Indrani Sinha-Hikim

Title(s)	Associate Adjunct Professor, Medicine
School	Medicine
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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E-cigarettes and Western Diet: Important Metabolic Risk Factors for Hepatic Diseases. Hepatology. 2019 06; 69(6):2442-2454. Hasan KM, Friedman TC, Shao X, Parveen M, Sims C, Lee DL, Espinoza-Derout J, Sinha-Hikim I, Sinha-Hikim AP. PMID: 30664268; PMCID: PMC6636679.

View in: PubMed Mentions: 17 Fields:
Gas Gastroenterology
Translation:Humans Animals
α7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata SK, Sinha-Hikim AP. PMID: 29272360; PMCID: PMC5776480.

View in: PubMed Mentions: 12 Fields:
End Endocrinology
Translation:Animals Cells
Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. Front Endocrinol (Lausanne). 2017; 8:23. Sinha-Hikim AP, Sinha-Hikim I, Friedman TC. PMID: 28239368; PMCID: PMC5300964.

View in: PubMed Mentions: 21 Fields:
End Endocrinology
Muscle Derived Stem Cells Stimulate Muscle Myofiber Repair and Counteract Fat Infiltration in a Diabetic Mouse Model of Critical Limb Ischemia. J Stem Cell Res Ther. 2016 Dec; 6(12). Tsao J, Kovanecz I, Awadalla N, Gelfand R, Sinha-Hikim I, White RA, Gonzalez-Cadavid NF. PMID: 28217409; PMCID: PMC5313052.

View in: PubMed Mentions: 6
Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res. 2017 04; 368(1):159-170. Sinha-Hikim I, Friedman TC, Falz M, Chalfant V, Hasan MK, Espinoza-Derout J, Lee DL, Sims C, Tran P, Mahata SK, Sinha-Hikim AP. PMID: 27917437; PMCID: PMC5813800.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology His Histology
Translation:Animals Cells
Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res. 2015 Apr; 47(4):280-3. Sinha-Hikim I, Duran P, Shen R, Lee M, Friedman TC, Davidson MB. PMID: 25011019; PMCID: PMC4648252.

View in: PubMed Mentions: 18 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model. Cell Tissue Res. 2014 Sep; 357(3):815-21. Sinha I, Sinha-Hikim AP, Wagers AJ, Sinha-Hikim I. PMID: 24859218; PMCID: PMC4149819.

View in: PubMed Mentions: 22 Fields:
Cel Cell Biology His Histology
Translation:Animals Cells
Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res. 2014 Jul; 46(8):568-73. Ivey R, Desai M, Green K, Sinha-Hikim I, Friedman TC, Sinha-Hikim AP. PMID: 24830635; PMCID: PMC4327908.

View in: PubMed Mentions: 11 Fields:
End Endocrinology Met Metabolism
Translation:Animals Cells
Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology. 2014 Mar; 155(3):865-72. Sinha-Hikim I, Friedman TC, Shin CS, Lee D, Ivey R, Sinha-Hikim AP. PMID: 24424058; PMCID: PMC3929732.

View in: PubMed Mentions: 17 Fields:
End Endocrinology
Translation:Animals Cells
Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging. J Gerontol A Biol Sci Med Sci. 2013 Jul; 68(7):749-59. Sinha-Hikim I, Sinha-Hikim AP, Parveen M, Shen R, Goswami R, Tran P, Crum A, Norris KC. PMID: 23459206; PMCID: PMC3674717.

View in: PubMed Mentions: 25 Fields:
Ger Geriatrics
Translation:Animals
Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. 2012 Dec; 153(12):5809-20. Friedman TC, Sinha-Hikim I, Parveen M, Najjar SM, Liu Y, Mangubat M, Shin CS, Lyzlov A, Ivey R, Shaheen M, French SW, Sinha-Hikim AP. PMID: 23093702; PMCID: PMC3512067.

