Ke Sheng

Title(s)Adjunct Professor, Radiation Oncology
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of A High Throughput Image-Guided IMRT System for Preclinical Research
    NIH R01CA259008Jun 18, 2021 - May 31, 2026
    Role: Principal Investigator
    Development of an ultra-high dose rate rotational linac for FLASH Radiotherapy
    NIH R01CA255432Mar 15, 2021 - Feb 28, 2026
    Role: Principal Investigator
    Robust IMPT with automated beam orientation and scanning spot optimization
    NIH R01CA230278Mar 1, 2019 - Feb 29, 2024
    Role: Principal Investigator
    Development of intensity modulated radiation therapy for small animal research
    NIH R21CA228160Dec 11, 2017 - Nov 30, 2020
    Role: Principal Investigator
    Development of a versatile robotic radiation therapy system
    NIH R44CA183390Jun 19, 2016 - Mar 31, 2021
    Role: Co-Principal Investigator
    Motion Management of Pancreatic Cancer in MRI-Guided Radiotherapy
    NIH R01CA188300Mar 1, 2015 - Feb 29, 2020
    Role: Principal Investigator
    A mechanistic model to derive lung tumor motion from whole surface tracking
    NIH R21CA161670Jul 1, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Predicting the lung ventilation change caused by radiation therapy
    NIH R21CA144063Mar 1, 2010 - Feb 28, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Hypoxia-informed RBE-weighted beam orientation optimization for intensity modulated proton therapy. Med Phys. 2024 Mar; 51(3):2320-2333. Ramesh P, Ruan D, Liu SJ, Seo Y, Braunstein S, Sheng K. PMID: 38345134; PMCID: PMC10940223.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Dosimetric predictors for genitourinary toxicity in MR-guided stereotactic body radiation therapy (SBRT): Substructure with fraction-wise analysis. Med Phys. 2024 Jan; 51(1):612-621. Pham J, Neilsen BK, Liu H, Cao M, Yang Y, Sheng K, Ma TM, Kishan AU, Ruan D. PMID: 38055353.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    3. Impact of Interfractional Bladder and Trigone Displacement and Deformation on Radiation Exposure and Subsequent Acute Genitourinary Toxicity: A Post Hoc Analysis of Patients Treated with Magnetic Resonance Imaging-Guided Prostate Stereotactic Body Radiation Therapy in a Phase 3 Randomized Trial. Int J Radiat Oncol Biol Phys. 2024 Mar 15; 118(4):986-997. Neilsen BK, Ma TM, Akingbemi WO, Neylon J, Casado MC, Sharma S, Sheng K, Ruan D, Low DA, Yang Y, Valle LF, Steinberg ML, Lamb JM, Cao M, Kishan AU. PMID: 37871887.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    4. A unified path seeking algorithm for IMRT and IMPT beam orientation optimization. Phys Med Biol. 2023 09 22; 68(19). Ramesh P, Valdes G, O'Connor D, Sheng K. PMID: 37659406.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Analytical HDR prostate brachytherapy planning with automatic catheter and isotope selection. Med Phys. 2023 Oct; 50(10):6525-6534. Frank CH, Ramesh P, Lyu Q, Ruan D, Park SJ, Chang AJ, Venkat PS, Kishan AU, Sheng K. PMID: 37650773; PMCID: PMC10635680.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Gell: A GPU-powered 3D hybrid simulator for large-scale multicellular system. PLoS One. 2023; 18(7):e0288721. Du J, Zhou Y, Jin L, Sheng K. PMID: 37463167; PMCID: PMC10353785.
      View in: PubMed   Mentions:    Fields:    
    7. Contrast-Enhanced Liver Magnetic Resonance Image Synthesis Using Gradient Regularized Multi-Modal Multi-Discrimination Sparse Attention Fusion GAN. Cancers (Basel). 2023 Jul 08; 15(14). Jiao C, Ling D, Bian S, Vassantachart A, Cheng K, Mehta S, Lock D, Zhu Z, Feng M, Thomas H, Scholey JE, Sheng K, Fan Z, Yang W. PMID: 37509207; PMCID: PMC10377331.
