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Indrani Sinha-Hikim

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone3235635959
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. E-cigarettes and Western Diet: Important Metabolic Risk Factors for Hepatic Diseases. Hepatology. 2019 06; 69(6):2442-2454. Hasan KM, Friedman TC, Shao X, Parveen M, Sims C, Lee DL, Espinoza-Derout J, Sinha-Hikim I, Sinha-Hikim AP. PMID: 30664268.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    2. a7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata SK, Sinha-Hikim AP. PMID: 29272360.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. Front Endocrinol (Lausanne). 2017; 8:23. Sinha-Hikim AP, Sinha-Hikim I, Friedman TC. PMID: 28239368.
      View in: PubMed   Mentions:
    4. Muscle Derived Stem Cells Stimulate Muscle Myofiber Repair and Counteract Fat Infiltration in a Diabetic Mouse Model of Critical Limb Ischemia. J Stem Cell Res Ther. 2016 Dec; 6(12). Tsao J, Kovanecz I, Awadalla N, Gelfand R, Sinha-Hikim I, White RA, Gonzalez-Cadavid NF. PMID: 28217409.
      View in: PubMed   Mentions:
    5. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res. 2017 04; 368(1):159-170. Sinha-Hikim I, Friedman TC, Falz M, Chalfant V, Hasan MK, Espinoza-Derout J, Lee DL, Sims C, Tran P, Mahata SK, Sinha-Hikim AP. PMID: 27917437.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res. 2015 Apr; 47(4):280-3. Sinha-Hikim I, Duran P, Shen R, Lee M, Friedman TC, Davidson MB. PMID: 25011019.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    7. Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model. Cell Tissue Res. 2014 Sep; 357(3):815-21. Sinha I, Sinha-Hikim AP, Wagers AJ, Sinha-Hikim I. PMID: 24859218.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res. 2014 Jul; 46(8):568-73. Ivey R, Desai M, Green K, Sinha-Hikim I, Friedman TC, Sinha-Hikim AP. PMID: 24830635.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology. 2014 Mar; 155(3):865-72. Sinha-Hikim I, Friedman TC, Shin CS, Lee D, Ivey R, Sinha-Hikim AP. PMID: 24424058.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging. J Gerontol A Biol Sci Med Sci. 2013 Jul; 68(7):749-59. Sinha-Hikim I, Sinha-Hikim AP, Parveen M, Shen R, Goswami R, Tran P, Crum A, Norris KC. PMID: 23459206.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    11. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. 2012 Dec; 153(12):5809-20. Friedman TC, Sinha-Hikim I, Parveen M, Najjar SM, Liu Y, Mangubat M, Shin CS, Lyzlov A, Ivey R, Shaheen M, French SW, Sinha-Hikim AP. PMID: 23093702.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    12. Effect of nicotine on body composition in mice. J Endocrinol. 2012 Mar; 212(3):317-26. Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. PMID: 22138237.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    13. Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure. Apoptosis. 2011 Jun; 16(6):563-73. Sinha-Hikim I, Shen R, Nzenwa I, Gelfand R, Mahata SK, Sinha-Hikim AP. PMID: 21424555.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    14. A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. Exp Mol Pathol. 2011 Aug; 91(1):419-28. Sinha-Hikim I, Sinha-Hikim AP, Shen R, Kim HJ, Kim H, French SW, Vaziri ND, Vaziri ND, Crum AC, Crum A, Rajavashisth TB, Norris KC. PMID: 21570964.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    15. Effects of a novel cystine-based glutathione precursor on oxidative stress in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2010 Sep; 299(3):C638-42. Sinha-Hikim I, Shen R, Paul Lee WN, Crum A, Vaziri ND, Norris KC. PMID: 20592243.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    16. Inhibition of apoptotic signalling in spermine-treated vascular smooth muscle cells by a novel glutathione precursor. Cell Biol Int. 2010 Apr 01; 34(5):503-11. Sinha-Hikim I, Shen R, Kovacheva E, Crum A, Vaziri ND, Norris KC. PMID: 20121705.