Nicole Marie Valenzuela

Title(s)Assistant Professor-in-Residence, Pathology and Laboratory Medicine
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    1. Spatial multiomics of arterial regions from cardiac allograft vasculopathy rejected grafts reveal novel insights into the pathogenesis of chronic antibody-mediated rejection. Am J Transplant. 2024 Jan 12. Nevarez-Mejia J, Pickering H, Sosa RA, Valenzuela NM, Fishbein GA, Baldwin WM, Fairchild RL, Reed EF. PMID: 38219867.
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    2. HLA-DPB1 genotype variants predict DP molecule cell surface expression and DP donor specific antibody binding capacity. Front Immunol. 2023; 14:1328533. Yin Y, Soe NN, Valenzuela NM, Reed EF, Zhang Q. PMID: 38274830; PMCID: PMC10808447.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. The Significance of Major Histocompatibility Complex Class I Chain-related Molecule A in Solid Organ and Hematopoietic Stem Cell Transplantation: A Comprehensive Overview. Transplantation. 2024 Jan 01; 108(1):115-126. Schinstock CA, Agrawal A, Valenzuela NM. PMID: 37218026.
      View in: PubMed   Mentions:    Fields:    
    4. The Transplant Bellwether: Endothelial Cells in Antibody-Mediated Rejection. J Immunol. 2023 11 01; 211(9):1276-1285. Franco-Acevedo A, Pathoulas CL, Murphy PA, Valenzuela NM. PMID: 37844279; PMCID: PMC10593495.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Human leukocyte antigen class I antibody-activated endothelium promotes CD206+ M2 macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy. Am J Transplant. 2024 Mar; 24(3):406-418. Nevarez-Mejia J, Jin YP, Pickering H, Parmar R, Valenzuela NM, Sosa RA, Heidt S, Fishbein GA, Rozengurt E, Baldwin WM, Fairchild RL, Reed EF. PMID: 38379280.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Virtual Crossmatch: By Any Other Name. Transplantation. 2023 Oct 01; 107(10):e274. Locke AF, Hickey M, Valenzuela NM, Butler C, Sosa R, Zheng Y, Gjertson D, Reed EF, Zhang Q. PMID: 37749817.
      View in: PubMed   Mentions:    Fields:    
    7. Personalizing kidney transplant donor-specific antibody surveillance: The devil is in the details. Am J Transplant. 2023 Dec; 23(12):1828-1831. Valenzuela NM, Mannon RB. PMID: 37661022.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Virtual and Reality: An Analysis of the UCLA Virtual Crossmatch Exchanges. Transplantation. 2023 08 01; 107(8):1776-1785. Locke AF, Hickey M, Valenzuela NM, Butler C, Sosa R, Zheng Y, Gjertson D, Reed EF, Zhang Q. PMID: 36944607; PMCID: PMC10358445.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. JAKinibs prevent persistent, IFNγ-autonomous endothelial cell inflammation and immunogenicity. Am J Physiol Cell Physiol. 2023 07 01; 325(1):C186-C207. Valenzuela NM. PMID: 37184230; PMCID: PMC10312316.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Corrigendum to 'Sensitization in transplantation: Assessment of Risk 2022 Working Group Meeting Report' [American Journal of Transplantation 23 (2023) 133-149]. Am J Transplant. 2023 May; 23(5):694. Tambur AR, Bestard O, Campbell P, Chong AS, Crespo M, Ford ML, Gebel HM, Heidt S, Hickey M, Jackson A, Kosmoliaptsis V, Lefaucheur C, Louis K, Mannon RB, Mengel M, Morris A, Pinelli DF, Reed EF, Schinstock C, Taupin JL, Valenzuela N, Wiebe C, Nickerson P. PMID: 36932020.
      View in: PubMed   Mentions:    Fields:    
    11. Sensitization in transplantation: Assessment of Risk 2022 Working Group Meeting Report. Am J Transplant. 2023 01; 23(1):133-149. Tambur AR, Bestard O, Campbell P, Chong AS, Barrio MC, Ford ML, Gebel HM, Heidt S, Hickey M, Jackson A, Kosmoliaptsis V, Lefaucheur C, Louis K, Mannon RB, Mengel M, Morris A, Pinelli DF, Reed EF, Schinstock C, Taupin JL, Valenzuela N, Wiebe C, Nickerson P. PMID: 36695615.
