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Parks, William C

Title(s)Professor, Medicine
Phone(424) 315-4307
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    Collapse Research 
    Collapse Research Activities and Funding
    Control of Macrophage Activation in Lung Disease
    NIH/NHLBI R01HL141078Apr 1, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Graduate Program in Biomedical Sciences and Translational Medicine
    NIH/NIGMS T32GM118288Jul 1, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Role of MMP10 in Macrophage Activation
    NIH/NHLBI R56HL128995Sep 8, 2015 - Aug 31, 2016
    Role: Principal Investigator
    MMP10 Control of Macrophage Activation in COPD
    NIH/NHLBI R01HL089455Jan 1, 2011 - Nov 30, 2014
    Role: Principal Investigator
    Airway Metalloproteinases in Mucosal Immunity
    NIH/NIAID R21AI083487Jun 5, 2009 - May 31, 2012
    Role: Principal Investigator
    American Society fo Matrix Biology 2008
    NIH/NIAMS R13AR056907Nov 25, 2008 - Jun 30, 2009
    Role: Principal Investigator
    Epithelial control of Neutrophil Activation
    NIH/NHLBI R01HL082658Jun 1, 2007 - Sep 30, 2012
    Role: Principal Investigator
    Epithelial MMPs in Airway Repair
    NIH/NHLBI R01HL077555Jul 1, 2004 - Jun 30, 2010
    Role: Principal Investigator
    Conference--2003 Tissue Repair And Regeneration
    NIH/NIAMS R13AR050005Jun 1, 2003 - May 31, 2004
    Role: Principal Investigator
    Regulation of Vascular Wall Extracellular Matrix
    NIH/NHLBI R01HL072554Apr 1, 2003 - Mar 31, 2007
    Role: Principal Investigator
    BIOLOGY OF THE CUTANEOUS EPITHELIUM
    NIH/NIAMS P01AR045254May 10, 1998 - Mar 31, 2004
    Role: Principal Investigator
    1997 GORDON CONFERENCE ON ELASTIN AND ELASTIC TISSUE
    NIH/NHLBI R13HL058443Jul 10, 1997 - Jun 30, 1998
    Role: Principal Investigator
    POSTTRANSCRIPTIONAL REGULATION OF TROPOELASTIN EXPRESSIO
    NIH/NHLBI R01HL048762Sep 30, 1992 - Sep 29, 1997
    Role: Principal Investigator
    CHARACTERIZATION OF TROPOELASTIN ISOFORMS
    NIH/NHLBI R29HL041040Jul 1, 1988 - Jun 30, 1993
    Role: Principal Investigator
    Dermatology Training Grant
    NIH/NIAMS T32AR007284Jul 1, 1978 - Jun 30, 1998
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rohani MG, Dimitrova E, Beppu A, Wang Y, Jefferies CA, Parks WC. Macrophage MMP10 Regulates TLR7-Mediated Tolerance. Front Immunol. 2018; 9:2817. PMID: 30564235.
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    2. Gharib SA, McMahan RS, Eddy WE, Long ME, Parks WC, Aitken ML, Manicone AM. Transcriptional and functional diversity of human macrophage repolarization. J Allergy Clin Immunol. 2019 Apr; 143(4):1536-1548. PMID: 30445062.
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    3. Purroy A, Roncal C, Orbe J, Meilhac O, Belzunce M, Zalba G, Villa-Bellosta R, Andrés V, Parks WC, Páramo JA, Rodríguez JA. Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification. Atherosclerosis. 2018 11; 278:124-134. PMID: 30268068.
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    4. Gharib SA, Manicone AM, Parks WC. Matrix metalloproteinases in emphysema. Matrix Biol. 2018 11; 73:34-51. PMID: 29406250.
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    5. Smigiel KS, Parks WC. Macrophages, Wound Healing, and Fibrosis: Recent Insights. Curr Rheumatol Rep. 2018 03 17; 20(4):17. PMID: 29550962.
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    6. Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. Extracellular matrix in lung development, homeostasis and disease. Matrix Biol. 2018 11; 73:77-104. PMID: 29524630.
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    7. Parimon T, Brauer R, Schlesinger SY, Xie T, Jiang D, Ge L, Huang Y, Birkland TP, Parks WC, Habiel DM, Hogaboam CM, Gharib SA, Deng N, Liu Z, Chen P. Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes. Am J Pathol. 2018 04; 188(4):1094-1103. PMID: 29355516.
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    8. Chang MY, Kang I, Gale M, Manicone AM, Kinsella MG, Braun KR, Wigmosta T, Parks WC, Altemeier WA, Wight TN, Frevert CW. Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1069-L1086. PMID: 28912382.
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    9. Eddy WE, Gong KQ, Bell B, Parks WC, Ziegler SF, Manicone AM. Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury. J Immunol. 2017 06 15; 198(12):4813-4822. PMID: 28500076.
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    10. Manicone AM, Gharib SA, Gong KQ, Eddy WE, Long ME, Frevert CW, Altemeier WA, Parks WC, Houghton AM. Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis. Am J Pathol. 2017 Jun; 187(6):1288-1300. PMID: 28399390.
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    11. Smigiel KS, Parks WC. Matrix Metalloproteinases and Leukocyte Activation. Prog Mol Biol Transl Sci. 2017; 147:167-195. PMID: 28413028.
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    12. Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA. Lung pericyte-like cells are functional interstitial immune sentinel cells. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 01; 312(4):L556-L567. PMID: 28188224.
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    13. Vandivort TC, Birkland TP, Domiciano TP, Mitra S, Kavanagh TJ, Parks WC. Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes. Int J Nanomedicine. 2017; 12:1019-1031. PMID: 28223796.
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    14. Secor PR, Michaels LA, Smigiel KS, Rohani MG, Jennings LK, Hisert KB, Arrigoni A, Braun KR, Birkland TP, Lai Y, Hallstrand TS, Bollyky PL, Singh PK, Parks WC. Filamentous Bacteriophage Produced by Pseudomonas aeruginosa Alters the Inflammatory Response and Promotes Noninvasive Infection In Vivo. Infect Immun. 2017 Jan; 85(1). PMID: 27795361.
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    15. Wight TN, Frevert CW, Debley JS, Reeves SR, Parks WC, Ziegler SF. Interplay of extracellular matrix and leukocytes in lung inflammation. Cell Immunol. 2017 02; 312:1-14. PMID: 28077237.
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    16. Sheih A, Parks WC, Ziegler SF. GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen. Mucosal Immunol. 2017 05; 10(3):705-715. PMID: 27731325.
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    17. Standage SW, Waworuntu RL, Delaney MA, Maskal SM, Bennion BG, Duffield JS, Parks WC, Liles WC, McGuire JK. Nonhematopoietic Peroxisome Proliferator-Activated Receptor-a Protects Against Cardiac Injury and Enhances Survival in Experimental Polymicrobial Sepsis. Crit Care Med. 2016 08; 44(8):e594-603. PMID: 26757163.
