    36. Conical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zone. J Neurosci. 2008 Apr 16; 28(16):4151-60. Zampighi GA, Fain N, Zampighi LM, Cantele F, Lanzavecchia S, Wright EM. PMID: 18417694.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    37. Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2. Am J Physiol Renal Physiol. 2008 Jun; 294(6):F1422-32. Sala-Rabanal M, Loo DD, Hirayama BA, Wright EM. PMID: 18367661.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Sodium-dependent reorganization of the sugar-binding site of SGLT1. Biochemistry. 2007 Nov 20; 46(46):13391-406. Hirayama BA, Loo DD, Díez-Sampedro A, Leung DW, Meinild AK, Lai-Bing M, Turk E, Wright EM. PMID: 17960916.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    39. Active sugar transport in health and disease. J Intern Med. 2007 Jan; 261(1):32-43. Wright EM, Hirayama BA, Loo DF. PMID: 17222166.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    40. Conformational dynamics of hSGLT1 during Na+/glucose cotransport. J Gen Physiol. 2006 Dec; 128(6):701-20. Loo DD, Hirayama BA, Karakossian MH, Meinild AK, Wright EM. PMID: 17130520.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    41. Imino sugars are potent agonists of the human glucose sensor SGLT3. Mol Pharmacol. 2007 Feb; 71(2):628-34. Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM. PMID: 17110502.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    42. Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 01; 574(Pt 1):149-66. Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM. PMID: 16627568.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    43. A reinvestigation of the secondary structure of functionally active vSGLT, the vibrio sodium/galactose cotransporter. Biochemistry. 2006 Feb 07; 45(5):1470-9. Turk E, Gasymov OK, Lanza S, Horwitz J, Wright EM. PMID: 16445289.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    44. Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter. J Gen Physiol. 2005 Jan; 125(1):13-36. Loo DD, Hirayama BA, Cha A, Bezanilla F, Wright EM. PMID: 15596535.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    45. Surprising versatility of Na+-glucose cotransporters: SLC5. Physiology (Bethesda). 2004 Dec; 19:370-6. Wright EM, Loo DD, Hirayama BA, Turk E. PMID: 15546855.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    46. Coupled sodium/glucose cotransport by SGLT1 requires a negative charge at position 454. Biochemistry. 2004 Oct 19; 43(41):13175-84. Díez-Sampedro A, Loo DD, Wright EM, Zampighi GA, Hirayama BA. PMID: 15476411.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    47. Local conformational changes in the Vibrio Na+/galactose cotransporter. Biochemistry. 2004 Mar 30; 43(12):3620-7. Veenstra M, Lanza S, Hirayama BA, Turk E, Wright EM. PMID: 15035632.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    48. Intestinal absorption in health and disease--sugars. Best Pract Res Clin Gastroenterol. 2003 Dec; 17(6):943-56. Wright EM, Martín MG, Turk E. PMID: 14642859.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    49. A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11753-8. Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H. PMID: 13130073.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    50. Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles. Biochemistry. 2003 Aug 05; 42(30):9147-52. Quick M, Tomasevic J, Wright EM. PMID: 12885248.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    51. The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb; 447(5):510-8. Wright EM, Turk E. PMID: 12748858.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    52. Structure of functional single AQP0 channels in phospholipid membranes. J Mol Biol. 2003 Jan 03; 325(1):201-10. Zampighi GA, Kreman M, Lanzavecchia S, Turk E, Eskandari S, Zampighi L, Wright EM. PMID: 12473462.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. Electrophysiological properties of the mouse Na+/Cl(-)-dependent taurine transporter (mTauT-1): steady-state kinetics: stoichiometry of taurine transport. Adv Exp Med Biol. 2003; 526:197-204. Sarkar HK, Wright EM, Boorer KJ, Loo DD. PMID: 12908601.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    54. Water pumps. J Physiol. 2002 Jul 01; 542(Pt 1):53-60. Loo DD, Wright EM, Zeuthen T. PMID: 12096049.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    55. Ligand-induced differences in secondary structure of the Vibrio parahaemolyticus Na+/galactose cotransporter. Biochemistry. 2002 Jun 25; 41(25):8082-6. le Coutre J, Turk E, Kaback HR, Wright EM. PMID: 12069600.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    56. Employing Escherichia coli to functionally express, purify, and characterize a human transporter. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8597-601. Quick M, Wright EM. PMID: 12077304.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    57. Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids. Plant J. 2002 Mar; 29(6):717-31. Fischer WN, Loo DD, Koch W, Ludewig U, Boorer KJ, Tegeder M, Rentsch D, Wright EM, Frommer WB. PMID: 12148530.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    58. Fluorescence studies of ligand-induced conformational changes of the Na(+)/glucose cotransporter. Biochemistry. 2002 Jan 29; 41(4):1250-8. Meinild AK, Hirayama BA, Wright EM, Loo DD. PMID: 11802724.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    59. Molecular basis for glucose-galactose malabsorption. Cell Biochem Biophys. 2002; 36(2-3):115-21. Wright EM, Turk E, Martin MG. PMID: 12139397.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    60. Renal Na(+)-glucose cotransporters. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F10-8. Wright EM. PMID: 11133510.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    61. Coupling between Na+, sugar, and water transport across the intestine. Ann N Y Acad Sci. 2000; 915:54-66. Wright EM, Loo DD. PMID: 11193601.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    62. Commentary on "Epithelial Fluid Transport--A Century of Investigation" News Physiol Sci. 1999 Jun; 14:98-100. Loo DD, Wright EM, Meinild AK, Klaerke DA, Zeuthen T. PMID: 11390830.
      View in: PubMed   Mentions: 1     Fields:    
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