View in: PubMed Mentions: 31 Fields:
End Endocrinology
Translation:Animals Cells
Effect of nicotine on body composition in mice. J Endocrinol. 2012 Mar; 212(3):317-26. Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. PMID: 22138237; PMCID: PMC3444240.

View in: PubMed Mentions: 30 Fields:
End Endocrinology
Translation:Animals
Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure. Apoptosis. 2011 Jun; 16(6):563-73. Sinha-Hikim I, Shen R, Nzenwa I, Gelfand R, Mahata SK, Sinha-Hikim AP. PMID: 21424555; PMCID: PMC4701037.

View in: PubMed Mentions: 20 Fields:
Cel Cell Biology
Translation:Humans Animals Cells PHPublic Health
A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. Exp Mol Pathol. 2011 Aug; 91(1):419-28. Sinha-Hikim I, Sinha-Hikim AP, Shen R, Kim HJ, Kim H, French SW, Vaziri ND, Vaziri ND, Crum AC, Crum A, Rajavashisth TB, Norris KC. PMID: 21570964; PMCID: PMC3191382.

View in: PubMed Mentions: 25 Fields:
Mol Molecular Biology Pat Pathology
Translation:Animals Cells
Effects of a novel cystine-based glutathione precursor on oxidative stress in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2010 Sep; 299(3):C638-42. Sinha-Hikim I, Shen R, Paul Lee WN, Crum A, Vaziri ND, Norris KC. PMID: 20592243; PMCID: PMC2944321.

View in: PubMed Mentions: 14 Fields:
Cel Cell Biology Phy Physiology
Translation:Humans Cells
Inhibition of apoptotic signalling in spermine-treated vascular smooth muscle cells by a novel glutathione precursor. Cell Biol Int. 2010 Apr 01; 34(5):503-11. Sinha-Hikim I, Shen R, Kovacheva E, Crum A, Vaziri ND, Norris KC. PMID: 20121705; PMCID: PMC3748361.

View in: PubMed Mentions: 6 Fields:
Cel Cell Biology
Translation:Humans Cells
Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology. 2010 Feb; 151(2):628-38. Kovacheva EL, Hikim AP, Shen R, Sinha I, Sinha-Hikim I. PMID: 20022929; PMCID: PMC2817626.

View in: PubMed Mentions: 71 Fields:
End Endocrinology
Translation:Humans Animals Cells
Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling. J Endocrinol. 2009 Apr; 201(1):129-39. Brown D, Hikim AP, Kovacheva EL, Sinha-Hikim I. PMID: 19144735; PMCID: PMC4732720.

View in: PubMed Mentions: 20 Fields:
End Endocrinology
Translation:Animals Cells
Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biol Reprod. 2009 Apr; 80(4):771-80. Jia Y, Castellanos J, Wang C, Sinha-Hikim I, Lue Y, Swerdloff RS, Sinha-Hikim AP. PMID: 19109224; PMCID: PMC2804830.

View in: PubMed Mentions: 24 Fields:
Rep Reproductive Medicine
Translation:Animals Cells
Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis. 2008 Jun; 13(6):822-32. Braga M, Sinha Hikim AP, Datta S, Ferrini MG, Brown D, Kovacheva EL, Gonzalez-Cadavid NF, Sinha-Hikim I. PMID: 18461459; PMCID: PMC4732709.

View in: PubMed Mentions: 62 Fields:
Cel Cell Biology
Translation:Animals Cells
Involvement of c-Jun NH2-terminal kinase and nitric oxide-mediated mitochondria-dependent intrinsic pathway signaling in cardiotoxin-induced muscle cell death: role of testosterone. Apoptosis. 2007 Nov; 12(11):1965-78. Sinha-Hikim I, Braga M, Shen R, Sinha Hikim AP. PMID: 17786558.

View in: PubMed Mentions: 19 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss. Fertil Steril. 2006 Jun; 85(6):1794-802. Herbst KL, Calof OM, Hsia SH, Sinha-Hikim I, Woodhouse LJ, Buchanan TA, Bhasin S. PMID: 16759927.

