Loading...

Ottolia, Michela

Title(s)Associate Professor-in-Residence, Anesthesiology
Phone47809
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of cellular calcium by cardiac sodium-calcium exchange
    NIH/NHLBI R01HL147569Apr 15, 2019 - Feb 28, 2023
    Role: Co-Principal Investigator
    The Cardiac Na-Ca exchanger: Defining the mechanisms of its operation and regulation
    NIH/NHLBI R01HL130308Apr 20, 2016 - Mar 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Yue X, Hazan A, Lotteau S, Zhang R, Torrente AG, Philipson KD, Ottolia M, Goldhaber JI. Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling. Cell Calcium. 2020 Jan 30; 87:102167. PMID: 32028091.
      View in: PubMed
    2. Scranton K, John S, Escobar A, Goldhaber JI, Ottolia M. Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications. Cell Calcium. 2019 Dec 11; 87:102140. PMID: 32070924.
      View in: PubMed
    3. John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. J Gen Physiol. 2018 02 05; 150(2):245-257. PMID: 29301861.
      View in: PubMed
    4. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. PMID: 25772291.
      View in: PubMed
    5. Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI. Na/Ca exchange and contraction of the heart. J Mol Cell Cardiol. 2013 Aug; 61:28-33. PMID: 23770352.
      View in: PubMed
    6. John SA, Liao J, Jiang Y, Ottolia M. The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7500-5. PMID: 23589872.
      View in: PubMed
    7. Nicoll DA, Ottolia M, Goldhaber JI, Philipson KD. 20 years from NCX purification and cloning: milestones. Adv Exp Med Biol. 2013; 961:17-23. PMID: 23224866.
      View in: PubMed
    8. Ottolia M, Philipson KD. NCX1: mechanism of transport. Adv Exp Med Biol. 2013; 961:49-54. PMID: 23224869.
      View in: PubMed
    9. John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1699-704. PMID: 21209335.
      View in: PubMed
    10. Ottolia M, Nicoll DA, John S, Philipson KD. Interactions between Ca2+ binding domains of the Na+-Ca2+ exchanger and secondary regulation. Channels (Austin). 2010 May-Jun; 4(3):159-62. PMID: 20224291.
      View in: PubMed
    11. Ottolia M, Nicoll DA, Philipson KD. Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger. J Biol Chem. 2009 Nov 20; 284(47):32735-41. PMID: 19801651.
      View in: PubMed
    12. Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J. Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger. J Biol Chem. 2009 May 29; 284(22):14688-92. PMID: 19332552.
      View in: PubMed
    13. Xie Y, Ottolia M, John SA, Chen JN, Philipson KD. Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart. Am J Physiol Cell Physiol. 2008 Aug; 295(2):C388-93. PMID: 18550703.
      View in: PubMed
    14. Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger? Channels (Austin). 2007 Nov-Dec; 1(6):397-9. PMID: 18690047.
      View in: PubMed
    15. Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):376-81. PMID: 18162557.
      View in: PubMed
    16. John SA, Ottolia M, Weiss JN, Ribalet B. Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor. Pflugers Arch. 2008 May; 456(2):307-22. PMID: 18071748.
      View in: PubMed
    17. Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18467-72. PMID: 17962412.
      View in: PubMed
    18. Ottolia M, John S, Xie Y, Ren X, Philipson KD. Shedding light on the Na+/Ca2+ exchanger. Ann N Y Acad Sci. 2007 Mar; 1099:78-85. PMID: 17446447.
      View in: PubMed
    19. Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD. What we know about the structure of NCX1 and how it relates to its function. Ann N Y Acad Sci. 2007 Mar; 1099:1-6. PMID: 17303833.
      View in: PubMed
    20. Ottolia M, Philipson KD, John S. Xenopus oocyte plasma membrane sheets for FRET analysis. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1519-22. PMID: 17166939.
      View in: PubMed
    21. Ottolia M, John S, Ren X, Philipson KD. Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization. J Biol Chem. 2007 Feb 09; 282(6):3695-701. PMID: 17158867.
      View in: PubMed
    22. Ottolia M, Nicoll DA, Philipson KD. Mutational analysis of the alpha-1 repeat of the cardiac Na(+)-Ca2+ exchanger. J Biol Chem. 2005 Jan 14; 280(2):1061-9. PMID: 15519995.