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    18. Gill SE, Nadler ST, Li Q, Frevert CW, Park PW, Chen P, Parks WC. Shedding of Syndecan-1/CXCL1 Complexes by Matrix Metalloproteinase 7 Functions as an Epithelial Checkpoint of Neutrophil Activation. Am J Respir Cell Mol Biol. 2016 08; 55(2):243-51. PMID: 26934670.
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    19. Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, Chen P. Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial Apoptosis. Am J Respir Crit Care Med. 2016 08 01; 194(3):333-44. PMID: 26959387.
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    20. McMahan RS, Birkland TP, Smigiel KS, Vandivort TC, Rohani MG, Manicone AM, McGuire JK, Gharib SA, Parks WC. Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation. J Immunol. 2016 08 01; 197(3):899-909. PMID: 27316687.
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    21. Gounder AP, Myers ND, Treuting PM, Bromme BA, Wilson SS, Wiens ME, Lu W, Ouellette AJ, Spindler KR, Parks WC, Smith JG. Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection. PLoS Pathog. 2016 Mar; 12(3):e1005474. PMID: 26933888; PMCID: PMC4774934.
    22. Vandivort TC, An D, Parks WC. An Improved Method for Rapid Intubation of the Trachea in Mice. J Vis Exp. 2016 Feb 22; (108):53771. PMID: 26968019.
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    23. Eldredge LC, Treuting PM, Manicone AM, Ziegler SF, Parks WC, McGuire JK. CD11b(+) Mononuclear Cells Mitigate Hyperoxia-Induced Lung Injury in Neonatal Mice. Am J Respir Cell Mol Biol. 2016 Feb; 54(2):273-83. PMID: 26192732.
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    24. Secor PR, Jennings LK, Michaels LA, Sweere JM, Singh PK, Parks WC, Bollyky PL. Biofilm assembly becomes crystal clear - filamentous bacteriophage organize the Pseudomonas aeruginosa biofilm matrix into a liquid crystal. Microb Cell. 2015 Dec 31; 3(1):49-52. PMID: 28357315.
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    25. Secor PR, Sweere JM, Michaels LA, Malkovskiy AV, Lazzareschi D, Katznelson E, Rajadas J, Birnbaum ME, Arrigoni A, Braun KR, Evanko SP, Stevens DA, Kaminsky W, Singh PK, Parks WC, Bollyky PL. Filamentous Bacteriophage Promote Biofilm Assembly and Function. Cell Host Microbe. 2015 Nov 11; 18(5):549-59. PMID: 26567508.
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    26. Gharib SA, Loth DW, Soler Artigas M, Birkland TP, Wilk JB, Wain LV, Brody JA, Obeidat M, Hancock DB, Tang W, Rawal R, Boezen HM, Imboden M, Huffman JE, Lahousse L, Alves AC, Manichaikul A, Hui J, Morrison AC, Ramasamy A, Smith AV, Gudnason V, Surakka I, Vitart V, Evans DM, Strachan DP, Deary IJ, Hofman A, Gläser S, Wilson JF, North KE, Zhao JH, Heckbert SR, Jarvis DL, Probst-Hensch N, Schulz H, Barr RG, Jarvelin MR, O'Connor GT, Kähönen M, Cassano PA, Hysi PG, Dupuis J, Hayward C, Psaty BM, Hall IP, Parks WC, Tobin MD, London SJ. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet. 2015 12 01; 24(23):6836-48. PMID: 26395457.
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    27. Jones HD, Yoo J, Crother TR, Kyme P, Ben-Shlomo A, Khalafi R, Tseng CW, Parks WC, Arditi M, Liu GY, Shimada K. Correction: Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration. PLoS One. 2015; 10(5):e0128735. PMID: 25996479.
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    28. Rohani MG, McMahan RS, Razumova MV, Hertz AL, Cieslewicz M, Pun SH, Regnier M, Wang Y, Birkland TP, Parks WC. MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages. J Invest Dermatol. 2015 Oct; 135(10):2377-2384. PMID: 25927164.
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    29. Apte SS, Parks WC. Metalloproteinases: A parade of functions in matrix biology and an outlook for the future. Matrix Biol. 2015 May-Jul; 44-46:1-6. PMID: 25916966.
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    30. Jones HD, Yoo J, Crother TR, Kyme P, Ben-Shlomo A, Khalafi R, Tseng CW, Parks WC, Arditi M, Liu GY, Shimada K. Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration. PLoS One. 2015; 10(4):e0123460. PMID: 25875775.
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    31. Rohani MG, Parks WC. Matrix remodeling by MMPs during wound repair. Matrix Biol. 2015 May-Jul; 44-46:113-21. PMID: 25770908.
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    32. Thomopoulos S, Parks WC, Rifkin DB, Derwin KA. Mechanisms of tendon injury and repair. J Orthop Res. 2015 Jun; 33(6):832-9. PMID: 25641114.
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    33. Wilson SS, Tocchi A, Holly MK, Parks WC, Smith JG. A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions. Mucosal Immunol. 2015 Mar; 8(2):352-61. PMID: 25118165.
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    34. Lee V, McMahan RS, Hu X, Gao X, Faustman EM, Griffith WC, Kavanagh TJ, Eaton DL, McGuire JK, Parks WC. Amphiphilic polymer-coated CdSe/ZnS quantum dots induce pro-inflammatory cytokine expression in mouse lung epithelial cells and macrophages. Nanotoxicology. 2015 May; 9(3):336-43. PMID: 24983898.
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    35. Yoo J, Manicone AM, McGuire JK, Wang Y, Parks WC. Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis. J Inflamm Res. 2014; 7:29-38. PMID: 24672255.
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    36. Giannandrea M, Parks WC. Diverse functions of matrix metalloproteinases during fibrosis. Dis Model Mech. 2014 Feb; 7(2):193-203. PMID: 24713275.
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    37. McMahan RS, Lee V, Parks WC, Kavanagh TJ, Eaton DL. In vitro approaches to assessing the toxicity of quantum dots. Methods Mol Biol. 2014; 1199:155-63. PMID: 25103807.
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    38. Toni M, Hermida J, Goñi MJ, Fernández P, Parks WC, Toledo E, Montes R, Díez N. Matrix metalloproteinase-10 plays an active role in microvascular complications in type 1 diabetic patients. Diabetologia. 2013 Dec; 56(12):2743-52. PMID: 24078057.
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    39. Rohani MG, Pilcher BK, Chen P, Parks WC. Cdc42 inhibits ERK-mediated collagenase-1 (MMP-1) expression in collagen-activated human keratinocytes. J Invest Dermatol. 2014 May; 134(5):1230-1237. PMID: 24352036.
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    40. Gill SE, Gharib SA, Bench EM, Sussman SW, Wang RT, Rims C, Birkland TP, Wang Y, Manicone AM, McGuire JK, Parks WC. Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages. Am J Respir Cell Mol Biol. 2013 Nov; 49(5):768-77. PMID: 23742180.