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology. 2010 Feb; 151(2):628-38. Kovacheva EL, Hikim AP, Shen R, Sinha I, Sinha-Hikim I. PMID: 20022929.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    18. Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling. J Endocrinol. 2009 Apr; 201(1):129-39. Brown D, Hikim AP, Kovacheva EL, Sinha-Hikim I. PMID: 19144735.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    19. Mitogen-activated protein kinase signaling in male germ cell apoptosis in the rat. Biol Reprod. 2009 Apr; 80(4):771-80. Jia Y, Castellanos J, Wang C, Sinha-Hikim I, Lue Y, Swerdloff RS, Sinha-Hikim AP. PMID: 19109224.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    20. Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis. 2008 Jun; 13(6):822-32. Braga M, Sinha Hikim AP, Datta S, Ferrini MG, Brown D, Kovacheva EL, Gonzalez-Cadavid NF, Sinha-Hikim I. PMID: 18461459.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    21. Involvement of c-Jun NH2-terminal kinase and nitric oxide-mediated mitochondria-dependent intrinsic pathway signaling in cardiotoxin-induced muscle cell death: role of testosterone. Apoptosis. 2007 Nov; 12(11):1965-78. Sinha-Hikim I, Braga M, Shen R, Sinha Hikim AP. PMID: 17786558.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    22. Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss. Fertil Steril. 2006 Jun; 85(6):1794-802. Herbst KL, Calof OM, Hsia SH, Sinha-Hikim I, Woodhouse LJ, Buchanan TA, Bhasin S. PMID: 16759927.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. J Clin Endocrinol Metab. 2006 Aug; 91(8):3024-33. Sinha-Hikim I, Cornford M, Gaytan H, Lee ML, Bhasin S. PMID: 16705073.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    24. Pharmacokinetics of a testosterone gel in healthy postmenopausal women. J Clin Endocrinol Metab. 2006 Jan; 91(1):136-44. Singh AB, Lee ML, Sinha-Hikim I, Kushnir M, Meikle W, Rockwood A, Afework S, Bhasin S. PMID: 16263817.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    25. Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older men. J Clin Endocrinol Metab. 2005 Jul; 90(7):3838-46. Gray PB, Singh AB, Woodhouse LJ, Storer TW, Casaburi R, Dzekov J, Dzekov C, Sinha-Hikim I, Bhasin S. PMID: 15827094.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    26. Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss. J Clin Endocrinol Metab. 2005 Mar; 90(3):1531-41. Choi HH, Gray PB, Storer TW, Calof OM, Woodhouse L, Singh AB, Padero C, Mac RP, Sinha-Hikim I, Shen R, Dzekov J, Dzekov C, Kushnir MM, Rockwood AL, Meikle AW, Lee ML, Hays RD, Bhasin S. PMID: 15613414.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    27. Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab. 2005 Feb; 90(2):678-88. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Mac RP, Lee M, Yarasheski KE, Sinha-Hikim I, Dzekov C, Dzekov J, Magliano L, Storer TW. PMID: 15562020.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCTClinical Trials
    28. Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab. 2005 Feb; 90(2):855-63. Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. PMID: 15522925.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. J Clin Endocrinol Metab. 2004 Oct; 89(10):5245-55. Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S. PMID: 15472231.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCellsCTClinical Trials
    30. The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol A Biol Sci Med Sci. 2003 Dec; 58(12):M1103-10. Bhasin S, Taylor WE, Singh R, Artaza J, Sinha-Hikim I, Jasuja R, Choi H, Gonzalez-Cadavid NF. PMID: 14684707.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    31. Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. Am J Physiol Endocrinol Metab. 2003 Oct; 285(4):E876-88. Reisz-Porszasz S, Bhasin S, Artaza JN, Shen R, Sinha-Hikim I, Hogue A, Fielder TJ, Gonzalez-Cadavid NF. PMID: 12824080.
