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Ottolia, Michela

Title(s)Associate Professor-in-Residence, Anesthesiology
Phone47809
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    Regulation of cellular calcium by cardiac sodium-calcium exchange
    NIH/NHLBI R01HL147569Apr 15, 2019 - Feb 28, 2023
    Role: Co-Principal Investigator
    The Cardiac Na-Ca exchanger: Defining the mechanisms of its operation and regulation
    NIH/NHLBI R01HL130308Apr 20, 2016 - Mar 31, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yue X, Hazan A, Lotteau S, Zhang R, Torrente AG, Philipson KD, Ottolia M, Goldhaber JI. Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling. Cell Calcium. 2020 Jan 30; 87:102167. PMID: 32028091.
      View in: PubMed
    2. Scranton K, John S, Escobar A, Goldhaber JI, Ottolia M. Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications. Cell Calcium. 2019 Dec 11; 87:102140. PMID: 32070924.
      View in: PubMed
    3. John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. J Gen Physiol. 2018 02 05; 150(2):245-257. PMID: 29301861.
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    4. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. PMID: 25772291.
      View in: PubMed
    5. Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI. Na/Ca exchange and contraction of the heart. J Mol Cell Cardiol. 2013 Aug; 61:28-33. PMID: 23770352.
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    6. John SA, Liao J, Jiang Y, Ottolia M. The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7500-5. PMID: 23589872.
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    7. Nicoll DA, Ottolia M, Goldhaber JI, Philipson KD. 20 years from NCX purification and cloning: milestones. Adv Exp Med Biol. 2013; 961:17-23. PMID: 23224866.
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    8. Ottolia M, Philipson KD. NCX1: mechanism of transport. Adv Exp Med Biol. 2013; 961:49-54. PMID: 23224869.
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    9. John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1699-704. PMID: 21209335.
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    10. Ottolia M, Nicoll DA, John S, Philipson KD. Interactions between Ca2+ binding domains of the Na+-Ca2+ exchanger and secondary regulation. Channels (Austin). 2010 May-Jun; 4(3):159-62. PMID: 20224291.
      View in: PubMed
    11. Ottolia M, Nicoll DA, Philipson KD. Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger. J Biol Chem. 2009 Nov 20; 284(47):32735-41. PMID: 19801651.
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    12. Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J. Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger. J Biol Chem. 2009 May 29; 284(22):14688-92. PMID: 19332552.
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    13. Xie Y, Ottolia M, John SA, Chen JN, Philipson KD. Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart. Am J Physiol Cell Physiol. 2008 Aug; 295(2):C388-93. PMID: 18550703.
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    14. Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger? Channels (Austin). 2007 Nov-Dec; 1(6):397-9. PMID: 18690047.
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    15. Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):376-81. PMID: 18162557.
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    16. John SA, Ottolia M, Weiss JN, Ribalet B. Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor. Pflugers Arch. 2008 May; 456(2):307-22. PMID: 18071748.
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    17. Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18467-72. PMID: 17962412.
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    18. Ottolia M, John S, Xie Y, Ren X, Philipson KD. Shedding light on the Na+/Ca2+ exchanger. Ann N Y Acad Sci. 2007 Mar; 1099:78-85. PMID: 17446447.
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    19. Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD. What we know about the structure of NCX1 and how it relates to its function. Ann N Y Acad Sci. 2007 Mar; 1099:1-6. PMID: 17303833.
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    20. Ottolia M, Philipson KD, John S. Xenopus oocyte plasma membrane sheets for FRET analysis. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1519-22. PMID: 17166939.
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    21. Ottolia M, John S, Ren X, Philipson KD. Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization. J Biol Chem. 2007 Feb 09; 282(6):3695-701. PMID: 17158867.
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    22. Ottolia M, Nicoll DA, Philipson KD. Mutational analysis of the alpha-1 repeat of the cardiac Na(+)-Ca2+ exchanger. J Biol Chem. 2005 Jan 14; 280(2):1061-9. PMID: 15519995.