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    41. Garcia-Irigoyen O, Carotti S, Latasa MU, Uriarte I, Fernández-Barrena MG, Elizalde M, Urtasun R, Vespasiani-Gentilucci U, Morini S, Banales JM, Parks WC, Rodriguez JA, Orbe J, Prieto J, Páramo JA, Berasain C, Ávila MA. Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair. Liver Int. 2014 Aug; 34(7):e257-70. PMID: 24119197.
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    42. Gharib SA, Johnston LK, Huizar I, Birkland TP, Hanson J, Wang Y, Parks WC, Manicone AM. MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis. J Leukoc Biol. 2014 Jan; 95(1):9-18. PMID: 23964118.
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    43. Lichtnekert J, Kawakami T, Parks WC, Duffield JS. Changes in macrophage phenotype as the immune response evolves. Curr Opin Pharmacol. 2013 Aug; 13(4):555-64. PMID: 23747023.
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    44. McConnachie LA, Botta D, White CC, Weldy CS, Wilkerson HW, Yu J, Dills R, Yu X, Griffith WC, Faustman EM, Farin FM, Gill SE, Parks WC, Hu X, Gao X, Eaton DL, Kavanagh TJ. The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice. PLoS One. 2013; 8(5):e64165. PMID: 23724032.
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    45. Murray MY, Birkland TP, Howe JD, Rowan AD, Fidock M, Parks WC, Gavrilovic J. Macrophage migration and invasion is regulated by MMP10 expression. PLoS One. 2013; 8(5):e63555. PMID: 23691065.
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    46. Tocchi A, Parks WC. Functional interactions between matrix metalloproteinases and glycosaminoglycans. FEBS J. 2013 May; 280(10):2332-41. PMID: 23421805.
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    47. Gharib SA, Altemeier WA, Van Winkle LS, Plopper CG, Schlesinger SY, Buell CA, Brauer R, Lee V, Parks WC, Chen P. Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells. Am J Respir Cell Mol Biol. 2013 Mar; 48(3):390-6. PMID: 23258229.
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    48. Koller FL, Dozier EA, Nam KT, Swee M, Birkland TP, Parks WC, Fingleton B. Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Lab Invest. 2012 Dec; 92(12):1749-59. PMID: 23044923.
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    49. Altemeier WA, Schlesinger SY, Buell CA, Brauer R, Rapraeger AC, Parks WC, Chen P. Transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion. J Biol Chem. 2012 Oct 12; 287(42):34927-35. PMID: 22936802.
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    50. Altemeier WA, Schlesinger SY, Buell CA, Parks WC, Chen P. Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly. J Cell Sci. 2012 Nov 01; 125(Pt 21):5188-95. PMID: 22899717.
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    51. Tanino Y, Chang MY, Wang X, Gill SE, Skerrett S, McGuire JK, Sato S, Nikaido T, Kojima T, Munakata M, Mongovin S, Parks WC, Martin TR, Wight TN, Frevert CW. Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):196-202. PMID: 22427536.
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    52. Orbe J, Barrenetxe J, Rodriguez JA, Vivien D, Orset C, Parks WC, Birkland TP, Serrano R, Purroy A, Martinez de Lizarrondo S, Angles-Cano E, Páramo JA. Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism. Circulation. 2011 Dec 20; 124(25):2909-19. PMID: 22104553.
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    53. Oganesian A, Yarov-Yarovoy V, Parks WC, Schwinn DA. Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19796-801. PMID: 22089237.
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    54. Manicone AM, Harju-Baker S, Johnston LK, Chen AJ, Parks WC. Epilysin (matrix metalloproteinase-28) contributes to airway epithelial cell survival. Respir Res. 2011 Oct 31; 12:144. PMID: 22040290.
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    55. Weldy CS, White CC, Wilkerson HW, Larson TV, Stewart JA, Gill SE, Parks WC, Kavanagh TJ. Heterozygosity in the glutathione synthesis gene Gclm increases sensitivity to diesel exhaust particulate induced lung inflammation in mice. Inhal Toxicol. 2011 Oct; 23(12):724-35. PMID: 21967497.
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    56. Hu JH, Du L, Chu T, Otsuka G, Dronadula N, Jaffe M, Gill SE, Parks WC, Dichek DA. Overexpression of urokinase by plaque macrophages causes histological features of plaque rupture and increases vascular matrix metalloproteinase activity in aged apolipoprotein e-null mice. Circulation. 2010 Apr 13; 121(14):1637-44. PMID: 20351234.
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    57. Tanino Y, Coombe DR, Gill SE, Kett WC, Kajikawa O, Proudfoot AE, Wells TN, Parks WC, Wight TN, Martin TR, Frevert CW. Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs. J Immunol. 2010 Mar 01; 184(5):2677-85. PMID: 20124102.
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    58. Gill SE, Kassim SY, Birkland TP, Parks WC. Mouse models of MMP and TIMP function. Methods Mol Biol. 2010; 622:31-52. PMID: 20135274.
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    59. Chen P, Parks WC. Role of matrix metalloproteinases in epithelial migration. J Cell Biochem. 2009 Dec 15; 108(6):1233-43. PMID: 19798678.
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    60. Gill SE, Huizar I, Bench EM, Sussman SW, Wang Y, Khokha R, Parks WC. Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury. Am J Pathol. 2010 Jan; 176(1):64-73. PMID: 20008147.
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    61. Chen P, Abacherli LE, Nadler ST, Wang Y, Li Q, Parks WC. MMP7 shedding of syndecan-1 facilitates re-epithelialization by affecting alpha(2)beta(1) integrin activation. PLoS One. 2009 Aug 10; 4(8):e6565. PMID: 19668337.
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    62. Ra HJ, Harju-Baker S, Zhang F, Linhardt RJ, Wilson CL, Parks WC. Control of promatrilysin (MMP7) activation and substrate-specific activity by sulfated glycosaminoglycans. J Biol Chem. 2009 Oct 09; 284(41):27924-32. PMID: 19654318.
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    63. Kim J, Swee M, Parks WC. Cytosolic SYT/SS18 isoforms are actin-associated proteins that function in matrix-specific adhesion. PLoS One. 2009 Jul 31; 4(7):e6455. PMID: 19649286.
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    64. Hayashida K, Parks WC, Park PW. Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines. Blood. 2009 Oct 01; 114(14):3033-43. PMID: 19638625.
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    65. Manicone AM, Birkland TP, Lin M, Betsuyaku T, van Rooijen N, Lohi J, Keski-Oja J, Wang Y, Skerrett SJ, Parks WC. Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia. J Immunol. 2009 Mar 15; 182(6):3866-76. PMID: 19265166.
