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Michela Ottolia

Title(s)Associate Professor-in-Residence, Anesthesiology
SchoolMedicine
Address760 Westwood Plaza BH-509B
Los Angeles CA 90024
Phone47809
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of cellular calcium by cardiac sodium-calcium exchange
    NIH/NHLBI R01HL147569Apr 15, 2019 - Feb 28, 2023
    Role: Co-Principal Investigator
    The Cardiac Na-Ca exchanger: Defining the mechanisms of its operation and regulation
    NIH/NHLBI R01HL130308Apr 20, 2016 - Mar 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling. Cell Calcium. 2020 05; 87:102167. Yue X, Hazan A, Lotteau S, Zhang R, Torrente AG, Philipson KD, Ottolia M, Goldhaber JI. PMID: 32028091.
      View in: PubMed   Mentions:    Fields:    
    2. Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications. Cell Calcium. 2020 05; 87:102140. Scranton K, John S, Escobar A, Goldhaber JI, Ottolia M. PMID: 32070924.
      View in: PubMed   Mentions:    Fields:    
    3. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. J Gen Physiol. 2018 02 05; 150(2):245-257. John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. PMID: 29301861.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. PMID: 25772291.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    5. Na/Ca exchange and contraction of the heart. J Mol Cell Cardiol. 2013 Aug; 61:28-33. Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI. PMID: 23770352.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    6. The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7500-5. John SA, Liao J, Jiang Y, Ottolia M. PMID: 23589872.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    7. 20 years from NCX purification and cloning: milestones. Adv Exp Med Biol. 2013; 961:17-23. Nicoll DA, Ottolia M, Goldhaber JI, Philipson KD. PMID: 23224866.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. NCX1: mechanism of transport. Adv Exp Med Biol. 2013; 961:49-54. Ottolia M, Philipson KD. PMID: 23224869.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1699-704. John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M. PMID: 21209335.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    10. Interactions between Ca2+ binding domains of the Na+-Ca2+ exchanger and secondary regulation. Channels (Austin). 2010 May-Jun; 4(3):159-62. Ottolia M, Nicoll DA, John S, Philipson KD. PMID: 20224291.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger. J Biol Chem. 2009 Nov 20; 284(47):32735-41. Ottolia M, Nicoll DA, Philipson KD. PMID: 19801651.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    12. Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger. J Biol Chem. 2009 May 29; 284(22):14688-92. Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J. PMID: 19332552.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    13. Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart. . 2008 Aug; 295(2):C388-93. Xie Y, Ottolia M, John SA, Chen JN, Philipson KD. PMID: 18550703.
      View in: PubMed   Mentions:
    14. How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger? Channels (Austin). 2007 Nov-Dec; 1(6):397-9. Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. PMID: 18690047.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):376-81. Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. PMID: 18162557.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    16. Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor. Pflugers Arch. 2008 May; 456(2):307-22. John SA, Ottolia M, Weiss JN, Ribalet B. PMID: 18071748.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    17. The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18467-72. Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. PMID: 17962412.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    18. Shedding light on the Na+/Ca2+ exchanger. Ann N Y Acad Sci. 2007 Mar; 1099:78-85. Ottolia M, John S, Xie Y, Ren X, Philipson KD. PMID: 17446447.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. What we know about the structure of NCX1 and how it relates to its function. Ann N Y Acad Sci. 2007 Mar; 1099:1-6. Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD. PMID: 17303833.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    20. Xenopus oocyte plasma membrane sheets for FRET analysis. . 2007 Apr; 292(4):C1519-22. Ottolia M, Philipson KD, John S. PMID: 17166939.
