Kenichi Shimada

Title(s)Associate Adjunct Professor, Pediatrics
SchoolMedicine
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    1. Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation. Elife. 2025 Jun 24; 14. Nosaka N, Borges V, Martinon D, Crother TR, Arditi M, Shimada K. PMID: 40553503; PMCID: PMC12187133.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Interleukin-1 Signaling on Vascular Smooth Muscle Cells Accelerates Atherosclerosis in a Murine Model of Kawasaki Disease. J Am Heart Assoc. 2025 Jun 03; 14(11):e040687. Chen S, Savas A, Atici A, Lee Y, Lane M, Aubuchon E, Moreira D, Hsu-Wilbraham A, Shimada K, Crother TR, Noval Rivas M, Arditi M. PMID: 40417796; PMCID: PMC12229219.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation. bioRxiv. 2025 Apr 03. Nosaka N, Borges V, Martinon D, Crother TR, Arditi M, Shimada K. PMID: 40236184; PMCID: PMC11996356.
      View in: PubMed   Mentions:
    4. Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice. Circ Res. 2025 Apr 11; 136(8):e53-e72. Jena PK, Wakita D, Gomez AC, Carvalho TT, Atici AE, Aubuchon E, Narayanan M, Lee Y, Fishbein MC, Takasato Y, Kurashima Y, Kiyono H, Cani PD, de Vos WM, Underhill DM, Devkota S, Chen S, Shimada K, Crother TR, Arditi M, Noval Rivas M. PMID: 40026151; PMCID: PMC11985309.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Redundant role of PAD2 and PAD4 in the development of cardiovascular lesions in a mouse model of Kawasaki disease vasculitis. Clin Exp Immunol. 2024 Nov 12; 218(3):314-328. Domiciano TP, Lee Y, Carvalho TT, Wakita D, Martinon D, Jena PK, Fert-Bober J, Borges V, Crother TR, Chen S, Moreira D, Van Eyk JE, Noval Rivas M, Arditi M, Shimada K. PMID: 39250707; PMCID: PMC11557146.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. The intestinal microbiota contributes to the development of immune-mediated cardiovascular inflammation and vasculitis in mice. bioRxiv. 2024 Jun 02. Jena PK, Wakita D, Gomez AC, Carvalho TT, Atici AE, Narayanan M, Lee Y, Fishbein MC, Cani PD, de Vos WM, Underhill DM, Devkota S, Chen S, Shimada K, Crother TR, Arditi M, Rivas MN. PMID: 38853964; PMCID: PMC11160596.
      View in: PubMed   Mentions:
    7. Long-term Follow-up of Hand-degloving Injury Treated by Conventional Methods. Plast Reconstr Surg Glob Open. 2024 May; 12(5):e5777. Ishii H, Moriya K, Narisawa H, Tsubokawa N, Maki Y, Shimada K. PMID: 38699283; PMCID: PMC11062683.
      View in: PubMed   Mentions: 1  
    8. Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer. NPJ Breast Cancer. 2024 Jan 02; 10(1):2. Guerriero JL, Lin JR, Pastorello RG, Du Z, Chen YA, Townsend MG, Shimada K, Hughes ME, Ren S, Tayob N, Zheng K, Mei S, Patterson A, Taneja KL, Metzger O, Tolaney SM, Lin NU, Dillon DA, Schnitt SJ, Sorger PK, Mittendorf EA, Santagata S. PMID: 38167908; PMCID: PMC10761880.