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    66. Wilson CL, Schmidt AP, Pirilä E, Valore EV, Ferri N, Sorsa T, Ganz T, Parks WC. Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7). J Biol Chem. 2009 Mar 27; 284(13):8301-11. PMID: 19181662.
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    67. Vaisar T, Kassim SY, Gomez IG, Green PS, Hargarten S, Gough PJ, Parks WC, Wilson CL, Raines EW, Heinecke JW. MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages. Mol Cell Proteomics. 2009 May; 8(5):1044-60. PMID: 19116209.
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    68. Chen P, McGuire JK, Hackman RC, Kim KH, Black RA, Poindexter K, Yan W, Liu P, Chen AJ, Parks WC, Madtes DK. Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity. Am J Pathol. 2008 May; 172(5):1256-70. PMID: 18385523.
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    69. Swee M, Wilson CL, Wang Y, McGuire JK, Parks WC. Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients. J Leukoc Biol. 2008 Jun; 83(6):1404-12. PMID: 18334539.
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    70. Luttrell IP, Swee M, Starcher B, Parks WC, Chitaley K. Erectile dysfunction in the type II diabetic db/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix. Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2204-11. PMID: 18326798.
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    71. Gill SE, Parks WC. Metalloproteinases and their inhibitors: regulators of wound healing. Int J Biochem Cell Biol. 2008; 40(6-7):1334-47. PMID: 18083622.
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    72. Kassim SY, Gharib SA, Mecham BH, Birkland TP, Parks WC, McGuire JK. Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa. Infect Immun. 2007 Dec; 75(12):5640-50. PMID: 17923522.
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    73. Parks WC. Matrix metalloproteinases: Introduction. Semin Cell Dev Biol. 2008 Feb; 19(1):1. PMID: 17662627.
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    74. Ra HJ, Parks WC. Control of matrix metalloproteinase catalytic activity. Matrix Biol. 2007 Oct; 26(8):587-96. PMID: 17669641.
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    75. Fu X, Parks WC, Heinecke JW. Activation and silencing of matrix metalloproteinases. Semin Cell Dev Biol. 2008 Feb; 19(1):2-13. PMID: 17689277.
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    76. Parks WC. What is the alpha2beta1 integrin doing in the epidermis? J Invest Dermatol. 2007 Feb; 127(2):264-6. PMID: 17228304.
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    77. Kuo E, Bharat A, Shih J, Street T, Norris J, Liu W, Parks W, Walter M, Patterson GA, Mohanakumar T. Role of airway epithelial injury in murine orthotopic tracheal allograft rejection. Ann Thorac Surg. 2006 Oct; 82(4):1226-33. PMID: 16996912.
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    78. Tan RJ, Fattman CL, Niehouse LM, Tobolewski JM, Hanford LE, Li Q, Monzon FA, Parks WC, Oury TD. Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in mice. Am J Respir Cell Mol Biol. 2006 Sep; 35(3):289-97. PMID: 16574944.
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    79. Fu X, Wang Y, Kao J, Irwin A, d'Avignon A, Mecham RP, Parks WC, Heinecke JW. Specific sequence motifs direct the oxygenation and chlorination of tryptophan by myeloperoxidase. Biochemistry. 2006 Mar 28; 45(12):3961-71. PMID: 16548523.
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    80. Kassim SY, Fu X, Liles WC, Shapiro SD, Parks WC, Heinecke JW. NADPH oxidase restrains the matrix metalloproteinase activity of macrophages. J Biol Chem. 2005 Aug 26; 280(34):30201-5. PMID: 15983040.
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    81. Atkinson JJ, Holmbeck K, Yamada S, Birkedal-Hansen H, Parks WC, Senior RM. Membrane-type 1 matrix metalloproteinase is required for normal alveolar development. Dev Dyn. 2005 Apr; 232(4):1079-90. PMID: 15739229.
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    82. Choi ET, Collins ET, Marine LA, Uberti MG, Uchida H, Leidenfrost JE, Khan MF, Boc KP, Abendschein DR, Parks WC. Matrix metalloproteinase-9 modulation by resident arterial cells is responsible for injury-induced accelerated atherosclerotic plaque development in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2005 May; 25(5):1020-5. PMID: 15746435.
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    83. Krampert M, Bloch W, Sasaki T, Bugnon P, Rülicke T, Wolf E, Aumailley M, Parks WC, Werner S. Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. Mol Biol Cell. 2004 Dec; 15(12):5242-54. PMID: 15371548.
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    84. Veinot JP, Prichett-Pejic W, Picard P, Parks W, Schwartz R, Seidah NG, Chretien M. Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model. Cardiovasc Pathol. 2004 Sep-Oct; 13(5):241-50. PMID: 15358338.
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    85. Parks WC, Wilson CL, López-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol. 2004 Aug; 4(8):617-29. PMID: 15286728.
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    86. Choi ET, Khan MF, Leidenfrost JE, Collins ET, Boc KP, Villa BR, Novack DV, Parks WC, Abendschein DR. Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in mice. Circulation. 2004 Mar 30; 109(12):1564-9. PMID: 15007005.
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    87. Fu X, Kao JL, Bergt C, Kassim SY, Huq NP, d'Avignon A, Parks WC, Mecham RP, Heinecke JW. Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation. J Biol Chem. 2004 Feb 20; 279(8):6209-12. PMID: 14670964.
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    88. Illman SA, Keski-Oja J, Parks WC, Lohi J. The mouse matrix metalloproteinase, epilysin (MMP-28), is alternatively spliced and processed by a furin-like proprotein convertase. Biochem J. 2003 Oct 01; 375(Pt 1):191-7. PMID: 12803542.
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    89. Parks WC. Matrix metalloproteinases in lung repair. Eur Respir J Suppl. 2003 Sep; 44:36s-38s. PMID: 14582900.
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    90. Leidenfrost JE, Khan MF, Boc KP, Villa BR, Collins ET, Parks WC, Abendschein DR, Choi ET. A model of primary atherosclerosis and post-angioplasty restenosis in mice. Am J Pathol. 2003 Aug; 163(2):773-8. PMID: 12875996.
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    91. McGuire JK, Li Q, Parks WC. Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium. Am J Pathol. 2003 Jun; 162(6):1831-43. PMID: 12759241.
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    92. Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin): an oxidative mechanism for restraining proteolytic activity during inflammation. J Biol Chem. 2003 Aug 01; 278(31):28403-9. PMID: 12759346.
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    93. Li Q, Park PW, Wilson CL, Parks WC. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell. 2002 Nov 27; 111(5):635-46. PMID: 12464176.
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    94. Parks WC. A confederacy of proteinases. J Clin Invest. 2002 Sep; 110(5):613-4. PMID: 12208861.
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    95. Lawson GW, Van Winkle LS, Toskala E, Senior RM, Parks WC, Plopper CG. Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airways. Am J Pathol. 2002 Jan; 160(1):315-27. PMID: 11786425.