      View in: PubMed   Mentions: 4     Fields:    
    12. Has the Time Come for Widespread MHC Class I MICA Genotyping in Solid Organ Transplantation? Transplantation. 2022 Dec 01; 106(12):2269-2270. Schinstock CA, Valenzuela NM. PMID: 36436096.
      View in: PubMed   Mentions: 1     Fields:    
    13. Sugar and spice: Fc glycosylation in antibody-mediated transplant rejection. Cell Rep Med. 2022 Nov 15; 3(11):100809. Valenzuela NM. PMID: 36384088.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Cross-Talk between HLA Class I and TLR4 Mediates P-Selectin Surface Expression and Monocyte Capture to Human Endothelial Cells. J Immunol. 2022 10 01; 209(7):1359-1369. Jin YP, Nevarez-Mejia J, Terry AQ, Sosa RA, Heidt S, Valenzuela NM, Rozengurt E, Reed EF. PMID: 36165200; PMCID: PMC9635437.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Late phase endothelial cell inflammation is characterized by interferon response genes and driven by JAK/STAT, not NFκB. Vascul Pharmacol. 2022 10; 146:107090. Valenzuela NM. PMID: 35908591.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Molecular Signature of Antibody-Mediated Chronic Vasculopathy in Heart Allografts in a Novel Mouse Model. Am J Pathol. 2022 07; 192(7):1053-1065. Tsuda H, Dvorina N, Keslar KS, Nevarez-Mejia J, Valenzuela NM, Reed EF, Fairchild RL, Baldwin WM. PMID: 35490714; PMCID: PMC9253905.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    17. Non-HLA Antibodies and Epitope Mismatches in Kidney Transplant Recipients With Histological Antibody-Mediated Rejection. Front Immunol. 2021; 12:703457. Crespo M, Llinàs-Mallol L, Redondo-Pachón D, Butler C, Gimeno J, Pérez-Sáez MJ, Burballa C, Buxeda A, Arias-Cabrales C, Folgueiras M, Sanz-Ureña S, Valenzuela NM, Reed EF, Pascual J. PMID: 34305943; PMCID: PMC8300190.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCTClinical Trials
    18. IFNγ, and to a Lesser Extent TNFα, Provokes a Sustained Endothelial Costimulatory Phenotype. Front Immunol. 2021; 12:648946. Valenzuela NM. PMID: 33936069; PMCID: PMC8082142.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses. Sci Rep. 2021 01 21; 11(1):1949. Gunawardana H, Romero T, Yao N, Heidt S, Mulder A, Elashoff DA, Valenzuela NM. PMID: 33479269; PMCID: PMC7820348.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    20. Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report. Am J Transplant. 2020 10; 20(10):2652-2668. Tambur AR, Campbell P, Chong AS, Feng S, Ford ML, Gebel H, Gill RG, Kelsoe G, Kosmoliaptsis V, Mannon RB, Mengel M, Reed EF, Valenzuela NM, Wiebe C, Dijke IE, Sullivan HC, Nickerson P. PMID: 32342639; PMCID: PMC7586936.