      View in: PubMed   Mentions: 5  
    9. Nationwide time-series surveys of pressure ulcer prevalence in Japan. J Wound Care. 2022 Dec 01; 31(Sup12):S40-S47. Fact-finding Committee of the Japanese Society of Pressure Ulcers, Konya C, Takeuchi Y, Nakagami G, Kitamura A, Morita K, Ishizawa M, Abe Y, Higuchi H, Mizuki T, Motegi SI, Shoju S, Shimada K, Tanaka K, Kawakami S, Sanada H. PMID: 36475842.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Overexpressed angiotensin-converting enzyme in neutrophils suppresses glomerular damage in crescentic glomerulonephritis. Am J Physiol Renal Physiol. 2022 10 01; 323(4):F411-F424. Saito S, Tatsumoto N, Cao DY, Nosaka N, Nishi H, Leal DN, Bernstein E, Shimada K, Arditi M, Bernstein KE, Yamashita M. PMID: 35979968; PMCID: PMC9484997.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18). Marek-Iannucci S, Ozdemir AB, Moreira D, Gomez AC, Lane M, Porritt RA, Lee Y, Shimada K, Abe M, Stotland A, Zemmour D, Parker S, Sanchez-Lopez E, Van Eyk J, Gottlieb RA, Fishbein MC, Karin M, Crother TR, Rivas MN, Arditi M. PMID: 34403365; PMCID: PMC8492304.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    12. NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis. Circ Res. 2021 10 15; 129(9):e183-e200. Porritt RA, Zemmour D, Abe M, Lee Y, Narayanan M, Carvalho TT, Gomez AC, Martinon D, Santiskulvong C, Fishbein MC, Chen S, Crother TR, Shimada K, Arditi M, Noval Rivas M. PMID: 34517723; PMCID: PMC8555446.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    13. Publisher Correction: Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nat Metab. 2021 May; 3(5):728. Weng JH, Koch PD, Luan HH, Tu HC, Shimada K, Ngan I, Ventura R, Jiang R, Mitchison TJ. PMID: 33953392.
      View in: PubMed   Mentions: 1     Fields:    
    14. Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nat Metab. 2021 04; 3(4):513-522. Weng JH, Koch PD, Luan HH, Tu HC, Shimada K, Ngan I, Ventura R, Jiang R, Mitchison TJ. PMID: 33846641; PMCID: PMC8175070.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    15. Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model. Front Immunol. 2020; 11:554725. Tumurkhuu G, Chen S, Montano EN, Ercan Laguna D, De Los Santos G, Yu JM, Lane M, Yamashita M, Markman JL, Blanco LP, Kaplan MJ, Shimada K, Crother TR, Ishimori M, Wallace DJ, Jefferies CA, Arditi M. PMID: 33072095; PMCID: PMC7541920.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    16. Potential Fast COVID-19 Containment With Trehalose. Front Immunol. 2020; 11:1623. Martinon D, Borges VF, Gomez AC, Shimada K. PMID: 32733488; PMCID: PMC7358456.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsPHPublic Health
    17. Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation. Sci Rep. 2020 07 01; 10(1):10748. Stokes ME, Small JC, Vasciaveo A, Shimada K, Hirschhorn T, Califano A, Stockwell BR. PMID: 32612149; PMCID: PMC7329873.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Sex-Specific Effects of the Nlrp3 Inflammasome on Atherogenesis in LDL Receptor-Deficient Mice. JACC Basic Transl Sci. 2020 Jun; 5(6):582-598. Chen S, Markman JL, Shimada K, Crother TR, Lane M, Abolhesn A, Shah PK, Arditi M. PMID: 32613145; PMCID: PMC7315187.