      View in: PubMed   Mentions:
    8. Technical note: Multi-MATE, a high-throughput platform for automated image-guided small-animal irradiation. Med Phys. 2023 Dec; 50(12):7383-7389. Jiang L, Ramesh P, Neph R, Sheng K. PMID: 37341036; PMCID: PMC10733545.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. An Efficient and Robust Method for Chest X-ray Rib Suppression That Improves Pulmonary Abnormality Diagnosis. Diagnostics (Basel). 2023 May 08; 13(9). Xu D, Xu Q, Nhieu K, Ruan D, Sheng K. PMID: 37175044; PMCID: PMC10177861.
      View in: PubMed   Mentions:
    10. Magnetic Resonance Imaging-Guided vs Computed Tomography-Guided Stereotactic Body Radiotherapy for Prostate Cancer: The MIRAGE Randomized Clinical Trial. JAMA Oncol. 2023 03 01; 9(3):365-373. Kishan AU, Ma TM, Lamb JM, Casado M, Wilhalme H, Low DA, Sheng K, Sharma S, Nickols NG, Pham J, Yang Y, Gao Y, Neylon J, Basehart V, Cao M, Steinberg ML. PMID: 36633877; PMCID: PMC9857817.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    11. Mask R-CNN assisted 2.5D object detection pipeline of 68Ga-PSMA-11 PET/CT-positive metastatic pelvic lymph node after radical prostatectomy from solely CT imaging. Sci Rep. 2023 01 30; 13(1):1696. Xu D, Ma M, Cao M, Kishan AU, Nickols NG, Scalzo F, Sheng K. PMID: 36717727; PMCID: PMC9886937.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Tomographic detection of photon pairs produced from high-energy X-rays for the monitoring of radiotherapy dosing. Nat Biomed Eng. 2023 03; 7(3):323-334. Lyu Q, Neph R, Sheng K. PMID: 36280738; PMCID: PMC10038801.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Dose and dose rate objectives in Bragg peak and shoot-through beam orientation optimization for FLASH proton therapy. Med Phys. 2022 Oct 12. Ramesh P, Gu W, Ruan D, Sheng K. PMID: 36222217.
      View in: PubMed   Mentions: 3     Fields:    
    14. An efficient rectangular optimization method for sparse orthogonal collimator based small animal irradiation. Phys Med Biol. 2022 09 28; 67(19). Jiang L, Lyu Q, Abdelhamid AMH, Hui S, Sheng K. PMID: 36084625; PMCID: PMC9595432.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    15. Fully automated segmentation of prostatic urethra for MR-guided radiation therapy. Med Phys. 2022 Sep 15. Xu D, Ma TM, Savjani R, Pham J, Cao M, Yang Y, Kishan AU, Scalzo F, Sheng K. PMID: 36106703.
      View in: PubMed   Mentions: 2     Fields:    
    16. Feasibility of a Novel Sparse Orthogonal Collimator-Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality. Front Oncol. 2022; 12:941814. Abdelhamid AMH, Jiang L, Zuro D, Liu A, Madabushi SS, Ghimire H, Wong JYC, Saldi S, Fulcheri C, Zucchetti C, Pierini A, Sheng K, Aristei C, Hui SK. PMID: 35924145; PMCID: PMC9339640.
      View in: PubMed   Mentions: 2  
    17. Urethral Interfractional Geometric and Dosimetric Variations of Prostate Cancer Patients: A Study Using an Onboard MRI. Front Oncol. 2022; 12:916254. Pham J, Savjani RR, Yoon SM, Yang T, Gao Y, Cao M, Hu P, Sheng K, Low DA, Steinberg M, Kishan AU, Yang Y. PMID: 35912253; PMCID: PMC9334678.
      View in: PubMed   Mentions: 2  
    18. Reformulated McNamara RBE-weighted beam orientation optimization for intensity modulated proton therapy. Med Phys. 2022 Apr; 49(4):2136-2149. Ramesh P, Lyu Q, Gu W, Ruan D, Sheng K. PMID: 35181892; PMCID: PMC9894336.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. A Prospective Phase II Study of Automated Non-Coplanar VMAT for Recurrent Head and Neck Cancer: Initial Report of Feasibility, Safety, and Patient-Reported Outcomes. Cancers (Basel). 2022 Feb 14; 14(4). Woods KE, Ma TM, Cook KA, Morris ED, Gao Y, Sheng K, Kishan AU, Hegde JV, Felix C, Basehart V, Narahara K, Shen Z, Tenn S, Steinberg ML, Chin RK, Cao M. PMID: 35205686; PMCID: PMC8870161.