      View in: PubMed   Mentions: 25     Fields:    
    21. Antibody-induced vascular inflammation skews infiltrating macrophages to a novel remodeling phenotype in a model of transplant rejection. Am J Transplant. 2020 10; 20(10):2686-2702. Wei X, Valenzuela NM, Rossetti M, Sosa RA, Nevarez-Mejia J, Fishbein GA, Mulder A, Dhar J, Keslar KS, Baldwin WM, Fairchild RL, Hou J, Reed EF. PMID: 32320528; PMCID: PMC7529968.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. Luminex screening first vs. direct single antigen bead assays: Different strategies for HLA antibody monitoring after kidney transplantation. Hum Immunol. 2020 Jun; 81(6):293-299. Burballa C, Pérez-Saéz MJ, Redondo-Pachón D, García C, Mir M, Arias-Cabrales C, Valenzuela NM, Reed EF, Pascual J, Crespo M. PMID: 32279925.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Abolishing serum interference in detection of HLA antibodies: Who, How, When and Why? Hum Immunol. 2019 Sep; 80(9):621-628. Greenshields AL, Jollet I, Liwski RS, Taupin JL, Valenzuela NM. PMID: 31383369.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Unraveling the role of the parenchyma in alloimmune responses. Am J Transplant. 2019 10; 19(10):2671-2672. Valenzuela NM. PMID: 31207023.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    25. Minimal data reporting standards for serological testing for histocompatibility. Hum Immunol. 2018 Dec; 79(12):865-868. Valenzuela NM, Askar M, Heidt S, Jindra P, Madbouly A, Pinelli D, Jackson A, Hidalgo LG. PMID: 30125598.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection. J Immunol. 2018 04 01; 200(7):2372-2390. Jin YP, Valenzuela NM, Zhang X, Rozengurt E, Reed EF. PMID: 29475988; PMCID: PMC5860975.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    27. The Biology of IgG Subclasses and Their Clinical Relevance to Transplantation. Transplantation. 2018 01; 102(1S Suppl 1):S7-S13. Valenzuela NM, Schaub S. PMID: 29266057.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    28. HLA Class I and Class II-Induced Intracellular Signaling and Molecular Associations in Primary Human Endothelial Cells. Methods Mol Biol. 2018; 1788:23-41. Valenzuela N, Soe NN, Li F, Zhang X, Jin YP, Reed EF. PMID: 28994032.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Complement-Mediated Enhancement of Monocyte Adhesion to Endothelial Cells by HLA Antibodies, and Blockade by a Specific Inhibitor of the Classical Complement Cascade, TNT003. Transplantation. 2017 07; 101(7):1559-1572. Valenzuela NM, Thomas KA, Mulder A, Parry GC, Panicker S, Reed EF. PMID: 28640789; PMCID: PMC5482566.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    30. Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapies. J Clin Invest. 2017 Jun 30; 127(7):2492-2504. Valenzuela NM, Reed EF. PMID: 28604384; PMCID: PMC5490786.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    31. Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. J Immunol Res. 2017; 2017:7903471. Butler CL, Valenzuela NM, Thomas KA, Reed EF. PMID: 28373996; PMCID: PMC5360970.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    32. New priorities: Analysis of the New Kidney Allocation System on UCLA patients transplanted from the deceased donor waitlist. Hum Immunol. 2017 Jan; 78(1):41-48. Hickey MJ, Zheng Y, Valenzuela N, Zhang Q, Krystal C, Lum E, Tsai EW, Lipshutz GS, Gritsch HA, Danovitch G, Veale J, Gjertson D, Cecka M, Reed EF. PMID: 27818166.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    33. Application of High-Throughput Next-Generation Sequencing for HLA Typing on Buccal Extracted DNA: Results from over 10,000 Donor Recruitment Samples. PLoS One. 2016; 11(10):e0165810. Yin Y, Lan JH, Nguyen D, Valenzuela N, Takemura P, Bolon YT, Springer B, Saito K, Zheng Y, Hague T, Pasztor A, Horvath G, Rigo K, Reed EF, Zhang Q. PMID: 27798706; PMCID: PMC5087893.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    34. Antibody Subclass Repertoire and Graft Outcome Following Solid Organ Transplantation. Front Immunol. 2016; 7:433. Valenzuela NM, Hickey MJ, Reed EF. PMID: 27822209; PMCID: PMC5075576.
      View in: PubMed   Mentions: 15     Fields:    
    35. Cytogenetic Insights into the Evolution of Chromosomes and Sex Determination Reveal Striking Homology of Turtle Sex Chromosomes to Amphibian Autosomes. Cytogenet Genome Res. 2016; 148(4):292-304. Montiel EE, Badenhorst D, Lee LS, Literman R, Trifonov V, Valenzuela N. PMID: 27423490.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    36. Alloantibody Generation and Effector Function Following Sensitization to Human Leukocyte Antigen. Front Immunol. 2016; 7:30. Hickey MJ, Valenzuela NM, Reed EF. PMID: 26870045; PMCID: PMC4740371.