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    96. Wassef M, Baxter BT, Chisholm RL, Dalman RL, Fillinger MF, Heinecke J, Humphrey JD, Kuivaniemi H, Parks WC, Pearce WH, Platsoucas CD, Sukhova GK, Thompson RW, Tilson MD, Zarins CK. Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. J Vasc Surg. 2001 Oct; 34(4):730-8. PMID: 11668331.
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    97. Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase. J Biol Chem. 2001 Nov 02; 276(44):41279-87. PMID: 11533038.
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    98. López-Boado YS, Wilson CL, Parks WC. Regulation of matrilysin expression in airway epithelial cells by Pseudomonas aeruginosa flagellin. J Biol Chem. 2001 Nov 02; 276(44):41417-23. PMID: 11527977.
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    99. Parks WC, López-Boado YS, Wilson CL. Matrilysin in epithelial repair and defense. Chest. 2001 Jul; 120(1 Suppl):36S-41S. PMID: 11451908.
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    100. Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC. Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen. J Biol Chem. 2001 Aug 03; 276(31):29368-74. PMID: 11359786.
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    101. Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA. Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction. J Biol Chem. 2001 Aug 03; 276(31):29375-81. PMID: 11359774.
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    102. Xu J, Clark RA, Parks WC. p38 mitogen-activated kinase is a bidirectional regulator of human fibroblast collagenase-1 induction by three-dimensional collagen lattices. Biochem J. 2001 Apr 15; 355(Pt 2):437-47. PMID: 11284732.
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    103. Henderson JP, Byun J, Williams MV, McCormick ML, Parks WC, Ridnour LA, Heinecke JW. Bromination of deoxycytidine by eosinophil peroxidase: a mechanism for mutagenesis by oxidative damage of nucleotide precursors. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1631-6. PMID: 11172002.
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    104. Parks WC, Shapiro SD. Matrix metalloproteinases in lung biology. Respir Res. 2001; 2(1):10-9. PMID: 11686860.
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    105. Lohi J, Wilson CL, Roby JD, Parks WC. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J Biol Chem. 2001 Mar 30; 276(13):10134-44. PMID: 11121398.
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    106. Betsuyaku T, Fukuda Y, Parks WC, Shipley JM, Senior RM. Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin. Am J Pathol. 2000 Aug; 157(2):525-35. PMID: 10934155.
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    107. Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol. 2000 Aug; 1(2):113-8. PMID: 11248802.
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    108. Robinson BW, Erle DJ, Jones DA, Shapiro S, Metzger WJ, Albelda SM, Parks WC, Boylan A. Recent advances in molecular biological techniques and their relevance to pulmonary research. Thorax. 2000 Apr; 55(4):329-39. PMID: 10722774.
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    109. López-Boado YS, Wilson CL, Hooper LV, Gordon JI, Hultgren SJ, Parks WC. Bacterial exposure induces and activates matrilysin in mucosal epithelial cells. J Cell Biol. 2000 Mar 20; 148(6):1305-15. PMID: 10725342.
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    110. Lohi J, Lehti K, Valtanen H, Parks WC, Keski-Oja J. Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene. Gene. 2000 Jan 25; 242(1-2):75-86. PMID: 10721699.
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    111. Parks WC. Matrix metalloproteinases in repair. Wound Repair Regen. 1999 Nov-Dec; 7(6):423-32. PMID: 10633001.
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    112. Zhang M, Pierce RA, Wachi H, Mecham RP, Parks WC. An open reading frame element mediates posttranscriptional regulation of tropoelastin and responsiveness to transforming growth factor beta1. Mol Cell Biol. 1999 Nov; 19(11):7314-26. PMID: 10523620.
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    113. Parks WC. Who are the proteolytic culprits in vascular disease? J Clin Invest. 1999 Nov; 104(9):1167-8. PMID: 10545513.
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    114. Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, López-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science. 1999 Oct 01; 286(5437):113-7. PMID: 10506557.
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    115. Zhang M, Parks WC. Posttranscriptional regulation of lung elastin expression involves binding of a developmentally regulated cytosolic protein to an open-reading frame cis-element in the messenger RNA. Chest. 1999 Jul; 116(1 Suppl):74S. PMID: 10424601.
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    116. Pilcher BK, Wang M, Qin XJ, Parks WC, Senior RM, Welgus HG. Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity. Ann N Y Acad Sci. 1999 Jun 30; 878:12-24. PMID: 10415717.
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    117. Pilcher BK, Dumin J, Schwartz MJ, Mast BA, Schultz GS, Parks WC, Welgus HG. Keratinocyte collagenase-1 expression requires an epidermal growth factor receptor autocrine mechanism. J Biol Chem. 1999 Apr 09; 274(15):10372-81. PMID: 10187826.
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    118. Mulvey MA, Lopez-Boado YS, Wilson CL, Roth R, Parks WC, Heuser J, Hultgren SJ. Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science. 1998 Nov 20; 282(5393):1494-7. PMID: 9822381.
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    119. Dunsmore SE, Saarialho-Kere UK, Roby JD, Wilson CL, Matrisian LM, Welgus HG, Parks WC. Matrilysin expression and function in airway epithelium. J Clin Invest. 1998 Oct 01; 102(7):1321-31. PMID: 9769324.
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    120. Madlener M, Parks WC, Werner S. Matrix metalloproteinases (MMPs) and their physiological inhibitors (TIMPs) are differentially expressed during excisional skin wound repair. Exp Cell Res. 1998 Jul 10; 242(1):201-10. PMID: 9665817.
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    121. Pilcher BK, Sudbeck BD, Dumin JA, Welgus HG, Parks WC. Collagenase-1 and collagen in epidermal repair. Arch Dermatol Res. 1998 Jul; 290 Suppl:S37-46. PMID: 9710382.
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    122. Grinnell F, Zhu M, Parks WC. Collagenase-1 complexes with alpha2-macroglobulin in the acute and chronic wound environments. J Invest Dermatol. 1998 May; 110(5):771-6. PMID: 9579544.
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    123. Sudbeck BD, Pilcher BK, Welgus HG, Parks WC. Induction and repression of collagenase-1 by keratinocytes is controlled by distinct components of different extracellular matrix compartments. J Biol Chem. 1997 Aug 29; 272(35):22103-10. PMID: 9268353.
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    124. Pilcher BK, Gaither-Ganim J, Parks WC, Welgus HG. Cell type-specific inhibition of keratinocyte collagenase-1 expression by basic fibroblast growth factor and keratinocyte growth factor. A common receptor pathway. J Biol Chem. 1997 Jul 18; 272(29):18147-54. PMID: 9218449.
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    125. Parks WC. Posttranscriptional regulation of lung elastin production. Am J Respir Cell Mol Biol. 1997 Jul; 17(1):1-2. PMID: 9224202.
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    126. Pilcher BK, Dumin JA, Sudbeck BD, Krane SM, Welgus HG, Parks WC. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix. J Cell Biol. 1997 Jun 16; 137(6):1445-57. PMID: 9182674.