      View in: PubMed   Mentions: 2  
    20. Dosimetric impact of interfraction prostate and seminal vesicle volume changes and rotation: A post-hoc analysis of a phase III randomized trial of MRI-guided versus CT-guided stereotactic body radiotherapy. Radiother Oncol. 2022 02; 167:203-210. Ma TM, Neylon J, Casado M, Sharma S, Sheng K, Low D, Yang Y, Steinberg ML, Lamb J, Cao M, Kishan AU. PMID: 34979212.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    21. Voxelwise Prediction of Recurrent High-Grade Glioma via Proximity Estimation-Coupled Multidimensional Support Vector Machine. Int J Radiat Oncol Biol Phys. 2022 04 01; 112(5):1279-1287. Lao Y, Ruan D, Vassantachart A, Fan Z, Ye JC, Chang EL, Chin R, Kaprealian T, Zada G, Shiroishi MS, Sheng K, Yang W. PMID: 34963559; PMCID: PMC8923952.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Bladder surface dose modeling in prostate cancer radiotherapy: An analysis of motion-induced variations and the cumulative dose across the treatment. Med Phys. 2021 Dec; 48(12):8024-8036. Lao Y, Cao M, Yang Y, Kishan AU, Yang W, Wang Y, Sheng K. PMID: 34734414; PMCID: PMC8683601.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Evaluation of T2-Weighted MRI for Visualization and Sparing of Urethra with MR-Guided Radiation Therapy (MRgRT) On-Board MRI. Cancers (Basel). 2021 Jul 16; 13(14). Pham J, Savjani RR, Gao Y, Cao M, Hu P, Sheng K, Low DA, Steinberg M, Kishan AU, Yang Y. PMID: 34298777; PMCID: PMC8307202.
      View in: PubMed   Mentions: 5  
    24. Using neural networks to extend cropped medical images for deformable registration among images with differing scan extents. Med Phys. 2021 Aug; 48(8):4459-4471. McKenzie EM, Tong N, Ruan D, Cao M, Chin RK, Sheng K. PMID: 34101198; PMCID: PMC8683602.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Clinical assessment of geometric distortion for a 0.35T MR-guided radiotherapy system. J Appl Clin Med Phys. 2021 Aug; 22(8):303-309. Neylon J, Cook KA, Yang Y, Du D, Sheng K, Chin RK, Kishan AU, Lamb JM, Low DA, Cao M. PMID: 34231963; PMCID: PMC8364259.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Fixed Beamline Optimization for Intensity Modulated Carbon-Ion Therapy. IEEE Trans Radiat Plasma Med Sci. 2022 Mar; 6(3):288-293. Ramesh P, Liu H, Gu W, Sheng K. PMID: 36092271; PMCID: PMC9457306.
      View in: PubMed   Mentions: 1  
    27. Interfractional Geometric Variations and Dosimetric Benefits of Stereotactic MRI Guided Online Adaptive Radiotherapy (SMART) of Prostate Bed after Radical Prostatectomy: Post-Hoc Analysis of a Phase II Trial. Cancers (Basel). 2021 Jun 04; 13(11). Cao M, Gao Y, Yoon SM, Yang Y, Sheng K, Ballas LK, Basehart V, Sachdeva A, Felix C, Low DA, Steinberg ML, Kishan AU. PMID: 34199881; PMCID: PMC8200117.
      View in: PubMed   Mentions: 5  
    28. Magnetic resonance imaging-guided stereotactic body radiotherapy for prostate cancer (mirage): a phase iii randomized trial. BMC Cancer. 2021 May 11; 21(1):538. Ma TM, Lamb JM, Casado M, Wang X, Basehart TV, Yang Y, Low D, Sheng K, Agazaryan N, Nickols NG, Cao M, Steinberg ML, Kishan AU. PMID: 33975579; PMCID: PMC8114498.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    29. Automated Non-Coplanar VMAT for Dose Escalation in Recurrent Head and Neck Cancer Patients. Cancers (Basel). 2021 Apr 15; 13(8). Woods K, Chin RK, Cook KA, Sheng K, Kishan AU, Hegde JV, Tenn S, Steinberg ML, Cao M. PMID: 33921062; PMCID: PMC8071369.
