Michela Ottolia

Title(s)Professor-in-Residence, Anesthesiology
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    Sodium Dependent Inactivation of the Na+-Ca2+ exchange: Relevance to Cardiac Function
    NIH R01HL152296Dec 18, 2020 - Nov 30, 2024
    Role: Principal Investigator
    Regulation of cellular calcium by cardiac sodium-calcium exchange
    NIH R01HL147569Apr 15, 2019 - Feb 28, 2023
    Role: Co-Principal Investigator
    The Cardiac Na-Ca exchanger: Defining the mechanisms of its operation and regulation
    NIH R01HL130308Apr 20, 2016 - Mar 31, 2021
    Role: Principal Investigator

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    1. Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1. Nat Commun. 2023 10 04; 14(1):6181. Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y. PMID: 37794011; PMCID: PMC10550945.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. An epilepsy-associated KV1.2 charge-transfer-center mutation impairs KV1.2 and KV1.4 trafficking. Proc Natl Acad Sci U S A. 2022 04 26; 119(17):e2113675119. Nilsson M, Lindström SH, Kaneko M, Wang K, Minguez-Viñas T, Angelini M, Steccanella F, Holder D, Ottolia M, Olcese R, Pantazis A. PMID: 35439054; PMCID: PMC9169947.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    3. The Cardiac Na+ -Ca2+ Exchanger: From Structure to Function. Compr Physiol. 2021 12 29; 12(1):2681-2717. Ottolia M, John S, Hazan A, Goldhaber JI. PMID: 34964124; PMCID: PMC8773166.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    4. Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current. J Gen Physiol. 2021 12 06; 153(12). Angelini M, Pezhouman A, Savalli N, Chang MG, Steccanella F, Scranton K, Calmettes G, Ottolia M, Pantazis A, Karagueuzian HS, Weiss JN, Olcese R. PMID: 34698805; PMCID: PMC8552156.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    5. Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia. J Am Heart Assoc. 2021 09 07; 10(17):e019273. Lotteau S, Zhang R, Hazan A, Grabar C, Gonzalez D, Aynaszyan S, Philipson KD, Ottolia M, Goldhaber JI. PMID: 34472363; PMCID: PMC8649274.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells. Am J Respir Cell Mol Biol. 2021 02; 64(2):224-234. Zyrianova T, Lopez B, Liao A, Gu C, Wong L, Ottolia M, Olcese R, Schwingshackl A. PMID: 33217242; PMCID: PMC7874395.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    7. Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling. Cell Calcium. 2020 05; 87:102167. Yue X, Hazan A, Lotteau S, Zhang R, Torrente AG, Philipson KD, Ottolia M, Goldhaber JI. PMID: 32028091; PMCID: PMC7153991.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications. Cell Calcium. 2020 05; 87:102140. Scranton K, John S, Escobar A, Goldhaber JI, Ottolia M. PMID: 32070924; PMCID: PMC7153995.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. J Gen Physiol. 2018 02 05; 150(2):245-257. John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. PMID: 29301861; PMCID: PMC5806679.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. PMID: 25772291; PMCID: PMC4376416.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    11. Na/Ca exchange and contraction of the heart. J Mol Cell Cardiol. 2013 Aug; 61:28-33. Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI. PMID: 23770352; PMCID: PMC3730535.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    12. The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7500-5. John SA, Liao J, Jiang Y, Ottolia M. PMID: 23589872; PMCID: PMC3645563.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    13. 20 years from NCX purification and cloning: milestones. Adv Exp Med Biol. 2013; 961:17-23. Nicoll DA, Ottolia M, Goldhaber JI, Philipson KD. PMID: 23224866; PMCID: PMC3903337.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    14. NCX1: mechanism of transport. Adv Exp Med Biol. 2013; 961:49-54. Ottolia M, Philipson KD. PMID: 23224869.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    15. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1699-704. John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M. PMID: 21209335; PMCID: PMC3029690.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    16. Interactions between Ca2+ binding domains of the Na+-Ca2+ exchanger and secondary regulation. Channels (Austin). 2010 May-Jun; 4(3):159-62. Ottolia M, Nicoll DA, John S, Philipson KD. PMID: 20224291.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    17. Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger. J Biol Chem. 2009 Nov 20; 284(47):32735-41. Ottolia M, Nicoll DA, Philipson KD. PMID: 19801651; PMCID: PMC2781690.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    18. Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger. J Biol Chem. 2009 May 29; 284(22):14688-92. Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J. PMID: 19332552; PMCID: PMC2685650.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    19. Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart. Am J Physiol Cell Physiol. 2008 Aug; 295(2):C388-93. Xie Y, Ottolia M, John SA, Chen JN, Philipson KD. PMID: 18550703; PMCID: PMC2518419.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    20. How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger? Channels (Austin). 2007 Nov-Dec; 1(6):397-9. Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. PMID: 18690047.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):376-81. Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. PMID: 18162557; PMCID: PMC2224220.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    22. Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor. Pflugers Arch. 2008 May; 456(2):307-22. John SA, Ottolia M, Weiss JN, Ribalet B. PMID: 18071748; PMCID: PMC4339035.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    23. The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18467-72. Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. PMID: 17962412; PMCID: PMC2141800.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    24. Shedding light on the Na+/Ca2+ exchanger. Ann N Y Acad Sci. 2007 Mar; 1099:78-85. Ottolia M, John S, Xie Y, Ren X, Philipson KD. PMID: 17446447.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    25. What we know about the structure of NCX1 and how it relates to its function. Ann N Y Acad Sci. 2007 Mar; 1099:1-6. Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD. PMID: 17303833.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    26. Xenopus oocyte plasma membrane sheets for FRET analysis. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1519-22. Ottolia M, Philipson KD, John S. PMID: 17166939.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    27. Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization. J Biol Chem. 2007 Feb 09; 282(6):3695-701. Ottolia M, John S, Ren X, Philipson KD. PMID: 17158867.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    28. Mutational analysis of the alpha-1 repeat of the cardiac Na(+)-Ca2+ exchanger. J Biol Chem. 2005 Jan 14; 280(2):1061-9. Ottolia M, Nicoll DA, Philipson KD. PMID: 15519995.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. Conformational changes of the Ca(2+) regulatory site of the Na(+)-Ca(2+) exchanger detected by FRET. Biophys J. 2004 Aug; 87(2):899-906. Ottolia M, Philipson KD, John S. PMID: 15298897; PMCID: PMC1304498.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    30. Activation of the cardiac Na+/Ca2+ exchanger by DEPC. Ann N Y Acad Sci. 2002 Nov; 976:85-8. Ottolia M, Schumann S, Nicoll DA, Philipson KD. PMID: 12502540.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    31. The Na+/Ca2+ exchange molecule: an overview. Ann N Y Acad Sci. 2002 Nov; 976:1-10. Philipson KD, Nicoll DA, Ottolia M, Quednau BD, Reuter H, John S, Qiu Z. PMID: 12502528.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    32. Toward a topological model of the NCX1 exchanger. Ann N Y Acad Sci. 2002 Nov; 976:11-8. Nicoll DA, Ottolia M, Philipson KD. PMID: 12502529.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. Split Na+-Ca2+ exchangers. Implications for function and expression. J Biol Chem. 2001 Jun 01; 276(22):19603-9. Ottolia M, John S, Qiu Z, Philipson KD. PMID: 11274218.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. Functional analysis of a disulfide bond in the cardiac Na(+)-Ca(2+) exchanger. J Biol Chem. 2000 Jan 07; 275(1):182-8. Santacruz-Toloza L, Ottolia M, Nicoll DA, Philipson KD. PMID: 10617603.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    35. Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor. J Biol Chem. 1999 Apr 30; 274(18):12278-83. Groh S, Marty I, Ottolia M, Prestipino G, Chapel A, Villaz M, Ronjat M. PMID: 10212196.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    36. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum. Brain Res. 1999 Jan 09; 815(2):410-3. Ottolia M, Babini E, Gazzotti P, Possani LD, Prestipino G. PMID: 9878856.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    37. A new topological model of the cardiac sarcolemmal Na+-Ca2+ exchanger. J Biol Chem. 1999 Jan 08; 274(2):910-7. Nicoll DA, Ottolia M, Lu L, Lu Y, Philipson KD. PMID: 9873031.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    38. Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes. FEBS Lett. 1998 May 01; 427(1):96-102. Ottolia M, Platano D, Qin N, Noceti F, Birnbaumer M, Toro L, Birnbaumer L, Stefani E, Olcese R. PMID: 9613607.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    39. A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes. Biochem Biophys Res Commun. 1998 Jan 14; 242(2):287-91. Pisciotta M, Ottolia M, Possani LD, Prestipino G. PMID: 9446786.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    40. Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle. Biochemistry. 1997 Sep 23; 36(38):11496-503. Treves S, Scutari E, Robert M, Groh S, Ottolia M, Prestipino G, Ronjat M, Zorzato F. PMID: 9298970.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    41. Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo). Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5427-31. Stefani E, Ottolia M, Noceti F, Olcese R, Wallner M, Latorre R, Toro L. PMID: 9144254; PMCID: PMC24695.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    42. Reconstitution in lipid bilayers of an ATP-sensitive K+ channel from pig coronary smooth muscle. J Membr Biol. 1996 Oct; 153(3):203-9. Ottolia M, Toro L. PMID: 8849415.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    43. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Recept Channels. 1995; 3(3):185-99. Wallner M, Meera P, Ottolia M, Kaczorowski GJ, Latorre R, Garcia ML, Stefani E, Toro L. PMID: 8821792.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    44. Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids. Biophys J. 1994 Dec; 67(6):2272-9. Ottolia M, Toro L. PMID: 7535111; PMCID: PMC1225611.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    45. Structural determinants in the interaction of Shaker inactivating peptide and a Ca(2+)-activated K+ channel. Biochemistry. 1994 Jun 14; 33(23):7220-8. Toro L, Ottolia M, Stefani E, Latorre R. PMID: 8003487.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
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