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    127. Doyle GA, Pierce RA, Parks WC. Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-beta site. J Biol Chem. 1997 May 02; 272(18):11840-9. PMID: 9115242.
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    128. Sudbeck BD, Pilcher BK, Pentland AP, Parks WC. Modulation of intracellular calcium levels inhibits secretion of collagenase 1 by migrating keratinocytes. Mol Biol Cell. 1997 May; 8(5):811-24. PMID: 9168468.
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    129. Doyle GA, Saarialho-Kere UK, Parks WC. Distinct mechanisms regulate TIMP-1 expression at different stages of phorbol ester-mediated differentiation of U937 cells. Biochemistry. 1997 Mar 04; 36(9):2492-500. PMID: 9054554.
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    130. Madlener M, Mauch C, Conca W, Brauchle M, Parks WC, Werner S. Regulation of the expression of stromelysin-2 by growth factors in keratinocytes: implications for normal and impaired wound healing. Biochem J. 1996 Dec 01; 320 ( Pt 2):659-64. PMID: 8973581.
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    131. Thompson RW, Parks WC. Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann N Y Acad Sci. 1996 Nov 18; 800:157-74. PMID: 8958991.
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    132. Vettraino IM, Roby J, Tolley T, Parks WC. Collagenase-I, stromelysin-I, and matrilysin are expressed within the placenta during multiple stages of human pregnancy. Placenta. 1996 Nov; 17(8):557-63. PMID: 8916203.
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    133. Dunsmore SE, Rubin JS, Kovacs SO, Chedid M, Parks WC, Welgus HG. Mechanisms of hepatocyte growth factor stimulation of keratinocyte metalloproteinase production. J Biol Chem. 1996 Oct 04; 271(40):24576-82. PMID: 8798721.
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    134. Fini ME, Parks WC, Rinehart WB, Girard MT, Matsubara M, Cook JR, West-Mays JA, Sadow PM, Burgeson RE, Jeffrey JJ, Raizman MB, Krueger RR, Zieske JD. Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury. Am J Pathol. 1996 Oct; 149(4):1287-302. PMID: 8863676.
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    135. Schuster DP, Crouch EC, Parks WC, Johnson T, Botney MD. Angiotensin converting enzyme expression in primary pulmonary hypertension. Am J Respir Crit Care Med. 1996 Oct; 154(4 Pt 1):1087-91. PMID: 8887612.
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    136. Halpert I, Sires UI, Roby JD, Potter-Perigo S, Wight TN, Shapiro SD, Welgus HG, Wickline SA, Parks WC. Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9748-53. PMID: 8790402.
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    137. Garlick JA, Parks WC, Welgus HG, Taichman LB. Re-epithelialization of human oral keratinocytes in vitro. J Dent Res. 1996 Mar; 75(3):912-8. PMID: 8675802.
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    138. Petrinec D, Liao S, Holmes DR, Reilly JM, Parks WC, Thompson RW. Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase. J Vasc Surg. 1996 Feb; 23(2):336-46. PMID: 8637112.
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    139. Saarialho-Kere UK, Vaalamo M, Puolakkainen P, Airola K, Parks WC, Karjalainen-Lindsberg ML. Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers. Am J Pathol. 1996 Feb; 148(2):519-26. PMID: 8579114.
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    140. Mariani TJ, Roby JD, Mecham RP, Parks WC, Crouch E, Pierce RA. Localization of type I procollagen gene expression in silica-induced granulomatous lung disease and implication of transforming growth factor-beta as a mediator of fibrosis. Am J Pathol. 1996 Jan; 148(1):151-64. PMID: 8546202.
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    141. Liapis H, Roby J, Birkland TP, Davila RM, Ritter D, Parks WC. In situ hybridization of human erythropoietin in pre- and postnatal kidneys. Pediatr Pathol Lab Med. 1995 Nov-Dec; 15(6):875-83. PMID: 8705198.
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    142. Williams EB, Halpert I, Wickline S, Davison G, Parks WC, Rottman JN. Osteopontin expression is increased in the heritable cardiomyopathy of Syrian hamsters. Circulation. 1995 Aug 15; 92(4):705-9. PMID: 7641347.
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    143. Cornelius LA, Nehring LC, Roby JD, Parks WC, Welgus HG. Human dermal microvascular endothelial cells produce matrix metalloproteinases in response to angiogenic factors and migration. J Invest Dermatol. 1995 Aug; 105(2):170-6. PMID: 7543547.
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    144. Saarialho-Kere UK, Crouch EC, Parks WC. Matrix metalloproteinase matrilysin is constitutively expressed in adult human exocrine epithelium. J Invest Dermatol. 1995 Aug; 105(2):190-6. PMID: 7636300.
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    145. Thompson RW, Holmes DR, Mertens RA, Liao S, Botney MD, Mecham RP, Welgus HG, Parks WC. Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J Clin Invest. 1995 Jul; 96(1):318-26. PMID: 7615801.
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    146. Swee MH, Parks WC, Pierce RA. Developmental regulation of elastin production. Expression of tropoelastin pre-mRNA persists after down-regulation of steady-state mRNA levels. J Biol Chem. 1995 Jun 23; 270(25):14899-906. PMID: 7797468.
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    147. Busiek DF, Baragi V, Nehring LC, Parks WC, Welgus HG. Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones. J Immunol. 1995 Jun 15; 154(12):6484-91. PMID: 7759883.
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    148. Saarialho-Kere UK, Vaalamo M, Airola K, Niemi KM, Oikarinen AI, Parks WC. Interstitial collagenase is expressed by keratinocytes that are actively involved in reepithelialization in blistering skin disease. J Invest Dermatol. 1995 Jun; 104(6):982-8. PMID: 7539470.
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    149. Holmes DR, Liao S, Parks WC, Thompson RW. Medial neovascularization in abdominal aortic aneurysms: a histopathologic marker of aneurysmal degeneration with pathophysiologic implications. J Vasc Surg. 1995 May; 21(5):761-71; discussion 771-2. PMID: 7539511.
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    150. Pierce RA, Mariencheck WI, Sandefur S, Crouch EC, Parks WC. Glucocorticoids upregulate tropoelastin expression during late stages of fetal lung development. Am J Physiol. 1995 Mar; 268(3 Pt 1):L491-500. PMID: 7900831.
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    151. Haviland DL, McCoy RL, Whitehead WT, Akama H, Molmenti EP, Brown A, Haviland JC, Parks WC, Perlmutter DH, Wetsel RA. Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung. J Immunol. 1995 Feb 15; 154(4):1861-9. PMID: 7836770.
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    152. Mariencheck MC, Davis EC, Zhang H, Ramirez F, Rosenbloom J, Gibson MA, Parks WC, Mecham RP. Fibrillin-1 and fibrillin-2 show temporal and tissue-specific regulation of expression in developing elastic tissues. Connect Tissue Res. 1995; 31(2):87-97. PMID: 15612324.