View in: PubMed Mentions: 6 Fields:
Rep Reproductive Medicine
Translation:Humans
Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. J Clin Endocrinol Metab. 2006 Aug; 91(8):3024-33. Sinha-Hikim I, Cornford M, Gaytan H, Lee ML, Bhasin S. PMID: 16705073.

View in: PubMed Mentions: 103 Fields:
End Endocrinology Met Metabolism
Translation:Humans Cells
Pharmacokinetics of a testosterone gel in healthy postmenopausal women. J Clin Endocrinol Metab. 2006 Jan; 91(1):136-44. Singh AB, Lee ML, Sinha-Hikim I, Kushnir M, Meikle W, Rockwood A, Afework S, Bhasin S. PMID: 16263817.

View in: PubMed Mentions: 10 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older men. J Clin Endocrinol Metab. 2005 Jul; 90(7):3838-46. Gray PB, Singh AB, Woodhouse LJ, Storer TW, Casaburi R, Dzekov J, Dzekov C, Sinha-Hikim I, Bhasin S. PMID: 15827094.

View in: PubMed Mentions: 49 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss. J Clin Endocrinol Metab. 2005 Mar; 90(3):1531-41. Choi HH, Gray PB, Storer TW, Calof OM, Woodhouse L, Singh AB, Padero C, Mac RP, Sinha-Hikim I, Shen R, Dzekov J, Dzekov C, Kushnir MM, Rockwood AL, Meikle AW, Lee ML, Hays RD, Bhasin S. PMID: 15613414.

View in: PubMed Mentions: 24 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab. 2005 Feb; 90(2):678-88. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Mac RP, Lee M, Yarasheski KE, Sinha-Hikim I, Dzekov C, Dzekov J, Magliano L, Storer TW. PMID: 15562020.

View in: PubMed Mentions: 151 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab. 2005 Feb; 90(2):855-63. Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. PMID: 15522925.

View in: PubMed Mentions: 10 Fields:
End Endocrinology Met Metabolism
Translation:Humans Animals Cells
Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. J Clin Endocrinol Metab. 2004 Oct; 89(10):5245-55. Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S. PMID: 15472231.

View in: PubMed Mentions: 93 Fields:
End Endocrinology Met Metabolism
Translation:Humans Cells CTClinical Trials
The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol A Biol Sci Med Sci. 2003 Dec; 58(12):M1103-10. Bhasin S, Taylor WE, Singh R, Artaza J, Sinha-Hikim I, Jasuja R, Choi H, Gonzalez-Cadavid NF. PMID: 14684707.

View in: PubMed Mentions: 57 Fields:
Ger Geriatrics
Translation:Humans Cells
Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. Am J Physiol Endocrinol Metab. 2003 Oct; 285(4):E876-88. Reisz-Porszasz S, Bhasin S, Artaza JN, Shen R, Sinha-Hikim I, Hogue A, Fielder TJ, Gonzalez-Cadavid NF. PMID: 12824080.

View in: PubMed Mentions: 115 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals
Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men. Am J Physiol Endocrinol Metab. 2003 Jul; 285(1):E197-205. Sinha-Hikim I, Roth SM, Lee MI, Bhasin S. PMID: 12670837.

View in: PubMed Mentions: 96 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Humans Cells CTClinical Trials
Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. Am J Physiol Endocrinol Metab. 2002 Jul; 283(1):E154-64. Sinha-Hikim I, Artaza J, Woodhouse L, Gonzalez-Cadavid N, Singh AB, Lee MI, Storer TW, Casaburi R, Shen R, Bhasin S. PMID: 12067856.

View in: PubMed Mentions: 105 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Humans Cells CTClinical Trials
Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. J Nutr Health Aging. 2002; 6(5):343-8. Yarasheski KE, Bhasin S, Sinha-Hikim I, Pak-Loduca J, Gonzalez-Cadavid NF. PMID: 12474026.