      View in: PubMed   Mentions: 30  
    19. Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury. Front Immunol. 2020; 11:207. Nosaka N, Martinon D, Moreira D, Crother TR, Arditi M, Shimada K. PMID: 32117318; PMCID: PMC7033480.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    20. Dietary adzuki bean paste dose-dependently reduces visceral fat accumulation in rats fed a normal diet. Food Res Int. 2020 04; 130:108890. Han KH, Ohashi S, Sasaki K, Nagata R, Pelpolage S, Fukuma N, Reed JD, Shimada KI, Kadoya N, Fukushima M. PMID: 32156348.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation. Immunity. 2019 09 17; 51(3):508-521.e6. Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M. PMID: 31471109; PMCID: PMC6751009.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    22. Autophagy Limits Inflammasome During Chlamydia pneumoniae Infection. Front Immunol. 2019; 10:754. Crother TR, Porritt RA, Dagvadorj J, Tumurkhuu G, Slepenkin AV, Peterson EM, Chen S, Shimada K, Arditi M. PMID: 31031755; PMCID: PMC6473188.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Cell. 2019 05 02; 177(4):910-924.e22. Nakanishi M, Mitchell RR, Benoit YD, Orlando L, Reid JC, Shimada K, Davidson KC, Shapovalova Z, Collins TJ, Nagy A, Bhatia M. PMID: 30982595.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    24. Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis. J Am Coll Cardiol. 2019 03 19; 73(10):1149-1169. Onat UI, Yildirim AD, Tufanli Ö, Çimen I, Kocatürk B, Veli Z, Hamid SM, Shimada K, Chen S, Sin J, Shah PK, Gottlieb RA, Arditi M, Erbay E. PMID: 30871699; PMCID: PMC6424590.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    25. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018 11 20; 49(5):873-885.e7. Shimada K, Porritt RA, Markman JL, O'Rourke JG, Wakita D, Noval Rivas M, Ogawa C, Kozhaya L, Martins GA, Unutmaz D, Baloh RH, Crother TR, Chen S, Arditi M. PMID: 30366765; PMCID: PMC6260980.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    26. Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. Cell Metab. 2018 09 04; 28(3):432-448.e4. Tumurkhuu G, Dagvadorj J, Porritt RA, Crother TR, Shimada K, Tarling EJ, Erbay E, Arditi M, Chen S. PMID: 29937375; PMCID: PMC6125162.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    27. Optimal tube length of orotracheal intubation for mice. Lab Anim. 2019 Feb; 53(1):79-83. Nosaka N, Crother TR, Chen S, Arditi M, Shimada K. PMID: 29649932; PMCID: PMC6203655.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    28. Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis. J Am Coll Cardiol. 2018 04 10; 71(14):1553-1570. Chen S, Shimada K, Crother TR, Erbay E, Shah PK, Arditi M. PMID: 29622163; PMCID: PMC6042865.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells. Cell Chem Biol. 2018 05 17; 25(5):585-594.e7. Shimada K, Reznik E, Stokes ME, Krishnamoorthy L, Bos PH, Song Y, Quartararo CE, Pagano NC, Carpizo DR, deCarvalho AC, Lo DC, Stockwell BR. PMID: 29576531; PMCID: PMC5959763.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    30. The Japanese registry for surgery of ischial pressure ulcers: STANDARDS-I. J Wound Care. 2018 03 02; 27(3):174-183. Yanagi H, Terashi H, Takahashi Y, Okabe K, Tanaka K, Kimura C, Ohura N, Goto T, Hashimoto I, Noguchi M, Sasayama J, Shimada K, Sugai A, Tanba M, Nakayama T, Tsuboi R, Sugama J, Sanada H. PMID: 29509114.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017 07 27; 547(7664):453-457. Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL. PMID: 28678785; PMCID: PMC5667900.
      View in: PubMed   Mentions: 946     Fields:    Translation:HumansCells
    32. Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis. Sci Rep. 2017 02 02; 7:41539. Domiciano TP, Wakita D, Jones HD, Crother TR, Verri WA, Arditi M, Shimada K. PMID: 28148962; PMCID: PMC5288648.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    33. CD8+ T Cells Contribute to the Development of Coronary Arteritis in the Lactobacillus casei Cell Wall Extract-Induced Murine Model of Kawasaki Disease. Arthritis Rheumatol. 2017 Feb; 69(2):410-421. Noval Rivas M, Lee Y, Wakita D, Chiba N, Dagvadorj J, Shimada K, Chen S, Fishbein MC, Lehman TJ, Crother TR, Arditi M. PMID: 27696768; PMCID: PMC5274597.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    34. Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis. Circ Res. 2016 Sep 02; 119(6):e76-90. Tumurkhuu G, Shimada K, Dagvadorj J, Crother TR, Zhang W, Luthringer D, Gottlieb RA, Chen S, Arditi M. PMID: 27384322; PMCID: PMC5010464.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    35. Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell. 2016 Jul 28; 166(3):624-636. Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, Cho HC, Popescu NI, Coggeshall KM, Arditi M, Underhill DM. PMID: 27374331; PMCID: PMC5534359.