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    153. Durmowicz AG, Parks WC, Hyde DM, Mecham RP, Stenmark KR. Persistence, re-expression, and induction of pulmonary arterial fibronectin, tropoelastin, and type I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension. Am J Pathol. 1994 Dec; 145(6):1411-20. PMID: 7992844.
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    154. Sudbeck BD, Parks WC, Welgus HG, Pentland AP. Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities. J Biol Chem. 1994 Nov 25; 269(47):30022-9. PMID: 7962003.
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    155. Parks WC, Roby JD. Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part IV: Effects on expression of extracellular matrix genes. Res Rep Health Eff Inst. 1994 Oct; (65 Pt 4):3-20; discussion 21-9. PMID: 7840908.
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    156. Nath RK, Parks WC, Mackinnon SE, Hunter DA, Markham H, Weeks PM. The regulation of collagen in fetal skin wounds: mRNA localization and analysis. J Pediatr Surg. 1994 Jul; 29(7):855-62. PMID: 7931957.
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    157. Saarialho-Kere UK, Pentland AP, Birkedal-Hansen H, Parks WC, Welgus HG. Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds. J Clin Invest. 1994 Jul; 94(1):79-88. PMID: 8040294.
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    158. Ståhle-Bäckdahl M, Inoue M, Guidice GJ, Parks WC. 92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen. J Clin Invest. 1994 May; 93(5):2022-30. PMID: 8182134.
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    159. Lee KA, Pierce RA, Mecham RP, Parks WC. Increased mesenchymal cell density accompanies induction of tropoelastin expression in developing elastic tissue. Dev Dyn. 1994 May; 200(1):53-67. PMID: 8081014.
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    160. Lee KA, Pierce RA, Davis EC, Mecham RP, Parks WC. Conversion to an elastogenic phenotype by fetal hyaline chondrocytes is accompanied by altered expression of elastin-related macromolecules. Dev Biol. 1994 May; 163(1):241-52. PMID: 8174780.
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    161. Mauviel A, Halcin C, Vasiloudes P, Parks WC, Kurkinen M, Uitto J. Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E2: selective enhancement of collagenase gene expression in human dermal fibroblasts in culture. J Cell Biochem. 1994 Apr; 54(4):465-72. PMID: 8014195.
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    162. Stenmark KR, Durmowicz AG, Roby JD, Mecham RP, Parks WC. Persistence of the fetal pattern of tropoelastin gene expression in severe neonatal bovine pulmonary hypertension. J Clin Invest. 1994 Mar; 93(3):1234-42. PMID: 8132763.
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    163. Saarialho-Kere UK, Kovacs SO, Pentland AP, Olerud JE, Welgus HG, Parks WC. Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing. J Clin Invest. 1993 Dec; 92(6):2858-66. PMID: 8254040.
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    164. Last JA, Gelzleichter T, Harkema J, Parks WC, Mellick P. Effects of 20 months of ozone exposure on lung collagen in Fischer 344 rats. Toxicology. 1993 Nov 12; 84(1-3):83-102. PMID: 8266340.
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    165. Saarialho-Kere UK, Welgus HG, Parks WC. Distinct mechanisms regulate interstitial collagenase and 92-kDa gelatinase expression in human monocytic-like cells exposed to bacterial endotoxin. J Biol Chem. 1993 Aug 15; 268(23):17354-61. PMID: 8394340.
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    166. Botney MD, Liptay MJ, Kaiser LR, Cooper JD, Parks WC, Mecham RP. Active collagen synthesis by pulmonary arteries in human primary pulmonary hypertension. Am J Pathol. 1993 Jul; 143(1):121-9. PMID: 7686340.
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    167. Shapiro SD, Doyle GA, Ley TJ, Parks WC, Welgus HG. Molecular mechanisms regulating the production of collagenase and TIMP in U937 cells: evidence for involvement of delayed transcriptional activation and enhanced mRNA stability. Biochemistry. 1993 Apr 27; 32(16):4286-92. PMID: 8476858.
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    168. Ståhle-Bäckdahl M, Parks WC. 92-kd gelatinase is actively expressed by eosinophils and stored by neutrophils in squamous cell carcinoma. Am J Pathol. 1993 Apr; 142(4):995-1000. PMID: 7682768.
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    169. Saarialho-Kere UK, Chang ES, Welgus HG, Parks WC. Expression of interstitial collagenase, 92-kDa gelatinase, and tissue inhibitor of metalloproteinases-1 in granuloma annulare and necrobiosis lipoidica diabeticorum. J Invest Dermatol. 1993 Mar; 100(3):335-42. PMID: 8382717.
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    170. Liptay MJ, Parks WC, Mecham RP, Roby J, Kaiser LR, Cooper JD, Botney MD. Neointimal macrophages colocalize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries. J Clin Invest. 1993 Feb; 91(2):588-94. PMID: 8432864.
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    171. Saarialho-Kere UK, Chang ES, Welgus HG, Parks WC. Distinct localization of collagenase and tissue inhibitor of metalloproteinases expression in wound healing associated with ulcerative pyogenic granuloma. J Clin Invest. 1992 Nov; 90(5):1952-7. PMID: 1430217.
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    172. Ståhle-Bäckdahl M, Sudbeck BD, Eisen AZ, Welgus HG, Parks WC. Expression of 92-kDa type IV collagenase mRNA by eosinophils associated with basal cell carcinoma. J Invest Dermatol. 1992 Oct; 99(4):497-503. PMID: 1402008.
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    173. Parks WC, Kolodziej ME, Pierce RA. Phorbol ester-mediated downregulation of tropoelastin expression is controlled by a posttranscriptional mechanism. Biochemistry. 1992 Jul 28; 31(29):6639-45. PMID: 1637804.
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    174. Pierce RA, Kolodziej ME, Parks WC. 1,25-Dihydroxyvitamin D3 represses tropoelastin expression by a posttranscriptional mechanism. J Biol Chem. 1992 Jun 05; 267(16):11593-9. PMID: 1597486.
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    175. Botney MD, Parks WC, Crouch EC, Stenmark K, Mecham RP. Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries. J Clin Invest. 1992 May; 89(5):1629-35. PMID: 1569202.
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    176. Parks WC, Roby JD, Wu LC, Grosso LE. Cellular expression of tropoelastin mRNA splice variants. Matrix. 1992 Apr; 12(2):156-62. PMID: 1603038.
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    177. Sudbeck BD, Jeffrey JJ, Welgus HG, Mecham RP, McCourt D, Parks WC. Purification and characterization of bovine interstitial collagenase and tissue inhibitor of metalloproteinases. Arch Biochem Biophys. 1992 Mar; 293(2):370-6. PMID: 1311165.
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    178. Botney MD, Kaiser LR, Cooper JD, Mecham RP, Parghi D, Roby J, Parks WC. Extracellular matrix protein gene expression in atherosclerotic hypertensive pulmonary arteries. Am J Pathol. 1992 Feb; 140(2):357-64. PMID: 1739129.