      View in: PubMed   Mentions: 23     Fields:    
    37. Antibodies to HLA Molecules Mimic Agonistic Stimulation to Trigger Vascular Cell Changes and Induce Allograft Injury. Curr Transplant Rep. 2015 Sep; 2(3):222-232. Valenzuela NM, Reed EF. PMID: 28344919; PMCID: PMC5365147.
      View in: PubMed   Mentions: 11  
    38. An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. Am J Transplant. 2015 Aug; 15(8):2037-49. Thomas KA, Valenzuela NM, Gjertson D, Mulder A, Fishbein MC, Parry GC, Panicker S, Reed EF. PMID: 25904443; PMCID: PMC4654252.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    39. The perfect storm: HLA antibodies, complement, FcγRs, and endothelium in transplant rejection. Trends Mol Med. 2015 May; 21(5):319-29. Thomas KA, Valenzuela NM, Reed EF. PMID: 25801125; PMCID: PMC4424065.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    40. Monocyte recruitment by HLA IgG-activated endothelium: the relationship between IgG subclass and FcγRIIa polymorphisms. Am J Transplant. 2015 Jun; 15(6):1502-18. Valenzuela NM, Trinh KR, Mulder A, Morrison SL, Reed EF. PMID: 25648976; PMCID: PMC4439339.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    41. Phosphorylated S6 kinase and S6 ribosomal protein are diagnostic markers of antibody-mediated rejection in heart allografts. J Heart Lung Transplant. 2015 Apr; 34(4):580-587. Li F, Wei J, Valenzuela NM, Lai C, Zhang Q, Gjertson D, Fishbein MC, Kobashigawa JA, Deng M, Reed EF. PMID: 25511749; PMCID: PMC4402106.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    42. Sex determination: why so many ways of doing it? PLoS Biol. 2014 Jul; 12(7):e1001899. Bachtrog D, Mank JE, Peichel CL, Kirkpatrick M, Otto SP, Ashman TL, Hahn MW, Kitano J, Mayrose I, Ming R, Perrin N, Ross L, Valenzuela N, Vamosi JC, Tree of Sex Consortium. PMID: 24983465; PMCID: PMC4077654.
      View in: PubMed   Mentions: 436     Fields:    Translation:HumansAnimalsCells
    43. Everolimus inhibits anti-HLA I antibody-mediated endothelial cell signaling, migration and proliferation more potently than sirolimus. Am J Transplant. 2014 Apr; 14(4):806-19. Jin YP, Valenzuela NM, Ziegler ME, Rozengurt E, Reed EF. PMID: 24580843; PMCID: PMC5555744.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    44. Antibody-mediated graft injury: complement-dependent and complement-independent mechanisms. Curr Opin Organ Transplant. 2014 Feb; 19(1):33-40. Valenzuela NM, McNamara JT, Reed EF. PMID: 24316758; PMCID: PMC4080796.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    45. HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcγRs. J Immunol. 2013 Jun 15; 190(12):6635-50. Valenzuela NM, Mulder A, Reed EF. PMID: 23690477; PMCID: PMC3885237.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    46. Antibodies in transplantation: the effects of HLA and non-HLA antibody binding and mechanisms of injury. Methods Mol Biol. 2013; 1034:41-70. Valenzuela NM, Reed EF. PMID: 23775730; PMCID: PMC3879955.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    47. Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo. Am J Transplant. 2013 Feb; 13(2):299-311. Valenzuela NM, Hong L, Shen XD, Gao F, Young SH, Rozengurt E, Kupiec-Weglinski JW, Fishbein MC, Reed EF. PMID: 23279566; PMCID: PMC3563267.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    48. HLA class I antibody-mediated endothelial and smooth muscle cell activation. Curr Opin Organ Transplant. 2012 Aug; 17(4):446-51. Zhang X, Valenzuela NM, Reed EF. PMID: 22710387; PMCID: PMC3880156.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    49. Are all sex chromosomes created equal? Trends Genet. 2011 Sep; 27(9):350-7. Bachtrog D, Kirkpatrick M, Mank JE, McDaniel SF, Pires JC, Rice W, Valenzuela N. PMID: 21962970.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    50. The link between major histocompatibility complex antibodies and cell proliferation. Transplant Rev (Orlando). 2011 Oct; 25(4):154-66. Valenzuela NM, Reed EF. PMID: 21803559; PMCID: PMC3177030.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
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