View in: PubMed Mentions: 115 Fields:
Ger Geriatrics Nut Nutritional Sciences
The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men. J Clin Endocrinol Metab. 2002 Jan; 87(1):136-43. Singh AB, Hsia S, Alaupovic P, Sinha-Hikim I, Woodhouse L, Buchanan TA, Shen R, Bross R, Berman N, Bhasin S. PMID: 11788637.

View in: PubMed Mentions: 47 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab. 2001 Dec; 281(6):E1172-81. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW. PMID: 11701431.

View in: PubMed Mentions: 218 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Humans CTClinical Trials
Pharmacokinetics of a transdermal testosterone system in men with end stage renal disease receiving maintenance hemodialysis and healthy hypogonadal men. J Clin Endocrinol Metab. 2001 Jun; 86(6):2437-45. Singh AB, Norris K, Modi N, Sinha-Hikim I, Shen R, Davidson T, Bhasin S. PMID: 11397836.

View in: PubMed Mentions: 14 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Pharmacokinetics of a novel testosterone matrix transdermal system in healthy, premenopausal women and women infected with the human immunodeficiency virus. J Clin Endocrinol Metab. 2000 Jul; 85(7):2395-401. Javanbakht M, Singh AB, Mazer NA, Beall G, Sinha-Hikim I, Shen R, Bhasin S. PMID: 10902784.

View in: PubMed Mentions: 3 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. JAMA. 2000 Feb 09; 283(6):763-70. Bhasin S, Storer TW, Javanbakht M, Berman N, Yarasheski KE, Phillips J, Dike M, Sinha-Hikim I, Shen R, Hays RD, Beall G. PMID: 10683055; PMCID: PMC3173037.

View in: PubMed Mentions: 72 Fields:
Med Medicine (General)
Translation:Humans CTClinical Trials
Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration. J Gravit Physiol. 1999 Oct; 6(2):11-5. Zachwieja JJ, Smith SR, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. PMID: 11543081.

View in: PubMed Mentions: 18 Fields:
Phy Physiology
Translation:Humans
Serum dihydrotestosterone and testosterone concentrations in human immunodeficiency virus-infected men with and without weight loss. J Androl. 1999 Sep-Oct; 20(5):611-8. Arver S, Sinha-Hikim I, Beall G, Guerrero M, Shen R, Bhasin S. PMID: 10520573.

View in: PubMed Mentions: 10 Fields:
Rep Reproductive Medicine Uro Urology
Translation:Humans CTClinical Trials
Testicular pathologic changes and the pituitary-testicular axis during human immunodeficiency virus infection. Endocr Pract. 1999 Jan-Feb; 5(1):1-9. Salehian B, Jacobson D, Swerdloff RS, Grafe MR, Sinha-Hikim I, McCutchan JA. PMID: 15251696.

View in: PubMed Mentions: 3 Fields:
End Endocrinology
Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14938-43. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M, Nair G, Arver S, Bhasin S. PMID: 9843994; PMCID: PMC24554.

View in: PubMed Mentions: 146 Fields:
Sci Science
Translation:Humans Animals Cells
Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels. J Clin Endocrinol Metab. 1998 Sep; 83(9):3155-62. Bhasin S, Storer TW, Asbel-Sethi N, Kilbourne A, Hays R, Sinha-Hikim I, Shen R, Arver S, Beall G. PMID: 9745419.

View in: PubMed Mentions: 20 Fields:
End Endocrinology Met Metabolism
Translation:Humans CTClinical Trials
The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab. 1998 Apr; 83(4):1312-8. Sinha-Hikim I, Arver S, Beall G, Shen R, Guerrero M, Sattler F, Shikuma C, Nelson JC, Landgren BM, Mazer NA, Bhasin S. PMID: 9543161.

View in: PubMed Mentions: 37 Fields:
End Endocrinology Met Metabolism
Translation:Humans Cells