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    179. Welgus HG, Senior RM, Parks WC, Kahn AJ, Ley TJ, Shapiro SD, Campbell EJ. Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation. Matrix Suppl. 1992; 1:363-7. PMID: 1480061.
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    180. Park PW, Roberts DD, Grosso LE, Parks WC, Rosenbloom J, Abrams WR, Mecham RP. Binding of elastin to Staphylococcus aureus. J Biol Chem. 1991 Dec 05; 266(34):23399-406. PMID: 1744133.
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    181. Durmowicz AG, Badesch DB, Parks WC, Mecham RP, Stenmark KR. Hypoxia-induced inhibition of tropoelastin synthesis by neonatal calf pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 1991 Nov; 5(5):464-9. PMID: 1718337.
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    182. Stenmark KR, Aldashev AA, Orton EC, Durmowicz AG, Badesch DB, Parks WC, Mecham RP, Voelkel NF, Reeves JT. Cellular adaptation during chronic neonatal hypoxic pulmonary hypertension. Am J Physiol. 1991 10; 261(4 Suppl):97-104. PMID: 1928459.
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    183. Botney M, Parks W, Stenmark K, Mecham R. Determination of transforming growth factor-beta mRNA levels in pulmonary arteries from normal and hypoxic calves. Chest. 1991 Mar; 99(3 Suppl):42S. PMID: 1997268.
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    184. Mecham RP, Stenmark KR, Parks WC. Connective tissue production by vascular smooth muscle in development and disease. Chest. 1991 Mar; 99(3 Suppl):43S-47S. PMID: 1997269.
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    185. Grosso LE, Parks WC, Wu LJ, Mecham RP. Fibroblast adhesion to recombinant tropoelastin expressed as a protein A-fusion protein. Biochem J. 1991 Feb 01; 273 ( Pt 3):517-22. PMID: 1996952.
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    186. Yeh HJ, Ruit KG, Wang YX, Parks WC, Snider WD, Deuel TF. PDGF A-chain gene is expressed by mammalian neurons during development and in maturity. Cell. 1991 Jan 11; 64(1):209-16. PMID: 1986867.
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    187. Hinek A, Botney MD, Mecham RP, Parks WC. Inhibition of tropoelastin expression by 1,25-dihydroxyvitamin D3. Connect Tissue Res. 1991; 26(3):155-66. PMID: 1769236.
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    188. Prosser IW, Whitehouse LA, Parks WC, Stahle-Bäckdahl M, Hinek A, Park PW, Mecham RP. Polyclonal antibodies to tropoelastin and the specific detection and measurement of tropoelastin in vitro. Connect Tissue Res. 1991; 25(3-4):265-79. PMID: 2060302.
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    189. Parks WC, Deak SB. Tropoelastin heterogeneity: implications for protein function and disease. Am J Respir Cell Mol Biol. 1990 May; 2(5):399-406. PMID: 2187489.
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    190. Prosser IW, Stenmark KR, Suthar M, Crouch EC, Mecham RP, Parks WC. Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization. Am J Pathol. 1989 Dec; 135(6):1073-88. PMID: 2596571.
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    191. Anderson DW, Epstein JS, Lee TH, Lairmore MD, Saxinger C, Kalyanaraman VS, Slamon D, Parks W, Poiesz BJ, Pierik LT. Serological confirmation of human T-lymphotropic virus type I infection in healthy blood and plasma donors. Blood. 1989 Nov 15; 74(7):2585-91. PMID: 2804381.
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    192. Parks WC, Mecham RP, Crouch EC, Orton EC, Stenmark KR. Response of lobar vessels to hypoxic pulmonary hypertension. Am Rev Respir Dis. 1989 Nov; 140(5):1455-7. PMID: 2817612.
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    193. Crouch EC, Parks WC, Rosenbaum JL, Chang D, Whitehouse L, Wu LJ, Stenmark KR, Orton EC, Mecham RP. Regulation of collagen production by medial smooth muscle cells in hypoxic pulmonary hypertension. Am Rev Respir Dis. 1989 Oct; 140(4):1045-51. PMID: 2478055.
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    194. Noguchi A, Reddy R, Kursar JD, Parks WC, Mecham RP. Smooth muscle isoactin and elastin in fetal bovine lung. Exp Lung Res. 1989 Jul; 15(4):537-52. PMID: 2767003.
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    195. Badesch DB, Lee PD, Parks WC, Stenmark KR. Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells. Biochem Biophys Res Commun. 1989 Apr 14; 160(1):382-7. PMID: 2653320.
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    196. Yeh H, Anderson N, Ornstein-Goldstein N, Bashir MM, Rosenbloom JC, Abrams W, Indik Z, Yoon K, Parks W, Mecham R. Structure of the bovine elastin gene and S1 nuclease analysis of alternative splicing of elastin mRNA in the bovine nuchal ligament. Biochemistry. 1989 Mar 21; 28(6):2365-70. PMID: 2543440.
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    197. Parks WC, Whitehouse LA, Wu LC, Mecham RP. Terminal differentiation of nuchal ligament fibroblasts: characterization of synthetic properties and responsiveness to external stimuli. Dev Biol. 1988 Oct; 129(2):555-64. PMID: 3417052.
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    198. Parks WC, Secrist H, Wu LC, Mecham RP. Developmental regulation of tropoelastin isoforms. J Biol Chem. 1988 Mar 25; 263(9):4416-23. PMID: 3346253.
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    199. Stenmark KR, Orton EC, Reeves JT, Voelkel NF, Crouch EC, Parks WC, Mecham RP. Vascular remodeling in neonatal pulmonary hypertension. Role of the smooth muscle cell. Chest. 1988 Mar; 93(3 Suppl):127S-133S. PMID: 3342691.
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    200. Mecham RP, Whitehouse LA, Wrenn DS, Parks WC, Griffin GL, Senior RM, Crouch EC, Stenmark KR, Voelkel NF. Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension. Science. 1987 Jul 24; 237(4813):423-6. PMID: 3603030.
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    201. Wrenn DS, Parks WC, Whitehouse LA, Crouch EC, Kucich U, Rosenbloom J, Mecham RP. Identification of multiple tropoelastins secreted by bovine cells. J Biol Chem. 1987 Feb 15; 262(5):2244-9. PMID: 2434478.
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    202. Parks WC, Drake RL. Insulin mediates the stimulation of pyruvate kinase by a dual mechanism. Biochem J. 1982 Nov 15; 208(2):333-7. PMID: 6760859.
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    203. Scolnick EM, Parks W, Kawakami T, Kohne D, Okabe H, Gilden R, Hatanaka M. Primate and murine type-C viral nucleic acid association kinetics: analysis of model systems and natural tissues. J Virol. 1974 Feb; 13(2):363-9. PMID: 4359298.
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