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    23. Ottolia M, Philipson KD, John S. Conformational changes of the Ca(2+) regulatory site of the Na(+)-Ca(2+) exchanger detected by FRET. Biophys J. 2004 Aug; 87(2):899-906. PMID: 15298897.
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    24. Ottolia M, Schumann S, Nicoll DA, Philipson KD. Activation of the cardiac Na+/Ca2+ exchanger by DEPC. Ann N Y Acad Sci. 2002 Nov; 976:85-8. PMID: 12502540.
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    25. Philipson KD, Nicoll DA, Ottolia M, Quednau BD, Reuter H, John S, Qiu Z. The Na+/Ca2+ exchange molecule: an overview. Ann N Y Acad Sci. 2002 Nov; 976:1-10. PMID: 12502528.
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    26. Nicoll DA, Ottolia M, Philipson KD. Toward a topological model of the NCX1 exchanger. Ann N Y Acad Sci. 2002 Nov; 976:11-8. PMID: 12502529.
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    27. Ottolia M, John S, Qiu Z, Philipson KD. Split Na+-Ca2+ exchangers. Implications for function and expression. J Biol Chem. 2001 Jun 01; 276(22):19603-9. PMID: 11274218.
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    28. Santacruz-Toloza L, Ottolia M, Nicoll DA, Philipson KD. Functional analysis of a disulfide bond in the cardiac Na(+)-Ca(2+) exchanger. J Biol Chem. 2000 Jan 07; 275(1):182-8. PMID: 10617603.
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    29. Groh S, Marty I, Ottolia M, Prestipino G, Chapel A, Villaz M, Ronjat M. Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor. J Biol Chem. 1999 Apr 30; 274(18):12278-83. PMID: 10212196.
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    30. Ottolia M, Babini E, Gazzotti P, Possani LD, Prestipino G. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum. Brain Res. 1999 Jan 09; 815(2):410-3. PMID: 9878856.
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    31. Nicoll DA, Ottolia M, Lu L, Lu Y, Philipson KD. A new topological model of the cardiac sarcolemmal Na+-Ca2+ exchanger. J Biol Chem. 1999 Jan 08; 274(2):910-7. PMID: 9873031.
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    32. Ottolia M, Platano D, Qin N, Noceti F, Birnbaumer M, Toro L, Birnbaumer L, Stefani E, Olcese R. Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes. FEBS Lett. 1998 May 01; 427(1):96-102. PMID: 9613607.
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    33. Pisciotta M, Ottolia M, Possani LD, Prestipino G. A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes. Biochem Biophys Res Commun. 1998 Jan 14; 242(2):287-91. PMID: 9446786.
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    34. Treves S, Scutari E, Robert M, Groh S, Ottolia M, Prestipino G, Ronjat M, Zorzato F. Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle. Biochemistry. 1997 Sep 23; 36(38):11496-503. PMID: 9298970.
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    35. Stefani E, Ottolia M, Noceti F, Olcese R, Wallner M, Latorre R, Toro L. Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo). Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5427-31. PMID: 9144254.
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    36. Ottolia M, Toro L. Reconstitution in lipid bilayers of an ATP-sensitive K+ channel from pig coronary smooth muscle. J Membr Biol. 1996 Oct; 153(3):203-9. PMID: 8849415.
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    37. Wallner M, Meera P, Ottolia M, Kaczorowski GJ, Latorre R, Garcia ML, Stefani E, Toro L. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Receptors Channels. 1995; 3(3):185-99. PMID: 8821792.
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    38. Ottolia M, Toro L. Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids. Biophys J. 1994 Dec; 67(6):2272-9. PMID: 7535111.
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    39. Toro L, Ottolia M, Stefani E, Latorre R. Structural determinants in the interaction of Shaker inactivating peptide and a Ca(2+)-activated K+ channel. Biochemistry. 1994 Jun 14; 33(23):7220-8. PMID: 8003487.
      View in: PubMed
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