      View in: PubMed   Mentions: 5  
    30. Quantitative Characterization of Tumor Proximity to Stem Cell Niches: Implications on Recurrence and Survival in GBM Patients. Int J Radiat Oncol Biol Phys. 2021 07 15; 110(4):1180-1188. Lao Y, Yu V, Pham A, Wang T, Cui J, Gallogly A, Chang E, Fan Z, Kaprealian T, Yang W, Sheng K. PMID: 33600888; PMCID: PMC8238898.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Treating Glioblastoma Multiforme (GBM) with super hyperfractionated radiation therapy: Implication of temporal dose fractionation optimization including cancer stem cell dynamics. PLoS One. 2021; 16(2):e0245676. Yu VY, Nguyen D, O'Connor D, Ruan D, Kaprealian T, Chin R, Sheng K. PMID: 33524046; PMCID: PMC7850476.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    32. ROAD: ROtational direct Aperture optimization with a Decoupled ring-collimator for FLASH radiotherapy. Phys Med Biol. 2021 01 29; 66(3):035020. Lyu Q, Neph R, O'Connor D, Ruan D, Boucher S, Sheng K. PMID: 33207321; PMCID: PMC8683603.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. DeepMC: a deep learning method for efficient Monte Carlo beamlet dose calculation by predictive denoising in magnetic resonance-guided radiotherapy. Phys Med Biol. 2021 01 29; 66(3):035022. Neph R, Lyu Q, Huang Y, Yang YM, Sheng K. PMID: 33181498.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Multi-task edge-recalibrated network for male pelvic multi-organ segmentation on CT images. Phys Med Biol. 2021 01 26; 66(3):035001. Tong N, Gou S, Chen S, Yao Y, Yang S, Cao M, Kishan A, Sheng K. PMID: 33197901.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. Weak Magnetic Fields Enhance the Efficacy of Radiation Therapy. Adv Radiat Oncol. 2021 May-Jun; 6(3):100645. Iwamoto KS, Sandstrom RE, Bryan M, Liu Y, Elgart SR, Sheng K, Steinberg ML, McBride WH, Low DA. PMID: 33748547; PMCID: PMC7966835.
      View in: PubMed   Mentions: 1  
    36. Automatic detection and segmentation of multiple brain metastases on magnetic resonance image using asymmetric UNet architecture. Phys Med Biol. 2021 01 13; 66(1):015003. Cao Y, Vassantachart A, Ye JC, Yu C, Ruan D, Sheng K, Lao Y, Shen ZL, Balik S, Bian S, Zada G, Shiu A, Chang EL, Yang W. PMID: 33186927.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    37. Self-channel-and-spatial-attention neural network for automated multi-organ segmentation on head and neck CT images. Phys Med Biol. 2020 12 11; 65(24):245034. Gou S, Tong N, Qi S, Yang S, Chin R, Sheng K. PMID: 32097892.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    38. Analysis of Geometric Performance and Dosimetric Impact of Using Automatic Contour Segmentation for Radiotherapy Planning. Front Oncol. 2020; 10:1762. Cao M, Stiehl B, Yu VY, Sheng K, Kishan AU, Chin RK, Yang Y, Ruan D. PMID: 33102206; PMCID: PMC7546883.
      View in: PubMed   Mentions: 9  
    39. Practical Safety Considerations for Integration of Magnetic Resonance Imaging in Radiation Therapy. Pract Radiat Oncol. 2020 Nov - Dec; 10(6):443-453. Hu Q, Yu VY, Yang Y, Hu P, Sheng K, Lee PP, Kishan AU, Raldow AC, O'Connell DP, Woods KE, Cao M. PMID: 32781246; PMCID: PMC8472473.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. Fraction-variant beam orientation optimization for intensity-modulated proton therapy. Med Phys. 2020 Sep; 47(9):3826-3834. Gu W, O'Connor D, Ruan D, Zou W, Dong L, Sheng K. PMID: 32564353; PMCID: PMC7845556.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    41. Artificial intelligence in radiotherapy: a technological review. Front Med. 2020 Aug; 14(4):431-449. Sheng K. PMID: 32728877.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    42. Self-paced DenseNet with boundary constraint for automated multi-organ segmentation on abdominal CT images. Phys Med Biol. 2020 07 13; 65(13):135011. Tong N, Gou S, Niu T, Yang S, Sheng K. PMID: 32657281.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. Linear energy transfer weighted beam orientation optimization for intensity-modulated proton therapy. Med Phys. 2021 Jan; 48(1):57-70. Gu W, Ruan D, Zou W, Dong L, Sheng K. PMID: 32542711; PMCID: PMC8216041.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    44. Quantifying vascular invasion in pancreatic cancer-a contrast CT based method for surgical resectability evaluation. Phys Med Biol. 2020 06 01; 65(10):105012. Lao Y, David J, Fan Z, Bian S, Shiu A, Chang EL, Sheng K, Yang W, Tuli R. PMID: 32187583; PMCID: PMC7316342.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. Image domain multi-material decomposition using single energy CT. Phys Med Biol. 2020 03 23; 65(6):065014. Xue Y, Luo C, Jiang Y, Yang P, Hu X, Zhou Q, Wang J, Hu X, Sheng K, Niu T. PMID: 32045890.