      View in: PubMed   Mentions: 304     Fields:    Translation:HumansAnimalsCells
    36. Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2016 05; 36(5):886-97. Wakita D, Kurashima Y, Crother TR, Noval Rivas M, Lee Y, Chen S, Fury W, Bai Y, Wagner S, Li D, Lehman T, Fishbein MC, Hoffman HM, Shah PK, Shimada K, Arditi M. PMID: 26941015; PMCID: PMC4850105.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    37. IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β. Arterioscler Thromb Vasc Biol. 2015 Dec; 35(12):2605-16. Lee Y, Wakita D, Dagvadorj J, Shimada K, Chen S, Huang G, Lehman TJ, Fishbein MC, Hoffman HM, Crother TR, Arditi M. PMID: 26515418; PMCID: PMC4662607.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    38. POPsicle for Fever! Cooling Down the Inflammasome. Immunity. 2015 Aug 18; 43(2):213-5. Shimada K, Crother TR, Arditi M. PMID: 26287676.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    39. Correction: Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration. PLoS One. 2015; 10(5):e0128735. Jones HD, Yoo J, Crother TR, Kyme P, Ben-Shlomo A, Khalafi R, Tseng CW, Parks WC, Arditi M, Liu GY, Shimada K. PMID: 25996479; PMCID: PMC4440726.
      View in: PubMed   Mentions: 2     Fields:    
    40. Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration. PLoS One. 2015; 10(4):e0123460. Jones HD, Yoo J, Crother TR, Kyme P, Ben-Shlomo A, Khalafi R, Tseng CW, Parks WC, Arditi M, Liu GY, Shimada K. PMID: 25875775; PMCID: PMC4395431.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    41. Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release. Immunity. 2015 Apr 21; 42(4):640-53. Dagvadorj J, Shimada K, Chen S, Jones HD, Tumurkhuu G, Zhang W, Wawrowsky KA, Crother TR, Arditi M. PMID: 25862090; PMCID: PMC4423803.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    42. Mast cells play an important role in chlamydia pneumoniae lung infection by facilitating immune cell recruitment into the airway. J Immunol. 2015 Apr 15; 194(8):3840-51. Chiba N, Shimada K, Chen S, Jones HD, Alsabeh R, Slepenkin AV, Peterson E, Crother TR, Arditi M. PMID: 25754739; PMCID: PMC4390505.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    43. A single infection with Chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in ApoE deficient mice. Cell Immunol. 2015 Mar; 294(1):25-32. Sorrentino R, Yilmaz A, Schubert K, Crother TR, Pinto A, Shimada K, Arditi M, Chen S. PMID: 25666507; PMCID: PMC4391498.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    44. Inflammation and pyroptosis mediate muscle expansion in an interleukin-1β (IL-1β)-dependent manner. J Biol Chem. 2015 Mar 06; 290(10):6574-83. Haldar S, Dru C, Choudhury D, Mishra R, Fernandez A, Biondi S, Liu Z, Shimada K, Arditi M, Bhowmick NA. PMID: 25596528; PMCID: PMC4358290.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    45. Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation. J Immunol. 2015 Feb 15; 194(4):1686-94. Tumurkhuu G, Dagvadorj J, Jones HD, Chen S, Shimada K, Crother TR, Arditi M. PMID: 25576596; PMCID: PMC4323992.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    46. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. PMID: 25262416; PMCID: PMC4201873.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    47. Incidence of lower eyelid complications after a transconjunctival approach: influence of repeated incisions. J Craniofac Surg. 2014 Jul; 25(4):1183-6. Yamashita M, Kishibe M, Shimada K. PMID: 25006893.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    48. Repair of orbital fracture: the antral balloon with implantable reservoir technique. J Craniofac Surg. 2014 Mar; 25(2):554-6. Yamashita M, Nishio A, Daizo H, Kishibe M, Shimada K. PMID: 24481163.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    49. The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):270-80. Jones HD, Crother TR, Gonzalez-Villalobos RA, Jupelli M, Chen S, Dagvadorj J, Arditi M, Shimada K. PMID: 24007300; PMCID: PMC3930947.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    50. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 Jan 16; 156(1-2):317-331. Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. PMID: 24439385; PMCID: PMC4076414.