      View in: PubMed
    23. Ottolia M, Philipson KD, John S. Conformational changes of the Ca(2+) regulatory site of the Na(+)-Ca(2+) exchanger detected by FRET. Biophys J. 2004 Aug; 87(2):899-906. PMID: 15298897.
      View in: PubMed
    24. Ottolia M, Schumann S, Nicoll DA, Philipson KD. Activation of the cardiac Na+/Ca2+ exchanger by DEPC. Ann N Y Acad Sci. 2002 Nov; 976:85-8. PMID: 12502540.
      View in: PubMed
    25. Philipson KD, Nicoll DA, Ottolia M, Quednau BD, Reuter H, John S, Qiu Z. The Na+/Ca2+ exchange molecule: an overview. Ann N Y Acad Sci. 2002 Nov; 976:1-10. PMID: 12502528.
      View in: PubMed
    26. Nicoll DA, Ottolia M, Philipson KD. Toward a topological model of the NCX1 exchanger. Ann N Y Acad Sci. 2002 Nov; 976:11-8. PMID: 12502529.
      View in: PubMed
    27. Ottolia M, John S, Qiu Z, Philipson KD. Split Na+-Ca2+ exchangers. Implications for function and expression. J Biol Chem. 2001 Jun 01; 276(22):19603-9. PMID: 11274218.
      View in: PubMed
    28. Santacruz-Toloza L, Ottolia M, Nicoll DA, Philipson KD. Functional analysis of a disulfide bond in the cardiac Na(+)-Ca(2+) exchanger. J Biol Chem. 2000 Jan 07; 275(1):182-8. PMID: 10617603.
      View in: PubMed
    29. Groh S, Marty I, Ottolia M, Prestipino G, Chapel A, Villaz M, Ronjat M. Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor. J Biol Chem. 1999 Apr 30; 274(18):12278-83. PMID: 10212196.
      View in: PubMed
    30. Ottolia M, Babini E, Gazzotti P, Possani LD, Prestipino G. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum. Brain Res. 1999 Jan 09; 815(2):410-3. PMID: 9878856.
      View in: PubMed
    31. Nicoll DA, Ottolia M, Lu L, Lu Y, Philipson KD. A new topological model of the cardiac sarcolemmal Na+-Ca2+ exchanger. J Biol Chem. 1999 Jan 08; 274(2):910-7. PMID: 9873031.
      View in: PubMed
    32. Ottolia M, Platano D, Qin N, Noceti F, Birnbaumer M, Toro L, Birnbaumer L, Stefani E, Olcese R. Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes. FEBS Lett. 1998 May 01; 427(1):96-102. PMID: 9613607.
      View in: PubMed
    33. Pisciotta M, Ottolia M, Possani LD, Prestipino G. A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes. Biochem Biophys Res Commun. 1998 Jan 14; 242(2):287-91. PMID: 9446786.
      View in: PubMed
    34. Treves S, Scutari E, Robert M, Groh S, Ottolia M, Prestipino G, Ronjat M, Zorzato F. Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle. Biochemistry. 1997 Sep 23; 36(38):11496-503. PMID: 9298970.
      View in: PubMed
    35. Stefani E, Ottolia M, Noceti F, Olcese R, Wallner M, Latorre R, Toro L. Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo). Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5427-31. PMID: 9144254.
      View in: PubMed
    36. Ottolia M, Toro L. Reconstitution in lipid bilayers of an ATP-sensitive K+ channel from pig coronary smooth muscle. J Membr Biol. 1996 Oct; 153(3):203-9. PMID: 8849415.
      View in: PubMed
    37. Wallner M, Meera P, Ottolia M, Kaczorowski GJ, Latorre R, Garcia ML, Stefani E, Toro L. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Receptors Channels. 1995; 3(3):185-99. PMID: 8821792.
      View in: PubMed
    38. Ottolia M, Toro L. Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids. Biophys J. 1994 Dec; 67(6):2272-9. PMID: 7535111.
      View in: PubMed
    39. Toro L, Ottolia M, Stefani E, Latorre R. Structural determinants in the interaction of Shaker inactivating peptide and a Ca(2+)-activated K+ channel. Biochemistry. 1994 Jun 14; 33(23):7220-8. PMID: 8003487.
      View in: PubMed