      View in: PubMed   Mentions: 1     Fields:    
    46. A novel energy layer optimization framework for spot-scanning proton arc therapy. Med Phys. 2020 Jun; 47(5):2072-2084. Gu W, Ruan D, Lyu Q, Zou W, Dong L, Sheng K. PMID: 32040214; PMCID: PMC7234928.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    47. Many-isocenter optimization for robotic radiotherapy. Phys Med Biol. 2020 02 10; 65(4):045003. Lyu Q, Neph R, Yu VY, Ruan D, Boucher S, Sheng K. PMID: 31851958; PMCID: PMC7100370.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    48. Multimodality image registration in the head-and-neck using a deep learning-derived synthetic CT as a bridge. Med Phys. 2020 Mar; 47(3):1094-1104. McKenzie EM, Santhanam A, Ruan D, O'Connor D, Cao M, Sheng K. PMID: 31853975; PMCID: PMC7067662.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    49. Technical Note: Robust individual thermoluminescence dosimeter tracking using optical fingerprinting. Med Phys. 2020 Jan; 47(1):267-271. Shang D, Gu W, Landers A, Woods K, Yu V, Neph R, Tenn S, Sheng K. PMID: 31677160.
      View in: PubMed   Mentions:    Fields:    
    50. A sparse orthogonal collimator for small animal intensity-modulated radiation therapy part I: Planning system development and commissioning. Med Phys. 2019 Dec; 46(12):5703-5713. Woods K, Nguyen D, Neph R, Ruan D, O'Connor D, Sheng K. PMID: 31621920; PMCID: PMC6899210.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    51. A sparse orthogonal collimator for small animal intensity-modulated radiation therapy. Part II: hardware development and commissioning. Med Phys. 2019 Dec; 46(12):5733-5747. Woods K, Neph R, Nguyen D, Sheng K. PMID: 31621091; PMCID: PMC8030274.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    52. Image-domain multimaterial decomposition for dual-energy computed tomography with nonconvex sparsity regularization. J Med Imaging (Bellingham). 2019 Oct; 6(4):044004. Lyu Q, O'Connor D, Niu T, Sheng K. PMID: 31620550; PMCID: PMC6792008.
      View in: PubMed   Mentions: 1  
    53. Automated 4π radiotherapy treatment planning with evolving knowledge-base. Med Phys. 2019 Sep; 46(9):3833-3843. Landers A, O'Connor D, Ruan D, Sheng K. PMID: 31233619; PMCID: PMC6739129.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    54. Scatter correction of cone-beam CT using a deep residual convolution neural network (DRCNN). Phys Med Biol. 2019 07 11; 64(14):145003. Jiang Y, Yang C, Yang P, Hu X, Luo C, Xue Y, Xu L, Hu X, Zhang L, Wang J, Sheng K, Niu T. PMID: 31117060.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    55. Parallel beamlet dose calculation via beamlet contexts in a distributed multi-GPU framework. Med Phys. 2019 Aug; 46(8):3719-3733. Neph R, Ouyang C, Neylon J, Yang Y, Sheng K. PMID: 31183871; PMCID: PMC6692225.
      View in: PubMed   Mentions: 4     Fields:    
    56. Robust beam orientation optimization for intensity-modulated proton therapy. Med Phys. 2019 Aug; 46(8):3356-3370. Gu W, Neph R, Ruan D, Zou W, Dong L, Sheng K. PMID: 31169917; PMCID: PMC6692214.