      View in: PubMed   Mentions:
    21. Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization. J Biol Chem. 2007 Feb 09; 282(6):3695-701. Ottolia M, John S, Ren X, Philipson KD. PMID: 17158867.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. Mutational analysis of the alpha-1 repeat of the cardiac Na(+)-Ca2+ exchanger. J Biol Chem. 2005 Jan 14; 280(2):1061-9. Ottolia M, Nicoll DA, Philipson KD. PMID: 15519995.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. Conformational changes of the Ca(2+) regulatory site of the Na(+)-Ca(2+) exchanger detected by FRET. Biophys J. 2004 Aug; 87(2):899-906. Ottolia M, Philipson KD, John S. PMID: 15298897.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Activation of the cardiac Na+/Ca2+ exchanger by DEPC. Ann N Y Acad Sci. 2002 Nov; 976:85-8. Ottolia M, Schumann S, Nicoll DA, Philipson KD. PMID: 12502540.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    25. The Na+/Ca2+ exchange molecule: an overview. Ann N Y Acad Sci. 2002 Nov; 976:1-10. Philipson KD, Nicoll DA, Ottolia M, Quednau BD, Reuter H, John S, Qiu Z. PMID: 12502528.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    26. Toward a topological model of the NCX1 exchanger. Ann N Y Acad Sci. 2002 Nov; 976:11-8. Nicoll DA, Ottolia M, Philipson KD. PMID: 12502529.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    27. Split Na+-Ca2+ exchangers. Implications for function and expression. J Biol Chem. 2001 Jun 01; 276(22):19603-9. Ottolia M, John S, Qiu Z, Philipson KD. PMID: 11274218.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    28. Functional analysis of a disulfide bond in the cardiac Na(+)-Ca(2+) exchanger. J Biol Chem. 2000 Jan 07; 275(1):182-8. Santacruz-Toloza L, Ottolia M, Nicoll DA, Philipson KD. PMID: 10617603.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    29. Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor. J Biol Chem. 1999 Apr 30; 274(18):12278-83. Groh S, Marty I, Ottolia M, Prestipino G, Chapel A, Villaz M, Ronjat M. PMID: 10212196.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    30. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum. Brain Res. 1999 Jan 09; 815(2):410-3. Ottolia M, Babini E, Gazzotti P, Possani LD, Prestipino G. PMID: 9878856.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    31. A new topological model of the cardiac sarcolemmal Na+-Ca2+ exchanger. J Biol Chem. 1999 Jan 08; 274(2):910-7. Nicoll DA, Ottolia M, Lu L, Lu Y, Philipson KD. PMID: 9873031.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    32. Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes. FEBS Lett. 1998 May 01; 427(1):96-102. Ottolia M, Platano D, Qin N, Noceti F, Birnbaumer M, Toro L, Birnbaumer L, Stefani E, Olcese R. PMID: 9613607.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    33. A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes. Biochem Biophys Res Commun. 1998 Jan 14; 242(2):287-91. Pisciotta M, Ottolia M, Possani LD, Prestipino G. PMID: 9446786.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    34. Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle. Biochemistry. 1997 Sep 23; 36(38):11496-503. Treves S, Scutari E, Robert M, Groh S, Ottolia M, Prestipino G, Ronjat M, Zorzato F. PMID: 9298970.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    35. Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo). Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5427-31. Stefani E, Ottolia M, Noceti F, Olcese R, Wallner M, Latorre R, Toro L. PMID: 9144254.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    36. Reconstitution in lipid bilayers of an ATP-sensitive K+ channel from pig coronary smooth muscle. J Membr Biol. 1996 Oct; 153(3):203-9. Ottolia M, Toro L. PMID: 8849415.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    37. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Recept Channels. 1995; 3(3):185-99. Wallner M, Meera P, Ottolia M, Kaczorowski GJ, Latorre R, Garcia ML, Stefani E, Toro L. PMID: 8821792.
      View in: PubMed   Mentions:
    38. Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids. Biophys J. 1994 Dec; 67(6):2272-9. Ottolia M, Toro L. PMID: 7535111.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    39. Structural determinants in the interaction of Shaker inactivating peptide and a Ca(2+)-activated K+ channel. Biochemistry. 1994 Jun 14; 33(23):7220-8. Toro L, Ottolia M, Stefani E, Latorre R. PMID: 8003487.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
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