      View in: PubMed   Mentions: 3368     Fields:    Translation:HumansAnimalsCells
    51. Three-dimensional computed tomography venography as a guide for cranioplasty in parietal cephalocele. J Craniofac Surg. 2014 Jan; 25(1):224-5. Yamashita M, Daizo H, Shimada K. PMID: 24406582.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    52. Intraoperative acquired pressure ulcer on lower lip: a complication of rhinoplasty. J Craniofac Surg. 2014 Jan; 25(1):e3-4. Yamashita M, Nishio A, Daizo H, Kishibe M, Shimada K. PMID: 24275776.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    53. Automatic volumetry of the cerebrospinal fluid space in idiopathic normal pressure hydrocephalus. Dement Geriatr Cogn Dis Extra. 2013 Jan; 3(1):489-96. Ishii K, Soma T, Shimada K, Oda H, Terashima A, Kawasaki R. PMID: 24516417; PMCID: PMC3919424.
      View in: PubMed   Mentions: 15  
    54. Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis. PLoS One. 2013; 8(10):e77447. Jupelli M, Shimada K, Chiba N, Slepenkin A, Alsabeh R, Jones HD, Peterson E, Chen S, Arditi M, Crother TR. PMID: 24204830; PMCID: PMC3808399.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    55. Plasmacytoid dendritic cells play a role for effective innate immune responses during Chlamydia pneumoniae infection in mice. PLoS One. 2012; 7(10):e48655. Crother TR, Ma J, Jupelli M, Chiba N, Chen S, Slepenkin A, Alsabeh R, Peterson E, Shimada K, Arditi M. PMID: 23119083; PMCID: PMC3485374.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    56. Innate immune responses to Chlamydia pneumoniae infection: role of TLRs, NLRs, and the inflammasome. Microbes Infect. 2012 Nov; 14(14):1301-7. Shimada K, Crother TR, Arditi M. PMID: 22985781; PMCID: PMC3511600.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    57. C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice. J Clin Invest. 2012 Sep; 122(9):3316-29. Kyme P, Thoennissen NH, Tseng CW, Thoennissen GB, Wolf AJ, Shimada K, Krug UO, Lee K, Müller-Tidow C, Berdel WE, Hardy WD, Gombart AF, Koeffler HP, Liu GY. PMID: 22922257; PMCID: PMC3428083.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    58. Marked acceleration of atherosclerosis after Lactobacillus casei-induced coronary arteritis in a mouse model of Kawasaki disease. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):e60-71. Chen S, Lee Y, Crother TR, Fishbein M, Zhang W, Yilmaz A, Shimada K, Schulte DJ, Lehman TJ, Shah PK, Arditi M. PMID: 22628430; PMCID: PMC3480341.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    59. Interleukin-1β is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease. Circulation. 2012 Mar 27; 125(12):1542-50. Lee Y, Schulte DJ, Shimada K, Chen S, Crother TR, Chiba N, Fishbein MC, Lehman TJ, Arditi M. PMID: 22361326; PMCID: PMC3337219.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    60. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012 Mar 23; 36(3):401-14. Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M. PMID: 22342844; PMCID: PMC3312986.