      View in: PubMed   Mentions: 16     Fields:    
    57. Noise Suppression in Image-Domain Multi-Material Decomposition for Dual-Energy CT. IEEE Trans Biomed Eng. 2020 02; 67(2):523-535. Jiang Y, Xue Y, Lyu Q, Xu L, Luo C, Yang P, Yang C, Wang J, Hu X, Zhang X, Sheng K, Niu T. PMID: 31095473.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. Shape constrained fully convolutional DenseNet with adversarial training for multiorgan segmentation on head and neck CT and low-field MR images. Med Phys. 2019 Jun; 46(6):2669-2682. Tong N, Gou S, Yang S, Cao M, Sheng K. PMID: 31002188; PMCID: PMC6581189.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    59. Single-arc VMAT optimization for dual-layer MLC. Phys Med Biol. 2019 05 02; 64(9):095028. Lyu Q, Neph R, Yu VY, Ruan D, Sheng K. PMID: 30844772.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    60. Motion Compensated Dynamic MRI Reconstruction With Local Affine Optical Flow Estimation. IEEE Trans Biomed Eng. 2019 11; 66(11):3050-3059. Zhao N, O'Connor D, Basarab A, Ruan D, Sheng K. PMID: 30794164; PMCID: PMC10919160.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    61. Robust optimization for intensity-modulated proton therapy with soft spot sensitivity regularization. Med Phys. 2019 Mar; 46(3):1408-1425. Gu W, Ruan D, O'Connor D, Zou W, Dong L, Tsai MY, Jia X, Sheng K. PMID: 30570164; PMCID: PMC6581199.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    62. Functional Blockade of Small GTPase RAN Inhibits Glioblastoma Cell Viability. Front Oncol. 2018; 8:662. Sheng KL, Pridham KJ, Sheng Z, Lamouille S, Varghese RT. PMID: 30671385; PMCID: PMC6331428.
      View in: PubMed   Mentions: 7  
    63. Fully automatic multi-organ segmentation for head and neck cancer radiotherapy using shape representation model constrained fully convolutional neural networks. Med Phys. 2018 Oct; 45(10):4558-4567. Tong N, Gou S, Yang S, Ruan D, Sheng K. PMID: 30136285; PMCID: PMC6181786.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    64. A novel optimization framework for VMAT with dynamic gantry couch rotation. Phys Med Biol. 2018 06 13; 63(12):125013. Lyu Q, Yu VY, Ruan D, Neph R, O'Connor D, Sheng K. PMID: 29786614; PMCID: PMC6075870.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    65. Respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK): Initial clinical experience on an MRI-guided radiotherapy system. Radiother Oncol. 2018 06; 127(3):467-473. Han F, Zhou Z, Du D, Gao Y, Rashid S, Cao M, Shaverdian N, Hegde JV, Steinberg M, Lee P, Raldow A, Low DA, Sheng K, Yang Y, Hu P. PMID: 29753549.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    66. VMAT optimization with dynamic collimator rotation. Med Phys. 2018 Jun; 45(6):2399-2410. Lyu Q, O'Connor D, Ruan D, Yu V, Nguyen D, Sheng K. PMID: 29659018; PMCID: PMC5997563.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    67. Technical Note: Iterative megavoltage CT (MVCT) reconstruction using block-matching 3D-transform (BM3D) regularization. Med Phys. 2018 Jun; 45(6):2603-2610. Lyu Q, Yang C, Gao H, Xue Y, O'Connor D, Niu T, Sheng K. PMID: 29663467; PMCID: PMC5997564.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    68. A career path for pure academic medical physicists in radiation oncology should be established. Med Phys. 2018 Jul; 45(7):2853-2856. Sheng K, Pawlicki T, Cai J. PMID: 29663405.