      View in: PubMed   Mentions: 90     Fields:    Translation:Animals
    32. Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men. Am J Physiol Endocrinol Metab. 2003 Jul; 285(1):E197-205. Sinha-Hikim I, Roth SM, Lee MI, Bhasin S. PMID: 12670837.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCellsCTClinical Trials
    33. Effects of an oral androgen on muscle and metabolism in older, community-dwelling men. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E120-8. Schroeder ET, Singh A, Bhasin S, Storer TW, Azen C, Davidson T, Martinez C, Sinha-Hikim I, Jaque SV, Terk M, Sattler FR. PMID: 12388137.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    34. Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. Am J Physiol Endocrinol Metab. 2002 Jul; 283(1):E154-64. Sinha-Hikim I, Artaza J, Woodhouse L, Gonzalez-Cadavid N, Singh AB, Lee MI, Storer TW, Casaburi R, Shen R, Bhasin S. PMID: 12067856.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCellsCTClinical Trials
    35. Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. J Nutr Health Aging. 2002; 6(5):343-8. Yarasheski KE, Bhasin S, Sinha-Hikim I, Pak-Loduca J, Gonzalez-Cadavid NF. PMID: 12474026.
      View in: PubMed   Mentions: 70     Fields:    
    36. The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men. J Clin Endocrinol Metab. 2002 Jan; 87(1):136-43. Singh AB, Hsia S, Alaupovic P, Sinha-Hikim I, Woodhouse L, Buchanan TA, Shen R, Bross R, Berman N, Bhasin S. PMID: 11788637.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCTClinical Trials
    37. Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab. 2001 Dec; 281(6):E1172-81. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW. PMID: 11701431.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansCTClinical Trials
    38. Pharmacokinetics of a transdermal testosterone system in men with end stage renal disease receiving maintenance hemodialysis and healthy hypogonadal men. J Clin Endocrinol Metab. 2001 Jun; 86(6):2437-45. Singh AB, Norris K, Modi N, Sinha-Hikim I, Shen R, Davidson T, Bhasin S. PMID: 11397836.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    39. Pharmacokinetics of a novel testosterone matrix transdermal system in healthy, premenopausal women and women infected with the human immunodeficiency virus. J Clin Endocrinol Metab. 2000 Jul; 85(7):2395-401. Javanbakht M, Singh AB, Mazer NA, Beall G, Sinha-Hikim I, Shen R, Bhasin S. PMID: 10902784.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    40. Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. JAMA. 2000 Feb 09; 283(6):763-70. Bhasin S, Storer TW, Javanbakht M, Berman N, Yarasheski KE, Phillips J, Dike M, Sinha-Hikim I, Shen R, Hays RD, Beall G. PMID: 10683055.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCTClinical Trials
    41. Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration. J Gravit Physiol. 1999 Oct; 6(2):11-5. Zachwieja JJ, Smith SR, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. PMID: 11543081.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    42. Serum dihydrotestosterone and testosterone concentrations in human immunodeficiency virus-infected men with and without weight loss. J Androl. 1999 Sep-Oct; 20(5):611-8. Arver S, Sinha-Hikim I, Beall G, Guerrero M, Shen R, Bhasin S. PMID: 10520573.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    43. Testicular pathologic changes and the pituitary-testicular axis during human immunodeficiency virus infection. Endocr Pract. 1999 Jan-Feb; 5(1):1-9. Salehian B, Jacobson D, Swerdloff RS, Grafe MR, Sinha-Hikim I, McCutchan JA. PMID: 15251696.
      View in: PubMed   Mentions: 1     Fields:    
    44. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14938-43. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M, Nair G, Arver S, Bhasin S. PMID: 9843994.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    45. Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels. J Clin Endocrinol Metab. 1998 Sep; 83(9):3155-62. Bhasin S, Storer TW, Asbel-Sethi N, Kilbourne A, Hays R, Sinha-Hikim I, Shen R, Arver S, Beall G. PMID: 9745419.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    46. The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab. 1998 Apr; 83(4):1312-8. Sinha-Hikim I, Arver S, Beall G, Shen R, Guerrero M, Sattler F, Shikuma C, Nelson JC, Landgren BM, Mazer NA, Bhasin S. PMID: 9543161.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
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