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    61. Phagosomal degradation increases TLR access to bacterial ligands and enhances macrophage sensitivity to bacteria. J Immunol. 2011 Dec 01; 187(11):6002-10. Wolf AJ, Arruda A, Reyes CN, Kaplan AT, Shimada T, Shimada K, Arditi M, Liu G, Underhill DM. PMID: 22031762; PMCID: PMC3221871.
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    62. Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis. 2012 Jan 01; 205(1):152-61. Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, Cooper AM, Yap GS, Arditi M, Shimada K, Duhadaway JB, Prendergast GC, Basaraba RJ, Mellor AL, Munn DH, Aliberti J, Karp CL. PMID: 21990421; PMCID: PMC3242739.
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    63. Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. PLoS One. 2011; 6(6):e21477. Shimada K, Crother TR, Karlin J, Chen S, Chiba N, Ramanujan VK, Vergnes L, Ojcius DM, Arditi M. PMID: 21731762; PMCID: PMC3121765.
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    64. Chlamydia pneumoniae infection induced allergic airway sensitization is controlled by regulatory T-cells and plasmacytoid dendritic cells. PLoS One. 2011; 6(6):e20784. Crother TR, Schröder NW, Karlin J, Chen S, Shimada K, Slepenkin A, Alsabeh R, Peterson E, Arditi M. PMID: 21695198; PMCID: PMC3112152.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    65. IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice. J Immunol. 2010 Nov 01; 185(9):5619-27. Chen S, Shimada K, Zhang W, Huang G, Crother TR, Arditi M. PMID: 20935201; PMCID: PMC3046880.
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    66. Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One. 2010 Sep 27; 5(9):e13027. Lowe EL, Crother TR, Rabizadeh S, Hu B, Wang H, Chen S, Shimada K, Wong MH, Michelsen KS, Arditi M. PMID: 20885960; PMCID: PMC2946405.
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    67. Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling. J Immunol. 2010 Jun 01; 184(11):6359-66. Gray P, Michelsen KS, Sirois CM, Lowe E, Shimada K, Crother TR, Chen S, Brikos C, Bulut Y, Latz E, Underhill D, Arditi M. PMID: 20435923; PMCID: PMC3057206.
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    68. Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses. Am J Respir Cell Mol Biol. 2010 Oct; 43(4):422-31. Sorrentino R, Gray P, Chen S, Shimada K, Crother TR, Arditi M. PMID: 19901344; PMCID: PMC2951872.
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    69. Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease. J Immunol. 2009 Oct 15; 183(8):5311-8. Schulte DJ, Yilmaz A, Shimada K, Fishbein MC, Lowe EL, Chen S, Wong M, Doherty TM, Lehman T, Crother TR, Sorrentino R, Arditi M. PMID: 19786535; PMCID: PMC3031986.
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    70. Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway. Infect Immun. 2009 Jul; 77(7):2683-90. Bulut Y, Shimada K, Wong MH, Chen S, Gray P, Alsabeh R, Doherty TM, Crother TR, Arditi M. PMID: 19398543; PMCID: PMC2708574.
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    71. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog. 2009 Apr; 5(4):e1000379. Shimada K, Chen S, Dempsey PW, Sorrentino R, Alsabeh R, Slepenkin AV, Peterson E, Doherty TM, Underhill D, Crother TR, Arditi M. PMID: 19360122; PMCID: PMC2660273.
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    72. Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. J Immunol. 2008 Nov 15; 181(10):7186-93. Chen S, Sorrentino R, Shimada K, Bulut Y, Doherty TM, Crother TR, Arditi M. PMID: 18981140; PMCID: PMC2662697.
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    73. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol. 2008 Nov 15; 181(10):7176-85. Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M. PMID: 18981139; PMCID: PMC2683843.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
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