      View in: PubMed   Mentions:    Fields:    
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    142. Semiconductor nanoparticles as energy mediators for photosensitizer-enhanced radiotherapy. Int J Radiat Oncol Biol Phys. 2008 Nov 01; 72(3):633-5. Yang W, Read PW, Mi J, Baisden JM, Reardon KA, Larner JM, Helmke BP, Sheng K. PMID: 19014777.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    143. The effect of respiratory motion variability and tumor size on the accuracy of average intensity projection from four-dimensional computed tomography: an investigation based on dynamic MRI. Med Phys. 2008 Nov; 35(11):4974-81. Cai J, Read PW, Sheng K. PMID: 19070231.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    144. Evaluation of coplanar partial left breast irradiation using tomotherapy-based topotherapy. Int J Radiat Oncol Biol Phys. 2008 Jun 01; 71(2):603-10. McIntosh A, Read PW, Khandelwal SR, Arthur DW, Turner AB, Ruchala KJ, Olivera GH, Jeswani S, Sheng K. PMID: 18474316.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    145. Is daily CT image guidance necessary for nasal cavity and nasopharyngeal radiotherapy: an investigation based on helical tomotherapy. J Appl Clin Med Phys. 2008 Jan 28; 9(1):36-46. Sheng K, Chow J, Hunter G, Larner J, Read P. PMID: 18449163; PMCID: PMC5721532.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    146. Estimation of error in maximal intensity projection-based internal target volume of lung tumors: a simulation and comparison study using dynamic magnetic resonance imaging. Int J Radiat Oncol Biol Phys. 2007 Nov 01; 69(3):895-902. Cai J, Read PW, Baisden JM, Larner JM, Benedict SH, Sheng K. PMID: 17889270.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    147. Evaluation of thoracic spinal cord motion using dynamic MRI. Radiother Oncol. 2007 Sep; 84(3):279-82. Cai J, Sheng K, Sheehan JP, Benedict SH, Larner JM, Read PW. PMID: 17692979.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    148. Dose as a function of lung volume and planned treatment volume in helical tomotherapy intensity-modulated radiation therapy-based stereotactic body radiation therapy for small lung tumors. Int J Radiat Oncol Biol Phys. 2007 Jul 15; 68(4):1229-37. Baisden JM, Romney DA, Reish AG, Cai J, Sheng K, Jones DR, Benedict SH, Read PW, Larner JM. PMID: 17513066.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    149. Direct measurement of lung motion using hyperpolarized helium-3 MR tagging. Int J Radiat Oncol Biol Phys. 2007 Jul 01; 68(3):650-3. Cai J, Miller GW, Altes TA, Read PW, Benedict SH, de Lange EE, Cates GD, Brookeman JR, Mugler JP, Sheng K. PMID: 17445997; PMCID: PMC3658834.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    150. A dosimetric comparison of non-coplanar IMRT versus Helical Tomotherapy for nasal cavity and paranasal sinus cancer. Radiother Oncol. 2007 Feb; 82(2):174-8. Sheng K, Molloy JA, Larner JM, Read PW. PMID: 17275112.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    151. Evaluation of the reproducibility of lung motion probability distribution function (PDF) using dynamic MRI. Phys Med Biol. 2007 Jan 21; 52(2):365-73. Cai J, Read PW, Altes TA, Molloy JA, Brookeman JR, Sheng K. PMID: 17202620.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    152. A motion phantom study on helical tomotherapy: the dosimetric impacts of delivery technique and motion. Phys Med Biol. 2007 Jan 07; 52(1):243-55. Kanagaki B, Read PW, Molloy JA, Larner JM, Sheng K. PMID: 17183139.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    153. A computer simulated phantom study of tomotherapy dose optimization based on probability density functions (PDF) and potential errors caused by low reproducibility of PDF. Med Phys. 2006 Sep; 33(9):3321-6. Sheng K, Cai J, Brookeman J, Molloy J, Christopher J, Read P. PMID: 17022227.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    154. Dose as a function of liver volume and planning target volume in helical tomotherapy, intensity-modulated radiation therapy-based stereotactic body radiation therapy for hepatic metastasis. Int J Radiat Oncol Biol Phys. 2006 Oct 01; 66(2):620-5. Baisden JM, Reish AG, Sheng K, Larner JM, Kavanagh BD, Read PW. PMID: 16904845.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    155. Intensity-modulated radiation therapy (IMRT) dosimetry of the head and neck: a comparison of treatment plans using linear accelerator-based IMRT and helical tomotherapy. Int J Radiat Oncol Biol Phys. 2006 Jul 01; 65(3):917-23. Sheng K, Molloy JA, Read PW. PMID: 16751074.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansPHPublic Health
    156. Imaging dose management using multi-resolution in CT-guided radiation therapy. Phys Med Biol. 2005 Mar 21; 50(6):1205-19. Sheng K, Jeraj R, Shaw R, Mackie TR, Paliwal BR. PMID: 15798317.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
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